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Sodium Potassium Chloride Symporter InhibitorsPotassium ChlorideSodium Chloride SymportersPotassiumNiobiumSodiumSodium-Potassium-Exchanging ATPaseSymportersChloridesPlasma Membrane Neurotransmitter Transport ProteinsOuabainPotassium CitratePotassium CompoundsHypokalemiaSodium ChloridePotassium ChannelsChloride ChannelsSodium Chloride Symporter InhibitorsMagnesium CompoundsTriamterenePregnancy Reduction, MultifetalBendroflumethiazideSodium ChannelsChlorellaCalcium ChlorideEuthanasia, AnimalProton-Phosphate SymportersCondimentsCitratesSodium-Phosphate Cotransporter ProteinsOsmolar ConcentrationSodium-Glucose Transporter 1KineticsBiological TransportPotassium Channel BlockersPotassium, DietaryBicarbonatesPotassium Channels, Inwardly RectifyingVinyl ChlorideMembrane PotentialsPotassium DeficiencyCalciumAmino Acid Transport SystemsMagnesiumHydrogen-Ion ConcentrationDiet, Sodium-RestrictedPotassium Channels, Voltage-GatedAcetylcholineCarrier ProteinsDiureticsMuscle ContractionSpironolactonePotassium IsotopesSodium, DietaryDose-Response Relationship, DrugNorepinephrineFurosemideBlood PressureMuscle, Smooth, VascularAcidosisRats, Sprague-DawleyMolecular Sequence DataHydrochlorothiazideAmino Acid SequenceVasoconstrictionHypertensionMesenteric ArteriesPolyvinyl ChlorideXenopus laevisPregnancy, EctopicNitroprussideMuscle RelaxationMembrane Transport ProteinsOocytesRabbitsVasodilationVasoconstrictor AgentsTime FactorsRats, WistarModels, MolecularShaker Superfamily of Potassium ChannelsSodium IsotopesCell MembraneGuinea PigsDogsBinding SitesPhosphatesMercuric ChlorideVasodilator AgentsKv1.3 Potassium ChannelMonosaccharide Transport ProteinsProtein Structure, SecondaryAdenosine TriphosphateKidney CalculiMuscle, SmoothBacterial ProteinsLeucinePotassium IodideRats, Inbred StrainsWater

InhibitorsNeurotransmitterTransportersDistal convolIons out of the cellInhibitTransporterGlucoseElectrolytesInhibitorAnionIncreasing sodium and waterThiazidesReabsorptionIntracellularUptakeMagnesiumAmount of sodiumBicarbonatePumpExcretionProteinRenalKidneysChannelsMechanismLithiumTransportGradientMembrane potentialNeutralWaterLoopHighAgentsEssential

Inhibitors3

• Sodium Potassium Chloride Symporter Inhibitors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
• This graph shows the total number of publications written about "Sodium Potassium Chloride Symporter Inhibitors" by people in this website by year, and whether "Sodium Potassium Chloride Symporter Inhibitors" was a major or minor topic of these publications. (umassmed.edu)
• Below are the most recent publications written about "Sodium Potassium Chloride Symporter Inhibitors" by people in Profiles. (umassmed.edu)

Neurotransmitter2

• A family of sodium chloride-dependent neurotransmitter symporters that transport the amino acid GLYCINE. (childrensmercy.org)
• Sodium chloride-dependent neurotransmitter symporters located primarily on the PLASMA MEMBRANE of serotonergic neurons. (musc.edu)

Transporters1

• It is well-established that the secondary active transporters Glt Tk and Glt Ph catalyze coupled uptake of aspartate and three sodium ions, but insight in the kinetic mechanism of transport is fragmentary. (nature.com)

Distal convol4

• Hydrochlorothiazide, a thiazide diuretic, inhibits water reabsorption in the nephron by inhibiting the sodium-chloride symporter (SLC12A3) in the distal convoluted tubule, which is responsible for 5% of total sodium reabsorption. (drugbank.com)
• Normally, the sodium-chloride symporter transports sodium and chloride from the lumen into the epithelial cell lining the distal convoluted tubule. (drugbank.com)
• By blocking the sodium-chloride symporter, hydrochlorothiazide effectively reduces the osmotic gradient and water reabsorption throughout the nephron.Hydrochlorothiazide, a thiazide diuretic, inhibits water reabsorption in the nephron by inhibiting the sodium-chloride symporter (SLC12A3) in the distal convoluted tubule, which is responsible for 5% of total sodium reabsorption. (drugbank.com)
• They inhibit the Na-Cl symporter in the distal convoluted tubule, leading to decreased sodium and water reabsorption. (medscape.com)

Ions out of the cell2

• It helps to move three sodium ions out of the cell in exchange of every two potassium ions that is brought into the cell by directly utilising energy in the form of ATP. (aakash.ac.in)
• Once the neurone reaches peak polarisation the sodium channels close and the potassium channels open allowing the flow of potassium ions out of the cell - this is called repolarization. (ncl.ac.uk)

Inhibit2

• Agents that inhibit SODIUM-POTASSIUM-CHLORIDE SYMPORTERS which are concentrated in the thick ascending limb at the junction of the LOOP OF HENLE and KIDNEY TUBULES, DISTAL. (umassmed.edu)
• Thiazides like cyclothiazide also inhibit sodium ion transport across the renal tubular epithelium through binding to the thiazide sensitive sodium-chloride transporter. (drugbank.com)

Transporter2

• Link to all annotated objects annotated to potassium ion transmembrane transporter activity. (planteome.org)
• Link to all direct and indirect annotations to potassium ion transmembrane transporter activity. (planteome.org)

Glucose2

• The transport protein, called the glucose symporter, uses the sodium gradient to power glucose movement into the cell. (hawaii.edu)
• Sodium and glucose both move into the cell. (hawaii.edu)

Electrolytes4

• It works in the kidneys to get rid of extra water and electrolytes (like sodium and potassium), which helps decrease swelling. (firebaseapp.com)
• INTRACELLULAR SPACE, maintained by processes in the body that regulate the intake and excretion of WATER and ELECTROLYTES, particularly SODIUM and POTASSIUM. (lookformedical.com)
• It works by blocking the absorption of sodium and chloride ions in the nephrons of the kidneys, which leads to an increased excretion of water and electrolytes. (buynoprescriptionrxxonline.net)
• By blocking the reabsorption of these ions, Lasix promotes the secretion of water and other electrolytes, such as potassium and magnesium, into the urine. (buynoprescriptionrxxonline.net)

Inhibitor1

• A pyridine and sulfonamide derivative that acts as a sodium-potassium chloride symporter inhibitor (loop diuretic). (bvsalud.org)

Anion2

• To maintain charge neutrality on the outside of cells every sodium cation is followed by a chloride anion. (hawaii.edu)
• There is also a growing body of evidence that the perchlorate anion may be reduced to chloride by plants. (cdc.gov)

Increasing sodium and water1

• [1] It works by increasing sodium and water loss in the urine. (mdwiki.org)

Thiazides2

• Thiazides also cause loss of potassium and an increase in serum uric acid. (drugbank.com)
• Thiazides cause vasodilation by activating calcium-activated potassium channels (large conductance) in vascular smooth muscles and inhibiting various carbonic anhydrases in vascular tissue. (drugbank.com)

Reabsorption5

• Bumetanide is a loop diuretic and works by decreasing the reabsorption of sodium by the kidneys. (firebaseapp.com)
• As a diuretic, cyclothiazide inhibits active chloride reabsorption at the early distal tubule via the Na-Cl cotransporter, resulting in an increase in the excretion of sodium, chloride, and water. (drugbank.com)
• Once sodium has entered the cell, it is transported out into the basolateral interstitium via the sodium-potassium ATPase, causing an increase in the osmolarity of the interstitium, thereby establishing an osmotic gradient for water reabsorption. (drugbank.com)
• By effectively inhibiting sodium reabsorption, they also reduce water reabsorption. (medscape.com)
• Spironolactone inhibits the aldosterone receptor in the cortical collecting duct, also limiting sodium and water reabsorption. (medscape.com)

Intracellular2

• The constant work of the sodium-potassium pump maintains the solute equilibrium and consequently, water distribution between intracellular and extracellular fluids. (hawaii.edu)
• The unequal movement of the positively charged sodium and potassium ions makes intracellular fluid more negatively charged than the extracellular fluid. (hawaii.edu)

Uptake2

• It is capable of transporting a variety organic anions and mediates sodium-independent uptake of bile in the liver. (nih.gov)
• Here, we systematically measured aspartate uptake rates in proteoliposomes containing purified Glt Tk , and derived the rate equation for a mechanism in which two sodium ions bind before and another after aspartate. (nature.com)

Magnesium1

• There are five perchlorate salts that are manufactured in substantial amounts: magnesium, potassium, ammonium, sodium, and lithium perchlorate. (cdc.gov)

Amount of sodium2

• Excessive amount of sodium in the blood. (lookformedical.com)
• In addition to preventing fluid buildup, the use of metolazone may allow the patient to relax the amount of sodium restriction that is required. (mdwiki.org)

Bicarbonate1

• Natriuresis may be accompanied by some loss of potassium and bicarbonate. (drugbank.com)

Pump7

• To restore balance, the sodium-potassium pump transfers sodium back to the extracellular fluid and water follows. (hawaii.edu)
• Every cycle of the sodium-potassium pump involves the movement of three sodium ions out of a cell, in exchange for two potassium ions into a cell. (hawaii.edu)
• You will soon learn that this charge gradient and the sodium-potassium pump are also essential for nerve conduction and muscle contraction. (hawaii.edu)
• The many functions of the sodium-potassium pump in the body account for approximately a quarter of total resting energy expenditure. (hawaii.edu)
• The sodium-potassium pump is the primary mechanism for cells to maintain water balance between themselves and their surrounding environment. (hawaii.edu)
• A very common ATPase driven ion pump found universally in all animal cells is the sodium-potassium pump, which helps in the maintenance of membrane potential of the cells. (aakash.ac.in)
• When hyperpolarisation occurs, the membrane must restore the potential back to its resting potential by transporting 3 Na + out of the cell and 2K + into the cell via the sodium potassium pump using ATP [3] . (ncl.ac.uk)

Excretion3

• Abnormally high potassium concentration in the blood, most often due to defective renal excretion. (lookformedical.com)
• This results in an increase in potassium excretion via the sodium-potassium exchange mechanism. (drugbank.com)
• Cyclothiazide increases excretion of sodium and chloride in approximately equivalent amounts. (drugbank.com)

Protein1

• The mechanism of action of Lasix involves the inhibition of the Na+/K+/2Cl- symporter, a protein located on the luminal membrane of the thick ascending limb of Henle's loop in the kidneys. (buynoprescriptionrxxonline.net)

Renal1

• It may result from potassium loss by renal secretion or by the gastrointestinal route, as by vomiting or diarrhea. (lookformedical.com)

Kidneys1

• It works by inhibiting the absorption of sodium and chloride ions in the kidneys, which results in increased urine production. (buynoprescriptionrxxonline.net)

Channels1

• It causes the voltage gated sodium channels to open allowing the flow of sodium ions into the cell resulting in depolarisation. (ncl.ac.uk)

Mechanism1

• The antihypertensive mechanism of cyclothiazide is less well understood although it may be mediated through its action on carbonic anhydrases in the smooth muscle or through its action on the large-conductance calcium-activated potassium (KCa) channel, also found in the smooth muscle. (drugbank.com)

Lithium1

• In summary, we show that sodium, but not lithium, up regulates the shunt of the glyoxylic acid in D. hansenii and we propose that this is an important metabolic adaptation to thrive in salty environments. (bvsalud.org)

Transport1

• A subclass of symporters that specifically transport SODIUM CHLORIDE and POTASSIUM CHLORIDE across cellular membranes in a tightly coupled process. (wakehealth.edu)

Gradient2

• The energy for this is provided by a sodium gradient established by sodium-potassium ATPases on the basolateral membrane. (drugbank.com)
• The cell (or more specifically the numerous sodium-potassium pumps in its membrane) continuously pumps sodium ions out to establish a chemical gradient. (hawaii.edu)

Membrane potential1

• During repolarisation, too many potassium ions move out of the cell causing the membrane potential to fall too low therefore resulting in hyperpolarisation. (ncl.ac.uk)

Neutral1

• Sodium ions also form ionic compounds with negative ions, a common example being the neutral ionic compound sodium chloride (NaCl), where the sodium ion has a positive +1 charge (Na + ) and the chloride ion has a negative -1 charge (Cl -1 ). (ncl.ac.uk)

Water3

• Potassium ion is a strong electrolyte that plays a significant role in the regulation of fluid volume and maintenance of the WATER-ELECTROLYTE BALANCE. (lookformedical.com)
• Water passively follows the sodium. (hawaii.edu)
• Sodium and free water retention occur, resulting in an increase in both volume and pressure in capacitance vessels. (medscape.com)

Loop1

• Furosemide is a loop diuretic that inhibits the Na + /2Cl - /K + (NKCC) symporter. (tocris.com)

High2

• Common side effects include low potassium , low sodium , gout , high blood sugar , and abdominal bloating. (mdwiki.org)
• The yeast accumulated sodium at high concentrations, which improved growth in salty media. (bvsalud.org)

Agents1

• Medical treatment at the last follow-up control included supplementation with potassium in 13, non-steroidal anti-inflammatory agents in 12 and gastroprotective drugs in five patients. (nih.gov)

Essential1

• Chloride Is essential for capacitation and for the capacitation-associated increase in tyrosine phosphorylation. (umassmed.edu)