• Analysis of the simocyclinone biosynthesis ( sim ) gene cluster of Streptomyces antibioticus Tü6040 led to the identification of a putative pathway specific regulatory gene simReg1 . (springeropen.com)
  • To date, the different types of regulators involved in polyene macrolide biosynthesis have been categorized as follows: (1) Streptomyces antibiotic regulatory protein (SARP) family regulator, such as ActII-orf4, which regulates actinorhodin biosynthesis, and CcaR, which regulates clavulanic biosynthesis. (biomedcentral.com)
  • Streptomyces glaucescens is a bacterium species from the genus of Streptomyces which has been isolated from soil. (wikipedia.org)
  • Berubicin, CNS's flagship drug prospect, is an anthracycline, a potent class of chemotherapy drugs stemmed from the Streptomyces germs strains, and used in the treatment of a variety of cancers. (windows.net)
  • last1= has generic name (help)CS1 maint: multiple names: authors list (link) List of Streptomyces species LPSN bacterio.net Deutsche Sammlung von Mikroorganismen und Zellkulturen [1] ATCC Hutchinson, C. Richard (November 1997). (wikipedia.org)
  • Streptomyces glaucescens produces tetracenomycin C, tetracenomycin D and tetracenomycin E. BAUMANN, R. (wikipedia.org)
  • used primers specific for ketosynthase (KS) domains and CYP450 enzymes to probe the DNA of Streptomyces sp. (wikimili.com)
  • 1.Daunorubicin Hydrochloride Injection must be given into a rapidly flowing intravenous infusion. (nih.gov)
  • 4.It is recommended that daunorubicin hydrochloride be administered only by physicians who are experienced in leukemia chemotherapy and in facilities with laboratory and supportive resources adequate to monitor drug tolerance and protect and maintain a patient compromised by drug toxicity. (nih.gov)
  • Daunorubicin hydrochloride may also inhibit polymerase activity, affect regulation of gene expression, and produce free radical damage to DNA. (nih.gov)
  • Daunorubicin hydrochloride possesses an antitumor effect against a wide spectrum of animal tumors, either grafted or spontaneous. (nih.gov)
  • Following intravenous injection of Daunorubicin hydrochloride, plasma levels of daunorubicin decline rapidly, indicating rapid tissue uptake and concentration. (nih.gov)
  • Daunorubicin hydrochloride is extensively metabolized in the liver and other tissues, mainly by cytoplasmic aldo-keto reductases, producing daunorubicinol, the major metabolite which has antineoplastic activity. (nih.gov)
  • Twenty-five percent of an administered dose of daunorubicin hydrochloride is eliminated in an active form by urinary excretion and an estimated 40% by biliary excretion. (nih.gov)
  • Although appropriate studies with daunorubicin hydrochloride have not been performed in the pediatric population, cardiotoxicity may be more frequent and occur at lower cumulative doses in children. (nih.gov)
  • These compounds, like daunorubicin and doxorubicin, show affinity to DNA, but some of their pharmacological properties and metabolism in animals as well as in humans are different in respect to those of the parent drugs. (nih.gov)
  • Different cytotoxicity and metabolism of doxorubicin, daunorubicin, epirubicin, esorubicin and idarubicin in cultured human and rat hepatocytes. (nih.gov)
  • Berubicin, CNS's flagship drug prospect, is an anthracycline, a powerful class of chemotherapy drugs obtained from the Streptomyces bacteria stress, and used in the treatment of a variety of cancers. (windows.net)
  • Because of the low yield of the biosynthetic process, the chemical conversion of daunorubicin to adriamycin represent the key-step of the development of the drug. (nih.gov)
  • Approximately 40% of the drug in the plasma is present as daunorubicinol within 30 minutes and 60% in 4 hours after a dose of daunorubicin. (nih.gov)