Loading...
  • liver
  • A limited number of studies have reported associations of markers of liver injury, including elevated concentrations of aspartate aminotransferase (AST) and alanine aminotransferase (ALT), with prospective risk of type 2 diabetes. (diabetesjournals.org)
  • However, only one study has adjusted for a detailed measure of insulin sensitivity (insulin sensitivity index [ S i ]), which is important given associations of obesity and S i with nonalcoholic fatty liver disease (NAFLD). (diabetesjournals.org)
  • Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. (sanger.ac.uk)
  • Data from clinical studies also support an effect of metadoxine on reducing indices of liver cell necrosis and fat accumulation in alcoholic fatty liver. (wikipedia.org)
  • Unwanted side effects include dizziness, reversible cholestatic jaundice, pseudoallergic reaction, and elevated levels of liver enzymes (transaminases and gamma-glutamyltransferase). (wikipedia.org)
  • risk
  • gamma-Glutamyltranspeptidase and incident stroke among Japanese men and women: the Circulatory Risk in Communities Study (CIRCS). (semanticscholar.org)
  • Gamma-glutamyl transferase and metabolic risk factors for cardiovascular disease. (semanticscholar.org)
  • Researchers, analyzing previous studies on the link between coffee consumption and heart failure, found that moderate coffee drinking as part of a daily routine may be linked with a significantly lower risk of heart failure. (seniorjournal.com)
  • There are many factors that play into a person's risk of heart failure, but moderate coffee consumption doesn't appear to be one of them,' said Elizabeth Mostofsky, Sc.D., lead study author and research fellow at Beth Israel. (seniorjournal.com)
  • Habitual coffee consumption is also associated with a lower risk of type 2 diabetes, with most studies showing the greatest reduction in risk with higher levels of coffee consumption. (seniorjournal.com)
  • OBJECTIVE -To investigate the association between serum γ-glutamyltransferase (GGT) and risk of metabolic syndrome and type 2 diabetes in Japanese male office workers. (diabetesjournals.org)
  • Methods -A prospective cohort study of 14 874 Finnish men and women aged 25 to 64 years who participated in a cardiovascular risk-factor survey in 1982 or 1987. (ahajournals.org)
  • Several studies have suggested a protective effect of intake of whole grains, but not refined grains on type 2 diabetes risk, but the dose-response relationship between different types of grains and type 2 diabetes has not been established. (springer.com)
  • We searched the PubMed database for studies of grain intake and risk of type 2 diabetes, up to June 5th, 2013. (springer.com)
  • Inverse associations were observed for subtypes of whole grains including whole grain bread, whole grain cereals, wheat bran and brown rice, but these results were based on few studies, while white rice was associated with increased risk. (springer.com)
  • Only few cross-sectional studies and prospective cohort studies were identified, and most of these suggested that eating meals irregularly is associated with a higher risk of the metabolic syndrome and cardiometabolic risk factors, including BMI and blood pressure. (cambridge.org)
  • This was supported by two randomised controlled intervention studies showing that consuming meals regularly for 2 weeks v. an irregular meal pattern, led to beneficial impact on cardiometabolic risk factors as lower peak insulin, lower fasting total and LDL-cholesterol, both in lean and obese women. (cambridge.org)
  • HIV infection was also identified in one study as a potential risk factor for cholangiocarcinoma, although it was unclear whether HIV itself or other correlated and confounding factors (e.g. hepatitis C infection) were responsible for the association. (wikipedia.org)
  • substantial
  • Dr. Johnson had studied medicine at Howard University College of Medicine and faced substantial discrimination in his medical career, being turned away from active duty during the Battle of the Bulge, despite being a first lieutenant and trained physician. (wikipedia.org)
  • type
  • RESEARCH DESIGN AND METHODS -The 15 original prospective cohort studies that were included comprise 11,959 incident cases of type 2 diabetes in 369,862 individuals who, on average, were followed for 12 years. (diabetesjournals.org)
  • Using a modified NCEP definition with BMI instead of waist circumference, we examined the association of serum GGT with metabolic syndrome and type 2 diabetes (as diagnosed with the 1997 revised criteria of the American Diabetes Association [ 18 ] for epidemiological studies) in Japanese male office workers and performed a longitudinal study to prospectively examine the association of serum GGT with the development of metabolic syndrome and type 2 diabetes. (diabetesjournals.org)
  • The functional transcripts which have been fully characterized have been grouped and classified as type I gamma-glutamyltransferase. (wikipedia.org)
  • Stroke
  • Relationship between blood pressure category and incidence of stroke and myocardial infarction in an urban Japanese population with and without chronic kidney disease: the Suita Study. (semanticscholar.org)
  • kidney
  • The study evaluated the nephroprotective potentials of methanolic extract (ME) and dichloromethane fraction (DCMF) of root-bark of Garcinia kola on gentamicin-induced nephrotoxicity in rats with a view to utilize the extracts of the root of G. Kola in the amelioration of antibiotic-induced kidney damage. (academicjournals.org)
  • vitro
  • An in vitro study showed that Acivicin at a concentration of 5 µM Acivicin inhibited by 78% the growth of human pancreatic carcinoma cells (MIA PaCa-2) after 72 hours in continuous culture. (wikipedia.org)
  • high
  • Metadoxine is a selective antagonist of the serotonin receptor subtype 5-HT2B and displays high affinity to the gamma-aminobutyric acid (GABA) transporter. (wikipedia.org)
  • Results
  • Study record managers: refer to the Data Element Definitions if submitting registration or results information. (clinicaltrials.gov)
  • In 2009, a Canadian-led group of investigators reported in the New England Journal of Medicine results from the first PBC genome-wide association study. (wikipedia.org)
  • Research
  • While there is a commonly held belief that regular coffee consumption may be dangerous to heart health, our research suggests that the opposite may be true,' said Murray Mittleman, M.D., Dr.P.H., senior study author and director of the Cardiovascular Epidemiology Research Unit at Beth Israel Deaconess Medical Center in Boston. (seniorjournal.com)
  • Studying irregular meal patterns fits in with the latest research focusing not only on what people eat but also when they eat, also called chrono-nutrition. (cambridge.org)
  • metabolism
  • Chrono-nutrition involves studying the impact of nutrition on metabolism via circadian patterns, including three aspects of time: (ir)regularity, frequency and clock time. (cambridge.org)
  • Cohort
  • The LIFE-Adult-Study is a population-based cohort study, which has recently completed the baseline examination of 10,000 randomly selected participants from Leipzig, a major city with 550,000 inhabitants in the east of Germany. (beds.ac.uk)
  • We included observational studies (cohort, case-control and cross-sectional studies) carried out in children or adults, measuring urinary BPA (uBPA), including at least 100 participants and published in English. (beds.ac.uk)
  • Given the potential importance for public health, prospective cohort studies with proper adjustment for dietary characteristics and identification of critical windows of exposure are urgently needed to further improve knowledge about potential causal links between BPA exposure and the development of chronic disease. (beds.ac.uk)
  • Dose
  • Phase I dose escalating studies conducted in 23 cancer patients administered acivicin with a concomitant 96-h i.v. infusion of a mixture of 16 amino acids showed reversible, dose-limiting CNS toxicity, characterized by lethargy, confusion and decreased mental status. (wikipedia.org)
  • evaluate
  • This study aimed to evaluate the clinical, haematological and biochemical responses to autologous blood transfusion and the feasibility of this practice in sheep. (biomedcentral.com)
  • Considering the lack of studies related to the use of autologous blood transfusions in sheep, as well as the possible clinical, haematological and biochemical changes caused by this therapeutic practice, coupled with the possible contribution of the technique in veterinary medicine surgical interventions, this study aimed to evaluate the clinical, haematological and biochemical responses of sheep undergoing autologous blood transfusions. (biomedcentral.com)
  • Thus, the aim of this study was to evaluate the conversion effect to everolimus (EVR) on HCV in adult kidney recipients. (bjn.org.br)
  • pregnancy
  • Popular belief - dating to a 1966 Masters and Johnson study - stated that pre-ejaculate may contain sperm that can cause pregnancy, which is a common basis of argument against the use of coitus interruptus (withdrawal) as a contraceptive method. (wikipedia.org)
  • Literature
  • The aim of the present study was to review the epidemiological literature on the relation between BPA exposure and the risk of cardiometabolic disorders. (beds.ac.uk)
  • further
  • Further study of these taxa is warranted and may lead to new therapeutic approaches to prevent periodontal disease. (wikipedia.org)
  • research
  • The study is conducted by the Leipzig Research Centre for Civilization Diseases (LIFE). (beds.ac.uk)
  • To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. (clinicaltrials.gov)
  • Importantly, though, no high-quality research studies of the effects of the drug in pregnant women were conducted. (wikipedia.org)
  • phase
  • Data from a large international, randomized, placebo-controlled, double-blind phase III study (IBIS-II) supports the use of anastrozole in the prevention of breast cancer in high-risk postmenopausal women [Cuzick . (drugs.com)
  • medicine
  • Dr. Johnson had studied medicine at Howard University College of Medicine and faced substantial discrimination in his medical career, being turned away from active duty during the Battle of the Bulge, despite being a first lieutenant and trained physician. (wikipedia.org)
  • specific
  • We were able to conduct outcome-specific meta-analyses including 12 studies. (beds.ac.uk)
  • Later experimental gingivitis studies, using culture, provided more information regarding the specific bacterial species present in plaque. (wikipedia.org)
  • drug
  • The three deaths in each of the two drug treatment arms and the single death in the placebo arm of the study were believed to be due to the natural course of the disease. (wikipedia.org)
  • In drug studies, cefovecin administered to dogs was 92.4% effective against skin infections (secondary superficial pyoderma, abscesses, and infected wounds). (wikipedia.org)
  • years
  • The study covers a main age range from 40-79 years with particular deep phenotyping in elderly participants above the age of 60. (beds.ac.uk)
  • blood
  • The aim of the study is to assess the beneficial effect of the short term consumption of the highly mineralized bicarbonated sodium water on blood lipid parameters compared to a low mineralized water. (clinicaltrials.gov)
  • independent
  • In 2012, two independent PBC association studies increased the total number of genomic regions associated to 26, implicating many genes involved in cytokine regulation such as TYK2, SH2B3 and TNFSF11. (wikipedia.org)