• Using PCR/single-strand conformation polymorphism analysis of the gene encoding GDH in 12 Japanese patients with persistent hyperinsulinemic hypoglycemia of infancy (PHHI), we found a mutation (Y266C) in one PHHI patient. (diabetesjournals.org)
  • Study aims and goal: A Phase 1b/2a multicenter, randomized, double-blind, placebo-controlled study to evaluate the safety, tolerability, PK, and PD of WVE-003 in adult patients with early-manifest HD who carry the targeted single nucleotide polymorphism (SNP)-SNP3. (ehdn.org)
  • Recognition of a similarly affected second cousin prompted a genome-wide homozygosity mapping study using high-density single nucleotide polymorphism (SNP) arrays. (clinicforspecialchildren.org)
  • The aim of this study was to investigate comprehensively the association between single nucleotide polymorphisms (SNPs) in all three NOS genes and FENO in an adult population, and to assess whether such associations are modified by asthma or atopy. (bmj.com)
  • C single nucleotide polymorphisms (SNPs). (biomedcentral.com)
  • When we talk about 'genetic privacy' we are referring to only that very tiny part of the human genome that is unique to each individual, the single nucleotide polymorphisms that occur once in roughly 1,300 bases in each individual's genetic code. (alrc.gov.au)
  • We evaluated the most significant single-nucleotide polymorphisms (SNP) in these loci using a worldwide consortium of 13 groups (PRACTICAL). (pedigree.org.au)
  • Large-scale genotyping studies have identified common variants (primarily single-nucleotide polymorphisms [SNPs]) with individually modest breast cancer risk that, in aggregate, account for considerable breast cancer susceptibility. (stanfordhealthcare.org)
  • Where we once genotyped a single variant in a single gene, my group now routinely analyzes millions of single nucleotide polymorphisms across the entire genome and evaluates large-scale population-based sequencing data. (uth.edu)
  • The efficacy and safety of chemo-free therapy in epidermal growth factor receptor tyrosine kinase inhibitor-resistant advanced non-small cell lung cancer: A single-arm, phase II study. (cdc.gov)
  • FcgRIIB is the single inhibitory Fc g receptor in mice and humans and contains a cytoplasmic immunoreceptor tyrosine-based inhibitory motif (ITIM) which instead downregulates cellular responses. (sanguinebio.com)
  • Variation in gene expression is an essential material for biological diversity among single cells, individuals and populations or species. (elsevierpure.com)
  • We determined the allelic and nucleotide diversity for MHC class I and class II genes using samples of 250 individuals from eight breeding population of Snowy Plovers. (biomedcentral.com)
  • There are three biomarkers of effect currently being applied to measure PO exposure in humans: DNA adducts, hemoglobin adducts, and sister chromatid exchanges (SCE). (who.int)
  • In molecular biology, this protein domain represents Tbf5 which stands for TTDA subunit of TFIIH basal transcription factor complex (also known as subunit 5 of RNA polymerase II transcription factor B), and Rex1 a type of nucleotide excision repair (NER) proteins. (wikipedia.org)
  • Rod cyclic nucleotide-gated (CNG) channels are modulated by changes in tyrosine phosphorylation catalyzed by protein tyrosine kinases (PTKs) and phosphatases (PTPs). (silverchair.com)
  • CPS I is the most plentiful single protein in hepatic mitochondria, accounting for about 20% of the matrix protein. (medscape.com)
  • Anlotinib in patients with recurrent platinum resistant/refractory ovarian cancer: a prospective, single arm, phase II study. (cdc.gov)
  • The original author Yutaro Asami explains the concept of the current study: "Since cell capture was mostly in form and parent ASO was released internally, we have suggested the introduction of a phosphodiester (PO) RNA of a more stable and easier-to-produce PO DNA compound. (newswingz.com)
  • Included also is an exposure to polyethylene (PE) study because PE metabolizes to PO. (who.int)
  • An occupational exposure study was performed to establish a relationship between ambient exposure to EO and PO in air and the formation of their respective adducts to Hb (Boogaard et al. (who.int)
  • Adducts to Hb are especially suitable because small molecules such as PO form chemically stable adducts with the N-terminal valine of Hb, N-(3-hydroxypropyl)valine (HOPrVal). (who.int)
  • CPS is derived from catabolism of amino acids into a 1-carbon compound (H 2 N-CO-PO 32 -), in which the carbon atom is derived from bicarbonate. (medscape.com)
  • Contained in your cells is your DNA, made of things called nucleotides, which are 0.6 nanometers. (twu.edu)
  • The four types most important to human structure and function are carbohydrates, lipids, proteins, and nucleotides. (chemicalindustrynews.com)
  • It is vast, yet fits within the nucleus of a single cell and challenges the human mind's concept of the finite. (twu.edu)
  • The nucleotide sequences in this region of variable promoters showed a high propensity for DNA bending and a periodic distribution of particular dinucleotides, encoding preferences for DNA-nucleosome interaction. (elsevierpure.com)
  • Members of one of these groups are characterized by a single transmembrane helix, and others contain amphipathic helices. (frontiersin.org)
  • Transcription/repair factor IIH (TFIIH) is essential for RNA polymerase II transcription and nucleotide excision repair. (wikipedia.org)
  • A functional group is a group of atoms linked by strong covalent bonds and tending to function in chemical reactions as a single unit. (chemicalindustrynews.com)
  • Nucleotide excision repair is a major pathway for repairing UV light-induced DNA damage in most organisms. (wikipedia.org)
  • REX1, which is short for, required for excision 1, is required for DNA repair in the single-celled, photosynthetic algae Chlamydomonas reinhardtii, and has homologues in other eukaryotes. (wikipedia.org)
  • Single-stranded structure-specific DNA endonuclease involved in DNA excision repair. (abcam.cn)
  • Makes the 3'incision in DNA nucleotide excision repair (NER). (abcam.cn)
  • Package: abs-guide Description-md5: c70e528b8b624e5738bdbd1b89e8b349 Description-sl: Napredni vodnik po skriptanju Bash Poglobljeno raziskovanje umetnosti lupinskih skriptov. (ubuntu.com)
  • crRNA and tracrRNA can be synthetically fused into a single RNA molecule, namely single guide RNA. (bvsalud.org)
  • SCE is not specific to PO exposures, and may be caused by other chemicals. (who.int)
  • Since the IARC review, three new occupational biomonitoring studies have been conducted: one in a chemical plant manufacturing glycols and glycol ethers from PO and two in PO producing plants. (who.int)
  • In molecular biology, this protein domain represents Tbf5 which stands for TTDA subunit of TFIIH basal transcription factor complex (also known as subunit 5 of RNA polymerase II transcription factor B), and Rex1 a type of nucleotide excision repair (NER) proteins. (wikipedia.org)
  • Nucleotide excision repair is a major pathway for repairing UV light-induced DNA damage in most organisms. (wikipedia.org)
  • Transcription/repair factor IIH (TFIIH) is essential for RNA polymerase II transcription and nucleotide excision repair. (wikipedia.org)
  • In addition, we demonstrate that the acrolein generated is highly toxic in glioma treated with an inhibitor of Nucleotide Excision Repair (NER). (oncotarget.com)
  • T4 PNK catalyzes the transfer and exchange of the terminal gamma position phosphate of ATP to the 5′-hydroxyl terminus of double- and single-stranded DNA, RNA and nucleoside 3′-monophosphate molecules. (qiagen.com)
  • The enzyme is used to remove 3′-phosphoryl groups from nucleotide/nucleoside or DNA and RNA in studies of gene expression and gene function. (qiagen.com)
  • CPS is derived from catabolism of amino acids into a 1-carbon compound (H 2 N-CO-PO 32 -), in which the carbon atom is derived from bicarbonate. (medscape.com)
  • AGENCY: The United States Patent and Trademark Office (USPTO or Office) is adopting the recently revised World Intellectual Property Organization (WIPO) Standard ST.26, version 1.6, approved November 25, 2022, for incorporation by reference into its regulations addressing application disclosures containing nucleotide and/ or amino acid sequences. (justia.com)
  • WIPO Standard ST.26 defines the disclosures of nucleotide and/or amino acid sequences in patent applications that must be presented in a sequence listing in XML format in the manner specified in the standard. (justia.com)
  • In biosynthesis, small molecules are built up and atoms rearranged to make the monomeric units required by the cell (amino acids, fatty acids, nucleotides). (angelfire.com)
  • Compared to the wild-type strain, the transcription levels of the zymogen TGase genes in the mutants increased significantly as indicated by quantitative real-time PCR, while the gene nucleotide sequences of the mutants did not change at all. (springer.com)
  • The transcription levels and the nucleotide sequences of the gene (pro- sm tg) encoding TGase zymogen were compared between the mutants and the wild-type strain to explain the reasons for the enhanced TGase production, which may provide a valuable guidance for further researches on mechanisms regarding ARTP effects on the whole cells and the intracellular bio-macromolecules. (springer.com)
  • Single-stranded exonuclease activity was determined in a 50 μL reaction containing 10,000 cpm of radiolabeled single-stranded DNA and 10 μL of enzyme solution. (qiagen.com)
  • These results suggest that the function of the 3' - 5' exonuclease activity of DNA polymerases is to remove mispaired nucleotides which have been incorrectly incorporated, thereby increasing the fidelity of template copying. (nih.gov)
  • An online browser, called 'Theta-Base' ( www.helmholtz-hiri.de/en/datasets/bacteroides ), is launched to interrogate the obtained gene expression data and annotations of ~4500 transcription start sites, untranslated regions, operon structures, and 269 noncoding RNA elements. (nature.com)
  • Since a substantial amount of normal size PO mRNA was present in these transformed Schwann cells, the lack of PO synthesis was apparently not the result of a deficiency of transcription. (cornell.edu)
  • In this work, we develop a computational framework and study evolution of the simplest transcription network between a single regulator, R and a single target protein, T. (biomedcentral.com)
  • We, as reported earlier, use the simplest transcription factor network possible (between a single regulator R and a target protein, T ) (Fig. 1 a) [ 16 ]. (biomedcentral.com)
  • These results are consistent with the possibility that the regulation of PO synthesis differs from that of MAG and CNPase synthesis and that PO synthesis may be controlled at the post-transcriptional level. (cornell.edu)
  • CPS II is exclusively cytosolic and is an important enzyme in de novo synthesis of pyrimidine nucleotides. (medscape.com)
  • Chain extension of such termini begins only after all mispaired nucleotides have been removed and a base- paired terminus is reached. (nih.gov)
  • It thus appears that the 3' - 5' exonuclease may serve a proofreading role in removing mispaired nucleotides at the growing end of a chain and that the polymerase will not extend a chain until the mispaired 3' terminus is removed. (nih.gov)
  • This parameter is the fraction of all permissible values of a biochemical parameter that can be accessed from its current value via a single mutation. (biomedcentral.com)
  • For each parameter, from its current value, movement via a single mutation is only permitted to k distinct values (highlighted in green). (biomedcentral.com)
  • T4 PNK also catalyzes the hydrolytic removal of 3′-PO 4 termini from DNA, RNA and deoxynucleoside 3′-monophosphates. (qiagen.com)
  • Dilutions of enzyme were made in 1X Reaction Buffer and added to 50 µL reactions containing 10 µM Oligo(dT) single-stranded DNA, 1X PNK Reaction Buffer, and 66 µM ATP and [γ 32 P]-ATP. (qiagen.com)
  • Cyclic mono- or oligonucleotide second messenger molecules are ubiquitously occurring in cells from all three domains of life and are implicated in a wide array of signaling networks at the single or multiple cell level. (nature.com)
  • A) deciding how many electrons are involved in bonding B) deciding if double bonds are present in a molecule C) formulating a statement of the octet rule D) determining the number of single bonds present in a molecule E) predicting the polarity of a bond 83) Which statement about electronegativity is … EINECS 280-502-6. (orielladigitaljournalism.com)
  • 5' exonuclease support earlier speculations (3, 7, 8) that this activity may be designed to remove mispaired nucleotides which have been incorrectly incorporated at the 3'-hydroxyl end of the double-stranded DNA and thereby serves a corrective function. (nih.gov)
  • Homogeneous transformed Schwann cell lines were established by single cell cloning. (cornell.edu)
  • In this report, we demonstrate that these SV40-transformed Schwann cells actively synthesize myelin-specific sulfatide, myelin-associated glycoprotein (MAG) and the glial cell marker 2':3'-cyclic nucleotide 3'-phosphodiesterase (CNPase). (cornell.edu)
  • Flap endonucleases cleave the downstream strand of the overlap flap structure precisely after the first base-paired nucleotide, creating a ligatable nick. (bvsalud.org)
  • These nucleases appear to perform complementary roles in trimming single-stranded ends of DNA chains and in enlarging nicks and gaps within helical regions of double-stranded DNA. (nih.gov)
  • We describe the sequence polymor- hospital, the patient was in a single room with trans- phisms over time among the 9 whole-virus genome mission-based air-handling precautions. (cdc.gov)
  • We offer simple pricing on our plasmids, based on ordering one plasmid at a time, a single price for a 96-well plate of plasmids , or our pre-made collections of plasmids. (dnasu.org)
  • In addition to simplifying the process for applicants filing in multiple countries, the ST.26 requirement to submit a single sequence listing in eXtensible Mark-up Language (XML) format provides better preservation, accessibility, and sorting of the submitted sequence data for the public. (justia.com)