• liver
  • A limited number of studies have reported associations of markers of liver injury, including elevated concentrations of aspartate aminotransferase (AST) and alanine aminotransferase (ALT), with prospective risk of type 2 diabetes. (diabetesjournals.org)
  • However, only one study has adjusted for a detailed measure of insulin sensitivity (insulin sensitivity index [ S i ]), which is important given associations of obesity and S i with nonalcoholic fatty liver disease (NAFLD). (diabetesjournals.org)
  • This hypothesis is supported by observational studies that have documented elevated prevalence rates of metabolic syndrome, IR, and/or type 2 diabetes among patients with NAFLD and NASH ( 8 , 9 ), as well as recent clinical trial data showing improvements in NASH and reductions in liver fat content after treatment with insulin-sensitizing agents, including the thiazolidinediones and metformin ( 10 - 13 ). (diabetesjournals.org)
  • Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. (sanger.ac.uk)
  • The purpose of this study is to understand the potential of a low sugar diet for the treatment of nonalcoholic fatty liver disease (NAFLD) in children. (clinicaltrials.gov)
  • Data from clinical studies also support an effect of metadoxine on reducing indices of liver cell necrosis and fat accumulation in alcoholic fatty liver. (wikipedia.org)
  • Unwanted side effects include dizziness, reversible cholestatic jaundice, pseudoallergic reaction, and elevated levels of liver enzymes (transaminases and gamma-glutamyltransferase). (wikipedia.org)
  • Epidemiologic
  • Epidemiologic study of the association of low-Km mitochondrial acetaldehyde dehydrogenase genotypes with blood pressure level and the prevalence of hypertension in a general population. (semanticscholar.org)
  • Epidemiologic studies have suggested that the lifetime risk of developing cholangiocarcinoma for a person with PSC is on the order of 10%-15%, although autopsy series have found rates as high as 30% in this population. (wikipedia.org)
  • Stroke
  • gamma-Glutamyltranspeptidase and incident stroke among Japanese men and women: the Circulatory Risk in Communities Study (CIRCS). (semanticscholar.org)
  • Relationship between blood pressure category and incidence of stroke and myocardial infarction in an urban Japanese population with and without chronic kidney disease: the Suita Study. (semanticscholar.org)
  • Although the reliability and validity of self-reported alcohol drinking habits, ie, the extent to which accurate information is provided by the respondent, has often been debated, 4 5 most studies on the relation of alcohol to stroke risk have relied on self-reported alcohol drinking. (ahajournals.org)
  • In the present article we report the results from the prospective study of a random sample of middle-aged Finnish people about the relation of self-reported alcohol drinking and serum GGT concentration to the risk of stroke. (ahajournals.org)
  • kidney
  • The study evaluated the nephroprotective potentials of methanolic extract (ME) and dichloromethane fraction (DCMF) of root-bark of Garcinia kola on gentamicin-induced nephrotoxicity in rats with a view to utilize the extracts of the root of G. Kola in the amelioration of antibiotic-induced kidney damage. (academicjournals.org)
  • participants
  • Our objective was to investigate the associations of elevated AST and ALT with incident type 2 diabetes among 906 participants in the Insulin Resistance Atherosclerosis Study who were nondiabetic at baseline. (diabetesjournals.org)
  • This study is currently recruiting participants. (clinicaltrials.gov)
  • Stable population consists of all ITT participants (received at least one injection of treatment) who had the same treatment group assignment in Study DFA102 and Study DFA102E, ie, ITT participants who were in Study DFA102 treatment groups Placebo, Pramlintide 360 + Metreleptin 1.25, Pramlintide 360 + Metreleptin 2.5 and Pramlintide 360 + Metreleptin 5.0. (clinicaltrials.gov)
  • vitro
  • An in vitro study showed that Acivicin at a concentration of 5 µM Acivicin inhibited by 78% the growth of human pancreatic carcinoma cells (MIA PaCa-2) after 72 hours in continuous culture. (wikipedia.org)
  • clinical
  • Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. (clinicaltrials.gov)
  • The remaining 8 patients not accounted for in the treated set were removed from all study analyses (explained in trial report) due to major good-clinical-practice violations at the site, and the inability to verify the validity of any patient level data. (clinicaltrials.gov)
  • type
  • The functional transcripts which have been fully characterized have been grouped and classified as type I gamma-glutamyltransferase. (wikipedia.org)
  • Clinically diagnosed cases of type 2 Diabetes Mellitus patients were included in the study with the age limit of 25-75 years. (ijpcr.com)
  • dose
  • The extract and DCMF did not elicit any adverse effect and a dose of 250 mg/kg bwt of ME and DCMF was selected for further studies. (academicjournals.org)
  • If Day 1 value was missing or after the first dose date of randomized study medication, the last available value on or prior to Day 1 was used. (clinicaltrials.gov)
  • Based on data from an exploratory pooled analysis of 70 patients who received the recommended dose of BLINCYTO in the Phase 1 or Phase 2 portions of the study, 27 patients (39 percent, 95 percent confidence interval [CI], 27-51 percent) achieved complete remission within the first two cycles. (prnewswire.com)
  • The recommended dose for this study was determined to be 5 μg/m 2 /day on Days 1-7 and 15 μg/m 2 /day on Days 8-28 for cycle 1, and 15 μg/m 2 /day on Days 1-28 for subsequent cycles. (prnewswire.com)
  • Phase I dose escalating studies conducted in 23 cancer patients administered acivicin with a concomitant 96-h i.v. infusion of a mixture of 16 amino acids showed reversible, dose-limiting CNS toxicity, characterized by lethargy, confusion and decreased mental status. (wikipedia.org)
  • dietary
  • However, it also highlights the need for more large-scale studies, including detailed dietary assessment to further advance the understanding of the impact of chrono-nutrition on public health. (cambridge.org)
  • high
  • Metadoxine is a selective antagonist of the serotonin receptor subtype 5-HT2B and displays high affinity to the gamma-aminobutyric acid (GABA) transporter. (wikipedia.org)
  • results
  • Study record managers: refer to the Data Element Definitions if submitting registration or results information. (clinicaltrials.gov)
  • In 2009, a Canadian-led group of investigators reported in the New England Journal of Medicine results from the first PBC genome-wide association study. (wikipedia.org)
  • examine
  • The purpose of the extension study is to examine the long-term (up to 1 year) safety, tolerability, and effect on body weight of treatment with pramlintide and metreleptin, administered as separate subcutaneous (SC) injections, in obese and overweight subjects. (clinicaltrials.gov)
  • metabolism
  • Chrono-nutrition involves studying the impact of nutrition on metabolism via circadian patterns, including three aspects of time: (ir)regularity, frequency and clock time. (cambridge.org)
  • medicine
  • Dr. Johnson had studied medicine at Howard University College of Medicine and faced substantial discrimination in his medical career, being turned away from active duty during the Battle of the Bulge, despite being a first lieutenant and trained physician. (wikipedia.org)
  • Molecular
  • This study showed that BLINCYTO can induce deep molecular remissions in children with highly refractory, multiply relapsed ALL," said senior author Lia Gore , M.D., professor of Pediatrics, Medical Oncology and Hematology, University of Colorado Anschutz Medical Campus. (prnewswire.com)
  • The name γ-glutamyltransferase is preferred by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology. (wikipedia.org)
  • research
  • Studying irregular meal patterns fits in with the latest research focusing not only on what people eat but also when they eat, also called chrono-nutrition. (cambridge.org)
  • To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. (clinicaltrials.gov)
  • extract
  • The study involved preparation of the extract, fractionation, phytochemical screening and evaluation of phenolics and flavonoid contents. (academicjournals.org)
  • The study concluded that, both the extract and fraction of G. kola root-bark elicited antioxidant and appreciable nephroprotective potentials. (academicjournals.org)
  • Upon studying calcium oxalate nucleation, ammi visnaga extract as a whole was shown to prolong nucleation time as well as change stone conformation, while khellin alone had no effect. (wikipedia.org)
  • data
  • 13 In the present study, data from the 3 areas and both study years are combined. (ahajournals.org)
  • The study is designed to provide long-term safety data for QVA149 in patients with moderate to severe chronic obstructive pulmonary disease (COPD). (clinicaltrials.gov)
  • Data from the '205 study were the basis of a supplemental Biologics License Application (sBLA) for BLINCYTO to include new data supporting the treatment of pediatric patients with Ph- relapsed or refractory B-cell precursor ALL. (prnewswire.com)
  • present
  • L-PGA is present in the diet and is produced endogenously by enzymatic conversion of gamma-glutamyl amino acids to L-PGA and free amino acids. (wikipedia.org)