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SquamousMalignantLeukoplakiaLaryngealMoist snuffSmokelessAckermanKeratosisFinelyLesionsChewingPipesSlowlyTypesEvidentAggressiveOral cancerSkinTermSurfaceGroundSitesLongSquamous cell carcinomasSalivary gland carcinomasViral wartsTumorsChewing tobacco and snuffSmokeless tobaccoBuccal mucosaSituCancersPharyngealEsophagealQuidVariantClinicalOccurRiskPrimaryTypeFactors

Squamous12

• The differential diagnosis includes other oral white lesions such as Leukoplakia, squamous cell carcinoma, oral candidiasis, lichen planus, white sponge nevus and contact stomatitis. (wikipedia.org)
• The risk of the lesion developing into oral cancer (generally squamous cell carcinoma and its variant verrucous carcinoma) is relatively low. (wikipedia.org)
• Oral florid papillomatosis is a type of verrucous carcinoma (VC) that is clinically evident as multiple squamous papillary nodules in the oral cavity and, less commonly, in the larynx, the pharynx, the esophagus, the middle ear, the maxillary antrum, the nasal fossa, and the bronchus. (medscape.com)
• Verrucous carcinoma of both the skin and the mucosa is an uncommon low-grade squamous cell carcinoma that is clinically evident as a slowly but relentlessly enlarging warty tumor, histologically characterized by local invasion with minimal dysplasia, if any, and biologically characterized by a low incidence of metastases. (medscape.com)
• The typical microscopic section shows a well-differentiated typical squamous cell carcinoma with verrucous clinical morphology. (medscape.com)
• Ackerman used the term verrucous carcinoma to denote the concept of a locally aggressive exophytic low-grade squamous cell carcinoma with little metastatic potential. (medscape.com)
• A number of HPV types are associated with squamous cell carcinoma, including HPV types 6 and 11. (medscape.com)
• Why verrucous carcinomas develop in some patients and ordinary squamous cell carcinomas develop in other patients is unclear. (medscape.com)
• Primary and invasive squamous cell carcinoma are treated with varying combinations of surgery and/or radiation. (medscape.com)
• The use of smokeless tobacco is associated with a spectrum of oral cavity lesions, including leukoplakia, speckled leukoplakia, erythroplasia, tobacco-associated keratosis, carcinoma in situ (CIS), verrucous carcinoma , and invasive squamous cell carcinoma (SCC) . (medscape.com)
• Squamous cell carcinoma, which means the cancer develops in the squamous cells that line the inside of the mouth or throat, is by far the most common type of oral cancer. (msdmanuals.com)
• The main categories of smokeless tobacco are oral squamous cell carcinoma, verrucous carcinoma, and other malignant disorders like erythroplakia, leukoplakia , tobacco pouch keratosis, and submucous fibrosis . (icliniq.com)

Malignant1

• In most reported cases, malignant transformation has occurring in individuals with a very long history of chewing tobacco or who use dry snuff. (wikipedia.org)

Leukoplakia1

• See also Verrucous Carcinoma , Proliferative Verrucous Leukoplakia , Cancers of the Oral Mucosa , and Smokeless Tobacco Lesions . (medscape.com)

Laryngeal2

• Oral, laryngeal, pharyngeal, and esophageal lesions of this type are generally known as a verrucous carcinoma or an Ackerman tumor. (medscape.com)
• [ 32 ] In an analysis of laryngeal verrucous carcinoma, HPV-16 DNA, HPV-18 DNA, or both were present in 13 of 29 cases. (medscape.com)

Moist snuff2

• Dipping tobacco ("moist snuff") is air or fire-cured, finely cut tobacco. (wikipedia.org)
• Three types of smokeless tobacco are commonly manufactured: loose-leaf chewing tobacco, moist snuff, and dry snuff. (medscape.com)

Smokeless2

• In the United States of America, the most common form of smokeless tobacco is dipping tobacco, although chewing tobacco is sometimes used by outdoor workers and dry snuff is common among females in the Southern states. (wikipedia.org)
• The term smokeless tobacco, also known as dip, plug, chew, or spit tobacco, refers to both chewing tobacco (coarse cut) and snuff (fine cut). (medscape.com)

Ackerman2

• Although the term verrucous carcinoma followed by its anatomical site would be the most comprehensive name, the historical name justifiably favors honoring 2 eminent physicians, Abraham Buschke (1868-1943) of Berlin and Ackerman (1905-1993). (medscape.com)
• Buschke was a legendary professor of dermatology, and Ackerman, the renowned professor of pathology, developed the concept of verrucous carcinoma. (medscape.com)

Keratosis1

• Snuff dipping is associated more with verrucous keratosis. (wikipedia.org)

Finely2

• Snuff is finely ground tobacco. (icliniq.com)
• So on, whereas non-smoking or chewing Tobacco includes snuff/naswar (roasted and finely powdered for inhalation), mawa, qiwam, and gutkha, Tobacco is combined with cloves and dipped into the mouth cavity in Indonesia. (fybix.com)

Lesions1

• Premalignant lesions and carcinoma in situ (CIS) may be permanently cured after excision or biopsy. (medscape.com)

Chewing2

• Oral snuff causes more pronounced changes in the oral mucosa than tobacco chewing. (wikipedia.org)
• Research has indicated that the use of chewing tobacco and snuff is strongly correlated with oral florid papillomatosis in many, but not all, patients. (medscape.com)

Pipes1

• When Columbus and his successors began to chronicle tobacco use in other nations, Indians began to use Tobacco in pipes, cigars, and snuff. (fybix.com)

Slowly1

• Verrucous carcinoma slowly extends into locally contiguous sites. (medscape.com)

Types2

• and (4) other cutaneous types, which include cutaneous verrucous carcinoma, papillomatosis cutis carcinoides, and papillomatosis cutis. (medscape.com)
• In one study, HPV types 6 and 11 were detected in 7 of 17 cases of oral verrucous carcinoma. (medscape.com)

Evident1

• It may be evident as a verrucous mass on the tongue. (medscape.com)

Aggressive1

• Perhaps, some patients with oral verrucous carcinoma die from a highly aggressive second primary oral cancer due to the same carcinogenic stimuli rather than a transformation of the verrucous carcinoma. (medscape.com)

Oral cancer1

• [ 24 ] Among Swedish men who had oral cancer and who used snuff, almost one half had verrucous carcinoma. (medscape.com)

Skin1

• Verrucous carcinoma of the skin and mucosa. (medscape.com)

Term1

• [ 2 ] described oral verrucous carcinoma and coined the term verrucous carcinoma. (medscape.com)

Surface1

• However, verrucous carcinoma can also occur on the cutaneous surface. (medscape.com)

Ground1

• Dry snuff is ground or pulverised tobacco leaves. (wikipedia.org)

Sites1

• Verrucous carcinoma usually appears in 3 main sites: the oropharynx, the genital tract, and the soles of the feet. (medscape.com)

Long1

• The possibility of chemical carcinogenesis of verrucous carcinoma of the oral cavity from tobacco has long been suggested. (medscape.com)

Squamous cell carcinomas3

• Almost all of the cancers are squamous cell carcinomas, also called squamous cell cancers. (can-c.in)
• 4. Analysis of p16(INK4A) expression of oral squamous cell carcinomas in Taiwan: prognostic correlation without relevance to betel quid consumption. (nih.gov)
• 13. Histological differentiation of primary oral squamous cell carcinomas in an area of betel quid chewing prevalence. (nih.gov)

Salivary gland carcinomas1

• Minor salivary gland carcinomas. (sunnysidedentistry.com)

Viral warts2

• Still others consider it a disease on a continuum between viral warts and verrucous carcinoma, rather than a verrucous carcinoma per se. (medscape.com)
• Therefore, these are not strong factors that distinguish viral warts from verrucous carcinoma. (medscape.com)

Tumors2

• Verrucous carcinoma tumors spread primarily by local invasion and only rarely metastasize. (medscape.com)
• 11. Survival of second and multiple primary tumors in patients with oral cavity squamous cell carcinoma in the betel quid chewing area. (nih.gov)

Chewing tobacco and snuff2

• Indeed, smokeless tobacco products, par- ticularly chewing tobacco and snuff, have recently emerged as popular products for the first time since the turn of the century. (nih.gov)
• Approximately 80% to 90% of oral cancer patients use tobacco products, including cigarettes, chewing tobacco, and snuff. (sunnysidedentistry.com)

Smokeless tobacco3

• In the United States of America, the most common form of smokeless tobacco is dipping tobacco, although chewing tobacco is sometimes used by outdoor workers and dry snuff is common among females in the Southern states. (wikipedia.org)
• The term smokeless tobacco, also known as dip, plug, chew, or spit tobacco, refers to both chewing tobacco (coarse cut) and snuff (fine cut). (medscape.com)
• [2] Additionally, the use of areca (betel) nut preparations in many parts of the world (south and southeast Asia) poses a significant risk, as does the use of snuff and other forms of smokeless tobacco. (nih.gov)

Buccal mucosa1

• 1. Univariate and multivariate analysis of prognostic significance of betel quid chewing in squamous cell carcinoma of buccal mucosa in Taiwan. (nih.gov)

Situ2

• Premalignant lesions and carcinoma in situ (CIS) may be permanently cured after excision or biopsy. (medscape.com)
• The earliest form of squamous cell cancer is called carcinoma in situ. (can-c.in)

Cancers2

• Squamous cell carcinoma makes up about 90% of all oral cancers. (sunnysidedentistry.com)
• There are many types of minor salivary gland cancers, including adenoid cystic carcinoma, mucoepidermoid carcinoma, and polymorphous low-grade adenocarcinoma . (can-c.in)

Pharyngeal1

• 5. Interaction between tumour necrosis factor-α gene polymorphisms and substance use on risk of betel quid-related oral and pharyngeal squamous cell carcinoma in Taiwan. (nih.gov)

Esophageal1

• 6. Risk of p53 gene mutation in esophageal squamous cell carcinoma and habit of betel quid chewing in Taiwanese. (nih.gov)

Quid4

• 10. Surgical outcome in patients with oral verrucous carcinoma: long-term follow-up in an endemic betel quid chewing area. (nih.gov)
• 12. Survivin expression predicts poorer prognosis in patients with areca quid chewing-related oral squamous cell carcinoma in Taiwan. (nih.gov)
• 16. Chewing areca nut, betel quid, oral snuff, cigarette smoking and the risk of oesophageal squamous-cell carcinoma in South Asians: a multicentre case-control study. (nih.gov)
• 20. Specific induction of the high-molecular-weight microtubule-associated protein 2 (hmw-MAP2) by betel quid extract in cultured oral keratinocytes: clinical implications in betel quid-associated oral squamous cell carcinoma (OSCC). (nih.gov)

Variant1

• The risk of the lesion developing into oral cancer (generally squamous cell carcinoma and its variant verrucous carcinoma) is relatively low. (wikipedia.org)

Clinical1

• The typical microscopic section shows a well-differentiated typical squamous cell carcinoma with verrucous clinical morphology. (medscape.com)

Occur2

• However, verrucous carcinoma can also occur on the cutaneous surface. (medscape.com)
• The evidence for causality is strongest for cancer of the oral cavity, wherein cancer may occur several times more frequently in snuff dippers compared to nontobacco users. (nih.gov)

Risk2

• The excess risk of cancer of the cheek and gum may reach nearly fiftyfold among long-term snuff users. (nih.gov)
• 8. Carcinoma and dysplasia in oral leukoplakias in Taiwan: prevalence and risk factors. (nih.gov)

Primary1

• Primary and invasive squamous cell carcinoma are treated with varying combinations of surgery and/or radiation. (medscape.com)

Type4

• Oral florid papillomatosis is a type of verrucous carcinoma (VC) that is clinically evident as multiple squamous papillary nodules in the oral cavity and, less commonly, in the larynx, the pharynx, the esophagus, the middle ear, the maxillary antrum, the nasal fossa, and the bronchus. (medscape.com)
• Oral florid papillomatosis is best defined as a type of verrucous carcinoma, although some consider it a separate entity. (medscape.com)
• Squamous cell carcinoma, which means the cancer develops in the squamous cells that line the inside of the mouth or throat, is by far the most common type of oral cancer. (msdmanuals.com)
• It is a type of squamous cell carcinoma and it's a low-grade (slow growing) cancer that rarely spreads to other parts of the body, but it can grow deeply into nearby tissue. (can-c.in)

Factors1

• 7. Squamous cell carcinoma of the oral tongue: an analysis of prognostic factors. (nih.gov)