Siderosis. Medical search. Frequent questions

Welcome to the "Contact the Superficial Siderosis Research Alliance" page. (livingwithss.com)
The Superficial Siderosis Research Alliance (SSRA) is a volunteer organization run by patients, caregivers, and friends, dedicated to raising awareness, supporting medical research, and providing resources for those affected by this ultra-rare neurodegenerative disorder. (livingwithss.com)

When used without qualification, it usually refers to an environmental disease of the lung, also known more specifically as pulmonary siderosis or Welder's disease, which is a form of pneumoconiosis. (wikipedia.org)
Pulmonary siderosis was first described in 1936 from X-ray images of the lungs of arc welders. (wikipedia.org)
Mild to moderate scarring of the lungs has been found in unusual cases of pulmonary siderosis. (wikipedia.org)
Because of this, it is not known for certain whether the inhalation of pure iron or rust can cause detrimental scarring of the lungs that has been seen in some cases of pulmonary siderosis. (wikipedia.org)
Still, studies have shown lack of silica in tissue samples collected from people with pulmonary siderosis. (wikipedia.org)
Pulmonary siderosis is caused by repeated inhalation of fine iron or rust dust that happens usually over a number of years. (wikipedia.org)
Pulmonary siderosis causes changes within the lungs that are clearly visible in tissue samples, x-ray images and other radiological studies. (wikipedia.org)
There is no cure for pulmonary siderosis or other interstitial lung diseases. (wikipedia.org)
Outcome of pulmonary siderosis is often good if the inhalation of iron or rust dust is permanently avoided. (wikipedia.org)
Still, it is not known if pulmonary siderosis causes cancer in welders specifically or if these cases of cancer appear due to entirely different factors. (wikipedia.org)
Although the term " siderosis " strictly just means any deposition of surplus iron in the body, when used as a stand-alone term it usually refers to pulmonary siderosis. (radiopaedia.org)

Chronic iron overload may arise primarily in genetic haemochromatosis in which there there is excessive iron absorption, or secondary to excessive intake from transfusions (transfusional siderosis), or to alcoholic liver cirrhosis. (sas-centre.org)
Transfusional siderosis is treated by subcutaneous infusion of desferrioxamine. (sas-centre.org)

Eye exposure to iron dust can also cause another form of siderosis, "ocular siderosis" or "siderosis bulbi", which can cause eye discoloration, but also eye damage, like cataracts and night blindness. (wikipedia.org)
Siderosis bulbi is caused by retention and oxidation of an iron-containing intraocular foreign body. (atlasrleye.com)
The foreign body should be removed before irreversible siderosis bulbi occurs. (atlasrleye.com)

By improving the understanding of superficial siderosis and the pathophysiology, research will explain the functional changes at a cellular level that are occurring within an individual due to superficial siderosis. (livingwithss.com)
Dr. Michael Levy, Harvard University and all hospitals involved in this project intend the tissue collected be used to further the work towards understanding the pathophysiology of the disease identified as superficial siderosis and once a better understanding is met to continue using available tissue and data in pursuit of improving treatments that might possibly one day help patients heal. (livingwithss.com)
Diverging pathophysiology in superficial siderosis with proximal upper limb amyotrophy. (nih.gov)

Both of the cases examined presented welder's siderosis. (cdc.gov)

Siderosis is the deposition of excess iron in body tissue. (wikipedia.org)
While we refer to incontinence as a symptom, it may be considered "secondary to superficial siderosis" because it results from the damage or dysfunction the deposition of iron causes. (livingwithss.com)
The increased deposition of iron in gastric mucosa is known as gastric siderosis. (ospublishers.com)
Rare adverse effects include chronic gastritis and deposition of iron in the gastric mucosa, known as gastric siderosis. (ospublishers.com)

Functional damage to the retina occurs at a very early stage, before extensive siderosis is apparent, and before stainable iron is detected in retinal tissues. (atlasrleye.com)

Superficial Siderosis 2015-2016 Getting a diagnosis was the first step. (livingwithss.com)

Idiopathic pulmonary haemosiderosis - a disease caused by lung capillary bleeding Hemosiderosis - accumulation of hemosiderin in body Superficial siderosis - accumulation of hemosiderin in brain Iron deficiency - also known as sideropenia Iron overload - accumulation of iron in body from any cause African iron overload Doig AT, Mclaughlin AI (1936). (wikipedia.org)

1947. Argyro-siderosis of the lungs in silver finishers. (cdc.gov)

End-of-life donation of the brain and spinal cord tissue for superficial siderosis research is the most generous gift you can make. (livingwithss.com)

Stress And Depression Have you ever wondered which is the most frequent and sometimes incapacitating superficial siderosis symptom? (livingwithss.com)

10%) in the LEQEMBI group were infusion reactions, ARIA-H (combined cerebral microhemorrhages, cerebral macrohemorrhages, and superficial siderosis), ARIA-E (edema/effusion), headache, and fall. (eisai.com)

A Nostalgic Look Back: Celebrating Success Stories for SS MonthOriginally published in April 2018, we're taking a moment during Superficial Siderosis Month to revisit some of the most inspiring personal journeys that have graced our pages. (livingwithss.com)

The name siderosis comes from Ancient Greek word for iron, sídēr(os), and has an -osis suffix. (wikipedia.org)
Siderosis may develop within weeks, but the course is variable depending on the iron content of the foreign body and its location. (atlasrleye.com)
In siderosis the lens epithelium takes on a yellow-brown or rusty appearance, from minute dots of intracellular iron. (atlasrleye.com)

Join us in our journey towards a future where a Superficial Siderosis diagnosis is no longer a life-altering condition. (livingwithss.com)

Most common adverse reactions (at least 10% and higher incidence compared to placebo): ARIA-Edema, headache, ARIA-H microhemorrhage, ARIA-H superficial siderosis, and fall. (nih.gov)

This is your direct line to the SSRA, a dedicated community of researchers, advocates, and supporters committed to advancing the understanding and treatment of superficial siderosis. (livingwithss.com)

Herein, we report a case of incidental finding of gastric siderosis in the workup of dyspepsia. (ospublishers.com)

The patient was diagnosed with incidental finding of gastric glandular siderosis. (ospublishers.com)

Cortical superficial siderosis (cSS) was associated with higher mRS at follow-up. (hindawi.com)
They focused on cerebral microbleeds (CMBs), white matter changes (WMHs), and cortical superficial siderosis (cSS) [ 6 ]. (hindawi.com)
Association of cortical superficial siderosis with post-stroke epilepsy. (amedeo.com)

Siderosis is sometimes associated with silicosis among iron ore miners if the exposure to free silica is severe enough to cause fibrotic changes and subsequent deterioration of the pulmonary function. (digitalfire.com)

When used without qualification, it usually refers to an environmental disease of the lung, also known more specifically as pulmonary siderosis or Welder's disease, which is a form of pneumoconiosis. (wikipedia.org)
It has been named siderosis, iron pneumoconiosis, hematite pneumoconiosis, iron pigmentation of the lung, and "arc welder's lung" , reflecting the fact that it has been seen in many occupational groups exposed to iron oxide fumes, including silver polishers. (digitalfire.com)

3.Ding J, Sieminski S, Yoganathan, P. Resolution of ocular siderosis glaucoma following removal of 30 year old intraocular foreign body. (kresgeeye.org)

Clinical expression of both sporadic and familial porphyria cutanea tarda most often requires exposure to environmental or infectious agents or the presence of coexisting conditions that adversely affect hepatocytes and result in hepatic siderosis. (medscape.com)

Whilst iron loading from blood transfusions may cause dilated cardiomyopathy in conditions such as thalassemia, the in-vivo prevalence of myocardial siderosis in HC is unclear, and its relation to left ventricular (LV) dysfunction is controversial. (nih.gov)
Most previous data on myocardial siderosis in HC has come from post-mortem studies. (nih.gov)
Overall however, the relation between myocardial siderosis and ferritin was weak (R2 0.20, p = 0.011). (nih.gov)
In the 10 genetically unconfirmed HC patients, 1 patient had mild myocardial siderosis but normal EF. (nih.gov)

Pulmonary siderosis was first described in 1936 from X-ray images of the lungs of arc welders. (wikipedia.org)
Mild to moderate scarring of the lungs has been found in unusual cases of pulmonary siderosis. (wikipedia.org)
Because of this, it is not known for certain whether the inhalation of pure iron or rust can cause detrimental scarring of the lungs that has been seen in some cases of pulmonary siderosis. (wikipedia.org)
Still, studies have shown lack of silica in tissue samples collected from people with pulmonary siderosis. (wikipedia.org)
Pulmonary siderosis is caused by repeated inhalation of fine iron or rust dust that happens usually over a number of years. (wikipedia.org)
Pulmonary siderosis causes changes within the lungs that are clearly visible in tissue samples, x-ray images and other radiological studies. (wikipedia.org)
There is no cure for pulmonary siderosis or other interstitial lung diseases. (wikipedia.org)
Outcome of pulmonary siderosis is often good if the inhalation of iron or rust dust is permanently avoided. (wikipedia.org)
Still, it is not known if pulmonary siderosis causes cancer in welders specifically or if these cases of cancer appear due to entirely different factors. (wikipedia.org)
Idiopathic pulmonary haemosiderosis - a disease caused by lung capillary bleeding Hemosiderosis - accumulation of hemosiderin in body Superficial siderosis - accumulation of hemosiderin in brain Iron deficiency - also known as sideropenia Iron overload - accumulation of iron in body from any cause African iron overload Doig AT, Mclaughlin AI (1936). (wikipedia.org)

Siderosis from iron dust inhalation has been found after prolonged exposure. (osha.gov)

Based on the first 69 published reports of superficial siderosis, it was calculated that 50% of cases are caused by an idiopathic chronic subarachnoid hemorrhage originating from an occult source, while the other 50% of cases are secondary to a known cause of subarachnoid hemorrhage such as a CNS tumor, arteriovenous malformation, or trauma. (medscape.com)
Other less common causes of chronic subarachnoid hemorrhage leading to superficial siderosis are post-surgical changes related to neurosurgeries (7%), brachial plexus injury (6%), amyloid angiopathy (3%), and chronic subdural hematomas. (medscape.com)

Removal of IOFB can stop the progression of siderosis. (capsulehealth.one)

If 10 or more new incident microhemorrhages or greater than 2 focal areas of superficial siderosis (radiographic severe ARIA-H) are observed, treatment may be continued with caution only after a clinical evaluation and a follow-up MRI demonstrates radiographic stabilization (i.e., no increase in size or number of ARIA-H). (drugs.com)

Cranial MRI showed symmetric thin rims of low signal intensity in T2- and T2*-weighted images in the cortex of the sylvian fissures, of the cerebellar hemispheres and vermis, and in the quadrigeminal plate consistent with superficial siderosis of the CNS. (nih.gov)
MR scan of brain with susceptibility-weighted imaging (figure 1A) and T 2 -weighted imaging (figure 1B) showed superficial siderosis involving the Sylvian fissures, brainstem structures, cerebellar sulci and surrounding the third and lateral ventricles. (bmj.com)

Superficial siderosis was first described almost 100 years ago, but only a handful of cases appeared in the literature before the widespread use of MRI enabled physicians to make the diagnosis without a biopsy, and to discover incidental asymptomatic cases. (medscape.com)
In addition to greatly improving the chances of an early diagnosis of superficial siderosis, the wide availability of MRI has revolutionized our understanding of the etiology of the condition. (medscape.com)
Before you post any information about someone living with a superficial siderosis diagnosis, please ensure that the individual has agreed to have their diagnosis or medical status shared publicly. (livingwithss.com)
Patients must rely on the personal and individualized medical advice of their qualified healthcare professionals before seeking any information related to your particular diagnosis or treatment of superficial siderosis or associated symptoms. (livingwithss.com)

Despite extensive imaging, a source of bleeding is often not evident during the evaluation of patients with superficial siderosis (SS) of the central nervous system. (ajnr.org)

Living With Superficial Siderosis and the SSRA is not a medical provider or healthcare facility and thus can neither diagnose superficial siderosis or associated symptoms nor endorse or recommend any specific medical treatments. (livingwithss.com)
What are the symptoms of Siderosis? (mysds.ca)
Siderosis does not often have symptoms. (mysds.ca)

The younger daughter had vitreal deposits, sensorimotor polyneuropathy, and acute sensorineural hearing but no evidence of siderosis on cranial MRI. (nih.gov)

Localization of specialized cells within the cerebellum, brainstem, and spinal cord to sequester heme explains the predisposition of these CNS structures to be most adversely affected in cases of superficial siderosis. (medscape.com)

Our social platforms are safe spaces for sharing and discussion, and tools the superficial siderosis community can use to support people with superficial siderosis and fight this disease. (livingwithss.com)

Gastric siderosis: An under-recognized and rare clinical entity. (nih.gov)

Modern technology in scanning just diagnosed my hearing loss four years ago - it's due to Superficial Siderosis, a rarely diagnosed condition due to a brain bleed within the cerebral spinal fluid, as a result of the tumour removal. (rnid.org.uk)

Most common adverse reactions (at least 10% and higher incidence compared to placebo): ARIA-Edema, headache, ARIA-H microhemorrhage, ARIA-H superficial siderosis, and fall. (nih.gov)

Superficial siderosis is a radiological or pathological condition in which hemosiderin-a product of the breakdown of blood-is deposited in the subpial layer of the CNS, which typically leads to progressive and irreversible neurological dysfunction. (medscape.com)

The SSRA/LWSS serves people living with superficial siderosis throughout the world. (livingwithss.com)

We maintain a presence on several social media sites as part of our commitment to transparency and to keep those in the superficial siderosis community apprised of our news and activities. (livingwithss.com)

Diseases5

Chemicals and Drugs3

Superficial Siderosis Research Alliance2

Pulmonary siderosis11

Transfusional Siderosis2

Bulbi3

Pathophysiology3

Welder's1

Deposition4

Stainable iron1

20161

Hemosiderosis1

Lungs1

Spinal1

Symptom1

Cerebral1

20181

Iron3

Journey1

Headache1

Treatment1

Case1

Patient1

Cortical superficial siderosis3

Silicosis1

Pneumoconiosis2

Ocular Siderosis1

Hepatic siderosis1

Myocardial siderosis4

Pulmonary10

Inhalation1

Chronic2

Progression1

Focal1

Cerebellar2

Diagnosis4

Patients1

Symptoms3

Sensorineural1

Adversely1

Disease1

Clinical1

Removal1

Common1

Condition1

People1

News1