• Studies using a derivative of chromosome conformation capture (3C) known as 'Hi-C' have revealed that long-range genomic contacts segregate TADs into an active (A) and inactive (B) compartment [ 37 ]. (biomedcentral.com)
  • Many techniques have been devised to capture the architectural information within whole genome [ 1 - 9 ], among which the High-throughput Chromosome Conformation Capture (Hi-C) technique has gained widespread adoption. (biomedcentral.com)
  • We probe the open conformation of human Hsp90α for druggable sites that overlap with these allosteric control elements, and identify three putative natural compound allosteric modulators: Cephalostatin 17, 20(29)-Lupene-3β-isoferulate and 3′-Bromorubrolide F. We assess the allosteric potential of these ligands by examining their effect on the conformational dynamics of the protein. (nature.com)
  • Illustration of Hsp90α in the open conformation. (nature.com)
  • Like other biological macromolecules such as polysaccharides and nucleic acids, proteins are essential parts of organisms and participate in virtually every process within cells. (transectscience.org)
  • Here we find that in Caenorhabditis elegans, mouse, rat and human neurons, dendritically and axonally polarized transmembrane proteins are recognized by endocytic machinery in the AIS, robustly endocytosed and targeted to late endosomes for degradation. (stanford.edu)
  • This new approach has been shown to preserve mobility and enzymatic activity of transmembrane proteins in the resulting nSLB. (lu.se)
  • All proteins manifest conformational changes (small or large) and/or vibrations that allow them do their function. (stackexchange.com)
  • A combination of molecular simulation with hydrogendeuterium-exchange mass spectrometry and electron paramagnetic resonance spectroscopy reveal an asymmetry across the membrane: ATP-induced conformational changes in the cytosolic cavity promote unfolded pre-protein structure, while the exterior cavity favours its formation. (elifesciences.org)
  • These findings suggest that fatty acid-protein complexes may have potential application value as carotenoid delivery vectors. (bvsalud.org)
  • To investigate the underlying molecular mechanism we analysed binding of polycomb group (PcG) repressive complexes (PRCs) and the spatial organization of the INK4b-ARF-INK4a locus. (biomedcentral.com)
  • Proteins can also work together to achieve a particular function, and they often associate to form stable protein complexes. (transectscience.org)
  • While the general sequence of SNARE complex formation is well-established, our knowledge on possible intermediates and stable off-pathway complexes is incomplete. (nature.com)
  • Various interior dynamics including self organization of macromolecules, protein conformation, movement of human thoracic diaphragm, formation of logarithmic spiral in nature were discussed in the light of potential energy of self gravity and kinetic energy of metabolic energy. (webmedcentral.com)
  • Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues. (transectscience.org)
  • The Protein Data Bank (PDB) is an archive of experimentally determined three-dimensional structures of biological macromolecules that serves a global community of researchers, educators, and students. (biokeanos.com)
  • The Protein Data Bank is the single worldwide archive of structural data of biological macromolecules. (biokeanos.com)
  • Juers and Matthews (9) showed that the area involved in macromolecules are usually determined after rapid cooling to protein-protein crystal contacts typically increases by 50% on cryogenic temperatures, some 150 -200 K below the normal phys- cooling to cryogenic temperature. (lu.se)
  • The figure shows RBMS1 protein scanning the DNA in search of its target sequence and binding to the sequence's nucleotides in a specific manner. (neelsb.com)
  • Proteins search and bind specific sequence in the background of billions of bases in the genome. (neelsb.com)
  • The work provides the first structural and dynamics characterization of human RBMS1 protein, that controls the expression of c-myc proto-oncogene inside the human cell by its interaction with 7 base pair consensus sequence within the 21 bp promoter/ autonomous origin of replication region 2 kb upstream of c-myc proto-oncogene. (neelsb.com)
  • Today, recognition and classification of sequence motifs and protein folds is a mature field, thanks to the availability of numerous comprehensive and easy to use software packages and web-based services. (biomedcentral.com)
  • Sequence Analysis: Primary sequence of human gb-crystallin (Accession No. CRGB-HUMAN) was retrieved from the SWISSPROT data bank.9 Sequence homology searches of the Protein databank, PDB10 using the basic BLAST algorithm11 were carried out independently for each primary sequence. (org.pk)
  • The RNA chain is decoded and translated by ribosomes to produce a polypeptide sequence, otherwise known as a protein. (ainews.one)
  • For example, the sequence AUG (in the mRNA) is a codon that specifies the amino acid methionine, which almost always specifies the beginning of a protein. (ainews.one)
  • Finally, the signal sequence is cleaved and the pre-protein is either folded or trafficked onwards. (elifesciences.org)
  • Proteins differ from one another primarily in their sequence of amino acids, which is dictated by the nucleotide sequence of their genes, and which usually results in protein folding into a specific three-dimensional structure that determines its activity. (transectscience.org)
  • The sequence of amino acid residues in a protein is defined by the sequence of a gene which is encoded in the genetic code. (transectscience.org)
  • The method relies on the fact that the 3D structure of proteins is often better conserved than their amino acid sequence. (microbenotes.com)
  • To identify appropriate templates, pair-wise sequence alignment methods such as BLAST can be used to identify proteins with high sequence homology to the query protein in the PDB. (microbenotes.com)
  • Sequence alignment is followed by the 3D model building of the target proteins. (microbenotes.com)
  • There are often gaps or insertions that can occur in sequence alignments when modeling proteins. (microbenotes.com)
  • We extended the boundary by 5 residues which lead to expression of highly stable RBMS1 protein. (neelsb.com)
  • The possibility to define custom motifs and search for their occurrence in other proteins permits the identification of recurrent arrangements of residues that could have structural implications. (biomedcentral.com)
  • For example, changing a residue that resides on the outside of the protein from a positively charged one like Lysine to a positively charged one like Arginine (both residues are very similar) will not have any effect on the structure of the protein, in most cases. (stackexchange.com)
  • It has been generally accepted that the principal driving force in protein folding is the hydrophobic effect4, which results in the burial of the hydrophobic residues in the core of the protein. (org.pk)
  • Short polypeptides, containing less than 20-30 residues, are rarely considered to be proteins and are commonly called peptides, or sometimes oligopeptides. (transectscience.org)
  • Shortly after or even during synthesis, the residues in a protein are often chemically modified by post-translational modification, which alters the physical and chemical properties, folding, stability, activity, and ultimately, the function of the proteins. (transectscience.org)
  • We characterized 5 atypical BSE-H isolates by analyzing their molecular and neuropathologic properties during transmission in transgenic mice expressing homologous bovine prion protein. (cdc.gov)
  • These findings demonstrate the capability of an atypical bovine prion to acquire classical BSE-like properties during propagation in a homologous bovine prion protein context and support the view that the epidemic BSE agent could have originated from such a cattle prion. (cdc.gov)
  • Homology modeling, also known as comparative modeling, is a method used to predict the 3D structure of a protein with an unknown structure by using the known structure of a homologous protein. (microbenotes.com)
  • begingroup$ @danieldelrey - There are proteins which are intrinsically disordered ( en.wikipedia.org/wiki/Intrinsically_disordered_proteins ) or that contain regions which are intrinsically disordered. (stackexchange.com)
  • The Database of Protein Disorder (DisProt) is a curated database that provides information about intrinsically disordered proteins that lack fixed 3D structure in their putatively native states, either in their entirety or in part. (biokeanos.com)
  • In comparison with seven state-of-art methods using two public datasets, from GM12878 and IMR90 cells, SuperTAD shows a significant enrichment of structural proteins around detected boundaries and histone modifications within TADs and displays a high consistency between various resolutions of identical Hi-C matrices. (biomedcentral.com)
  • Particularly, among the enzyme inhibitors, proteases are a kind of enzymes that hydrolyze proteins by cutting protein peptide bonds in organisms, which determine the size, composition, spatial conformation and final degradation of proteins. (natural-foundation-science.org)
  • active site active transport Transport of a substance (such as a protein or drug) across a cell membrane against a concentration gradient. (wikipedia.org)
  • As other coronaviruses, 6-9 SARS-CoV-2 exploits host proteins to initiate cell-entry, in particular TMPRSS2 and ACE2, two membrane-bound proteins expressed in the upper and lower respiratory tract. (rsc.org)
  • Their unique hourglass-shaped architecture is highly conserved among different bacterial membrane proteins and other biological channels. (ibecbarcelona.eu)
  • MARV assembles and buds from the host cell plasma where MARV matrix protein (mVP40) dimers associate with anionic lipids at the plasma membrane inner leaflet and undergo a dynamic and extensive self-oligomerization into the structural matrix layer. (uci.edu)
  • The bulk of protein secretion and membrane protein insertion is conducted by the ubiquitous Sec translocon. (elifesciences.org)
  • The SNARE complex assembles from the vesicular protein Synaptobrevin-2 as well as SNAP25 (synaptosome-associated protein of 25 kDa) and Syntaxin-1, which are both anchored to the presynaptic membrane 2 . (nature.com)
  • Fusion of synaptic vesicles with the presynaptic membrane occurs in the presence of the NSF (N-ethylmaleimide-sensitive-factor) / α-SNAP (α-soluble NSF attachment protein) disassembly machinery. (nature.com)
  • While many studies have been focused on the membrane structure, the dynamics of such systems are crucial for the function of the membrane including membrane bound proteins. (lu.se)
  • Native membrane derived polymer-supported lipid bilayers (nSLBs) are poised to bridge the gap between live cell experiments and traditional model membrane architectures that by offering a combination of accessibility by surface sensitive analytical instrumentation and a composition which more closely resembles cellular membranes by displaying a diversity of endogenous membrane proteins, lipids, and carbohydrates. (lu.se)
  • Due to the lack of detergent solubilization and reconstitution steps, the nSLBs created using this approach contain essentially all of the native lipids, as well as the membrane-associated proteins and carbohydrates from the donor membrane. (lu.se)
  • Although intracellular signal transduction is often portrayed as a protein kinase 'domino effect', the counterbalancing function of phosphatases, and thus the control of phosphatase activity, is equally relevant to proper regulation of cellular function. (ac.be)
  • Perilipin 5 (PLIN5) is a lipid-droplet-associated protein that coordinates intracellular lipolysis in highly oxidative tissues and is thought to regulate lipid metabolism in response to phosphorylation by protein kinase A (PKA). (uci.edu)
  • Phosphatidylinositol 4,5-bisphosphate (PI4,5P2, hereafter referred to as PIP2) either binds to intracellular proteins and directly modulates their subcellular localization and activity or acts as a precursor for the generation of other second messengers. (biomedcentral.com)
  • By immobilizing specific proteins, it is possible to influence various components of the cell and dictate cell function and fate, as well as enable detection of specific intracellular mechanisms for further study. (rpi.edu)
  • powerful alternative to gene delivery, which is the current standard method for expression of specific proteins in cells. (rpi.edu)
  • The structural and functional integrity of this overhang is based on its association with a constellation of specific proteins, some of them belonging to the shelterin complex [ 10 ]. (hindawi.com)
  • What does this gene/protein do? (cancerindex.org)
  • Following this, the differentially expressed genes (DEGs) were included in Gene Ontology enrichment, and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway, protein‑protein interaction network and survival analyses. (cancerindex.org)
  • Recognition of c-myc gene promoter by human RBMS1 protein. (neelsb.com)
  • In this background we have worked on human RBMS1 protein that has been shown to directly regulate the c-myc gene expression levels in cancerous cells. (neelsb.com)
  • In contrast, loss-of-function mutations in the let-7 microRNA gene prevent a developmental decline in dendritic growth ability, whereas loss-of-function mutations in its direct target, the lin-41 tripartite motif protein gene, cause further decline. (stanford.edu)
  • The LIN-14 transcription factor likely directly represses dma-1 gene expression through a transcriptional means, whereas the LIN-41 tripartite motif protein likely indirectly promotes dma-1 gene expression through a posttranscriptional means. (stanford.edu)
  • The particular phrase and collection of Translocation Related Tissue layer Protein Only two (TRAM2) have been diverse throughout high and low sexual interest drakes, suggesting that it could certainly be a choice gene in connection with drake's libido. (3c-likeproteasesignals.com)
  • By means of two examples, graphene nanoribbons and dimensionally stable dendrimers, I describe complex polymer syntheses and their great benefits for electronics on the one hand and gene therapy on the other. (mpg.de)
  • One of the few antigens against which mammals develop protective immunity is the highly polymorphic OspC protein, encoded by the ospC gene on the cp26 plasmid. (cdc.gov)
  • By means of DNA sequencing of a large sample collection of the pathogen from across the United States, we studied the gene for the bacterium's highly diverse OspC protein, protective immunity against which develops in animals. (cdc.gov)
  • To exert stimulatory or repressive effects on transcription, accessible regulatory DNA elements must be in close spatial proximity to susceptible genes. (biomedcentral.com)
  • Protein Phosphatase 2A (PP2A) is a widely expressed family of protein phosphatases made of a core dimer, composed of a catalytic (C) subunit and a structural (A) subunit, in association with a third variable regulatory (B) subunit. (ac.be)
  • 1 Reversible protein phosphorylation is an important regulatory mechanism that controls the activities of a myriad of proteins and is thus involved in virtually every major physiological process. (ac.be)
  • Several agents have been developed to target these key regulatory proteins that are essential for HIV replication. (biomedcentral.com)
  • Water occupying wide ( 50 Å) biomolecules some 200 K below their normal physiological channels in protein crystals behaves like bulk water, transform- temperature range. (lu.se)
  • With the exception of therapeutic antibodies, many proteins are degraded if administered orally and most often cannot cross cell membranes. (3c-likeproteasesignals.com)
  • Transport of proteins across membranes is a fundamental process, achieved in every cell by the 'Sec' translocon. (elifesciences.org)
  • The encapsulation and compartmentalisation of cells has necessitated the evolution of machineries that conduct proteins across membranes, including for protein secretion and organellar import. (elifesciences.org)
  • To achieve this, the neuronal SNARE (i.e., soluble N -ethylmaleimide-sensitive factor attachment protein receptor) complex brings the vesicle and presynaptic membranes in close proximity, thereby, mediating the fusion of the two membranes resulting in exocytosis of neurotransmitters. (nature.com)
  • Mounting evidence suggests that the genetic disorders/mutation and diseases change not only the protein expression patterns but also membranes themselves. (lu.se)
  • However, Pauling never ceased advocating his valence bond theory, which continued to be used, for example, to explain the planarity of the peptide bond in proteins. (ucpress.edu)
  • Sometimes proteins have non-peptide groups attached, which can be called prosthetic groups or cofactors. (transectscience.org)
  • The redox inhibitory conformations were energetically and statistically favored and supported the evidence from wet laboratory experiments reported in the literature. (biomedcentral.com)
  • In the past, most of the attention was focused primarily on protein kinases and on their regulation, mainly because phosphatases were then viewed as simple housekeeping enzymes. (ac.be)
  • But advances in the understanding of protein phosphatases make now clear that these enzymes are precisely regulated and are as important as kinases in the regulation of cellular processes involving protein phosphorylation. (ac.be)
  • Many proteins are enzymes that catalyze biochemical reactions and are vital to metabolism. (transectscience.org)
  • The MEROPS database is an information resource for peptidases (also termed proteases, proteinases and proteolytic enzymes) and the proteins that inhibit them. (biokeanos.com)
  • Scope includes mutations and abnormal protein expression. (cancerindex.org)
  • Recently, 2 atypical, presumably sporadic forms of BSE have been associated with 2 distinct prion strains that are characterized mainly by distinct Western blot profiles of abnormal protease-resistant prion protein (PrP res ), named high-type (BSE-H) and low-type (BSE-L), that also differed from classical BSE. (cdc.gov)
  • Prion diseases are characterized by specific histopathologic lesions and deposits of an abnormal conformational isoform (PrP Sc ) of the host-encoded physiologic prion protein (PrP C ) in the central nervous system. (cdc.gov)
  • Abnormal or misfielded proteins are degraded more rapidly either due to being targeted for destruction or due to being unstable. (transectscience.org)
  • Subsequently, a variety of further patterns and regularities ( e.g. , [ 2 - 4 ]) in protein structures have been found, that have proven useful in the context of protein structure determination and quality assessment of determined structures. (biomedcentral.com)
  • But we are still far away from an unbiased structure prediction of thermodynamically and/or kinetically stable structures of molecules on surfaces. (degruyter.com)
  • The Protein Data Bank in Europe (PDBe) is the European resource for the collection, organisation and dissemination of data on biological macromolecular structures. (biokeanos.com)
  • Today, 90% of all protein crystal therefore be viewed as a continuous temperature-jump relax- structures are determined from diffraction data recorded at ation experiment, where different degrees of freedom partici- temperatures of 90-120 K (3). (lu.se)
  • Therefore, proteins with similar sequences are likely to have similar structures. (microbenotes.com)
  • This method is becoming increasingly important as the number of experimentally determined structures is limited compared to the number of protein sequences available. (microbenotes.com)
  • As the gap between the number of protein sequences and experimentally determined structures continues to grow, homology modeling has an increasingly important role to play in filling this gap. (microbenotes.com)
  • The first step in this process is identifying and selecting appropriate template structures from the Protein Data Bank (PDB). (microbenotes.com)
  • The rigid body parts are picked up from the template protein structures and brought together using tools like 3D-JIGSAW, BUILDER, and SWISS-MODEL. (microbenotes.com)
  • The spatial restraint method builds protein structures by applying spatial restraints to guide the building of a model that closely matches the template structure. (microbenotes.com)
  • The NMR structure of free RBMS1 was solved, as the protein did not crystallize, most likely due to its inherent flexibility, which we confirmed through NMR relaxation dynamics. (neelsb.com)
  • The 90 KDa heat shock protein (Hsp90) is a highly conserved molecular chaperone crucially involved in maintaining cellular homoeostasis in organisms from most kingdoms of life with the exception of archea 1 . (nature.com)
  • AlphaFold's Protein Structure Database provides open access to protein structure predictions for the human proteome and 20 other organisms to accelerate scientific research. (ainews.one)
  • Proteins perform a vast array of functions within organisms, including catalyzing metabolic reactions, DNA replication, responding to stimuli providing structure to cells and organisms, and molecules from one location to another. (transectscience.org)
  • The SWISS-MODEL Repository is a database of annotated 3D protein structure models generated by the SWISS-MODEL homology-modelling pipeline for protein sequences of selected model organisms. (biokeanos.com)
  • acetylation acetyl-CoA A molecule that participates in many biochemical reactions in protein, carbohydrate, and lipid metabolism, notably the citric acid cycle. (wikipedia.org)
  • Simplified representation illustrating the backbone conformation, colored by secondary structure. (transectscience.org)
  • The surface view of the crystal structure of RBMS1 protein is shown bound with the bases of nucleotides of c-myc promoter. (neelsb.com)
  • We determined the 2.57 Å crystal structure of RBMS1 in its promoter DNA bound state that provided atomic-resolution insight into specific binding of individual nucleotides of DNA with the protein. (neelsb.com)
  • Hsp90's diverse array of clientele implicate the chaperone in several associated biological functions and place it at the intersection of various fundamental cellular pathways, where it acts as a central hub in maintaining numerous protein interaction networks 1 . (nature.com)
  • Although viewed as a constitutive housekeeping enzyme in the past, PP2A is a highly regulated phosphatase and is emerging as an important regulator of multiple cellular processes involving protein phosphorylation. (ac.be)
  • 2 Protein phosphatase 2A (PP2A) is a very abundant - it accounts for as much as 1% of total cellular proteins - ubiquitous and remarkably conserved enzyme. (ac.be)
  • In NSEC research at RPI, silica nanoparticles have been used as carriers to deliver into the cell cytoplasm a variety of proteins that can influence cellular behavior. (rpi.edu)
  • DEC-205 (CD205), a member of the macrophage mannose receptor protein family, is the prototypic endocytic receptor of dendritic cells, whose ligands include phosphorothioated cytosine-guanosine (CpG) oligonucleotides, a motif often seen in bacterial or viral DNA. (uci.edu)
  • Here we describe the 3.2 Å cryo-EM structure of human DEC-205, thereby illuminating the structure of the mannose receptor protein family. (uci.edu)
  • Entry of HIV-1 into human lymphoid requires activities of viral envelope glycoproteins gp120 and gp41, and two host-cell proteins, the primary receptor CD4 and a chemokine co-receptor. (biomedcentral.com)
  • Pauling believed that protein shapes-independently of amino acid sequences-determined antibody specificity and biological specificity in general. (ucpress.edu)
  • By now you get the idea that cells generate proteins, which are sequences of amino acids. (ainews.one)
  • The database gives access to protein sequences, nucleic acid sequences and structural information on conopeptides. (biokeanos.com)
  • Is it possible to change an amino acid within a protein but not affecting that protein's functions? (stackexchange.com)
  • The work has implications for understanding general mechanism of protein-DNA interactions that involves sliding, hopping and diffusion during stochastic target search process in a dense nucleus. (neelsb.com)
  • showing the cavities through the channel, with the protein in grey surface, the pre-protein pore constrictions in red (SecY) or purple (SecA) mesh, and the SecY plug in red helix. (elifesciences.org)
  • 4 While proteins can be phosphorylated on nine amino acids, serine, threonine and tyrosine phosphorylation are by far the most predominant in eukaryotic cells. (ac.be)
  • FLIM-FRET analysis of protein-protein interactions showed that PLIN5 S155 phosphorylation regulates PLIN5 interaction with adipose triglyceride lipase at the lipid droplet, but not with α-β hydrolase domain-containing 5. (uci.edu)
  • long range interactions within the protein molecule. (flashcardmachine.com)
  • Understanding specificity of protein-DNA interactions is a long-standing question that has been attempted to understand many times by scientists all over the world. (neelsb.com)
  • PDBsum provides an overview of every macromolecular structure deposited in the Protein Data Bank (PDB), giving schematic diagrams of the molecules in each structure and of the interactions between them. (biokeanos.com)
  • 2016). Here, we show that ATP enhances this process by modulating secondary structure formation within the translocating protein. (elifesciences.org)
  • In protein expression, we are particularly interested in mRNA, which acts as a portable transcript, of the instructions written in genes, to ribosomes, the cell's machinery responsible for producing a protein. (ainews.one)
  • Once formed, proteins only exist for a certain period and are then degraded and recycled by the cell's machinery through the process of protein turnover. (transectscience.org)
  • involves formation of a multimeric protein. (flashcardmachine.com)
  • One option involves modulation of the protein through allosteric activation/inhibition. (nature.com)
  • Decoding involves reading the correct code at a right time by DNA binding proteins. (neelsb.com)
  • Protein structure prediction is an important aspect of computational biology that aims to determine the three-dimensional (3D) structure of a protein. (microbenotes.com)
  • Homology modeling is one of the computational methods of protein structure prediction. (microbenotes.com)
  • Model building: The automated homology model building was performed using the protein structure-modeling program MODELLER 4.13 Reliability of the predicted homology models was assessed by the ENERGY command of the MODELLER. (org.pk)
  • This requires an efficient and highly specific interaction between protein and DNA that control some of the most important processes pertaining to cell survival and growth. (neelsb.com)
  • Hi-C applies high-throughput sequencing to collect fragments that are ligated due to spatial proximity within the genome. (biomedcentral.com)
  • SUPERFAMILY is a database of structural and functional annotation for all proteins and genomes. (biokeanos.com)
  • Proteins also have structural or mechanical functions, such as actin and myosin in muscle and the proteins in the cytoskeleton, which form a system of scaffolding that maintains cell shape. (transectscience.org)
  • Other proteins are important in cell signaling, immune responses, cell adhesion, and the cell cycle. (transectscience.org)
  • In addition, a third cell-surface protein called protein disulfide isomerase (PDI) is found to play a major role in HIV-1 entry. (biomedcentral.com)
  • Macrocyclic scaffolds are particularly attractive for designing selective G-quadruplex ligands essentially because, on one hand, they show a poor affinity for the "standard" B-DNA conformation and, on the other hand, they fit nicely with the external G-quartets of quadruplexes. (hindawi.com)
  • Neurons are highly polarized cells that face the fundamental challenge of compartmentalizing a vast and diverse repertoire of proteins in order to function properly1. (stanford.edu)
  • In vitro assays confirm that both drugs inhibit the human protein TMPRSS2, a SARS-Cov-2 spike protein activator. (rsc.org)
  • Although multiple agent strains have been identified in sheep scrapie ( 1 , 2 ) and human CJD ( 3 , 4 ), early evidence showed that BSE was caused by a single major strain ( 5 , 6 ) with the ability to efficiently cross the species barriers and showing stable features even when transmitted to other species. (cdc.gov)
  • A) Organization of the human INK4b-ARF-INK4a locus (not drawn to scale), encoding three distinct proteins, p15 INK4b , p14 ARF and p16 INK4a . (biomedcentral.com)
  • Same thing when changing an Alanine to a Valine: they are so similar to one another that it would be difficult to find a case where swapping them would cause the protein to change shape or for its function to be destroyed. (stackexchange.com)
  • In this paper, we describe an extension of DeepView/Swiss-PdbViewer through which structural motifs may be defined and searched for in large protein structure databases, and we show that common structural motifs involved in stabilizing protein folds are present in evolutionarily and structurally unrelated proteins, also in deeply buried locations which are not obviously related to protein function. (biomedcentral.com)
  • The main reason for our interest in general ( i.e. , sequentially non-contiguous) structural motifs, is the crucial role played by side-chains in the correct packing of proteins. (biomedcentral.com)
  • p15 INK4b and p16 INK4a are closely related proteins and both act on the Rb-pathway through the inhibition of the proliferation-promoting cyclin-dependent kinases CDK4 and CDK6. (biomedcentral.com)