Studies human retrovirus htlv ii antigens. Medical search. Frequent questions

HTLV-1 may be the etiological agent of adult T-cell leukemia/lymphoma (ATL), an extremely ASP9521 intense T-cell malignancy (evaluated in guide 43). (arcticcirclescotland.com)
Adult T-cell leukemia/lymphoma (ATLL) is a rare and aggressive disease caused by human T-cell lymphotropic virus type 1 that predominantly affects Japanese and Caribbean populations. (oncotarget.com)

A previous finding of antibodies against BLV in humans led us to examine the possibility of human infection with BLV. (cdc.gov)
This study could not determine whether the antibodies were a response to infection or merely to heat-inactivated BLV consumed in food products. (cdc.gov)
The finding of antibodies to BLV in humans prompted us to investigate human tissues for evidence of infection with BLV by using liquid-phase PCR (L-PCR), sequencing, in situ PCR, and immunohistochemical (IHC) testing. (cdc.gov)
Tests to detect antibody to HTLV-III will be licensed and commercially available in the United States in the near future to screen blood and plasma for laboratory evidence of infection with the virus. (cdc.gov)
Data regarding the interval between infection with HTLV-III and seroconversion are limited. (cdc.gov)
Nonetheless, currently available ELISA tests can be expected to identify most persons with HTLV-III infection. (cdc.gov)
Since the JHK-3 cell line also contains Epstein-Barr virus DNA and nuclear antigen and a 196-nm viral particle of unusual morphology, this particle will be identified and its relationship determined, if any, to JHK viral infection. (ncf-net.org)
On the other hand, zero of six rabbits inoculated with 729.ACH.p13 cells didn't create viral infection, whereas six of six rabbits inoculated with wild-type HTLV-1-expressing cells (729.ACH) were contaminated seeing that measured by antibody replies, proviral fill, and HTLV-1 p19 matrix antigen creation from former mate vivo-cultured PBMC. (arcticcirclescotland.com)
Human immunodeficiency virus (HIV) infection results from 1 of 2 similar retroviruses (HIV-1 and HIV-2) that destroy CD4+ lymphocytes and impair cell-mediated immunity, increasing risk of certain infections and cancers. (msdmanuals.com)
HIV infection can be diagnosed by antibody, nucleic acid (HIV RNA), or antigen (p24) testing. (msdmanuals.com)
Human Immunodeficiency Virus (HIV) Infection in Infants and Children Human immunodeficiency virus (HIV) infection is caused by the retrovirus HIV-1 (and less commonly by the related retrovirus HIV-2). (msdmanuals.com)
Moreover, The use of animals as surrogate rine host, can provide a platform for animal models for tumour viruses in hosts for the study of human tu- in vivo infection. (who.int)
Infection of human brain cells by HIV-1: restricted virus production in chronically infected human glial cell lines. (microbiologyresearch.org)
Rickinson, A.B. and Moss, D.J. (1997) Human Cytotoxic T Lymphocyte Responses to Epstein-Barr Virus Infection. (scirp.org)
Further screening of brain samples, virus isolation, and infection studies are needed to estimate the significance of these findings and the causative association of BoRV CH15 with neurological disease and encephalitis in cattle. (biomedcentral.com)

The pathogen is certainly connected with lymphocyte-mediated inflammatory illnesses also, such HTLV-1-linked myelopathy-tropical spastic paraparesis (16, 24, 27). (arcticcirclescotland.com)
p13II mRNA is certainly expressed in a variety of HTLV-1-contaminated cell lines isolated from scientific sufferers of ATL and HTLV-1-linked myelopathy-tropical spastic paraparesis (5, 36), and circulating cytotoxic lymphocytes particular to ORF II items (i.e., p13II and p30II) have already been discovered both in HTLV-1-contaminated ATL sufferers and in asymptomatic people (34). (arcticcirclescotland.com)

In these studies no antibodies against BLV were detected, prompting Burridge to conclude in his review article, "There is no epidemiological or serological evidence from human studies to indicate that BLV can infect man" ( 5 ). (cdc.gov)
The advent of immunoblotting, ≈100 times more sensitive than techniques of the 1970s ( 6 ), enabled the detection of antibodies reactive with recombinant purified BLV p24 capsid protein in serum samples from 39% of 257 self-selected human volunteers ( 7 ). (cdc.gov)
The ELISA test has been used in many research programs for detecting antibodies to HTLV-III in patients with AIDS and with AIDS-related conditions. (cdc.gov)
Thomas A. Waldmann (21 September 1930 - 25 September 2021) was an American immunologist who has worked on therapeutic monoclonal antibodies to the IL-2 receptor, Interleukin 15 (IL-15), and Adult T-cell Leukemia (ATL). (wikipedia.org)
and human T -cell antigens recognized by certain monoclonal antibodies on both immature and mature T -cells. (science-connections.com)
This study aimed to assess the seroprevalence and correlates of HBV, HCV, HDV, and HTLV 1&2 antibodies among MSM in Ouagadougou, Burkina Faso. (biomedcentral.com)
Anti-HTLV 1&2 antibodies were found in 4.0% (95% CI: 2.3-6.8) of MSM. (biomedcentral.com)
Presence of anti-HTLV 1&2 antibodies was associated with history of genital or anal lesions and injection drug use. (biomedcentral.com)
This study aimed to assess the seroprevalence and correlates of hepatitis B, C and D virus and anti-HTLV 1&2 antibodies among MSM, a high-risk population in Burkina Faso. (biomedcentral.com)
Positive for antibodies against HIV or HTLV-1 7. (mycancergenome.org)

In relation to "CFS", the most-studied viruses have been the Epstein-Barr Virus (EBV) and the Human Herpes Virus-6 (HHV-6). (investinme.org)
In relation to "pure" ME, the most studied viruses (and for which there is extensive evidence) have been the enteroviruses, usually Coxsackie B (CBV). (investinme.org)
Since several animal RNA tumor viruses (Klein 1980) and cells of the putative human retroviruses isolated to date (Bronson et al. (science-connections.com)
Studies on community-acquired pneumonias consistently demonstrate viruses to be the second most common etiologic cause (behind Streptococcus pneumoniae ), ranging from 13-50% of diagnosed cases. (medscape.com)
Men who have sex with men (MSM) are considered to be at significant risk for sexually transmitted infections (STI) and bloodborne viruses including viral hepatitis types B, C, and D (HBV, HCV, and HDV) and human T-cell leukemia virus types 1 and 2 (HTLV 1&2). (biomedcentral.com)
These viruses, called human T-cell leukaemia/lymphoma virus type III (HTLV-III) and AIDS-associated retrovirus (ARV), seem to have many characteristics in common with LAV and probably represent independent isolates of the LAV prototype. (pasteur.fr)
Retroviruses are enveloped RNA viruses defined by their mechanism of replication via reverse transcription to produce DNA copies that integrate into the host cell's genome. (msdmanuals.com)
This Journal welcomes basic research as well as pre-clinical and clinical studies of novel diagnostic tools, vaccines, anti-viral therapies and considers articles on all aspects of human viruses and retrovirus research. (medcraveonline.com)
One exception is hu- humanized SCID mice, the use of al oncogenic viruses that are strictly man T-cell lymphotropic virus type 1 surrogate hosts has not proven very species-specific, causing cancer in (HTLV-1): in addition to its ability to useful for defining tumour site con- humans only. (who.int)
Animal models for human tumour mental animals is not easy to answer does induce adult T-cell leukaemia/ viruses that make use of animal virus- for these agents, because cancer bi- lymphoma (ATLL), albeit in monkeys es are scarce. (who.int)
For other human tumour virus- primate species are related to the hu- tween data in humans and in experi- es, the use of humanized severe man tumour viruses, the incidence of mental animals is not obvious. (who.int)
Human Coronaviruses and Other Respiratory Viruses: Underestimated Opportunistic Pathogens of the Central Nervous System? (mdpi.com)
Respiratory viruses infect the human upper respiratory tract, mostly causing mild diseases. (mdpi.com)
The majority of emerging infectious diseases in humans are of animal origin, and many of them are caused by neuropathogenic viruses. (biomedcentral.com)
Retroviruses are single-stranded positive-sense RNA viruses that incorporate their genomes as proviruses into host chromosomal genomes after reverse transcription to cDNA. (biomedcentral.com)

However, unlike other oncogenic retroviruses, deltaretroviruses have an additional region, tax (trans-activating region of the X gene), which has regulatory functions and is oncogenic to host cells. (cdc.gov)
For instance, mice are able to reconstitute most lymphomas in monkeys and humans woodchuck hepatitis virus induces major components of the human provides strong support for a direct hepatocellular carcinoma (HCC) haematolymphoid system including oncogenic role of EBV in vivo. (who.int)
McLaughlin-Drubin, M.E. and Munger, K. (2009) Oncogenic Activities of Human Papillomaviruses. (scirp.org)

If the evidence obtained substantiates its novelty, additional goals will include exploring in depth its biology and molecular genetics and establishing its possible relationship to human disease, especially chronic fatigue immune deficiency syndrome (CFIDS), leukemia, and lymphoma. (ncf-net.org)
The treatment of HTLV-1+ lymphoma T-cells with either oleandrin or a N. oleander extract did not significantly inhibit viral replication or the release of p19Gag-containing particles into the culture supernatants. (longdom.org)
We therefore investigated whether oleandrin or a N. oleander extract could inhibit virus transmission from a GFP-expressing HTLV-1+ lymphoma T-cell-line to huPBMCs in co-culture assays. (longdom.org)

Nora Chapman et al from the Enterovirus Research Laboratory, Department of Pathology and Microbiology, University of Nebraska Medical Centre, have shown that human enteroviruses Coxsackie B can naturally delete sequence from the 5' end of the RNA genome and that this deletional mechanism results in long-term viral persistence, which has substantially altered the previously held view (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2440640/?tool=pubmed). (investinme.org)
This present study describes the development and use of sensitive PCR and RT-PCR assays to test DNA and RNA from 589 PCa tumor samples obtained from the Charité hospital in Berlin (Germany) for the presence of proviral XMRV DNA and corresponding viral transcripts. (biomedcentral.com)
Epidemiological studies indicate that semen, cervical and vaginal secretions, breast milk, and blood and blood products are the predominant, if not exclusive, vehicles for viral transmission (Staprans and Feinberg 1997). (health.am)
However, neither rFWPV nor rVV were able to express transgenes under the control of late viral promoters, indicating that both rFWPV and rVV infections are arrested at an early stage in human DCs. (lookformedical.com)
Latest research reveal a substantial function for HTLV-1 accessories proteins in the entire lifestyle routine of HTLV-1, particularly through the early stage from the viral infections of lymphocytes (evaluated in sources 12, 28, and 32). (arcticcirclescotland.com)
Although initial research reported that HTLV-1 ORF II was dispensable for viral infections in vitro (15, 37), disruption of pX ORF II within an HTLV-1 proviral clone that blocks appearance of full-length p30II by itself or both p30II and p13II significantly decreased viral infectivity and web host humoral response in rabbits (2, 39). (arcticcirclescotland.com)
These scholarly studies, however, still left open up the relevant issue from the function of p13IWe by itself in viral infectivity in vivo. (arcticcirclescotland.com)
The viral genome is longer than any other human retroviral genome (9.1-9.2 kilobases). (pasteur.fr)
Unlike HIV-1, extracellular HTLV-1 particles are poorly infectious and viral transmission typically occurs via direct intercellular interactions across a virological synapse. (longdom.org)
Inoculation with a high dose strains of LMP1 transgenic mice vide a powerful tool in mechanistic of EBV caused a B-cell lymphopro- were established that express LMP1 studies on the role of individual viral liferative disorder in these mice, under the control of the immunoglob- genes in cancer. (who.int)
Despois de entraren na célula diana, o xenoma de ARN viral convértese (por reversotranscrición ) en ADN bicatenario pola acción do encima codificado no virus transcriptase inversa que se transporta en forma de encima xa formado dentro da partícula vírica, xunto co propio xenoma. (wikipedia.org)

The antibody tests are modifications of the enzyme-linked immunosorbent assay (ELISA), which uses antigens derived from whole disrupted HTLV-III (5). (cdc.gov)
In different studies, HTLV-III antibody was found to range from 68% to 100% of patients with AIDS, and in 84%-100% of persons with related conditions, such as unexplained generalized lymphadenopathy (5-7). (cdc.gov)
In contrast to the above groups, HTLV-III antibody has been detected in fewer than 1% of persons with no known risks for AIDS (4-10). (cdc.gov)
Additionally, a recent study described several asymptomatic individuals infected with HTLV-III for more than 6 months in the absence of detectable antibody (17,18). (cdc.gov)
HTLV-III has been isolated from blood, semen, and saliva and has been recovered from many individuals in the presence of antibody (19,20). (cdc.gov)
He defined the IL-2 receptor subunits IL-2R beta and IL-2R alpha using the first reported anticytokine monoclonal antibody (anti-Tac) leading to the definition of the IL-2R alpha as a target for the therapy of leukemia and autoimmune diseases. (wikipedia.org)
A monoclonal antibody (anti-Tac) reactive with activated and functionally mature human T cells. (wikipedia.org)
In this investigation a human RCC tissue microarray (TMA) (n=374) predominantly consisting of the most common histological tumor subtypes was hybridized with an ERV-K env antibody and correlated with patient clinical data. (frontiersin.org)
In this study, we analyzed four trades of rapid tests (OnSite Chagas Ab Combo Rapid Test-United States, SD Bioline Chagas AB-United States, WL Check Chagas-Argentina, and TR Chagas Bio-Manguinhos-Brazil) using a panel of 190 samples, including sera from 111 infected individuals, most of whom had low T. cruzi antibody levels. (bvsalud.org)

Our data will be the first to point the fact that HTLV-1 mitochondrion-localizing proteins p13II comes with an important biological function through the early stage of virus infections in vivo. (arcticcirclescotland.com)
Individual T-lymphotropic pathogen type 1 (HTLV-1) is certainly classified being a complicated retrovirus and an associate from the genus as well as the 3 lengthy terminal do it again that encodes the regulatory proteins Taxes and Rex, aswell as several non-structural accessories proteins, p12I, p27I, p13II, and p30II (12, 16, 28, 30). (arcticcirclescotland.com)
Much less is well known about the accessories proteins p13II, a singly spliced item of the next open reading body (ORF II) from the pX gene area. (arcticcirclescotland.com)
Mechanism of action of regulatory proteins encoded by complex retroviruses. (microbiologyresearch.org)
This increased susceptibility to degradation of ws-PrP compared to the classical PrP may be due to an instability issue caused by glycosylation differences between the two proteins. (tam-receptor.com)

In contrast to normal T -cells, neoplastic mature T -cells respond directly to TCGF, requiring no prior lectin or antigen in vitro activation. (science-connections.com)
The botanical glycoside, oleandrin, derived from extracts of Nerium oleander , has previously been shown to reduce the levels of the gp120 envelope glycoprotein on human immunodeficiency virus type-1 (HIV-1) particles and inhibit HIV-1 infectivity in vitro . (longdom.org)
These results demonstrated that both oleandrin and the crude phytoextract inhibited the formation of virological synapses and the transmission of HTLV-1 in vitro . (longdom.org)
These in vitro, and their expression in these human tumour virus. (who.int)

In the early 80s Waldmann studied immunoglobulin gene rearrangement in and cell surface markers on acute lymphocyte leukemias. (wikipedia.org)
We then inserted the genes encoding lacZ, luciferase (luci), and envelope of human T-lymphotropic virus type 1 (HTLV-1 env) into the TK gene of CaPV to evaluate its suitability as an expression vector. (lookformedical.com)
Antigen gene transfer to cultured human dendritic cells using recombinant avipoxvirus vectors. (lookformedical.com)
In this report, the effects are assessed of two well-characterized antimicrobial amphipathic peptides (melittin and cecropin) on human immunodeficiency virus 1 (HIV-1) replication and gene expression in acutely infected cells at subtoxic concentrations. (microbiologyresearch.org)
HIV LTR activity was also reduced in human cells stably transfected with retroviral expression plasmids for the melittin or cecropin gene. (microbiologyresearch.org)

so far, however, only the human retroviruses human immunodeficiency virus (HIV) and human T-cell lymphotrophic virus type I (HTLV-I), the simian retroviruses, and coxsackievirus B have been etiologically connected with the disease. (medscape.com)

We therefore tested whether oleandrin or an extract from N. oleander could also inhibit the infectivity of the human T-cell leukemia virus type-1 (HTLV-1) -a related enveloped retrovirus and emerging tropical infectious agent. (longdom.org)
These findings prompted us to investigate whether oleandrin could similarly inhibit another related retrovirus, the HTLV-1. (longdom.org)

More than 20 million people are infected by HTLV 1&2 worldwide, and West Africa is considered a highly endemic area [ 23 ]. (biomedcentral.com)
HIV-1 causes most HIV infections worldwide, but HIV-2 causes a substantial proportion of infections in parts of West Africa. (msdmanuals.com)

In cattle, known retroviruses are bovine leukemia virus (BLV) of the genus Deltaretrovirus , bovine immunodeficiency virus (BIV) of the genus Lentivirus , and bovine foamy virus (BFV) of the genus Bovispumavirus [ 16 ]. (biomedcentral.com)

Although this virus has been given several names, including human T-lymphotropic virus type III (HTLV-III) (2), lymphadenopathy-associated virus (LAV) (3), and AIDS-associated retrovirus (ARV) (4), it is referred to as HTLV-III in this discussion. (cdc.gov)
Waldmann studied adult T-cell leukemia that develops in individuals infected with the retrovirus human T-cell lymphotropic virus-1 (HTLV-1). (wikipedia.org)
The causative agent of ATLL has been identified as the human T cell lymphotropic virus type 1 (HTLV-1) [ 2 - 4 ], which is endemic to Japan, the Caribbean islands, Central and South America, and parts of sub-Saharan Africa [ 5 ]. (oncotarget.com)

He demonstrated that it is bound to IL-15 R alpha on the surface of antigen presenting cells and presented in trans to T-cells in an immune synapse. (wikipedia.org)
Research has intensified to understand ERV protein function and their role as tumor antigens and targets for cancer (immune) therapy. (frontiersin.org)
In people with sIBM, the muscle cells display "flags" telling the immune system that they are infected or damaged (the muscles ubiquitously express MHC class I antigens) and this immune process leads to the death of muscle cells. (wikidoc.org)
Advances in understanding the role of dendritic cells (DCs) as the major antigen (Ag)-presenting cell type of the immune system combined with the recent development of methods for the ex vivo expansion of human DCs have opened the possibility for the transfer of tumor Ags to DCs with a view toward tumor immunotherapy. (lookformedical.com)
Lymphadenopathy-associated virus (LAV) is a human retrovirus first isolated from a homosexual patient with lymphadenopathy syndrome, frequently a prodrome or a benign form of acquired immune deficiency syndrome (AIDS). (pasteur.fr)
This work led us to the conclusion that both the form and the method of delivery of specific antigens strongly affect the produced immune response. (cancer.gov)
In contrast, classical immune (type I/ II) cytokine receptors do not have intrinsic protein kinase activity but associate with the Janus family of kinases (JAKs). (openrheumatologyjournal.com)

Dr. Waldmann demonstrated that the HTLV-1 encoded protein Tax constitutively activates two autocrine (IL-2R/IL-2, IL-15R/IL-15) and one paracrine (IL-9) system. (wikipedia.org)
Predicated on the lengthy amount of and the reduced percentage of people ASP9521 who develop ATL latency, transformation of contaminated lymphocytes is thought to be initiated through the induction of mobile genes and modifications in mobile activation and loss of life pathways by HTLV-1 protein (18, 35). (arcticcirclescotland.com)
The major core protein of LAV is antigenically unrelated to other known retroviral antigens. (pasteur.fr)
Effects of the human immunodeficiency virus type 1 Tat protein on the expression of inflammatory cytokines. (microbiologyresearch.org)
Human immunodeficiency virus Vpr product is a virion-associated regulatory protein. (microbiologyresearch.org)

Introduction: tropical Spastic Paraparesis or HTLV-associated Myelopathy (HAM/TSP) is a chronic infectious and inflammatory disease that can interfere with various aspects of individuals life and, thereby alter their Quality of Life (QoL). (bvsalud.org)
Production of infectious, cell-free virus was inhibited in a dose-dependent manner, with ID 50 values in the range 0·9-1·5 μM for melittin and 2-3 μM for cecropin. (microbiologyresearch.org)

5% of these cattle, which are excluded from the market as a result ( 1 ), but BLV-infected lymphocytes are also found in the blood and milk of subclinically infected cows ( 2 ). (cdc.gov)
The root mechanisms where HTLV-1 establishes a continual infections and transforms lymphocytes continues HDAC9 to be extensively looked into but incompletely grasped. (arcticcirclescotland.com)
Cytotoxic effect on lymphocytes of Tat from human immunodeficiency virus (HIV-1). (microbiologyresearch.org)
Natural HIV-1 Nef accelerates virus replication in primary human lymphocytes. (microbiologyresearch.org)

In this study, we conducted a seroepidemiological survey to determine the prevalence and clinical profiles of CD in 217 individuals from an impoverished rural community in Southern Bahia, Brazil. (bvsalud.org)
The overall prevalence of CD in the studied community was 0.92%, detected through latent class analysis (LCA). (bvsalud.org)
This study shows that HBV, HCV and HTLV 1&2 prevalence among MSM in Burkina is high and suggests that comprehensive STI prevention and sexual health education services for this group are needed. (biomedcentral.com)

Paul Berg (US) for his fundamental studies of the biochemistry of nucleic acids, with particular regard to recombinant-DNA and Walter Gilbert (US) and Frederick Sanger (GB) for their contributions concerning the determination of base sequences in nucleic acids shared the Nobel Prize in Chemistry. (deltastate.edu)

[ 7 ] Os lentivirus teñen moitas morfoloxías e propiedades biolóxicas en común. (wikipedia.org)
Several retroviruses, including members of the genera Lentivirus , Gammaretrovirus , and Deltaretrovirus have been shown to cause disease in the CNS. (biomedcentral.com)

The salient features of our putative new virus must be compared with those of known retroviruses. (ncf-net.org)

In Sub-Saharan Africa, very few data exist on hepatitis B, C, and D as well as on HTLV 1&2 epidemiology among MSM. (biomedcentral.com)
Hepatitis C virus antigens enzyme immunoassay for one-step diagnosis of hepatitis C virus coinfection in human immunodeficiency virus infected individuals. (uc.edu)
that is histopathological y very simi- T cel s, B cel s, natural kil er cel s, LMP1 of EBV can transform ro- lar to that caused by hepatitis B vi- macrophages, and dendritic cells, dent fibroblasts and is expressed rus (HBV) in humans, but it does so and this humanized mouse model in most of the human cancers as- through a different mechanism. (who.int)
Hoang, H., Akihiro, T. and Norifumi, K. (2014) Role of Hepatitis B Virus DNA Integration in Human Hepatocarcinogenesis. (scirp.org)

He studied the IL-2/IL-2 receptor system in the growth of normal and neoplastic cells. (wikipedia.org)
He studied the role played by the receptor for interleukin-2 (IL-2) on the growth, differentiation and regulation of normal and neoplastic T-cells. (wikipedia.org)
A novel retrovirus, human T -celllymphomaleukemia virus (HTLV), has been isolated from the fresh and cultured cells of two of these patients. (science-connections.com)
Subsequent characterization of this virus has shown that it is not significantly related to any known animal retrovirus, is not an endogenous (genetically transmitted) virus of man, and so far has been associated only with fresh or cultured T -cells from patients with T -cell neoplasia. (science-connections.com)
These results suggest that HTLV infected some mature T -cells of some people and that it might be involved in some neoplasias involving these cells. (science-connections.com)
1975) have required the establishment of continuously growing cell lines from the disease of origin or cocultivation of these cells with previously established cell lines, the ability to grow malignant T -cells in long-term culture could facilitate the isolation of retroviruses from these diseased states. (science-connections.com)
Although there are many immunologic and cytochemical differences between mature hu man T- and B-Iymphocytes, human T -cells are primarily distinguished by their participation in cell mediated immunity and possession of receptors for sheep red blood cells. (science-connections.com)
The elaboration of immunoglobulins and presence of receptors for EBV are most characteristic of human B-cells. (science-connections.com)
Future long-range goals include the study of is (sic) molecular epidemiology, possibly oncogene involvement, and the role of cytokines and transforming or growth factors in JHK-infected cells. (ncf-net.org)
iv) reverse transcriptase: (v) infectivity for various somatic cells and (vi) reactivity with serum from J.H. and selected patients in order to help determine its possible role in humans disease. (ncf-net.org)
CD4+ T-cells and other lymphocyte subsets in persons infected with human immunodeficiency virus (HIV). (cdc.gov)
T-cell numbers were derived from three measurements deter- attributable to the decrease in the number of T cells that bear mined with two different instruments, a hematology analyzer the CD4 receptor ( 5-9 ). (cdc.gov)
In sporadic inclusion body myositis [MY-oh-sigh-tis] muscle, two processes, one autoimmune and the other degenerative, appear to occur in the muscle cells in parallel. (wikidoc.org)
The inflammation aspect is characterized by the cloning of T cells that appear to be driven by specific antigens to invade muscle fibers. (wikidoc.org)
Dalakas 2006, says "we can say that two processes, one autoimmune and the other degenerative, occur in the muscle cells in parallel. (wikidoc.org)
Dalakas 2006 suggests that a chain of events causes IBM -- some sort of virus, likely a retrovirus , triggers the cloning of T cells . (wikidoc.org)
These T cells appear to be driven by specific antigens to invade muscle fibers. (wikidoc.org)
Induction of CD8+ cytotoxic T cells is considered one of the important correlates for the protective efficacy of candidate human immunodeficiency virus type 1 (HIV-1) vaccines. (lookformedical.com)
A individual 729 B-cell range that expresses a molecular clone of HTLV-1 mutated to selectively ablate p13II appearance (729.ACH.p13) was produced and compared for infectivity with 729 B cells expressing the wild-type molecular clone (729.ACH). (arcticcirclescotland.com)
The steps in chemical metabolism within all the cells in the human body are mediated by specific enzymes that act as highly specialized chemical catalysts. (joessciencescorner.net)
However, the collected virus particles from treated cells exhibited reduced infectivity on primary human peripheral blood mononuclear cells (huPBMCs). (longdom.org)
Specific ablation of HIV-Tat expressing cells by conditionally toxic retroviruses. (microbiologyresearch.org)

Single-platform technology (SPT) is designed to enable de- system and managing the health care of persons infected with terminations of both absolute and percentage lymphocyte sub- human immunodeficiency virus (HIV) ( 1-4 ). (cdc.gov)
A canarypox vaccine expressing multiple human immunodeficiency virus type 1 genes given alone or with rgp120 elicits broad and durable CD8+ cytotoxic T lymphocyte responses in seronegative volunteers. (lookformedical.com)
Collectively, these observations indicate a definite function for p13II in HTLV-1 infections and a potential function in HTLV-1-mediated lymphocyte change. (arcticcirclescotland.com)

4) After stimulation with lipopolysaccharide and calcium ionophore A23187, culture supernatants of clones c18A and c29A showed cytotoxic activity against human melanoma A375 Met-Mix and other cell lines which were resistant to the tumor necrosis factor, lymphotoxin and interleukin 1. (comparewords.com)
Evidence points toward a T-cell-mediated cytotoxic process directed against unidentified muscle antigens. (medscape.com)

As part of this endeavor, we were studying the metabolism of immunoglobulin molecules. (nih.gov)

That recommendation was made to decrease the risk of AIDS associated with the administration of blood or blood products, which accounts for about 2% of all reported AIDS cases in the United States. (cdc.gov)
Evidence has shown that a newly recognized retrovirus is the cause of AIDS. (cdc.gov)
HTLV-III has been isolated from the blood of 85% or more of seropositive individuals with AIDS (21), lymphadenopathy, or other AIDS-associated conditions (2) and from three of four mothers of infants with AIDS (2). (cdc.gov)
AIDS-defining illnesses occurring in treatment-experienced HIV-1-infected persons followed in the ACTG Longitudinal Linked Randomized Trials (ALLRT) study [Abstract 1017]. (prelekara.sk)
The Human Retrovirus Section designed, developed and tested vaccines and immunotherapies for AIDS and cancer. (cancer.gov)
The Human Retrovirus Section focused on the development of innovative vaccines and immunotherapies for AIDS and cancer based on the understanding of basic mechanisms, and by combining our expertise in molecular biology, virology and immunology. (cancer.gov)

It would seem reasonable then to survey human T -cell malignancies for the presence of retroviruses. (science-connections.com)

ERVs and related sequences are estimated at ~400,000 copies or 4.6% of the human genome, including genomic proviruses like 5' long terminal repeat (LTR)-gag-pol-env-3' LTR ( 1 ). (frontiersin.org)

Serum specimens obtained were tested for the presence of HBV, HCV, HDV and HTLV-1&2 infections. (biomedcentral.com)

Concerns that this virus might infect humans through exposure to food products from subclinically infected animals prompted 10 studies that used what were then (1975-1979) state-of-the-art immunologic methods to test serum samples from a collective total of 1,761 humans, including cancer patients, farm workers, and veterinarians ( 5 ). (cdc.gov)
LacZ recombinant FWPV (rFWPV) was found subsequently to infect human DCs that had been cultured ex vivo from peripheral blood monocytes. (lookformedical.com)
For this reason, the infect humans, this virus can infect cordance between humans and ex- question about tumour site concor- several other species - including perimental animals. (who.int)

Cellular factors regulate transactivation of human immunodeficiency virus type 1. (microbiologyresearch.org)

Haller, K., Stubenrauch, F. and Pfister, H. (1995) Differentiation-Dependent Transcription of the Epidermodysplasia Verruciformis-Associated Human Papillomavirus Type 5 in Benign Lesions. (scirp.org)
Despite the roughly 60 type I/II cytokines discovered, there are only four members in the JAK kinase family. (openrheumatologyjournal.com)

this file supplies the natural data of preliminary experiments performed using 2 enzyme dilutions in order to discover out the dilution that greatest fitted with requirements 1 and 2 described in the outcomes portion of the manuscript (automated sugars releasing assay: substrate focus). (tam-receptor.com)

In previous studies from this laboratory "activated" (by lectins) lymphoblasts from either peripheral blood or bone marrow from normal human donors were grown continuously with TCGF. (science-connections.com)

Resistance assays fall into two classes: genotyping examines the virus for mutations known to confer drug resistance, whereas phenotyping tests the susceptibility of the patient's virus to specific medications. (health.am)
For several of the human tu- and various assays demonstrated an sues. (who.int)

Due to the close contact between farm animals and humans, pathogens are easily transmitted between these hosts. (biomedcentral.com)

Journal of Human Virology & Retrovirology (JHVRV) is a multi-disciplinary internationally reviewed and accepted open access Journal which covers the recent breakthrough discoveries in the field of human virology and retrovirology. (medcraveonline.com)

Through our study, it was possible to monitor individuals who were unaware of their clinical condition, thus improving their quality of life. (bvsalud.org)
A related focus area was the study of the biology and clinical applications of cytokines in vaccines and immunotherapies for cancer. (cancer.gov)
Indeed, a N. oleander -derived drug, PBI-05204, which contains oleandrin as a bioactive agent, has completed both Phase I and initial Phase II clinical trials to test its efficacy and safety in patients with advanced solid cancers [ 21 ]. (longdom.org)

Transfecting these cell lines with a codon optimized ERV-K113 env overexpressing CMV vector was performed with or without 5'-Aza-2'-deoxycytidine (Aza) treatment to sustain promoter de-methylation. (frontiersin.org)

We conclude that host range-restricted FWPV can be used efficiently to transfer Ag genes to human DCs ex vivo and may have a role in the development of tumor immunotherapy protocols. (lookformedical.com)

Our finding of BLV in human tissues indicates a risk for the acquisition and proliferation of this virus in humans. (cdc.gov)

The following is a direct quotation from the CRISP search: ' Abstract Grant Number: 3RO1A132710-0353 PI Name: Grossberg, Sidney E. PI Title Project Title: JHK VIRUS Abstract: our goal is to determine by morphologic, genetic, biochemical, and immulogic means whether the JHK virus, an enveloped virus, and enveloped, 80-nm, RNA virus produced constitutively by a B lymphoblastoid cell line established in our laboratory, is a new human retrovirus. (ncf-net.org)

Human molecular genetics. (psu.edu)

Anatomy30

Organisms39

Diseases17

Chemicals and Drugs97

Analytical, Diagnostic and Therapeutic Techniques and Equipment28

Phenomena and Processes46

Disciplines and Occupations1

Information Science4

Named Groups2

Health Care3

Geographicals1

Adult T-cell l2

Infection15

Myelopathy-tropical spastic par2

Antibodies10

Viruses15

Oncogenic3

Lymphoma3

Viral11

Antibody9

Proteins5

Vitro4

Gene5

Lymphotrophic virus1

Inhibit2

West Africa2

Bovine Leuke1

Lymphotropic3

Immune7

Protein5

Infectious2

Lymphocytes4

Prevalence3

Nucleic1

Lentivirus2

Putative1

Hepatitis4

Cells22

Lymphocyte3

Cytotoxic2

Immunoglobulin1

AIDS6

Malignancies1

Genome1

Presence1

Infect3

Immunodeficiency virus type1

Type2

Enzyme1

Peripheral blood1

Assays2

Pathogens1

Virology1

Clinical3

Promoter1

Genes1

Proliferation1

ABSTRACT1

Molecular1