AnatomyDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesTechnology, Industry, AgricultureHealth Care
MethotrexateSodiumPolyglutamic AcidAntirheumatic AgentsSodium ChannelsFolic Acid AntagonistsTetrahydrofolate DehydrogenaseArthritis, RheumatoidAminopterinAntimetabolites, AntineoplasticLeukemia L1210Reduced Folate Carrier ProteinSodium, DietaryTrimetrexateFolic AcidSodium ChlorideDrug Therapy, Combinationgamma-Glutamyl HydrolaseLeucovorinTetrahydrofolatesDrug ResistanceAbortifacient Agents, NonsteroidalCyclophosphamideTreatment OutcomeImmunosuppressive AgentsAntineoplastic Combined Chemotherapy ProtocolsSulfasalazineDrug Administration ScheduleVincristineSodium Channel BlockersSodium IsotopesDeoxyuridinePrecursor Cell Lymphoblastic Leukemia-LymphomaDose-Response Relationship, Drug6-MercaptopurineDermatologic AgentsSodium Dodecyl SulfatePregnancy, EctopicSodium BicarbonateFluorouracilFormyltetrahydrofolatesBiological TransportFolate Receptors, GPI-AnchoredSodium AzideDoxorubicinEpithelial Sodium ChannelsSodium NitriteKineticsPhosphoribosylaminoimidazolecarboxamide FormyltransferaseInjections, SpinalSodium CompoundsOsteosarcomaPrednisoneCytarabineTime FactorsLeukemia, LymphoidSodium SalicylateThymidylate SynthaseHydroxychloroquineCentral Nervous System NeoplasmsPregnancy, TubalSarcoma 180IsoxazolesCromolyn SodiumPteroylpolyglutamic AcidsAsparaginasePsoriasisGestational Trophoblastic DiseaseProbenecidRemission InductionGold Sodium ThiomalateHydroxymethyl and Formyl TransferasesDouble-Blind MethodAdministration, OralAntibodies, MonoclonalMucositisSodium HypochloritePotassiumSodium AcetateSodium Chloride, DietaryCarcinoma, Ehrlich TumorNucleotide DeaminasesVinblastineCombined Modality TherapyInfusions, ParenteralKidneyNAV1.5 Voltage-Gated Sodium ChannelArthritis, JuvenileArthritis, PsoriaticCell LineBiological Transport, ActiveTrophoblastic NeoplasmsLeukemia L5178CisplatinDiet, Sodium-RestrictedDrug InteractionsSodium FluorideSeverity of Illness IndexHydrogen-Ion ConcentrationHypoxanthines
ChlorideBicarbonatePhenytoinDMARDsToxicityInjectionRheumatoid arthritisIntrathecalNSAIDsExcretionNaproxenHydroxideCyclophosphamideDosageHigh-doseInjectableAzathioprineUrineDHFRCytarabineDrugsDoseCytotoxicLeucovorinTabletsPatientsDosesDISEASESInfusionPrescriptionDrugCommonlySideRapidlyTreatmentWaterLevelsTreatProducts
Chloride2
  • sodium chloride, water for injection, and sodium hydroxide to adjust pH. (medbroadcast.com)
  • To further characterize the Drosophila-based prescreen to detect developmental toxicants, the following 8 chemicals were evaluated - methyl mercury chloride (MMC), methotrexate (MTX), L-phenylalanine (LPA), sodium arsenate heptahydrate (SAH), cadmium chloride (CC), vinblastine sulfate (VBS), aminopterin (APN) and mitomycin C (MC). (cdc.gov)
Bicarbonate9
Phenytoin10
DMARDs1
Toxicity4
  • Such patients require especially careful monitoring for toxicity, and require dose reduction or, in some cases, discontinuation of methotrexate administration. (nih.gov)
  • Toxicity of methotrexate compared with azathioprine in the treatment of rheumatoid arthritis. (nih.gov)
  • Dosage and duration of calcium folinate rescue primarily depend on the type and dosage of methotrexate therapy, the occurrence of toxicity symptoms, and the individual excretion capacity for methotrexate. (janusinfo.se)
  • Mammalian cells used in biopharma manufacturing may exhibit toxicity to USP-grade Methotrexate, thus Methotrexate, EvoPure ® is also available. (toku-e.com)
Injection2
  • The usual adult starting dose of methotrexate is 10 mg to 25 mg per week in one dose (tablet or injection) or 2.5 mg (tablet) to 5 mg taken every 12 hours for 3 doses once weekly. (medbroadcast.com)
  • RediTrex (methotrexate) injection is designed for the treatment of adult and pediatric patients with rheumatoid arthritis, as well as adults with psoriasis. (salesandmarketingnetwork.com)
Rheumatoid arthritis4
  • Methotrexate may be considered for the treatment of psoriasis or rheumatoid arthritis if other treatments have failed. (drugs.com)
  • One hundred thirty-one patients with rheumatoid arthritis treated with either azathioprine sodium (n = 37, 102.7 +/- 32.9 mg/d) or methotrexate sodium (n = 94, 8.4 +/- 3.0 mg/wk) were followed up for 38 +/- 23.3 months to determine the nature, frequency, and potential predictors of "major" toxic reactions. (nih.gov)
  • Cumberland will launch two injectable methotrexate product lines within the U.S., with both product offerings intended for the treatment of active rheumatoid arthritis, juvenile idiopathic arthritis and severe psoriasis. (salesandmarketingnetwork.com)
  • Fairbanks, LD et al (1999) Methotrexate inhibits the first committed step of purine biosynthesis in mitogen-stimulated human T-lymphocytes: A metabolic basis for efficacy in rheumatoid arthritis? (toku-e.com)
Intrathecal1
  • Methotrexate, an antimetabolite, may be given via the intrathecal route when it is necessary to get chemotherapy past the blood-brain barrier. (wikipedia.org)
NSAIDs1
  • Analysis of heterologous expression systems of rOAT1 in oocytes and culture cells revealed that rOAT1 has the ability to transport anionic drugs, such as β-lactam antibiotics, NSAIDs, methotrexate, and antiviral drugs, as well as various endogenous organic anions and exogenous substances. (aspetjournals.org)
Excretion2
  • Methotrexate: Decreased excretion. (pediatriconcall.com)
  • In addition to calcium folinate administration, measures to ensure the prompt excretion of methotrexate (maintenance of high urine output and alkalinisation of urine) are integral parts of the calcium folinate rescue treatment. (janusinfo.se)
Naproxen6
  • Treximet ( sumatriptan and naproxen sodium) is a combination of a headache medicine and a nonsteroidal anti-inflammatory drug ( NSAID ) used to treat migraine headaches. (rxlist.com)
  • Treximet is a tablet with a fixed dose combination of 85 mg sumatriptan and 500 mg naproxen sodium. (rxlist.com)
  • Our Treximet (sumatriptan and naproxen sodium) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. (rxlist.com)
  • TREXIMET is a combination of sumatriptan, a serotonin (5-HT) 1b/1d receptor agonist (triptan), and naproxen sodium, a non-steroidal anti-inflammatory drug, indicated for the acute treatment of migraine with or without aura in adults and pediatric patients 12 years of age and older. (nih.gov)
  • Tween ® 80 and sodium deoxycholate, on (i) the physical, mechanical, and biological properties of ultradeformable vesicles, and (ii) the administration of naproxen sodium-loaded multidrug ultradeformable vesicles for the transdermal route in order to obtain therapeutically meaningful drug concentrations in the target tissues and to potentiate its anti-inflammatory effect by association with the antioxidant drug idebenone. (mdpi.com)
  • Ones you can get without a prescription include ibuprofen (Advil, Motrin IB, others) and naproxen sodium (Aleve). (mayoclinic.org)
Hydroxide1
Cyclophosphamide1
  • Patients with uveitis who are not responding well to steroid treatment and patients who have side effects from other medicines used to treat uveitis (such as cyclosporine, cyclophosphamide, methotrexate or azathioprine) or have refused treatment because of possible side effects of these medicines may be eligible for this study. (drugpatentwatch.com)
Dosage2
  • Sex, drug dosage, response to prior slow-acting antirheumatic drug therapy, concurrent use of salicylates, and age did not predict major toxic reactions secondary to methotrexate treatment, but the methotrexate-treated patients who experienced a major toxic reaction had a significantly greater mean level of blood urea nitrogen at the time of their reaction compared with the control group. (nih.gov)
  • Since the calcium folinate rescue dosage regimen depends heavily on the posology and method of the intermediate- or high-dose methotrexate administration, the methotrexate protocol will dictate the dosage regimen of calcium folinate rescue. (janusinfo.se)
High-dose2
  • refer to the applied intermediate or high dose methotrexate protocol for posology and method of administration of calcium folinate. (janusinfo.se)
  • This study investigated relationships between accumulation of methotrexate and gene expression levels of solute carrier and ATP-binding cassette transporters in cancer cells after a single and high-dose X-ray irradiation. (frontiersin.org)
Injectable8
Azathioprine2
  • Thirty-one methotrexate-treated patients (33%) and 11 patients (30%) receiving azathioprine experienced a major toxic reaction during the study period. (nih.gov)
  • The majority of patients in each treatment group (79 for methotrexate and 29 for azathioprine) experienced one or more "minor" toxic reactions during the follow-up period. (nih.gov)
Urine2
  • Urine pH values will be checked to ensure alkalosis prior to the commencement of methotrexate. (wikipedia.org)
  • Hepatorenal syndrome is diagnosed when a creatinine clearance rate of less than 40 mL/min is present or when a serum creatinine level of greater than 1.5 mg/dL, a urine volume of less than 500 mL/day, and a urine sodium level of less than 10 mEq/L are present. (medscape.com)
DHFR5
  • Many different protein fragment designs have been used with PCA, however the highest-throughput version uses a split murine dihydrofolate reductase (mDHFR) that, once reconstructed, allows colony growth on agar containing the S. cerevisiae DHFR inhibitor methotrexate (MTX). (nature.com)
  • Methotrexate is a selective agent for dihydrofolate reductase (DHFR)- transfected cells, and a nucleic acid synthesis inhibitor in protein expression systems, thus can be used as an ancillary material in upstream biomanufacturing applications. (toku-e.com)
  • In cancerous cells, Methotrexate acts as an allosteric inhibitor of dihydrofolate reductase (DHFR), an enzyme involved in the folic acid metabolic pathway, catalyzing the conversion of dihydrofolate to tetrahydrofolate. (toku-e.com)
  • Methotrexate is commonly used in the dihydrofolate reductase (DHFR) selection system as a selection antibiotic to select for DHFR- deficient CHO cells that have been transfected with DHFR genes. (toku-e.com)
  • however, cells that overproduce DHFR can tolerate higher concentrations of Methotrexate. (toku-e.com)
Cytarabine1
Drugs2
  • Like other cytotoxic drugs, methotrexate may induce "tumor lysis syndrome" in patients with rapidly growing tumors. (nih.gov)
  • Methotrexate has an average rating of 6.6 out of 10 from a total of 328 ratings on Drugs.com. (drugs.com)
Dose3
  • Malignant lymphomas, which may regress following withdrawal of methotrexate, may occur in patients receiving low-dose methotrexate and, thus, may not require cytotoxic treatment. (nih.gov)
  • The dose of methotrexate varies depending on the type of cancer being treated and body weight or size. (medbroadcast.com)
  • The usual adult dose of methotrexate is 7.5 mg taken as one dose once weekly by mouth or 2.5 mg taken every 12 hours for 3 doses once weekly. (medbroadcast.com)
Cytotoxic1
  • Maleki H et al (2017) Methotrexate-loaded PLGA nanoparticles: Preparation, characterization and their cytotoxic effect on human glioblastoma U87MG cells. (toku-e.com)
Leucovorin1
Tablets1
Patients2
  • Methotrexate elimination is reduced in patients with impaired renal functions, ascites, or pleural effusions. (nih.gov)
  • Life-table analysis suggested toxic reactions posed a greater risk of treatment termination in methotrexate-treated patients compared with the lack or loss of efficacy. (nih.gov)
Doses3
  • Methotrexate-induced lung disease, including acute or chronic interstitial pneumonitis, is a potentially dangerous lesion, which may occur acutely at any time during therapy and has been reported at low doses. (nih.gov)
  • Severe, occasionally fatal, skin reactions have been reported following single or multiple doses of methotrexate. (nih.gov)
  • Calcium folinate rescue is necessary when methotrexate is given at doses exceeding 500 mg/m2 body surface and should be considered with doses of 100 mg - 500 mg/m2 body surface. (janusinfo.se)
DISEASES1
Infusion2
Prescription1
  • Refilling your prescription is easy and convenient with Marc's online prescription refills.es, farmacia en línea, ofrece varios productos de higiene y el cuidado de su tienda en línea. (apsia.org)
Drug3
  • Under these circumstances, methotrexate is known as a disease-modifying antirheumatic drug (DMARD). (medbroadcast.com)
  • The anticancer drug methotrexate (MTX) shows affinity for solute carrier (SLC) and ATP-binding cassette (ABC) transporters. (frontiersin.org)
  • Dec. 2, 2019 -- (Healthcare Sales & Marketing Network) -- Cumberland Pharmaceuticals Inc. (NASDAQ: CPIX), a specialty pharmaceutical company, today announced that it has received approval from the U.S. Food and Drug Administration (FDA) for RediTrex , its new line of methotrexate products. (salesandmarketingnetwork.com)
Commonly1
  • Cancer cell lines were selected from lung and cervical cancer cell line that are commonly used for stereotactic body radiotherapy and effective with methotrexate. (frontiersin.org)
Side1
  • methotrexate side effects in more detail. (drugs.com)
Rapidly1
Treatment2
  • Discontinue methotrexate first and, if the lymphoma does not regress, appropriate treatment should be instituted. (nih.gov)
  • Caffeine may reduce the effectiveness of methotrexate in the treatment of arthritis. (drugs.com)
Water1
  • Methotrexate is soluble in DMSO but practically insoluble in water. (toku-e.com)
Levels1
  • SAA-stimulated levels of released IL-6, IL-8, and sVCAM-1 from HCAEC were significantly attenuated by methotrexate, fluvastatin, and etoricoxib. (hindawi.com)
Treat2
  • Methotrexate is used to treat certain types of cancer such as leukemia, non-Hodgkin's lymphoma, breast cancer, head and neck cancer, stomach cancer, bladder cancer, bone cancer, and choriocarcinoma (a type of uterine cancer). (medbroadcast.com)
  • When used to treat cancer, methotrexate works by blocking an enzyme process in cancer cells so they cannot grow. (medbroadcast.com)
Products1