Structural protein folding. Medical search. Frequent questions

Membrane proteins interact with biological membranes either by inserting into it, or being tethered via a covalently attached lipid. (wikipedia.org)
It is estimated that 20-30% of all genes in most genomes encode membrane proteins. (wikipedia.org)
They constitute one of the main types of protein (alongside globular, fibrous and membrane proteins). (wikipedia.org)
I am a plant cell biologist and protein biochemist at Oxford Brookes University with expertise in the structure and function of the plant endoplasmic reticulum (ER), membrane proteins and auxin biosynthesis using biochemical techniques as well as high-resolution live cell imaging. (brookes.ac.uk)
I further investigated membrane proteins and the targeting of tail-anchored proteins at Sheffield Hallam University. (brookes.ac.uk)
This was the first meeting to gather such a critical mass of scientists with shared interests into how membrane proteins attain their native fold. (biophysics.org)
Finally, it was shown how these new insights are exploited for structure prediction and novel design of membrane proteins. (biophysics.org)

The reason why Peter Lansbury and others used the term 'natively unfolded' for a-synuclein and other proteins, especially peptides, is that they do not exist, to a significant degree, in the same kind of stable structure that larger native proteins like myoglobin do. (alzforum.org)
Time scales of water dynamics at biological interfaces: peptides, proteins and cells. (lu.se)
This method ( 10 ) mea- chemical-induced skin sensitization is the ability of a chemical, sured the depletion of the peptides after treatment with excess either as such or after ex/in cutaneo activation, to covalently electrophile for 24 h and adopted the percent depletion (dp) as react with a carrier protein or peptide ( 6 ), resulting in an the reactivity index of a given chemical. (cdc.gov)

In molecular biology, protein fold classes are broad categories of protein tertiary structure topology. (wikipedia.org)
Dr. Hurt focuses on computational structural biology, including protein folding, docking, and molecular dynamics. (web3d.org)
1 Program in Structural and Computational Biology and Molecular Biophysics, Verna and Marrs McLean Department of Biochemistry, Baylor College of Medicine, Houston, Texas 77030, USA. (nih.gov)
The Research Department of Structural and Molecular Biology (SMB) is an outstanding place to begin a research career. (ucl.ac.uk)
UCL and the Department of Biological Sciences at Birkbeck created the Institute for Structural Biology (ISMB), one of the largest research centres for research in multidisciplinary research around structural biology in the world. (ucl.ac.uk)
Recognizing similarities and deriving relationships among protein molecules is a fundamental requirement in present-day biology. (nih.gov)
Small-angle scattering is becoming a mainstream technique for structural molecular biology. (iucr.org)
With SAS emerging as a mainstream structural biology technique, and a growing market in commercial instrumentation as well as new SAS beamlines at synchrotron and neutron sources, there has been considerable community drive for the establishment of publication requirements and standards for structural biology applications. (iucr.org)
Users do not have to have any previous bioinformatics or structural biology experience. (lu.se)
Section F, Structural biology communications. (lu.se)

They are one of the common types of protein along with soluble globular proteins, fibrous proteins, and disordered proteins. (wikipedia.org)
A large scale test of computational protein design: folding and stability of nine completely redesigned globular proteins. (nih.gov)
Dorothy is most well known as the mother of the " cyclol structure " - the first structural model ever developed to describe folded, globular proteins. (prometheanworld.com)
2023. Replacement of the native cis prolines by alanine leads to simplification of the complex folding mechanism of a small globular protein. . (ncbs.res.in)

Many of the skills first encountered in the Proteins unit are reinforced in the Biochemistry/Medical Biochemistry semester 4 tutorial program. (manchester.ac.uk)
When we're taught biochemistry, we see proteins in their physiologically active forms. (alzforum.org)

Our research expertise is world-recognized in areas such as bacterial secretion, aging, signal transduction, protein folding, drug metabolism and cellular protein trafficking. (ucl.ac.uk)

The encoded protein represents the A2 form, which is a monomeric protein with different biochemical properties from the A1 and A3 forms. (nih.gov)
Structural, biochemical and biophysical experimentation was presented side-by-side with molecular dynamics simulations, providing a wide range of approaches to investigate this complex biological process. (biophysics.org)
Structural and mechanistic understanding of protein function has lagged behind due to the challenging and lowthroughput nature of structural and biochemical approaches. (lu.se)

Because protein molecules are highly dynamic, constant chaperone surveillance is required to ensure protein homeostasis (proteostasis). (nature.com)
She showed that alternate structural shapes of protein molecules could result in substantially different effects. (todayinsci.com)
Inferring functional similarities between protein molecules by comparing their binding sites is still largely exploratory and not as yet a routine protocol. (nih.gov)
To provide core knowledge of the form, function and role of protein molecules in biological processes and further enable an understanding of biological phenomena at the molecular level. (manchester.ac.uk)
He loved microscopes and watching the proteins and molecules that make up cells move around. (biophysics.org)
Structural changes in the excited state are associated with residues that interact with water molecules that have well defined positions and are found at these positions in all crystal structures of CI2. (lu.se)
We hypothesize that the interactions between the substituted residues and the well-ordered water molecules links subtle structural changes around the substituted residues to the region in the protein that experience slow conformational changes. (lu.se)
Nanosecond to microsecond protein dynamics probed by magnetic relaxation dispersion of buried water molecules. (lu.se)

2018. Mechanism of aggregation and membrane interactions of mammalian prion protein. . (ncbs.res.in)
2018. Mechanistic and Structural Origins of the Asymmetric Barrier to Prion-like Cross-Seeding between Tau-3R and Tau-4R. . (ncbs.res.in)
2018. The Osmolyte TMAO Modulates Protein Folding Cooperativity by Altering Global Protein Stability. . (ncbs.res.in)
2018. Site-specific time-resolved FRET reveals local variations in the unfolding mechanism in an apparently two-state protein unfolding transition. . (ncbs.res.in)
2018. Structural mechanisms of oligomer and amyloid fibril formation by the prion protein. . (ncbs.res.in)

Select appropriate experimental techniques for protein purification and characterization (conformation and stability), and describe the relative precision of various approaches and the assumptions implied by each method. (manchester.ac.uk)
2017. Identification and structural characterization of the precursor conformation of the prion protein which directly initiates misfolding and oligomerization. . (ncbs.res.in)

Transport of proteins across membranes is a fundamental process, achieved in every cell by the 'Sec' translocon. (elifesciences.org)
The encapsulation and compartmentalisation of cells has necessitated the evolution of machineries that conduct proteins across membranes, including for protein secretion and organellar import. (elifesciences.org)
I am committed to interdisciplinary research, and an example of the successes gained from this approach is the project with Prof A Nabok (Engineering Sheffield Hallam University) using total internal reflection ellipsometry to quantify protein-membrane interactions on native plant membranes and human cell lines. (brookes.ac.uk)
From there, topics covered recent progress on which biophysical forces contribute to stabilizing the native membrane protein fold and how lipid membranes, detergents or surfactants influence the conformational space these important proteins sample. (biophysics.org)

Both studies suggest that defects in rhodopsin glycosylation are associated with impairment of protein folding or stability. (jneurosci.org)
It is however less clear how such processes may perturb the overall folding stability of a protein. (lu.se)

Four large classes of protein that are generally agreed upon by the two main structure classification databases (SCOP and CATH). (wikipedia.org)
SCOPe: Structural Classification of Proteins - extended. (berkeley.edu)
SCOP: Structural Classification of Proteins and ASTRAL. (berkeley.edu)

To benefit from the enormous amount of structural data that is being rapidly accumulated, it is essential to have high throughput tools that enable large scale binding site comparison. (nih.gov)
LU-Fold specialises in high-throughput prediction of protein complexes to predict novel protein-protein interactions. (lu.se)
We run as a service, accessing national high performance computing infrastructure to make high-throughput structural predictions. (lu.se)

Several mutations in the N terminus of the G-protein-coupled receptor rhodopsin disrupt NXS/T consensus sequences for N-linked glycosylation (located at N2 and N15) and cause sector retinitis pigmentosa in which the inferior retina preferentially degenerates. (jneurosci.org)
Although protein structures have been solved by experiments at an increasing rate, a flood of new sequences have been determined even more rapidly due to the advance of sequencing technologies[ 6 , 7 ]. (biomedcentral.com)
Similarities can be present at various levels which can be detected through comparison of protein sequences or their structural folds. (nih.gov)
2021. Mapping Distinct Sequences of Structure Formation Differentiating Multiple Folding Pathways of a Small Protein. . (ncbs.res.in)
For HMPV, the existence of different genetic lineages has been described on the basis of variation in a limited set with F being one of the most conserved proteins and G the of available sequences. (cdc.gov)
In addition, we analyzed the genetic diversity of sequences of the G protein and neutralization tests by HMPV by phylogenetic analysis of sequences obtained for using monoclonal antibodies that also recognize the G pro- part of the fusion protein (n = 84) and the complete attach- tein, but these subgroups belonged to one serotype (21). (cdc.gov)
On the basis of APV type C, a possible second serotype, was identified sequence diversity between attachment protein genes and based on the lack of cross-reactivity with antisera specific the differences in virus neutralization titers, two HMPV for groups A and B, and the nucleotide sequences also serotypes were defined. (cdc.gov)

Proteins can be designed from scratch (de novo design) or by making calculated variations on a known protein structure and its sequence (known as protein redesign). (wikipedia.org)
Rational protein design approaches make protein-sequence predictions that will fold to specific structures. (wikipedia.org)
Based on primary sequence comparisons, β subunits are predicted to be modular structures composed of five domains (A-E) that are related to the large family of membrane-associated guanylate kinase proteins. (jneurosci.org)
Finally, the signal sequence is cleaved and the pre-protein is either folded or trafficked onwards. (elifesciences.org)
2022. Differentiating between the sequence of structural events on alternative pathways of folding of a heterodimeric protein. . (ncbs.res.in)
Since protein structure is more conserved over evolutionary timescales than its amino acid sequence, reliable structure prediction by AlphaFold has revolutionised our ability to predict protein function. (lu.se)

Numerous protein structures are the result of rational design and do not exist in nature. (wikipedia.org)
These structure-based terms are commonly derived from statistics of structural properties observed in representative structures (knowledge-based statistical potentials). (biomedcentral.com)
We have used this method to study cytochrome c folding kinetics in the previously inaccessible time range 80 μs to 3 ms. To eliminate the heme-ligand exchange chemistry that complicates and slows the folding kinetics by trapping misfolded structures, measurements were made with the imidazole complex. (jascoinc.com)
Most proteins must fold into defined three-dimensional structures to gain functional activity. (nature.com)
Cryo-EM structures reveal multiple stages of bacterial outer membrane protein folding. (nih.gov)
Although the structures of rotavirus and other members of the Reoviridae have been extensively studied, little is known about the structures of virus-encoded non-structural proteins that are essential for genome replication and packaging. (nih.gov)
You will learn how proteins are produced, how they fold into their secondary and tertiary structures and how they interact with each other. (manchester.ac.uk)
Functional proteins that do not have unique, stable, folded, three-dimensional native structures or that possess non-ordered regions under physiological conditions. (bvsalud.org)
LU-Fold is a Lund University-based facility for helping researchers predict protein structures of interest using the cutting-edge method AlphaFold2 ( Nature Methods method of the year, 2021). (lu.se)

Intrinsically disordered proteins lack a fixed or ordered three-dimensional structure. (wikipedia.org)
2021. Microsecond dynamics during the binding-induced folding of an intrinsically disordered protein. . (ncbs.res.in)

Structural Insights into the Mechanism of Dynamin Superfamily Proteins. (nih.gov)
p27 binds cyclin-CDK complexes through a sequential mechanism involving binding-induced protein folding. (mpg.de)
Prion protein are known as disease agents, but her work with yeast prion proteins also demonstrated a mechanism of protein-only inheritance. (todayinsci.com)

N-linked glycosylation is the most prevalent posttranslational modification of plasma membrane and secretory proteins and participates in many important biological roles such as protein folding, intracellular targeting, immune response, cell adhesion, and protease resistance. (jneurosci.org)
The tertiary structure of proteins provides crucial information for understanding molecular mechanisms of biological functions. (biomedcentral.com)
Proteins are involved in virtually all biological processes and their structure is key to their function. (manchester.ac.uk)
In contrast to its biological competitor, ubiquitin, which is recycled, FAT10 is degraded along with its target protein which appears wasteful at first glance. (asianage.com)

The non-structural protein NSP2 of rotavirus, which exhibits nucleoside triphosphatase, single-stranded RNA binding, and nucleic-acid helix-destabilizing activities, is a major component of viral replicase complexes. (nih.gov)
Therefore, by measuring the FRET efficiency (e.g. by observing the emission of the two fluorophores under excitation of the donor), spatial information can be determined in the 3-10 nm range, making FRET a 'spectroscopic ruler' 2 well matched to the dimensions of biomolecules such as nucleic acids and proteins 3 . (nature.com)

This ability to exploit structure within a pre-protein is an unexplored area of protein transport, which may apply to other protein transporters, such as those of the endoplasmic reticulum and mitochondria. (elifesciences.org)

This includes gene, protein and metabolic networks, cellular architecture and intracellular dynamics, cell communication and motility, cell division and differentiation, tissue formation and organogenesis, tissue and organ functions, changes in population characteristics as a consequence of interaction of organisms with their physical environment, with individuals of their own species, and with organisms of other species. (nih.gov)
Other members of this subfamily, respiratory syncy- ity of the attachment protein gene (12,13). (cdc.gov)
The CALR gene provides instructions for making a protein with multiple functions, including ensuring the proper folding of newly formed proteins and maintaining the correct levels of stored calcium in cells. (medlineplus.gov)
The TET2 gene provides instructions for making a protein whose function is unknown. (medlineplus.gov)
The protein produced from the MPL gene, called thrombopoietin receptor, turns on (activates) the pathway, and the JAK2 protein transmits signals after activation. (medlineplus.gov)
The gene encoding these proteins is FANCM . (medscape.com)
Influenza virus non-structural protein 1 (NS1) counteracts host antiviral innate immune responses by inhibiting Retinoic acid inducible gene-I (RIG-I) activation. (cdc.gov)

But in the cellular environment, newly synthesized proteins are at great risk of aberrant folding and aggregation, potentially forming toxic species. (nature.com)
Hartl, F. U. Molecular chaperones in cellular protein folding. (nature.com)
Skach, W. R. Cellular mechanisms of membrane protein folding. (nature.com)

There is considerable use of graphs and underlying theory in the description of properties of proteins and how these are studied. (manchester.ac.uk)

Identifying conformational-selection and induced-fit aspects in the binding-induced folding of PMI from Markov state modeling of atomistic simulations. (mpg.de)
2019. Binding-induced folding under unfolding conditions: Switching between induced fit and conformational selection mechanisms. . (ncbs.res.in)

LIMR scientists have generated a unique patient-derived huMab that recognizes a common structural feature of all mammalian and bacterial amyloid proteins. (mainlinehealth.org)

Describe the features of proteins which lead to successful folding, post-translational modification and degradation. (manchester.ac.uk)
Its attachment to a target protein is a signal for its degradation. (asianage.com)
Experiments show that the loose folding and the disordered extension of the FAT10 protein have an important regulatory function that actually simplifies the degradation of the target molecule. (asianage.com)

I want to get the latest chemistry news from C&EN in my inbox every week. (acs.org)
Deepened knowledge on the biophysical chemistry of proteins with emphasis on properties rather than methods. (lu.se)

RNA codons and protein synthesis. (crossref.org)
During protein synthesis at the ribosome numerous factors act early on the nascent polypeptide chain. (lu.se)

Effective encoding of residue contact information is crucial for protein structure prediction since it has a unique role to capture long-range residue interactions compared to other commonly used scoring terms. (biomedcentral.com)
Among various structure-based terms, residue-residue contact potentials[ 21 - 23 ] are unique in that they capture long-range interactions in a protein structure[ 24 ]. (biomedcentral.com)
Program access grant to the STFC Harwell Laser Facility 'The Plant Cell Initiative: Protein interactions in the higher plant secretory pathway' 2017-2021 (approximate value of £200K). (brookes.ac.uk)
3) Protein interactions and enzyme characterization. (manchester.ac.uk)
Destabilization of polar interactions in the prion protein triggers misfolding and oligomerization. (ncbs.res.in)
2017. A Dry Transition State More Compact Than the Native State Is Stabilized by Non-Native Interactions during the Unfolding of a Small Protein. . (ncbs.res.in)
Our data provide the structural framework for interactions of co-translational factors at the ribosomal tunnel exit. (lu.se)
They are characterized by extraordinary structural flexibility and plasticity, which enable them to adopt different conformations in response to different stimuli or different interactions. (bvsalud.org)
For example, we can predict pairwise interactions of a protein of interest with all other proteins in a proteome to find new binding partners and molecular binding interfaces. (lu.se)

Beetle hyperactive antifreeze protein (AFP) has a unique ability to maintain a supercooling state of its body fluids, however, less is known about its origination. (mdpi.com)
High water mobility on the ice-binding surface of a hyperactive antifreeze protein. (lu.se)

Dynamin regulates the dynamics and mechanical strength of the actin cytoskeleton as a multifilament actin-bundling protein. (nih.gov)
We used the method for the investigation of the folding dynamics of proteins, and revealed the unexpected heterogeneity in the unfolded state of BdpA and ubiquitin. (nii.ac.jp)
In addition, investigations of the dynamics of proteins in the environment mimicking nucleus might become possible. (nii.ac.jp)
We previously found that the stabilizing double mutant L49I/I57V in the small protein chymotrypsin inhibitor 2 from barley led to distributed increased nanosecond and faster dynamics. (lu.se)
How proteins modify water dynamics. (lu.se)
Analysis of protein dynamics simulations by a stochastic point process approach. (lu.se)
Hydration dynamics of a halophilic protein in folded and unfolded states. (lu.se)
Slow internal protein dynamics from water 1 H magnetic relaxation dispersion. (lu.se)
Does the dynamic Stokes shift report on slow protein hydration dynamics? (lu.se)
Dynamics at the protein-water interface from 17 O spin relaxation in deeply supercooled solutions. (lu.se)

Here I pursued my scientific interests in subcellular protein localisation, bioinformatics, and mathematical modelling. (brookes.ac.uk)

They describe groups of proteins that share similar amino acid and secondary structure proportions. (wikipedia.org)
Describe protein folds in terms of secondary structural elements and the restrictions on peptide structure imposed by the planarity of the peptide bond. (manchester.ac.uk)

The course aims at demonstrating the workflow from sample purification to determining the atomic structure of a soluble or membrane protein. (epfl.ch)
Hepatic excretory capacity is low both because of low concentrations of the binding protein ligandin in the hepatocytes and because of low activity of glucuronyl transferase, the enzyme responsible for binding bilirubin to glucuronic acid, thus making bilirubin water soluble (conjugation). (medscape.com)

BLM encodes 1417 amino acids that code for a protein in the nuclear matrix of growing cells, which is a member of the RecQ family of helicases. (medscape.com)

2021. Structural Characterization of the Cooperativity of Unfolding of a Heterodimeric Protein Using Hydrogen Exchange-Mass Spectrometry. . (ncbs.res.in)

Protein Folding and Neurodegeneration: Biophysics to the Rescue? (alzforum.org)

MMDB and VAST+: tracking structural similarities between macromolecular complexes. (nih.gov)

A combination of molecular simulation with hydrogendeuterium-exchange mass spectrometry and electron paramagnetic resonance spectroscopy reveal an asymmetry across the membrane: ATP-induced conformational changes in the cytosolic cavity promote unfolded pre-protein structure, while the exterior cavity favours its formation. (elifesciences.org)
On the relationship between docking scores and protein conformational changes in HIV-1 protease. (mpg.de)
Slow conformational changes are often directly linked to protein function. (lu.se)

Protein superfamily SCOP database CATH database FSSP database Hubbard, Tim J. P. (wikipedia.org)

To avoid these dangers, cells invest in a complex network of molecular chaperones, which use ingenious mechanisms to prevent aggregation and promote efficient folding. (nature.com)
Recent advances suggest that an age-related decline in proteostasis capacity allows the manifestation of various protein-aggregation diseases, including Alzheimer's disease and Parkinson's disease. (nature.com)
Figure 1: Competing reactions of protein folding and aggregation. (nature.com)
Ellis, R. J. & Minton, A. P. Protein aggregation in crowded environments. (nature.com)
See also David Thirumalai's Emerging Ideas on the Molecular Basis of Protein and Peptide Aggregation ' (.pdf). (alzforum.org)
2022. Evolutionarily conserved proline residues impede the misfolding of the mouse prion protein by destabilizing an aggregation-competent partially unfolded form . (ncbs.res.in)

The amyloid protein Aß is a therapeutic target for immunological clearance in AD. (mainlinehealth.org)
The LIMR huMab bind a universal structural fold present in nature in all amyloid proteins. (mainlinehealth.org)

The "Membrane Protein Folding" meeting, organized jointly by the Biophysical Society and the Korean Institute for Advanced Studies, held in Seoul mid-May, provided a vibrant stage for membrane protein folding scientists to exchange ideas and hold stimulating discussions. (biophysics.org)

The JAK2 and MPL genes provide instructions for making proteins that promote the growth and division (proliferation) of blood cells. (medlineplus.gov)
The proteins produced from the JAK2 and MPL genes are both part of a signaling pathway called the JAK/STAT pathway, which transmits chemical signals from outside the cell to the cell's nucleus. (medlineplus.gov)

To seek the most effective definition of residue contacts for template-based protein structure prediction, we evaluated 45 different contact definitions, varying bases of contacts and distance cutoffs, in terms of their ability to identify proteins of the same fold. (biomedcentral.com)
A proper encoding of residue contact information is crucial for structure prediction because in principle, a full distance map or a residue contact map has sufficient information for reconstructing the tertiary structure of a protein[ 25 ]. (biomedcentral.com)

In yeast, the canonical Hsp70 protein Ssb acts together with the ribosome associated complex (RAC), which consists of the inactive Hsp70 protein Ssz and the Hsp40 protein Zuotin. (lu.se)

Bartlett, A. I. & Radford, S. E. An expanding arsenal of experimental methods yields an explosion of insights into protein folding mechanisms. (nature.com)
Structure determination of Ssb and RAC together with ribosome binding studies provide detailed insights into the interplay of this chaperone system, which evolved to link translation and protein folding. (lu.se)

However, revealing the detailed relationship between structural modifications and functional changes remains challenging owing to the lack of information on reaction intermediates and of a systematic way of connecting them to the measured kinetic parameters. (iucr.org)
probes, molecular reporters and fluorescent indicators for structural or functional imaging or microscopy/nanoscopy. (nih.gov)

Membrane-mediated cooperativity of proteins. (mpg.de)

The largest deterioration of the fold recognition was observed for β-class proteins when the threading methods were used because the average alignment accuracy was worst for this fold class. (biomedcentral.com)
2022. Native State Hydrogen Exchange-Mass Spectrometry Methods to Probe Protein Folding and Unfolding. . (ncbs.res.in)

Earlier this year, Gemma Atkinson established an AlphaFold facility at Lund University, LU-Fold https://atkinson-lab.com/lu-fold/ . (lu.se)

In prokaryotes, SecYEG associates with the motor ATPase SecA to carry out translocation for pre-protein secretion. (elifesciences.org)
The bulk of protein secretion and membrane protein insertion is conducted by the ubiquitous Sec translocon. (elifesciences.org)

The structural comparison shows that the binding affinities and configurations of the substrate (CO 2 ) and product (HCO 3 − ) are altered in the V143I variant and the water network in the water-replenishment pathway is restructured, while the proton-transfer pathway remains mostly unaffected. (iucr.org)
Through the JAK/STAT pathway, these two proteins promote the proliferation of blood cells, particularly a type of blood cell known as a megakaryocyte. (medlineplus.gov)

This structural similarity suggests that the nucleotide-binding site is located inside the cleft between the two domains. (nih.gov)

2017. Expression and purification of single cysteine-containing mutant variants of the mouse prion protein by oxidative refolding. . (ncbs.res.in)

Small proteins typically have a tertiary structure that is maintained by disulphide bridges (cysteine-rich proteins), metal ligands (metal-binding proteins), and or cofactors such as heme. (wikipedia.org)

My additional independent research on ER localisation and splicing in auxin biosynthesis showed for the first time ER-localisation for an auxin biosynthetic protein. (brookes.ac.uk)

We found that overall the residue contact pattern can distinguish protein folds best when contacts are defined for residue pairs whose Cβ atoms are at 7.0 Å or closer to each other. (biomedcentral.com)
Distinguish between various modes of protein-protein interaction and catalysis. (manchester.ac.uk)

Mutations affecting glycosylation of the heptahelical G-protein-coupled receptor rhodopsin are associated with retinitis pigmentosa (RP), a disease characterized by progressive degeneration of photoreceptors. (jneurosci.org)

The current results might open a new research field of investigating proteins based on the assimilation of data obtained by single molecule method and MD calculation. (nii.ac.jp)

showing the cavities through the channel, with the protein in grey surface, the pre-protein pore constrictions in red (SecY) or purple (SecA) mesh, and the SecY plug in red helix. (elifesciences.org)

Anatomy17

Organisms100

Diseases8

Chemicals and Drugs64

Analytical, Diagnostic and Therapeutic Techniques and Equipment30

Phenomena and Processes38

Disciplines and Occupations1

Information Science4

Health Care2

Membrane proteins7

Peptides3

Biology10

Globular4

Biochemistry2

Signal transduction1

Biochemical3

Molecules8

20185

Conformation2

Membranes4

Stability2

Classification3

High-throughput3

Sequences7

Sequence6

Structures9

Intrinsically2

Mechanism3

Biological4

Nucleic2

Endoplasmic reticulum1

Gene7

Cellular3

Properties of proteins1

Binding-induced2

Bacterial1

Degradation3

Chemistry2

Synthesis2

Interactions9

Hyperactive antifreeze protein2

Dynamics10

Bioinformatics1

Describe2

Soluble2

Amino Acids1

Characterization1

Biophysics1

Complexes1

Conformational changes3

SCOP1

Aggregation6

Amyloid2

Biophysical1

Genes2

Structure prediction2

Yeast1

Insights2

Functional2

Cooperativity1

Methods2

Lund University1

Secretion2

Pathway2

Similarity1

Purification1

Tertiary structure1

Biosynthesis1

Distinguish2

Glycosylation1

Single molecule1

Mesh1