• Aminoglycoside Antibiotics. (wikipedia.org)
  • Aminoglycoside antibiotics are composed of amino groups attached to glycosides. (goldbio.com)
  • The extraordinary virtuosity of streptomycetes as producers of secondary metabolites, including most of the antibiotics and anti-cancer agents in wide use, is associated with the developmental complexity of Streptomyces colonies, which have a vegetative substrate mycelium and a spore-bearing aerial mycelium. (biomedcentral.com)
  • Macrolides are a class of antibiotics discovered in the bacterium Streptomyces . (medscape.com)
  • In vitro inactivation of aminoglycoside antibiotics by beta-lactam antibiotics is well doc-umented. (elephantcare.org)
  • Pharmacology - Tobramycin, like the other aminoglycoside antibiotics, act on susceptible bacteria presumably by irreversibly binding to the 30S ribosomal subunit thereby inhibit-ing protein synthesis. (elephantcare.org)
  • The aminoglycoside antibiotics are inactive against fungi, viruses and most anaerobic bacteria. (elephantcare.org)
  • The inherent toxicity of the aminoglycosides limit their systemic use to serious infec-tions when there is either a documented lack of susceptibility to other less toxic antibiotics or when the clinical situation dictates immediate treatment of a presumed gram negative infection before culture and susceptibility results are reported. (elephantcare.org)
  • These enzymes inactivate aminoglycoside antibiotics through acetylation of the 3-amino group of the compound. (mcmaster.ca)
  • One group of bacteria, the Streptomyces, produces most of the medically important antibiotics. (icr.org)
  • 3] Streptomyces release antibiotics into the soil in a sort of 'biochemical warfare' scenario to eliminate competing organisms from their environment. (icr.org)
  • Streptomyces-produced quinolone and coumarin antibiotics, such as novobiocin, interfere with a protein called gyrase that assists in the normal separation of double-stranded DNA during replication of DNA or transcription of messenger RNA. (icr.org)
  • Ribosomes, the structures where protein synthesis is catalyzed, are the targets of many other Streptomyces antibiotics such as spectinomycin, tetracycline, and streptomycin. (icr.org)
  • Capreomycin sulfate is a peptide antibiotic , commonly grouped with the aminoglycosides, which is given in combination with other antibiotics for MDR-tuberculosis. (medchemexpress.com)
  • A category of aminoglycoside N-acetyltransferase enzymes with modification regiospecificity based at the 3-amino group of the respective antibiotic. (mcmaster.ca)
  • GLYCOSYLATION of other compounds with these amino sugars results in AMINOGLYCOSIDES. (lookformedical.com)
  • Plazomicin Sulfate is a derivative of Sisomicin and a novel aminoglycoside antibiotic that binds to the bacterial 30S ribosomal subunit, thereby inhibiting protein synthesis in a concentration-dependent manner, with broad-spectrum antimicrobial activity against aerobic Gram-negative bacteria, and can be used in studies related to pyelonephritis. (abmole.com)
  • Hygromycin B is purified from the bacterium Streptomyces hydroscopicus to be applied as an aminoglycoside antibiotic against bacteria, fungi and higher eukaryotic cells. (zellx-biochem.de)
  • Streptomyces mashuensis is a bacterium species from the genus of Streptomyces which has been isolated from soil in Japan. (wikipedia.org)
  • In Streptomyces coelicolor , bldA encodes the only tRNA for a rare leucine codon, UUA. (biomedcentral.com)
  • Yujin Jeong, Ji-Nu Kim, Min Woo Kim, Giselda Bucca, Suhyung Cho, Yeo Joon Yoon, Byeng-Gee Kim, Jung-Hye Roe, Sun Chang Kim, Colin P. Smith and Byung-Kwan Cho "The dynamic transcriptional and translational landscape of the model antibiotic producer Streptomyces coelicolor A3(2)" Nature Communications (2016) 2 Jun. (yeojoonyoon.com)
  • By sequence similarity analysis and functional assays from the species Streptomyces lividans TK23, S. coelicolor A3(2) and S. glaucescens GLA.O, first hints for a widespread lack of MalP and presence of AmlE in the class Actinobacteria were given. (frontiersin.org)
  • Identification, functional and structural characterization of novel aminoglycoside phosphotransferase APH(3â ³)-Id from Streptomyces rimosus subsp. (bvsalud.org)
  • Cloning and characterization of a 3-N-aminoglycoside acetyltransferase gene, aac(3)-Ib, from Pseudomonas aeruginosa. (mcmaster.ca)
  • Aminoglycosides and sulfonamides are only effective against aerobic organisms, while nitroimidazoles are generally only effective for anaerobes. (microbiologyinfo.com)
  • However, we previously demonstrated that the grisemycin (grm) cluster contained cryptic dehydratase and epimerase genes by heterologous expression of this biosynthetic gene cluster in Streptomyces lividans and proposed that two genes (grmH and grmL) with unknown functions catalyze dehydration and epimerization reactions. (hokudai.ac.jp)
  • Several independent gene clusters containing varying lengths of type I polyketide synthase genes were isolated from 'Streptomyces nanchangensis' NS3226, a producer of nanchangmycin and meilingmycin. (microbiologyresearch.org)
  • Many of the 147 genes were "function unknown", and may represent unknown aspects of Streptomyces biology. (biomedcentral.com)
  • Aminoglycosides target the 30S ribosomal subunit, specifically binding to the 16S rRNA and S12 protein. (toku-e.com)
  • Miocamycin is a macrolide antibiotic of Streptomyces origin that inhibits protein synthesis by binding to the bacterial 70S ribosome and is effective against a wide range of Gram-positive and Gram-negative microorganisms. (abmole.com)
  • Eunji Kim, Myoung Chong Song, Myoun Su Kim, Ji Yoon Beom, Jin A Jung, Hang Su Cho, Yeo Joon Yoon "One-Pot Combinatorial Biosynthesis of Glycosylated Anthracyclines by Cocultivation of Streptomyces Strains Producing Aglycones and Nucleotide Deoxysugars" ACS Combinatorial Science (2017)10 Apr. (yeojoonyoon.com)
  • The resultant product is no longer sensitive to aminoglycoside-modifying enzymes, a strategy that antibiotic-producing species employ to counter drug resistance in competing species. (hokudai.ac.jp)
  • Beta-lactam and aminoglycoside resistance rates and mechanisms among Pseudomonas aeruginosa in French general practice (community and private healthcare centres). (mcmaster.ca)