A recent paper from the Martin lab explores the evolutionary connection between calcium-binding beta/gamma crystallin proteins and the structural beta/gamma crystallins of the eye lens. (uci.edu)
Contrary to the prevailing assumption, we have found that the clumping is not caused by a decrease in protective alpha-crystallin proteins," Tobias Madl, Gottfried Schatz Research Center at MedUni Graz, described the first surprising result. (anton-paar.com)
Using small-angle X-ray scattering (SAXS) and other methods, the researchers observed that the balance of the three most common proteins in the lens that developed cataracts - alpha, beta and gamma crystalline - was particularly disturbed. (anton-paar.com)
A heterogeneous family of water-soluble structural proteins found in cells of the vertebrate lens. (lookformedical.com)
Alpha-crystallins also act as molecular chaperones that bind to denatured proteins, keep them in solution and thereby maintain the translucency of the lens. (lookformedical.com)
SCOP: Structural Classification of Proteins and ASTRAL. (berkeley.edu)
Structural analysis of the rate-limiting transition states in the folding of Im7 and Im9: similarities and differences in the folding of homologous proteins. (shengsci.com)
Fasciculin 2 and toxin alpha proteins belong to the same structural family of three-fingered snake toxins. (shengsci.com)
[13] [14] Because proteins share a common structural feature known as the polypeptide backbone, all proteins have the potential to misfold under some circumstances. (wikipedia.org)
[15] However, only a relatively small number of proteins are linked to proteopathic disorders, possibly due to structural idiosyncrasies of the vulnerable proteins. (wikipedia.org)
A general property of disordered proteins is their structural expansion that results in a high macromolecular flexibility. (lu.se)
A subclass of crystallins expressed highly in lens of diurnal Australian MARSUPIALS and in neural tissue, muscle, and kidney in humans. (bvsalud.org)
Protein7
The tunicate beta/gamma crystallin from Ciona intestinalis, which is known to bind calcium, is also capable of binding a wide variety of other divalent cations, which is highly unusual for a metal-binding protein. (uci.edu)
In contrast, the human lens protein gammaS-crystallin, which contains defunct calcim-binding sites binding sites, does not bind any divalent cations and aggregates readily in the presence of zinc. (uci.edu)
The fast sulfide association rate constant can be related to the presence of Gln(64)E7, as the heme distal residue, together with the protein structural properties in the CD-E distal region. (shengsci.com)
Stability of a structural scaffold upon activity transfer: X-ray structure of a three fingers chimeric protein. (shengsci.com)
Micrograph of a section of the cerebral cortex from a person with Alzheimer's disease , immunostained with an antibody to amyloid beta (brown), a protein fragment that accumulates in amyloid plaques and cerebral amyloid angiopathy . (wikipedia.org)
[9] However, some proteinaceous lesions lack birefringence and contain few or no classical amyloid fibrils, such as the diffuse deposits of amyloid beta (Aβ) protein in the brains of people with Alzheimer's. (wikipedia.org)
It is not a structural protein accounting for the transparency of the human lens unlike other crystallins but instead plays a role in thyroid hormone bioavailability. (bvsalud.org)
Lens3
This type of information about how the vertebrate lens crystallins evolved away from ion-binding and toward independent stability is critical to understanding their function in the eye lens. (uci.edu)
Beta-crystallin A4 (CRYBA4) is a member of the beta/gamma-crystallin family which are the dominant structural components of the vertebrate eye lens. (prospecbio.com)
With the help of the SAXS method, we were even able to elucidate the internal structure of crystallins in intact eye lenses for the first time. (anton-paar.com)
Alpha, beta, and delta crystallins occur in avian and reptilian lenses, while alpha, beta, and gamma crystallins occur in all other lenses. (lookformedical.com)
Gene1
Given these experimental evidences, the integration of high-throughput transcriptional data with gene structural information and functional characteristics represents a major challenge for bioinformatics and computational biology. (biomedcentral.com)
Fold2
[5] [6] The propeptide region has an open-sandwich antiparallel-alpha/antiparallel-beta fold, with two alpha-helices and four beta-strands with a (beta/alpha/beta)x2 topology. (wikipedia.org)
There is induction of at least 30-fold of beta maj globin transcription after cells are treated with either dime. (shengsci.com)
Species1
The method applies Bayesian probabilistic model to analyze scattering data from mixtures of oligomeric species, allows for a modeling large structural ensembles, can be used to assess uncertainty of all parameters and minimizes over-fitting. (lu.se)
Molecular2
The research results were published in the renowned scientific journal 'Nature Structural & Molecular Biology' . (anton-paar.com)
By enabling both time resolution and structural detail Time-Resolved Small Angle X-ray/Neutron Scattering (TR-SAXS/TR-SANS) is uniquely suited to interrogate complex self-assembly reactions and to provide a molecular understanding of self-assembly pathways. (lu.se)
Organization2
The heme pocket structural organization of HbI is in keeping with its ligand binding properties. (shengsci.com)
Indeed, an integrated approach would allow deciphering how the structural organization of genomes influences its functional utilization. (biomedcentral.com)
The transcription of the beta-globin genes in mouse erythroleukemia cells has been examined by hybridizing labeled RNA obtained from isolated nuclei after chain elongation in the presence of [alpha-32P]UTP. (shengsci.com)
Structure1
Gamma-crystallins are similar in structure to BETA-CRYSTALLINS in that they both form into a Greek key-like structure. (lookformedical.com)
Form1
Beta-crystallins construct aggregates of various sizes and are able to self-associate to form dimers or to form heterodimers with other beta-crystallins. (prospecbio.com)
Resolution1
To overcome this problem we develop a method that combines a computational structural modeling (which delivers atomic-resolution structures) with experimental data (which provides information about the population of different states). (lu.se)
Cells1
Induced transcription of the mouse beta-globin transcription unit in erythroleukemia cells. (shengsci.com)
Vertebrate2
Crystallins are the dominant structural components of the vertebrate eye lens. (nih.gov)
10. Sequence analysis of frog alpha-crystallin cDNA and its deduced primary structure: comparison of alpha A subunit chains among different vertebrate species. (nih.gov)
Sequences2
18. The amino-terminal sequences of four major carp gamma-crystallin polypeptides and their homology with frog and calf gamma-crystallins. (nih.gov)
1. Sequence characterization of gamma-crystallins from lip shark (Chiloscyllium colax): existence of two cDNAs encoding gamma-crystallins of mammalian and teleostean classes. (nih.gov)
Previous attempts to crystallize mammalian γS-crystallin were unsuccessful. (nih.gov)
Genes3
Cerulean cataracts of congenital or childhood onset can be due to mutations in genes that encode various lens crystallins. (arizona.edu)
Differentially expressed genes involved in several important signaling pathways, lens structural components, organelle loss, and denucleation were also highlighted to provide insights into lens development and lens fiber differentiation. (molvis.org)
The transcription of the beta-globin genes in mouse erythroleukemia cells has been examined by hybridizing labeled RNA obtained from isolated nuclei after chain elongation in the presence of [alpha-32P]UTP. (shengsci.com)
Endogenous1
15. Octopus S-crystallins with endogenous glutathione S-transferase (GST) activity: sequence comparison and evolutionary relationships with authentic GST enzymes. (nih.gov)
Descriptor1
Crystallins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (wakehealth.edu)
Family1
12. Sequence analysis of frog rho-crystallin by cDNA cloning and sequencing: a member of the aldo-keto reductase family. (nih.gov)
Major2
This graph shows the total number of publications written about "Crystallins" by people in this website by year, and whether "Crystallins" was a major or minor topic of these publications. (wakehealth.edu)
3. Characterization of gamma-crystallin from a catfish: structural characterization of one major isoform with high methionine by cDNA sequencing. (nih.gov)
Hemoglobin1
Structural bases for sulfide recognition in Lucina pectinata hemoglobin I. (shengsci.com)
High3
A high refractive index increment can lower the crystallin concentration required to achieve a suitable refractive power of the lens, and thereby reduce the propensity of crystallins to aggregate and form cataract. (nih.gov)
To achieve a sufficiently high refractive index increment, a global shift in the amino acid composition is required, which can naturally explain the highly unusual amino acid composition of gamma crystallins and their functional homologues. (nih.gov)
17. Carp gamma-crystallins with high methionine content: cloning and sequencing of the complementary DNA. (nih.gov)
Features1
Energetics of MazG unfolding in correlation with its structural features. (shengsci.com)
Unique1
Unique secondary and tertiary structure of shark gamma-crystallin. (nih.gov)
Fish1
6. Characterization of gamma-crystallins from a hybrid teleostean fish: multiplicity of isoforms as revealed by cDNA sequence analysis. (nih.gov)
Results1
The research results were published in the renowned scientific journal 'Nature Structural & Molecular Biology' . (anton-paar.com)