Spondyloarthritis spondylitis ankylosing. Medical search. Frequent questions

These drugs are for people with severe active ankylosing spondylitis or severe non-radiographic axial spondyloarthritis who have tried non-steroidal anti-inflammatory drugs (NSAIDs), but they have not worked. (nice.org.uk)
In 2019, the US Food and Drug Administration (FDA) approved certolizumab for treatment of nonradiographic axial spondyloarthritis (nr-axSpA) with objective inflammation. (medscape.com)
adults with active non-radiographic axial spondyloarthritis with objective signs of inflammation. (nih.gov)
TALTZ is indicated for the treatment of adult patients with active non-radiographic axial spondyloarthritis (nr-axSpA) with objective signs of inflammation. (nih.gov)
Axial spondyloarthritis (also often referred to as axSpA) is a chronic, autoinflammatory disease predominantly affecting the axial skeleton (sacroiliac joints and spine). (wikipedia.org)
The best-known member of the axial spondyloarthritis disease family is ankylosing spondylitis. (wikipedia.org)
The 2009 introduction of the expression axial spondyloarthritis made it possible to refer to (1) less severe forms of spondylitis, (2) the early phase of ankylosing spondylitis and (3) ankylosing spondylitis itself collectively. (wikipedia.org)
Along with peripheral spondyloarthritis, reactive arthritis, psoriatic arthritis and enteropathic arthritis (or inflammatory bowel disease-associated spondyloarthritis), axial spondyloarthritis belongs to the spondyloarthritis disease family, also known as the spondyloarthritides or spondyloarthropathies. (wikipedia.org)
Likewise, reactive arthritis can transform into chronic axial spondyloarthritis. (wikipedia.org)
Axial spondyloarthritis can be differentiated from peripheral spondyloarthritis in terms of the areas of the body affected. (wikipedia.org)
Axial spondyloarthritis can be divided into two classes: Non-radiographic axial spondyloarthritis (nr-axSpA): This term encompasses both the early disease stage of ankylosing spondylitis, in which no radiographic changes are visible yet, as well as less severe forms of ankylosing spondylitis. (wikipedia.org)
Radiographic axial spondyloarthritis: Synonym for ankylosing spondylitis. (wikipedia.org)
This class is termed radiographic axial spondyloarthritis due to the unambiguous diagnosis through radiographic changes in the sacroiliac joints and/or spine. (wikipedia.org)
Axial spondyloarthritis is predominantly marked by inflammatory pain and/or stiffness affecting the lower back, hips and/or buttocks. (wikipedia.org)
People with axial spondyloarthritis may experience alternating periods of remission and flare-ups. (wikipedia.org)
It is recommended that patients be formally evaluated for axial spondyloarthritis if they complain of inflammatory back pain and stiffness lasting at least three months, particularly if they are under the age of 45 and/or have a family history of the disease. (wikipedia.org)
Patients being examined for axial spondyloarthritis may have x-rays, or radiographs, taken of their pelvis to check for signs of sacroilitis (often one of the first manifestations of the disease) and structural damage. (wikipedia.org)
Their presence distinguishes radiographic axial spondyloarthritis from nr-axSpA. (wikipedia.org)
Blood work may also play a role in the diagnosis of axial spondyloarthritis. (wikipedia.org)
Some people with axial spondyloarthritis may test positive for elevated C-reactive protein, or CRP, depending on their disease activity. (wikipedia.org)
There is currently no cure for axial spondyloarthritis, but there are various disease management strategies. (wikipedia.org)
Axial spondyloarthritis mainly affects the spine and sacroiliac joints, which connect the hip bones to the spine. (medicalnewstoday.com)
Axial spondyloarthritis (axSpA) is an inflammatory disease of the axial skeleton associated with significant pain and disability. (bmj.com)
Efficacy and safety of infliximab plus naproxen versus naproxen alone in patients with early, active axial spondyloarthritis: results from the double-blind, placebo-controlled INFAST study, Part 1. (benthamscience.com)
8. Incidence and Prevalence of Major Adverse Cardiovascular Events in Rheumatoid Arthritis, Psoriatic Arthritis, and Axial Spondyloarthritis. (nih.gov)
10. Extent of axial damage in psoriatic arthritis and spondyloarthritis: comparative data from the BEPAS and (Be-)GIANT multicentre cohorts. (nih.gov)
The objective of this review is to address AS and the recently defined disorder of non-radiographic axial spondyloarthritis. (racgp.org.au)
This review will focus on ankylosing spondylitis (AS) and the recently defined disorder of non-radiographic axial SpA. (racgp.org.au)
The National Axial Spondyloarthritis Society is the only charity in the UK dedicated to supporting anyone affected by ankylosing spondylitis (AS). (milton-keynes.gov.uk)
Adding methotrexate to adalimumab (Humira) in axial spondyloarthritis was associated with reduced immunogenicity, as shown by a lower rate of developing antidrug antibodies, French researchers reported. (medpagetoday.com)
Methotrexate is not approved for use in axial spondyloarthritis because it has not demonstrated symptomatic benefits. (medpagetoday.com)
In this prospective randomized trial, we demonstrate that methotrexate significantly reduced the immunogenicity and ameliorated adalimumab concentration, as a surrogate of drug exposure, in axial spondyloarthritis patients," the investigators wrote. (medpagetoday.com)
those with a related disease called non-radiographic axial spondyloarthritis (nr-AxSpA) have similar symptoms as ankylosing spondylitis, but without damage you can see imaging. (creakyjoints.org)
The research on how ankylosing spondylitis and axial spondyloarthritis affects women is fascinating, ongoing, and sometimes contradictory. (creakyjoints.org)
What's New in Axial Spondyloarthritis? (medscape.org)
Dr Atul Deodhar summarizes key information from a virtual symposium on axial spondyloarthritis. (medscape.org)
An expert panel discusses strategies for achieving remission in patients with axial spondyloarthritis and the role of TNF inhibitors. (medscape.org)
New research presented this week at ACR Convergence, the American College of Rheumatology's annual meeting, found that an innovative new artificial neural network can detect radiographic sacroiliitis in patients with suspected axial spondyloarthritis, a progressive disease that is more common in young adults (Abstract #1919). (reachmd.com)
Many people with axial spondyloarthritis (axial SpA) progress to having a degree of spinal fusion, specifically in the case of ankylosing spondylitis. (reachmd.com)
The FDA has approved upadacitinib for the treatment of non-radiographic axial spondyloarthritis (nr-axSpA) based on a short-term study that demonstrated improved pain, function and other symptoms of nr-axSpA in patients with active disease. (the-rheumatologist.org)
Spondyloarthritis is an umbrella term used to describe a family of disorders, including ankylosing spondylitis, non-radiographic axial spondyloarthritis, psoriatic arthritis, reactive arthritis , enteropathic arthritis and undifferentiated spondyloarthritis. (dermnetnz.org)
Ankylosing spondylitis (AS), sometimes referred to as radiographic axial spondyloarthritis (axSpA), is a chronic inflammatory rheumatic disease that affects the axial skeleton, potentially leading to structural and functional impairments and diminished quality of life [ 1 , 2 , 3 , 4 ]. (springeropen.com)
Reuma-check" performance of a comprehensive fast-track program for the diagnosis of axial spondyloarthritis in South America. (biomedcentral.com)
Peripheral spondyloarthritis affects the peripheral joints in your legs and arms, while axial spondyloarthritis appears in your spine and the joints of your pelvis (called the sacroiliac joints). (aminoco.com)
Ankylosing spondylitis (AS), a spondyloarthropathy, is a chronic, multisystem inflammatory disorder involving primarily the sacroiliac (SI) joints and the axial skeleton. (medscape.com)
The outcome in patients with axial spondyloarthritis, including AS, is generally good compared with that in patients with a disease such as rheumatoid arthritis. (medscape.com)

1. Are ankylosing spondylitis, psoriatic arthritis and undifferentiated spondyloarthritis associated with an increased risk of cardiovascular events? (nih.gov)
3. Undifferentiated spondyloarthritis vs ankylosing spondylitis and psoriatic arthritis: a real-life prospective cohort study of clinical presentation and response to treatment. (nih.gov)
4. Incidence of extra-articular manifestations in ankylosing spondylitis, psoriatic arthritis and undifferentiated spondyloarthritis: results from a national register-based cohort study. (nih.gov)
5. Back pain and health status in patients with clinically diagnosed ankylosing spondylitis, psoriatic arthritis and other spondyloarthritis: a cross-sectional population-based study. (nih.gov)
9. Ankylosing spondylitis, psoriatic arthritis, and risk of malignant lymphoma: a cohort study based on nationwide prospectively recorded data from Sweden. (nih.gov)
11. Tuberculosis Risk in Ankylosing Spondylitis, Other Spondyloarthritis, and Psoriatic Arthritis in Sweden: A Population-Based Cohort Study. (nih.gov)
12. Comorbidities Associated with Psoriatic Arthritis Compared with Non-psoriatic Spondyloarthritis: A Cross-sectional Study. (nih.gov)
14. Role of comorbidities in spondyloarthritis including psoriatic arthritis. (nih.gov)
When people with psoriatic arthritis feel pain in their spine and sacroiliac joints (the joints that link your pelvis to your lower spine), it's called psoriatic spondylitis. (floridamedicalclinic.com)
In January, upadacitinib was approved for use in Europe as a 15 mg, once-daily dose to treat patients with psoriatic arthritis and ankylosing spondylitis. (the-rheumatologist.org)
Psoriatic arthritis is a form of spondyloarthritis . (dermnetnz.org)
The approval makes Xeljanz the first JAK inhibitor approved to treat ankylosing spondylitis and Rinvoq the second approved for psoriatic arthritis. (creakyjoints.org)
The authors carry out a depth analysis of the current state of spondyloarthritis (SpA), including psoriatic arthritis (PsA) in the region. (biomedcentral.com)

Because spondyloarthritis does not share genetic risk factors, a presence of disease specific autoantibodies, nor a response to therapies targeting the T-cell or B-cells of the immune system which seem to be important in other autoimmune diseases such as lupus and rheumatoid arthritis, the cause of spondyloarthritis is likely to be different than those of autoimmune diseases. (hss.edu)
6. Is ankylosing spondylitis a risk factor for cardiovascular disease, and how do these risks compare with those in rheumatoid arthritis? (nih.gov)
and showed that in synovium of rheumatoid arthritis a contrast disease of seronegative spondyloarthritis, transcription factor Sox4 contributes to the pathogenesis of chronic inflammation by CXCL13 production from CD4+ T cells. (nii.ac.jp)
His main interest is Rheumatology patients who have conditions such as: Systemic Lupus Erythematosus, Rheumatoid Arthritis, Spondyloarthritis like Ankylosing Spondylitis, Crystal induces arthritis like Gout, Scleroderma, and other collagen diseases. (azhd.ae)

Ankylosing spondylitis (AS) is a chronic form of arthritis. (medlineplus.gov)
AS is the main member of a family of similar forms of arthritis called spondyloarthritis. (medlineplus.gov)
UPDATED July 25, 2013 ) - A major observational study in ankylosing spondylitis (AS) published online July 1 in Arthritis & Rheumatism revealed that tumor necrosis factor (TNF) inhibitors significantly reduced the risk for radiographic progression, that the benefit became apparent after nearly 4 years of treatment, and that the benefit was lost if treatment began late. (medscape.com)
This study will explore how genes may influence the severity of ankylosing spondylitis, a form of arthritis that affects the spine. (nih.gov)
Notices will also be sent to local chapters of the Arthritis Foundation and the Spondylitis Association of America. (nih.gov)
Spondyloarthritis is a group of diseases characterized by inflammation in the spine (spondylitis) and joints (arthritis). (bangkokhospital.com)
Spinal arthritis or Spondyloarthritis is a common form of chronic arthritis among U.S. adults. (cdc.gov)
In spondyloarthritis, these small posterior joints between the ribs and the spine may become affected by arthritis resulting in reduced chest expansion. (cdc.gov)
Treatment Reactive arthritis (previously called Reiter syndrome) is a spondyloarthritis causing inflammation of the joints and tendon attachments at the joints, often related to an infection. (msdmanuals.com)
Ankylosing spondylitis is an inflammatory form of arthritis that primarily affects the lower back and sacroiliac joints, where the spine connects with the pelvis - though it frequently causes pain in other joints, as well as such systemic symptoms as inflammatory bowel disease and psoriasis. (creakyjoints.org)
A 2012 study published in the journal Arthritis Care & Research estimates that spondyloarthritis - a group of related types of arthritis that includes AS - affects up to 1 percent of the U.S. population, or roughly 3 million people. (creakyjoints.org)
Inflammatory back pain is a type of chronic pain (pain that lasts more than 3 months) that is associated with spondyloarthritis , a type of arthritis that causes inflammation in the spine. (floridamedicalclinic.com)
Spondyloarthritis is a subtype of arthritis that can involve the spine, and sometimes, the joints of the arms and legs, as well as the skin, intestines, or eyes. (reachmd.com)
Ankylosing spondylitis (AS) is a form of arthritis. (healthline.com)
A nkylosing spondylitis , P soriasis, A cute anterior uveitis , I nflammatory bowel disease, R eactive arthritis . (amboss.com)
Spondyloarthritis is a group of diseases that cause arthritis. (aminoco.com)
Spondyloarthritis is an overarching name for several inflammatory rheumatic diseases that are the cause of arthritis. (aminoco.com)
Arthritis often affects your joints , and spondyloarthritis causes inflammation within the tendons and ligaments of your bones, referred to as entheses. (aminoco.com)
One of the most common types of spondylitis, the stiffness and pain associated with this kind of arthritis target your ligaments and joints in your spine. (aminoco.com)
Spondyloarthritis and its subcategories of arthritis seem to run in families, indicating that genes may play a role in increasing your risk. (aminoco.com)
New research supported, in part, by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), has brought scientists a step closer to understanding the genetic mechanisms underlying ankylosing spondylitis, a chronic inflammatory form of arthritis that predominantly affects the spine and pelvis. (nih.gov)
Ankylosing spondylitis is an incurable inflammatory arthritis of the spine that most often begins in young adulthood and can lead to life-long inflexibility, posture changes, and pain. (nih.gov)

adults with active ankylosing spondylitis. (nih.gov)
TALTZ is indicated for the treatment of adult patients with active ankylosing spondylitis. (nih.gov)

Ankylosing spondylitis (AS) is a chronic (Miasmatic), progressive (Miasmatic), painful inflammatory rheumatic disease (Pseudopsora), which affects the spinal joints, in particular the sacroiliac joints and the lumbar spine. (hpathy.com)
Previously, the diagnosis of ankylosing spondylitis required advanced changes on plain radiographs of the sacroiliac joints. (bmj.com)
Joint fusion of sacroiliac joints is the characteristic feature of ankylosing spondylitis. (acc.org)

Progressors were defined as having change of more than 1 unit/year by the modified Stokes Ankylosing Spondylitis Spine Score (mSASSS). (medscape.com)
As the spine becomes progressively ankylosed (Pseudopsora/ Sycosis), spinal rigidity (Sycosis) and secondary osteoporosis predispose to spinal fracture (Syphilis), presenting as acute, severe, well localised pain (Psora). (hpathy.com)
Ankylosing spondylitis is defined as an inflammatory disease that, over time, can cause some of the small bones in the spine (vertebrae) to fuse. (bangkokhospital.com)
Ankylosing spondylitis is one type of spondyloarthritis, defined as a long-term inflammation of the joints of the spine. (bangkokhospital.com)
The OWD may be abnormal in kyphosis (forward curvature of the upper thoracic spine) due to either spondyloarthritis or osteoporosis, as well as in other conditions such as postural instability, congenital spinal deformity and marked obesity. (cdc.gov)
Spondyloarthritis (also called spondyloarthropathy or spondyloarthritides) is a term used to describe a group of diseases that cause prominent joint inflammation, affect the spine and other joints, and share certain other characteristics. (msdmanuals.com)
Treatment Ankylosing spondylitis is a spondyloarthritis characterized by inflammation of the spine (spondylitis), large joints, and fingers and toes, resulting in stiffness and pain. (msdmanuals.com)
Did you know that back pain could be an alarm bell for ankylosing spondylitis, an inflammatory disease that may lead to impaired mobility in the spine and other joints? (mountelizabeth.com.sg)
Ankylosing spondylitis is a rare inflammatory disease that causes your spine to fuse together over time. (floridamedicalclinic.com)
Symptoms of this condition typically appear in early adulthood and are similar to ankylosing spondylitis, but does not involve the spine fusing. (floridamedicalclinic.com)
Ankylosing spondylitis (AS) is a disease that causes pain and stiffness in the spine. (springeropen.com)

When Do Symptoms of Ankylosing spondylitis Begin? (nih.gov)
If warning signs and symptoms of ankylosing spondylitis arise, medical attention and treatment must be sought immediately. (bangkokhospital.com)

The guidance has been incorporated into NICE's guideline on spondyloarthritis in over 16s: diagnosis and management (NG65). (nice.org.uk)
Dr Lui's key research interest is in the early diagnosis and treatment of spondyloarthritis. (mountelizabeth.com.sg)
This type of spondyloarthritis is characterized by a cluster of symptoms that doesn't fit neatly into a specific spondyloarthritis diagnosis. (aminoco.com)

13. Cancer risk in patients with spondyloarthritis treated with TNF inhibitors: a collaborative study from the ARTIS and DANBIO registers. (nih.gov)
Tumor necrosis factor (TNF) inhibitors such as adalimumab and infliximab (Remicade) can be effective for spondyloarthritis, but up to one-quarter of patients stop the therapy within a year because of primary or secondary loss of efficacy. (medpagetoday.com)

To relieve pain and stiffness, common medicines prescribed in patients with ankylosing spondylitis are pain killer drugs, nonsteroidal anti-inflammatory drugs (NSAIDs) and anti- rheumatic drugs as well as other groups of medications. (bangkokhospital.com)
The pain and stiffness from ankylosing spondylitis can strike not just in the lower back, pelvis, and hips, but other joints as well as entheses, which are connective tissue that link ligaments and tendons to bones. (creakyjoints.org)

No definite disease-modifying treatment exists for individuals with ankylosing spondylitis (AS) although biologic agents show evidence of such activity. (medscape.com)
At week 52, major improvement in the Ankylosing Spondylitis Disease Activity Score (ASDAS) had occurred in 42% of patients receiving certolizumab, compared with 7% of those receiving placebo. (medscape.com)
More than 80% of patients with the ankylosing spondylitis variant test positive for the HLA-B27 biomarker, but not everyone with this biomarker will develop disease. (wikipedia.org)
Spondyloarthritis is generally considered to be a seronegative disease, meaning tests for rheumatoid factor and other autoantibodies typically come back negative. (wikipedia.org)
Dr. Ashany: A recent article reviewing multiple studies on the subject concluded that in Ankylosing Spondylitis , there is evidence supporting exercise interventions in improving physical function, disease activity, and chest expansion compared to patients who don't exercise. (hss.edu)
Dr. Ashany: Spondyloarthritis (SpA) is a chronic immune-mediated inflammatory disease of unknown origin. (hss.edu)
To characterise the immunohistological features of sacroiliitis in ankylosing spondylitis (AS) at different disease stages. (bmj.com)
In ankylosing spondylitis (AS) 1 and undifferentiated SpA, 2 sacroiliitis is the most frequent clinical finding and the presumed first manifestation of the disease. (bmj.com)
However, if back pain progresses to chronic and severe pain without adequate response to given treatments, it might strongly indicate arthritic disease, called ankylosing spondylitis. (bangkokhospital.com)
Nonetheless, people who have this gene might not have ankylosing spondylitis and vice versa, patient can develop the disease without having this gene. (bangkokhospital.com)
Despite the lack of regulatory approval for methotrexate in spondyloarthritis, the drug is often used among patients who have peripheral disease manifestations. (medpagetoday.com)
Along with antidrug antibody detection, patients were assessed for clinical response according to the Ankylosing Spondylitis Disease Activity Score (ASDAS) at weeks 4, 8, 12, and 26. (medpagetoday.com)
Ankylosing spondylitis may be portrayed as a 'man's disease' - but it's anything but to the hundreds of thousands of women living with it, many undiagnosed. (creakyjoints.org)
Let's get this out of the way: "Ankylosing spondylitis is not a man's disease. (creakyjoints.org)
In particular the gene HLA-B27 has been pinpointed for its tie to ankylosing spondylitis-it's been shown that people who have this gene have a higher risk of the disease. (aminoco.com)
Association of Long Noncoding RNAs Polymorphisms With Ankylosing Spondylitis, Vogt-Koyanagi-Harada Disease, and Behcet's Disease. (cdc.gov)
For almost three decades, scientists have known that a genetic marker called human leukocyte antigen (HLA)-B27 is associated with the development of ankylosing spondylitis, a disease that can lead to spinal fusion and internal organ damage if inflammation is not stopped. (nih.gov)
But while most people with ankylosing spondylitis have the genetic marker, only a small percentage-perhaps one to five percent-of people with the gene develop the disease, suggesting other genes and factors are involved. (nih.gov)
The study identified several new genetic regions associated with ankylosing spondylitis risk, and offered new insights into how another recently identified gene, ERAP1, interacts with HLA-B27 in the disease. (nih.gov)
Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility. (nih.gov)
IRP researchers led by Michael M. Ward, M.D. , partnered with the International Genetics of Ankylosing Spondylitis Consortium to compare genes from thousands of people with ankylosing spondylitis to those from people without the disease. (nih.gov)

This work was also supported by the NIAMS Intramural Research Program, the Australo-Anglo-American Spondyloarthritis Consortium and the Wellcome Trust Case Control Consortium 2. (nih.gov)

Impact of extra-articular spondyloarthritis manifestations and comorbidities on drug retention of a first TNF-inhibitor in ankylosing spondylitis: a population-based nationwide study. (nih.gov)

The two types of spondyloarthritis are determined by the parts of your body that are targeted. (aminoco.com)

17. Association of spondyloarthritis and sarcoidosis: A retrospective observational population-based matched cohort study. (nih.gov)

Spondyloarthritis can also develop in people with no characteristics of other specific spondyloarthritis (undifferentiated spondyloarthritis). (msdmanuals.com)

This guidance replaces NICE technology appraisal guidance on adalimumab, etanercept and infliximab for ankylosing spondylitis (TA143) and golimumab for the treatment of ankylosing spondylitis (TA233). (nice.org.uk)
Imaging helps doctors recognize signs of ankylosing spondylitis (AS) and recommend treatment. (medicalnewstoday.com)
Biological treatment of ankylosing spondylitis: a nationwide study of treatment trajectories on a patient level in clinical practice. (nih.gov)
To explore the possibility that co-administration of methotrexate with a TNF inhibitor could lessen the likelihood of development of antidrug antibodies and loss of treatment efficacy, the researchers recruited adult patients with spondyloarthritis in 2013 and 2014 from the network of Western France University Hospitals. (medpagetoday.com)
Is TNF Inhibitor Treatment Necessary for Ankylosing Spondylitis Patients in Remission? (patientworthy.com)
Unfortunately, there is no cure for spondyloarthritis, but recognizing the symptoms early and finding a treatment plan that works well for you can help you continue to lead an active and productive life. (aminoco.com)

The Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) scale has demonstrated good internal consistency and responsiveness to changes in clinical status among patients with ankylosing spondylitis (AS). (springeropen.com)
We have read with great interest the article "Prevalence, demographics, and clinical characteristics of Latin American patients with spondyloarthritis" by Gustavo Citera et al. (biomedcentral.com)
Prevalence, demographics, and clinical characteristics of Latin American patients with spondyloarthritis. (biomedcentral.com)
Comparison of clinical manifestations according to HLA-B(27) genotype in ankylosing spondylitis patients: real-world evidence from smart management system for spondyloarthritis]. (cdc.gov)

are usually negative in spondyloarthritis (hence, these disorders are also called the seronegative spondyloarthropathies). (msdmanuals.com)

Men are more likely to develop ankylosing spondylitis than are women while onset generally occurs in late adolescence or early adulthood. (bangkokhospital.com)

Juvenile-onset spondyloarthritis affects the lower extremities, often affects joints on opposite sides of the body to different degrees, and begins most commonly in boys aged 7 to 16. (msdmanuals.com)

Mulleman's group noted that in retrospective studies, similar reductions in immunogenicity were seen among patients with spondyloarthritis receiving infliximab in combination with methotrexate. (medpagetoday.com)

Get information about the primary signs/symptoms and the various treatments and techniques to manage spondyloarthritis in children and teens. (spondylitis.org)
Signs of spondyloarthritis most commonly develop in two phases, with pain, inflammation, and stiffness being followed by the breaking down of your bones. (aminoco.com)

He was also the chief physician who spearheaded the service and research in the spondyloarthritis clinic at SGH's Autoimmunity and Rheumatology Centre. (mountelizabeth.com.sg)
He has also been a peer reviewer in several rheumatology journals in the field of spondyloarthritis. (mountelizabeth.com.sg)

Spondylitis means inflammation of the spinal vertebrae. (hpathy.com)
Spondyloarthritis is often associated with physical impairment due to decreased spinal mobility and can lead to early mortality. (cdc.gov)

People who have the HLA-B27 gene are at a greatly increased risk of developing ankylosing spondylitis. (bangkokhospital.com)
Many people have never heard of ankylosing spondylitis until they or someone they know gets diagnosed with it, but it's more common than you think. (creakyjoints.org)
You most commonly see teenagers and people in their early 20s, particularly men, affected by spondyloarthritis. (aminoco.com)
The study shows that ERAP1 is associated with ankylosing spondylitis only in people who are HLA-B27 positive, pointing to a possible key mechanism by which HLA-B27 contributes to the development of ankylosing spondylitis through the aberrant processing of antigens by ERAP1. (nih.gov)

Dr. Ashany: Spondyloarthritis is thought to occur in individuals with a genetic susceptibility for the condition that is then exposed to an environmental trigger. (hss.edu)
Definite cause of ankylosing spondylitis remains unknown, although genetic alterations seem to be involved. (bangkokhospital.com)
The team discovered 13 new genetic markers associated with ankylosing spondylitis and confirmed the importance of 12 previously identified biomarkers. (nih.gov)

New Use for Methotrexate in Spondyloarthritis? (medpagetoday.com)
In a group of 107 patients with spondyloarthritis, 25% of those given methotrexate along with adalimumab developed antidrug antibodies by week 26 compared with 47.3% of those who received adalimumab as monotherapy, for a relative risk of 0.53 (95% CI 0.31-0.91), reported Denis Mulleman, MD, PhD, of the University of Tours, and colleagues. (medpagetoday.com)

The predominance of a role for these innate system cells over the lymphocytes of the adaptive immune system cells suggests an auto-inflammatory rather than an autoimmune origin of inflammation in spondyloarthritis. (hss.edu)

Anatomy5

Diseases14

Chemicals and Drugs7

Analytical, Diagnostic and Therapeutic Techniques and Equipment5

Disciplines and Occupations1

Health Care2

Axial46

Psoriatic arthritis13

Rheumatoid arthritis4

Arthritis22

Active ankylosing2

Sacroiliac joints3

Spine11

Symptoms of ankylosing2

Diagnosis3

Inhibitors2

Pain and stiffness2

Disease21

Intramural Research Program1

Extra-articular1

Types of spondyloarthritis1

Observational1

Specific spondyloarthritis1

Treatment6

Clinical4

Disorders1

Early adulthood1

Joints1

Infliximab1

Signs2

Rheumatology2

Spinal2

People4

Genetic3

Methotrexate2

Autoimmune1