Tropical spastic parAtaxiaParaplegiaMyelopathyWeaknessSpasticityOnsetPatientsLower limbsAutonomicSevereDiagnosisSpinal cordPoorly understoodBilateralNonspecificAbnormalitiesBladder dysfunctionProgressiveSensoryNeurologicMeningitisCerebellarLesionsNeuropathyMyalgiaClinical signsSeverityNeurological signsDiseaseBowelSyndromeInfectionMonthsAstheniaMuscular
Tropical spastic par2
- Tropical neuropathy is a class of illnesses with similar signs and symptoms, including konzo, tropical spastic paraparesis (TSP), and tropical ataxic neuropathy (TAN). (wikipedia.org)
- The prevalence rates of the other less common neurological disorders were 62 for hemiparesis (15 of which were for cerebrovascular accidents), 20 for cerebral palsy, 16 for optic atrophy, 12 for perceptive deafness, 10 for tropical spastic paraparesis, 7 for Parkinson's disease and 5 for motor neuron disease, ataxia and chorea/athetosis. (nih.gov)
Ataxia5
- Spinocerebellar ataxia type 3 (SCA3), also known as Machado-Joseph disease (MJD), is characterized by progressive cerebellar ataxia and variable findings including pyramidal signs, a dystonic-rigid extrapyramidal syndrome, significant peripheral amyotrophy and generalized areflexia, progressive external ophthalmoplegia, action-induced facial and lingual fasciculations, and bulging eyes. (nih.gov)
- The epilepsy, parkinsonism, progressive ataxia, spastic paraparesis, and demyelinating polyneuropathy occur in the clinical picture of a neurological nature. (amedi.sk)
- Bulbar signs, ataxia, palatal myoclonus, spastic paraparesis with hyperreflexia, and autonomic dysfunction are the most observed clinical manifestations. (biomedcentral.com)
- A disorder where degeneration of certain parts of the brain and spinal cord results in symptoms such as blindness, tremor, speech problems and ataxia. (checkorphan.org)
- This is a sign that the dorsal column or peripheral nerve is affected, and one should look for peripheral neuropathy, pernicious anemia, multiple sclerosis, and Friedreich's ataxia. (checkorphan.org)
Paraplegia5
- Symptoms and signs of hereditary spastic paraplegia include spastic leg paresis, with progressive gait difficulty, hyperreflexia, clonus, and extensor plantar responses. (msdmanuals.com)
- Hereditary spastic paraplegia is suggested by a family history and any signs of spastic paraplegia. (msdmanuals.com)
- They will develop slight or incomplete hind end paralysis (paraparesis), which will progress to total rear end paralysis (paraplegia), accompanied by varying degrees of urinary and/or fecal incontinence. (rehabvet.com)
- The hallmarks of acute spinal cord infarction are a sudden, apoplectic onset of severe back or neck pain (50-80% of cases) accompanied by paraparesis or paraplegia [ 4 ]. (biomedcentral.com)
- Patients with late-onset spastic paraplegia should be screened for underlying leukodystrophies, irrespective of the presence of additional complicating symptoms and neuroimaging abnormalities. (dovepress.com)
Myelopathy3
- However, with the use of thoracolumbar orthosis, his symptoms/signs stabilized, although partial lower leg myelopathy was present. (unboundmedicine.com)
- Approximately 15% of patients follow a primary progressive or progressive relapsing course from disease onset, usually characterized by symptoms of progressive myelopathy (gait instability, spasticity, bladder symptoms) and cognitive impairment. (medscape.com)
- While the causes of myelopathy may be multiple, the acuity of presentation and symptom onset frame a practical approach to the differential diagnosis. (bvsalud.org)
Weakness6
- A neurologist determined signs of peripheral facial palsy with brachial weakness and nuchal rigidity. (cdc.gov)
- We present a series of 5 patients who experienced low back pain, progressive numbness, weakness and even paraparesis. (unboundmedicine.com)
- True muscle weakness is a primary symptom of a variety of skeletal muscle diseases, including muscular dystrophy and inflammatory myopathy. (rxharun.com)
- The patient complained for the first time of symptoms of stiffness and weakness of legs. (openventio.org)
- Neurological function is impaired in affected individuals, and they can experience progressive stiffness and weakness in their legs (paraparesis), muscle twitches (myoclonus), or intellectual disability. (nih.gov)
- The presenting symptoms of ISCM vary from pain, sensory loss, weakness, urinary incontinence to pseudo Brown-Sequard and/or Brown-Sequard syndrome [ 5 ]. (biomedcentral.com)
Spasticity3
- Spastic paraparesis is stiffness, or spasticity, in the muscles of both the arms and legs (spastic quadriparesis) or in the muscles of both legs (spastic paraparesis). (childneurologyfoundation.org)
- Treat symptoms (eg, baclofen for spasticity, physical therapy). (msdmanuals.com)
- Hereditary spastic paraplegias (HSPs) encompass a group of neurodegenerative disorders with lower limb spasticity due to degeneration of the corticospinal tract as most prominent sign. (biomedcentral.com)
Onset3
- The patient recalled a tick bite after a walk in a forest in his neighborhood 2 weeks before symptom onset. (cdc.gov)
- He recalled multiple tick bites and a bite by a sick squirrel in the weeks before symptom onset. (cdc.gov)
- Have a length of disease duration since PMS disease symptom onset =10 years if baseline EDSS =5.0 and =15 years if baseline EDSS >5.0. (who.int)
Patients10
- Infected patients may also have symptoms of autonomic dysfunction leading to constipation and, in some cases, sexual dysfunction. (medscape.com)
- Three patients (males, black, ages 37, 40 and 57) attended a university clinic with a progressive paraparesis of obscure origin. (scielo.br)
- Some patients suffer from severe tetra- or paraparesis. (lymetalk.net)
- Approximately 60% of patients with myelitis have additional signs of encephalitis and around 40% have cranial nerve involvement. (lymetalk.net)
- Whereas all patients showed clinical signs of spastic paraparesis, MEPs were normal in 27% of patients and revealed a broad spectrum with axonal or demyelinating features in the others. (biomedcentral.com)
- In all patients with spondylodiscitis, infective endocarditis should be considered, particularly in patients with heart valve disease history, since spondylodiscitis may be the presenting sign of an infective endocarditis. (scirp.org)
- Abnormalities of colonic activity and slow transit time have been demonstrated in patients with MS. A pathoanatomical explanation of slowed transit time is unidentified, and Clare Fowler has suggested, that the symptom of constipation could be a mechanism similar to that which causes fatigue in MS. (parkinsonsinfoclub.com)
- Patients with severe paraparesis may complain of difficulty in switching on the mechanism of defecation. (parkinsonsinfoclub.com)
- Serious neurological toxicity (including irreversible paraparesis and quadraparesis) has been reported in patients who received LEUSTATIN Injection by continuous infusion at high doses (4 to 9 times the recommended dose for Hairy Cell Leukemia). (nih.gov)
- Le présent article décrit les manifestations cliniques, le diagnostic et la prise en charge de la schistosomiase médullaire chez cinq patients admis dans les hôpitaux Shaab et Ibn Khaldoun de Khartoum entre 1997 et 2007. (who.int)
Lower limbs1
- Neurological examination revealed paraparesis, hypoesthesia of the lower limbs with L4-L5 root distribution. (scirp.org)
Autonomic1
- in particular, there were no bulbar, cognitive or autonomic symptoms and no neck pain. (bmj.com)
Severe5
- Less severe versions may cause progressive stiffening in the legs, also known as spastic paraparesis. (childneurologyfoundation.org)
- It is the most common symptom of ARG1-D. It occurs in both severe and milder cases. (childneurologyfoundation.org)
- Long-term complications such as muscular and cardiac symptoms as well as liver fibrosis/cirrhosis and hepatocellular carcinoma may have a severe impact on prognosis and quality of life. (nih.gov)
- A 10-year-old neutered male Siberian Husky presented with paraparesis and severe lethargy. (e-jvc.org)
- A 10-year-old neutered male Siberian Husky dog presented to the Veterinary Medical Teaching Hospital of Chungnam National University with severe lethargy and two months of paraparesis. (e-jvc.org)
Diagnosis2
- Diagnosis should be made properly, especially because symptoms/signs cannot be explained purely on the basis of the available images. (unboundmedicine.com)
- Early signs and symptoms of these illnesses are nonspecific or mimic other illnesses, which can make diagnosis challenging. (cdc.gov)
Spinal cord2
- Typical symptoms of relapses may be referable to demyelinating pathology involving the optic nerves (e.g. optic neuritis), brainstem (e.g. internuclear ophthalmoplegia) or spinal cord (e.g. partial myelitis), although non-specific symptoms referable to the cerebral hemispheres or other brain regions can also occur (Katz Sand and Lublin, 2013). (medscape.com)
- Predictably, the syndrome of symptoms varies with the level of the spinal cord in which the lesion occurs. (biomedcentral.com)
Poorly understood1
- More than one in 10 people successfully treated with antibiotics for Lyme disease go on to develop chronic, sometimes debilitating and poorly understood symptoms of fatigue and brain fog that may last for years after their initial infection has cleared up. (lymetalk.net)
Bilateral2
- One patient who referred disease duration of more than 16 years, showed diminished deep reflexes, bilateral Babinski's sign, diminished sensation of vibration, abnormal bladder function and back pain. (scielo.br)
- Bilateral lower extremity paresis is referred to as PARAPARESIS. (bvsalud.org)
Nonspecific2
- The symptoms are nonspecific and overlap with fibromyalgia and chronic fatigue syndrome. (arkansasbluecross.com)
- The clinical presentation is often nonspecific with symptoms including headache Headache The symptom of pain in the cranial region. (lecturio.com)
Abnormalities2
- Special attention should be paid to the neurologic examination, evaluation for lymphadenopathy, and signs of hematologic abnormalities. (medscape.com)
- Electrophysiological abnormalities correlated with the severity of clinical symptoms. (biomedcentral.com)
Bladder dysfunction1
- Symptoms of bowel dysfunction are not nearly as frequent as bladder dysfunction, indicating a more complex mechanism than the result of spinal lesions. (parkinsonsinfoclub.com)
Progressive2
- A 29-year-old man was admitted on November 25, 2009, because of a progressive spastic paraparesis which had proceeded over the previous 2 months. (openventio.org)
- A 51-year-old Iranian woman presented with 2-month history of progressive unremitting back pain, exacerbated at night, superimposed on a creeping paraparesis. (biomedcentral.com)
Sensory1
- Peripheral nervous system manifestations of Lyme disease include paresthesias or radicular pain with only minimal sensory signs. (arkansasbluecross.com)
Neurologic1
- 3. Are there other neurologic signs? (checkorphan.org)
Meningitis1
- A 59-year-old man was admitted to the neurology department of a hospital in Belgium with paraparesis and meningitis. (cdc.gov)
Cerebellar1
- These signs should suggest a cerebellar tumor or acoustic neuroma. (checkorphan.org)
Lesions2
- The area postrema syndrome consists of uncontrollable vomiting, brain stem lesions, and weight loss symptoms and has been reported in association with inherited white matter disorders such as AxD [ 4 ]. (biomedcentral.com)
- If multiple lesions are present, it is considered a sign of early disseminated disease. (arkansasbluecross.com)
Neuropathy1
- With the appropriate examination and supportive tests however, a neurologist should be able to distinguish the symptoms of peripheral neuropathy from other conditions, including PD, that may cause similar symptoms. (parkinsonsinfoclub.com)
Myalgia1
- A case described separately is a 29-year-old male patient with indeterminate myalgia and no SPG signs in whom SPAST previously reported mutation p.Ala430Thr de novo was an unexpected MPS finding. (hspersunite.org.au)
Clinical signs1
- Clinical signs gradually improved, and the patient showed normal ambulation 40 days after treatment initiation. (e-jvc.org)
Severity1
- Symptoms can vary depending on the severity of the disorder. (childneurologyfoundation.org)
Neurological signs2
- For those which developed neurological signs of EAE, to facilitate access to food and hydration, mashed water and food had been positioned lower. (buyresearchchemicalss.net)
- On admission, it is essential to evaluate any neurological signs and to carefully document the extent of any neurological deficit. (biomedcentral.com)
Disease5
- Babinski's sign and bladder disturbance were also present in the patient with six years of disease. (scielo.br)
- Diagnostic criteria for HSP included (i) spastic paraparesis or spastic tetraparesis with legs earlier and more severely affected than arms or (ii) spastic paraparesis as early and prominent sign of a neurodegenerative multisystem disease after exclusion of other causes. (biomedcentral.com)
- To exclude secondary forms of spastic paraparesis standard diagnostic procedures covered MRI of head and spine, vitamin B12 and folic acid levels, very long chain fatty acids (VLCFA), neurometabolic screening (Krabbe disease, metachromatic leukodystrophy, GM1-gangliosidosis, GM2-gangliosidoses Tay Sachs and Sandhoff, Gaucher disease) and cerebrospinal fluid analysis. (biomedcentral.com)
- None of outdated animals demonstrated macroscopic symptoms of disease at necropsy. (buyresearchchemicalss.net)
- Any one of these three signs and symptoms should suggest Ménière's disease or other labyrinthine disease as well as eighth nerve pathology. (checkorphan.org)
Bowel1
- Spastic paraparesis can also include difficulties with walking or with bowel or bladder control. (childneurologyfoundation.org)
Syndrome1
- People with Troyer syndrome can experience a variety of signs and symptoms. (medlineplus.gov)
Infection4
- You should keep an eye out for swelling, redness, or pus around your wounds since these signs may indicate an infection. (augerlaw.com)
- Symptoms of pharyngitis range from a mild upper respiratory tract infection to exudative pharyngitis. (scirp.org)
- No infectious aetiology had been found despite performing detailed investigation to detect any sign of cysticercosis, brucellosis and/or HTLV infection. (biomedcentral.com)
- Symptoms depend upon worm load (number of worms), anatomical location of parasites, duration of infection and host immune system reactions. (wikitropica.org)
Months3
- Symptoms can develop over days or several months. (lymetalk.net)
- The absence of cobalamin leads to impaired growth, a shortage of blood cells, and many other signs and symptoms that usually become apparent within the first weeks or months of life. (nih.gov)
- In case of persistent symptoms/signs after hospital discharge or after acute il ness, it is recommended to complete the CRF at 3-month intervals, for as long as needed, or at 6 months interval, if no symptoms persist (see figure below). (who.int)
Asthenia1
- Asthenia is a symptom of a number of different conditions. (rxharun.com)
Muscular1
- Término general que hace referencia a un grado de debilidad muscular leve a moderado, que en ocasiones se utiliza como sinónimo de PARÁLISIS (pérdida extensa o completa de la función motora). (bvsalud.org)