• Consistent with increase in serum T, piperine increased Leydig cell number, cell size, and multiple steroidogenic pathway proteins, including steroidogenic acute regulatory protein, cholesterol side-chain cleavage enzyme, 3β-hydroxysteroid dehydrogenase 1, 17α-hydroxylase/20-lyase, and steroidogenic factor 1 expression levels. (frontiersin.org)
  • Increase in SF-1 protein and detection in the steroidogenic Leydig cells and testicular cords coincides with development. (wikipedia.org)
  • His past medical history is significant for gonadal agenesis, testicular implants placement at age 16, bipolar type 1 diagnosed 2 years ago before the presentation. (scirp.org)
  • Congenital agonadism is also known as congenital anorchia, male gonadal agenesis, testicular agenesis, vanishing testes syndrome, regressed testes syndrome [1]. (scirp.org)
  • The diagnosis is made in the absence of palpable testis in the testicular sac and is sometimes discovered in young male children as with our patient or based on regular healthy appointments [1]. (scirp.org)
  • Selected oxidative stress parameters and testicular and adrenal steroidogenic capacities of adult mice were measured. (biomedcentral.com)
  • Steroidogenic factor-1 (SF-1, NR5A1) is a transcription factor that plays an essential role in the development of adrenal glands and gonads. (endocrine-abstracts.org)
  • Background: Individuals with NR5A1 mutations encoding steroidogenic factor-1 (SF1) develop a phenotypically broad range of disorders of sexual development (DSD). (elsevierpure.com)
  • Comprehensive sequence analysis of the NR5A1 gene encoding steroidogenic factor 1 in a large group of infertile males. (cdc.gov)
  • A novel mutation in steroidogenic factor (SF1/NR5A1) gene in a patient with 46 XY DSD without adrenal insufficiency. (cdc.gov)
  • Key regulators identified in this context include the STAT1:STAT2 heterodimer and interferon regulatory factor family proteins. (bvsalud.org)
  • Using in situ hybridization with SF-1 cRNA specific probe detected gene transcripts in adrenocortical cells, Leydig cells, and ovarian theca and granulosa cells. (wikipedia.org)
  • For in vitro studies, immature Leydig cells were isolated from 35-day-old male rats and treated with 50 μM piperine in the presence of different steroidogenic stimulators/substrates for 24 h. (frontiersin.org)
  • Analysis of mouse SF-1 cDNA revealed sequence similarities with Drosophila fushi tarazu factor I (FTZ-F1) which regulates the fushi tarazu homeobox gene. (wikipedia.org)
  • We showed that SF-1 dosage differentially regulates the expression of numerous and distinct genes, involved in a variety of biological processes, suggesting that fine regulation of SF-1 dosage is a critical determinant of its action during adrenal development, function and tumourigenesis. (endocrine-abstracts.org)
  • METHODS: Firstly, we downloaded the GC and glycolysis-related microarray datasets from TCGA and MSigDB databases and took the intersection to screen out the transcription factor LHX9 that regulates GC glycolytic metabolic reprogramming. (bvsalud.org)
  • Phosphorylated STAT3 (p-STAT3), as a transcription factor, binds to and regulates its target gene such as POMC gene, playing the physiological function of leptin. (biomedcentral.com)
  • These similar phenotypes suggest that SF-1 and DAX-1 act in the same pathway(s) of endocrine development. (duke.edu)
  • The striking colocalization of SF-1 and Dax-1 supports the model that they are intimately linked in a common pathway of endocrine development. (duke.edu)
  • Red wine polyphenolic compounds inhibit vascular endothelial growth factor expression in vascular smooth muscle cells by preventing the activation of the p38 mitogen-activated protein kinase pathway. (igbmc.fr)
  • Steroidogenic pathway for cortisol, aldosterone, and sex steroid synthesis. (medscape.com)
  • The steroidogenic factor 1 (SF-1) protein is a transcription factor involved in sex determination by controlling the activity of genes related to the reproductive glands or gonads and adrenal glands. (wikipedia.org)
  • For example, SF-1 cDNA shares an identical 1017 base-pair sequence with embryonal long terminal repeat-binding protein (ELP) cDNA isolated from embryonal carcinoma cells, differing only in their terminal ends. (wikipedia.org)
  • However, in the ovaries, gonadal sexual differentiation is facilitated by reductions in SF-1 transcript and protein. (wikipedia.org)
  • RACK1 depends on protein kinase C activity to translocate from the perinuclear region to the cell periphery and associates with the plasma membrane through interactions with KERATIN-1 and INTEGRIN BETA-1. (bvsalud.org)
  • In a new study published in Cell Reports , researchers led by the National Institute for Physiological Sciences (NIPS) employed a high fat diet-fed mouse model to demonstrate how neurons that express a protein called steroidogenic factor 1 (SF1) influence inflammation in different regions or "depots" of fat. (technologynetworks.com)
  • Spermatogenic phenotype of testis-specific protein, Y-encoded, 1 (TSPY1) dosage deficiency is independent of variations in TSPY-like 1 (TSPYL1) and TSPY-like 5 (TSPYL5): a case-control study in a Han Chinese population. (nih.gov)
  • SF-1 is considered an orphan receptor as high-affinity naturally occurring ligands have yet to be identified. (wikipedia.org)
  • The Effects of NLY01, a Novel Glucagon-Like Peptide-1 Receptor Agonist, on Cuprizone-Induced Demyelination and Remyelination: Challenges and Future Perspectives. (neurotree.org)
  • Mutations to CDK7 prevent interaction with the basal transcription factor, TFIIH, and formation of CDK-activating kinase complex. (wikipedia.org)
  • We identified new functional interactions between SF-1 and neuron-restrictive silencer factor/RE1-silencing transcription factor (NRSF/REST) suggesting that SF-1 has a broader role than initially thought in regulating tissue-specific gene expression programs. (endocrine-abstracts.org)
  • However, classification based upon the driving transcription factor for each adenoma subtype is emerging as an additional method for classification. (cap.org)
  • Antibodies directed against the transcription factors steroidogenic factor 1 (SF1) and transcription factor 1 (Pit-1) are becoming useful diagnostic tools. (cap.org)
  • A third transcription factor, pituitary cell-restricted T box factor (Tpit), drives corticotroph adenomas but its antibody is not yet commercially available as an IHC marker. (cap.org)
  • Adenomas driven by the transcription factor SF1, which are exclusively of the gonadotroph type, are a common subtype encountered by the surgical pathologist. (cap.org)
  • Transcription factors (TFs) bind to specific regions of DNA known as transcription factor binding sites (TFBSs) and modulate gene expression by interacting with the transcriptional machinery. (bvsalud.org)
  • Mutations of the orphan nuclear receptors, steroidogenic factor 1 (SF-1) and DAX-1, cause complex endocrine phenotypes that include impaired adrenal development and hypogonadotrophic hypogonadism. (duke.edu)
  • SF-1 levels is strongly expressed at the onset of follicular development in theca and granulosa cells which precedes expression of the aromatase enzyme responsible for estrogen biosynthesis. (wikipedia.org)
  • The synthesis of estrogens in breast tissue is catalyzed by the enzyme aromatase, which is encoded by the gene cytochrome P450 family 19 subfamily A member 1 (CYP19A1). (spandidos-publications.com)
  • Expression levels of mRNA for neurosteroidogenic enzymes 17β-HSD, 5α-reductase, 3α-HSD and cytochrome P450 aromatase in the fetal wild type and SF-1 knockout mouse brain. (arnes.si)
  • At the same time, in these groups, there was an increase in the level of aromatase, malondialdehyde, cholesterol, and steroidogenic factor-1 (SF-1) expression in the adrenal cortex and an enhancement in histological lesions. (biomedcentral.com)
  • Effects of Deletion of Mutant Huntingtin in Steroidogenic Factor 1 Neurons on the Psychiatric and Metabolic Phenotype in the BACHD Mouse Model of Huntington Disease. (lu.se)
  • Scholars@Duke publication: Steroidogenic factor 1 and Dax-1 colocalize in multiple cell lineages: potential links in endocrine development. (duke.edu)
  • The ovaries no longer have follicles and their function, as a steroidogenic endocrine organ does not work anymore. (bvsalud.org)
  • We identified fetal and adult testis expressed-1 (FATE1), a cancer testis antigen (CTA), as a new dosage-dependent target of SF-1. (endocrine-abstracts.org)
  • In mouse embryos, SF-1 expression in the urogenital ridge and brain either preceded or coincided with Dax-1 expression, with coordinate expression thereafter in the adrenal cortex, testis, ovary, hypothalamus, and anterior pituitary. (duke.edu)
  • It is suggested that the syndrome is due to regression of the testis at the late stage of prenatal development [1]. (scirp.org)
  • SF-1 expression is localized to adult steroidogenic tissues correlating with known expression profiles of steroid hydroxylases. (wikipedia.org)
  • SF-1 specific antibody studies confirmed expression profile of SF-1 in rats and humans corresponding to sites of transcript detection. (wikipedia.org)
  • SF-1 transcripts precede the onset of SRY expression in the fetal testes hinting at gonadal developmental role. (wikipedia.org)
  • Multiple level regulation of SF-1 activity is exerted by interaction with cofactors, post-translational modifications and epigenetic gene expression regulation. (endocrine-abstracts.org)
  • The slightly earlier onset of SF-1 expression and its ability to bind specifically to a conserved sequence in the Dax-1 5'-flanking region suggested that SF-1 may activate Dax-1 expression. (duke.edu)
  • However, promoter activity of Dax-1 5'-flanking sequences did not require this potential SF-1-responsive element, and Dax-1 expression was unimpaired in knockout mice lacking SF-1, establishing that SF-1 is not required for Dax-1 gene expression in these settings. (duke.edu)
  • Steroidogenic factor-1: a key regulator of gonadotroph gene expression. (nih.gov)
  • We have gained crucial insights into molecular factors and pathways of the cells generating either the supporting gonadal cells or germ cells of both sexes. (lidsen.com)
  • Wilms' tumor suppressor gene 1 (WT1) is the gene responsible for the developmental process of AGP. (biomedcentral.com)
  • Other critical domains of SF-1 include a proline-rich hinge region, ligand-binding domain, and a C-terminal activation domain for transcriptional interactions. (wikipedia.org)
  • Transcription factors 3: nuclear receptors. (embl.de)
  • The autosomal recessive form is due to a mutation or deletion of the gene that codes for steroidogenic factor 1 (SF-1) on chromosome 9q33 (OMIM 184757). (medscape.com)
  • The influence of gonadal steroid hormones on immunoreactive kisspeptin in the preoptic area and arcuate nucleus of developing agonadal mice with a genetic disruption of Steroidogenic factor-1. (arnes.si)
  • Altered position of cell bodies and fibers in the ventromedial region in SF-1 knockout mice. (arnes.si)
  • Although the frequency has been estimated in Japan at 1 case per 12,500 births, clinical experience indicates that this disease is not as common as congenital adrenal hyperplasia due to 21-hydroxylase deficiency (incidence is approximately 1 per 10,000-15,000 births worldwide). (medscape.com)
  • SF-1 is a critical regulator of reproduction, regulating the transcription of key genes involved in sexual development and reproduction, most notably StAR and P450SCC. (wikipedia.org)
  • SF1 drives gonadotroph adenomas while Pit-1 drives GH, PRL, and TSH adenomas. (cap.org)
  • Embryonic mouse SF-1 transcripts have been discovered to localize within regions of the developing diencephalon and subsequently in the ventromedial hypothalamic nucleus (VMH) suggesting roles beyond steroidogenic maintenance. (wikipedia.org)
  • SF-1 transcripts initially localize to the urogenital ridge before SF-1 expressing cells resolve into distinct adrenocortical and gonadal precursors that ultimately give rise to adrenal cortex and gonads. (wikipedia.org)
  • High serum FSH is not a risk factor for low bone mineral density in infertile men. (nih.gov)
  • Indeed, WT1 and its target steroidogenic factor-1 (SF-1) are present early in the AGP development process. (biomedcentral.com)
  • Metabolic traits are another key factor, and they may trigger infertility, which can affect the normal development and function of the ovaries as well. (lidsen.com)
  • Genital ambiguity occurs in 1 in 4,500 births, and ovotesticular disorder of sexual development occurs in fewer than 10% of all disorders of sexual development. (medscape.com)
  • Finally, we utilized the leads to inform the evaluation of the neutralizing HIV-1 antibody elicited in SHIV-infected rhesus macaques broadly, RHA1.V2.01, which binds the apex from the Env trimer in a fashion that mimics the binding mode of PGT145. (epf2013.org)
  • The immunohistochemistry was carried out on neutral buffered formalin-fixed paraffin-embedded tissue sections by using the monoclonal antibody of HIF-1α. (ijpmonline.org)
  • By employing multiple genomic approaches, we defined different levels of regulation in transcriptome, miRNome and more recently on regulome exerted by SF-1 dosage. (endocrine-abstracts.org)
  • Our studies involving both cell lines and transgenic mouse studies showed that an increased SF-1 dosage activates adrenocortical cell proliferation and causes adrenocortical neoplasia. (endocrine-abstracts.org)
  • Diacylglycerols can have many different combinations of fatty acids attached at both the C-1 and C-2 positions. (hmdb.ca)
  • 1984 Aug;247(2 Pt 1):E173-80. (nih.gov)
  • Fig. 1: Main physiological and metabolic adjustments during gestation. (nature.com)
  • The greatly increased prevalence of type 2 diabetes and some metabolic diseases closely related with the rapidly growing obesity epidemic around the world, which due to an energy imbalance caused by unhealthy lifestyles and nutrient overload [ 1 ]. (biomedcentral.com)