• In molecular biology, the lipid-binding serum glycoproteins family, also known as the BPI/LBP/Plunc family or LBP/BPI/CETP family represents a family which includes mammalian lipid-binding serum glycoproteins and/or proteins containing a structural motif known as the BPI fold. (wikipedia.org)
  • It has been predicted that nearly half of all human proteins are glycosylated indicating the significance of glycoproteins in human health and disease. (firebaseapp.com)
  • Glycosylation, a post-translational modification affects the biophysical, functional and biochemical properties and provides structural complexity for these proteins. (amrita.edu)
  • SCOP: Structural Classification of Proteins and ASTRAL. (berkeley.edu)
  • However, analogous proteins may have structural homology although this is not a prerequisite. (hindawi.com)
  • The virion envelope surrounding the nucleocapsid contains the following structural proteins: S (spike), M (matrix), E (envelope) and N (nucleocapsid). (iucr.org)
  • The proteins produced from these genes are pieces (subunits) of a protein complex called glycoprotein (GP)Ib-IX-V. This complex is found on the surface of platelets and plays an important role in blood clotting . (medlineplus.gov)
  • Table 1 lists the major structural proteins coded for by the HIV genome. (cdc.gov)
  • Cholesteryl ester transfer protein (CETP) is a glycoprotein that facilitates the transfer of lipids (cholesteryl esters and triglycerides) between the different lipoproteins that transport them through plasma, including HDL, LDL, VLDL and chylomicrons. (wikipedia.org)
  • Most previous structural studies on S protein have been conducted at pH 8.0, but knowledge of the conformational propensities under both physiological and endosomal pH conditions is important to inform vaccine development. (nih.gov)
  • Productive folding of the protein moiety is facilitated during this period by the calnexin/calreticulin cycle in mammalian cells, which relies on G1M9-specific lectin-type chaperones (calnexin and calreticulin) associated with the oxidoreductase ERp57, and UDP-glucose:glycoprotein glucosyltransferases 1 and 2, which are capable of re-adding glucose to M9 if the protein moiety is not yet folded. (elifesciences.org)
  • The structural biology laboratory utilises a variety of techniques including Protein Crystallography, Cryo-electron Microscopy and associated techniques such as Isothermal Titration Calorimetry, which are then combined with functional studies or serve as a basis for structure-based drug design. (nottingham.ac.uk)
  • A total of five major Open Reading Frames (ORF) were found in COVID-19: the ORF 1a/b region coding replicase and other enzymes, the spike or S protein ORF, M or membrane glycoprotein ORF, E or small membrane protein ORF and the N or nucleocapsid ORF ( fig. 1 )[ 5 ]. (ijpsonline.com)
  • The spike glycoprotein sequence was retrieved from protein data bank (PDB) database. (ijpsonline.com)
  • One of these structural changes altered the protein so that it could no longer function for viral resistance. (usda.gov)
  • The other structural change allowed normal viral resistance to occur but affected the shape of the protein on the surface of cells. (usda.gov)
  • Endoglycan, also named Podocalyxin-like 2 protein, is a type I transmembrane glycoprotein. (rndsystems.com)
  • The results of Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses suggested that glycoproteins are involved in various functions, such as the regulation of cell growth, cell adhesion, cellular component organization and protein binding, as well as multiple pathways, including p53, Notch and mTOR signaling pathways. (spandidos-publications.com)
  • SARS-CoV-2 spike glycoprotein mediates receptor binding and subsequent membrane fusion. (kcl.ac.uk)
  • abstract = "SARS-CoV-2 spike glycoprotein mediates receptor binding and subsequentmembrane fusion. (kcl.ac.uk)
  • Spike (S) glycoprotein of SARS-CoV2 exists chiefly in two conformations, open and closed. (nih.gov)
  • Spike glycoprotein (PDB Id: 6VSB) of the coronavirus was selected and analysed using immune epitope database server for prediction of potential immunogenic B and T-cell epitopes. (ijpsonline.com)
  • Contagious human coronavirus (SARS-CoV-2) binds to the receptors of human host cells by transmembrane spike glycoprotein that makes homotrimers protruding from viral surface region[ 9 , 10 ]. (ijpsonline.com)
  • Spike glycoprotein has two subunits, S1-responsible for its binding to host cell membrane receptors and S2-responsible for the fusion of viral and host cellular membrane[ 8 , 11 ]. (ijpsonline.com)
  • Tissue, cells or virus corresponding to Human coronavirus SARS-CoV-2 Spike Glycoprotein S1. (abcam.com)
  • Recombinant Anti-SARS-CoV-2 Spike Glycoprotein S1 antibody (ab273073) is a Human IgG1 Recombinant version of CR3022 for research use only. (abcam.com)
  • The viral envelope glycoprotein D from bovine herpesviruses 1 and 5 (BoHV-1 and -5), two important pathogens of cattle, is a major component of the virion and plays a critical role in the pathogenesis of herpesviruses. (biomedcentral.com)
  • DIVA vaccines include genetically engineered gene-deleted viruses, for example gE − virus, and subunit or vectored vaccines based on a viral envelope glycoprotein such as gD. (biomedcentral.com)
  • ii) Determination of the platelet receptor glycoprotein Ib extracellular domain and von Willebrand factor A1 domain structures (iii) determination of the coagulation factor xi structure. (nottingham.ac.uk)
  • Structural basis of the leukocyte integrin Mac-1 I-domain interactions with the platelet glycoprotein Ib. (nottingham.ac.uk)
  • Cauwenberghs N, Vanhoorelbeke K, Vauterin S, Deckmyn H. Structural determinants within platelet glycoprotein Ibalpha involved in its binding to von Willebrand factor. (medlineplus.gov)
  • Li R, Emsley J. The organizing principle of the platelet glycoprotein Ib-IX-V complex. (medlineplus.gov)
  • Clopidogrel selectively inhibits adenosine diphosphate (ADP) binding to platelet receptors and subsequent ADP-mediated activation of glycoprotein GPIIb/IIIa complex, thereby inhibiting platelet aggregation. (medscape.com)
  • Electrospray ionization-ion trap mass spectrometry effectively reveals the structural characterization of complex N-linked glycoprotein oligosaccharides, enabling detailed analysis of their linkages and structures. (consensus.app)
  • Electrospray ionization-ion trap mass spectrometry, with its capacity to perform multiple stages of fragmentation (MSn), is demonstrated as an effective method for the structural characterization of permethylated N-linked complex glycoprotein oligosaccharides. (consensus.app)
  • Characterization of the human cytomegalovirus envelope glycoproteins. (microbiologyresearch.org)
  • Inducing broad spectrum neutralizing antibodies against challenging pathogens such as HIV-1 is a major vaccine design goal, but may be hindered by conformational instability within viral envelope glycoproteins (Env). (ox.ac.uk)
  • Elucidation of the structural correlates of a cross-linked viral glycoprotein will allow more rational use of this methodology for vaccine design, and reveals a strategy with promise for eliciting neutralizing antibodies needed for an effective HIV-1 vaccine. (ox.ac.uk)
  • Glycoprotein D is essential for virus penetration into permissive cells and thus is a major target for virus neutralizing antibodies during infection. (biomedcentral.com)
  • Subunit, DNA and vectored vaccine candidates have been developed using this glycoprotein as the primary antigen, demonstrating that gD has the capacity to induce robust virus neutralizing antibodies and strong cell-mediated immune responses, as well as protection from clinical symptoms, in target species. (biomedcentral.com)
  • Structural flexibility of a conserved antigenic region in hepatitis C virus glycoprotein E2 recognized by broadly neutralizing antibodies. (ox.ac.uk)
  • UNLABELLED: Neutralizing antibodies (NAbs) targeting glycoprotein E2 are important for the control of hepatitis C virus (HCV) infection. (ox.ac.uk)
  • Neutralizing antibodies detect a disulfide-linked glycoprotein complex within the envelope of human cytomegalovirus. (microbiologyresearch.org)
  • Monoclonal antibodies to the FLAG epitope served to monitor cell surface expression for functional analysis of the BFIV21 class I glycoprotein. (usda.gov)
  • Similarities between the physical structures of avian and mammalian MHC class I glycoproteins have been proposed by comparative alignment of their amino acid sequences. (usda.gov)
  • O-Glycoprotease (IMPa) cleaves a variety of glycoproteins and glycopeptides containing mucin-type O-glycans with or without sialic acid, including Tn-antigen (GalNAc-α-Ser/Thr). (neb.com)
  • In contrast, a site directed substitution in residue 34 dramatically alters ALV antigen presentation by the BFIV21 class I glycoprotein. (usda.gov)
  • VEGF is a dimeric glycoprotein with structural homology to PDGF. (ihcworld.com)
  • It belongs to the CD34/Podocalyxin family of sialomucins that share structural similarity and sequence homology. (rndsystems.com)
  • Structural modelling has confirmed that CR3022 targets a conserved epitope between SARS-CoV and SARS-CoV2 in the RBD domain (32245784, 32065055). (abcam.com)
  • BPI contains two domains that adopt the same structural fold, even though they have little sequence similarity. (wikipedia.org)
  • Afin de remédier à ce problème et d'étudier les variations génétiques et antigéniques des virus A(H1N1)pdm09 et H3N2, nous avons procédé à des analyses génétiques et phylogénétiques des gènes de l'hémagglutinine (HA) et de la neuraminidase (NA) de ces virus, sur la période 2011-2013 en Jordanie. (who.int)
  • A unique, chimeric class I glycoprotein was constructed by incorporating an epitope tag (FLAG) at the N terminus. (usda.gov)
  • The chimeric class I glycoprotein was expressed in target cells using an ALV derived retrovirus vector (RCASBP). (usda.gov)
  • Structural determinants of coiled coil mechanics. (mpg.de)
  • O-Glycoprotease (IMPa) is a broad specificity protease that cleaves the peptide bonds of a glycoprotein or glycopeptide immediately N-terminal to a serine or threonine residue containing a mucin-type O-linked glycan with or without sialylation. (neb.com)
  • It recognizes mucin-type O-glycans in glycoproteins or glycopeptides, including branched and sialylated structures, and cleaves the peptide bond immediately N-terminal to a glycosylated serine or threonine residue. (neb.com)
  • Finally, the application of this glycoprotein in new vaccine design is reviewed, taking its structural and functional characteristics into consideration. (biomedcentral.com)
  • The basic molecular defect results from mutations in the gene encoding the glycoprotein fibrillin-1 ( FBN1 ), which is the main component of microfibrils and helps anchor cells to the extracellular matrix. (msdmanuals.com)
  • Electrospray ionization-ion trap mass spectrometry for structural analysis of complex N-linked glycoprotein oligosaccharides. (consensus.app)
  • Complex glycan structural features, such as N-acetyllactosamine antenane, neuraminic acids, and nonreducing terminal GlcNAc monosaccharides, commonly suppress cross-ring and core saccharide cleavages in traditional MS/MS experiments. (consensus.app)
  • To explore the structural basis of this m144 function, we have determined the three-dimensional structure of an m144/beta2-microglobulin (beta2m) complex at 1.9A resolution. (rcsb.org)
  • Virions are spherical or pleomorphic (80-120 nm in diameter) and present projections of surface glycoproteins (5-10 nm) embedded in a lipid bilayer envelope. (europa.eu)
  • I was promoted to Reader in 2004 and moved to the University of Nottingham to found the Crystallography Laboratory which is within the Medicinal Chemistry and Structural Biology Research Division of the School of Pharmacy. (nottingham.ac.uk)
  • Section D, Structural biology. (nottingham.ac.uk)
  • Both EDEM3 and EDEM1 trimmed M8B from a glycoprotein efficiently. (elifesciences.org)
  • MUC glycoproteins: Potential biomarkers and molecular targets for cancer therapy. (amrita.edu)
  • Home Publications MUC glycoproteins: Potential biomarkers and molecular targets for cancer therapy. (amrita.edu)
  • Human cytomegalovirus (HCMV) purified from cell culture contains two dominant structural phosphoproteins with apparent molecular weights of 65000 and 150000, designated as pp65 and ppl50 respectively. (microbiologyresearch.org)
  • Glycoproteins can be sequentially digested with O-Glycoprotease (IMPa) followed by Trypsin-ultra Mass Spectrometry Grade ( NEB #P8101 ). (neb.com)
  • The aim of the present study was to elucidate the potential diagnostic value of urinary N‑glycoprotein in patients with IgA nephropathy (IgAN) using mass spectrometry (MS). All procedures were performed between June 2021 and June 2023 at Guangan People's Hospital (Guangan, China). (spandidos-publications.com)
  • This review highlights the structural and functional characteristics of BoHV-1, BoHV-5 and where appropriate, Human herpesvirus gD, as well as its role in viral entry and interactions with host cell receptors. (biomedcentral.com)
  • Here we describe the structural and functional properties of the prokaryotic SLC11 transporter EcoDMT. (nature.com)
  • The most important open questions concern the structure of the transporter in an outward-facing conformation and whether, similar to their eukaryotic counterparts, transport in the prokaryotic transporters would be coupled to H + . To resolve these questions we have investigated the structural and functional properties of the SLC11 transporter from the bacterium Eremococcus coleocola (EcoDMT). (nature.com)
  • To investigate the physical structure of the chicken class I glycoprotein we have cloned the cDNA representing the BFIV locus of the B21 haplotype. (usda.gov)
  • We show here that one of the most conserved antigenic sites within the major glycoprotein E2 (amino acids 412 to 423), which is disordered in the recently reported crystal structure of an E2 core fragment, can adopt different conformations in the context of the infectious virus particle. (ox.ac.uk)
  • A region of 13 amino acid residues, corresponding to the amino-terminal portion of the alpha2 helix, is missing in the electron density map, suggesting an area of structural flexibility that may be involved in ligand binding. (rcsb.org)
  • Sequential mannose trimming of N -glycan, from M9 to M8B and then to oligosaccharides exposing the α1,6-linked mannosyl residue (M7A, M6, and M5), facilitates endoplasmic reticulum-associated degradation of misfolded glycoproteins (gpERAD). (elifesciences.org)
  • Together with the neutralizing capacity of the 3/11 Fab fragment, this indicates an unexpected structural flexibility within this epitope. (ox.ac.uk)
  • Aberrant immunostaining pattern of the CD24 glycoprotein in clinical samples and experimental models of pediatric medulloblastomas. (lu.se)
  • The presence in orange juice of compounds that specifically inhibit the P-glycoprotein (P-gp) drug efflux transporter, but not the cytochrome P450 (CYP) isozyme CYP3A4, was investigated. (aspetjournals.org)
  • Our previous studies on the structure and function of the transition-metal ion transporter from Staphylococcus capitis (ScaDMT) have revealed the general architecture of the SLC11/NRAMP family and they provided initial insight into the structural basis of selective transition-metal ion transport 16 . (nature.com)
  • However, the HCMV strains tested in this study produced the large structural phosphoprotein (ppl50) in about equal amounts. (microbiologyresearch.org)
  • HAVCR1 is a type I trans-membrane structural glycoprotein located in the renal proximal tubule epithelial cells. (prospecbio.com)
  • The diagram illustrates the main structural features of the virion. (powershow.com)
  • Lassa fe- Lassa virus in many more districts and states in en- ver is endemic in West Africa and has been reported demic countries of the West African sub-region and from Sierra Leone, Guinea, Liberia, and Nigeria4-7. (folkhalsomyndigheten.se)
  • Peissert S., Schlosser A., Kendel R., Kuper J., Kisker C. Structural basis for CDK7 activation by MAT1 and Cyclin H . Proc Natl Acad Sci U S A. 2020 Oct 27;117(43):26739-26748. (uni-wuerzburg.de)
  • Structural Basis fort he Recruitment of Ctf18-RFC to the Replisome. (uni-wuerzburg.de)
  • Structural basis of centromeric cohesion protection. (le.ac.uk)
  • Peu de renseignements sont disponibles sur les mutations des virus saisonniers de la grippe A(H1N1)pdm09 et H3N2 en Jordanie. (who.int)
  • L'analyse a porté sur les séquences complètes des gènes de l'HA et de la NA de 16 échantillons positifs au virus H1N1 prélevés dans le cadre de cette étude, ainsi que sur 21 séquences publiées de l'HA et 20 séquences publiées de la NA, issues de virus jordaniens disponibles sur les bases de données de gènes en ligne. (who.int)
  • Mucins belong to a heterogeneous group of large O-glycoproteins that can be either secreted or membrane-bound. (amrita.edu)