Sialic acids. Medical search. Frequent questions

Sialic acid can "hide" mannose antigens on the surface of host cells or bacteria from mannose-binding lectin. (wikipedia.org)
A sialic-acid-specific lectin from ovine placental cotyledons was purified by affinity chromatography on bovine submaxillary mucin-agarose followed by gel filtration, and it showed a molecular weight of 65,000 by sodium dodecylsulfate-polyacrylamide gel electrophoresis. (illinois.edu)
Haemagglutination inhibition assays of different saccharides, glycoproteins and glycolipids indicate that this lectin has affinity for sialic acid, which is enhanced by its O-acetylation. (illinois.edu)
Description: A sandwich ELISA kit for detection of Sialic Acid Binding Ig Like Lectin 6 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (therabio.org)
Description: A sandwich quantitative ELISA assay kit for detection of Human Sialic Acid Binding Ig Like Lectin 10 (SIGLEC10) in samples from serum, plasma, tissue homogenates or other biological fluids. (therabio.org)
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Sialic Acid Binding Ig Like Lectin 10 (SIGLEC10) in serum, plasma, tissue homogenates and other biological fluids. (therabio.org)

Salla disease is a less severe form of sialic acid storage disease. (medlineplus.gov)
Salla disease, or the adult form of sialic acid storage disease, becomes apparent as early as infancy. (medicinelearners.com)

Mutations in the SLC17A5 gene cause all forms of sialic acid storage disease. (medlineplus.gov)
Different gene mutations lead to infantile or adult forms of sialic acid storage disease. (medicinelearners.com)

The structural studies of sialic acid synthesizing enzymes will aid to reveal possible importance of sialic acids for bacterial survival in the host, and in turn enable the development of highly selective antibiotics. (uit.no)
Chemical biology tools have increasingly revealed the importance of sialic acids as a major signal in physiology and disease. (medicineinnovates.com)

The most common member of this group is N-acetylneuraminic acid (Neu5Ac or NANA) found in animals and some prokaryotes. (wikipedia.org)
We show that hemagglutination involves selective recognition of the non-human sialic acid N-glycolylneuraminic acid (Neu5Gc) but not N-acetylneuraminic acid (Neu5Ac), which differs by only one oxygen atom from Neu5Gc. (nih.gov)
The N-acetylneuraminic acid (NANA) standard is a quantitative standard of NIST-F and USP traceable Neu5Ac monosaccharide. (qa-bio.com)
Common forms include N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuraminic acid (Neu5Gc). (cabio.com)
Thus, in the present research we performed two different approaches in order to obtain polymeric (poly(d,l-lactide-co-glycolide), PLGA) NPs surface decorated with the sialic acid N-acetylneuraminic acid (Neu5Ac). (unimore.it)
Thus, the new Neu5Ac-modified PLGA polyester represent a useful starting material for the preparation of NPs surface decorated with this sialic acid. (unimore.it)
We demonstrate that SiaT rescues an strain lacking its endogenous sialic acid transporter when grown on the sialic acids -acetylneuraminic acid (Neu5Ac) or -glycolylneuraminic acid (Neu5Gc). (instem.res.in)
Sialic Acid/N-acetylneuraminic acid ke lentsoe le akaretsang bakeng sa N- kapa O-substituted derivatives of neuraminic acid, e robong carbon monosaccharide.Hape ke lebitso la setho se tloaelehileng sa sehlopha sena, N-acetylneuraminic acid (Neu5Ac kapa NANA) mme lena ke lebitso le sebelisoang ke CIMA. (zhuoerchem.com)

Sialic acid is a sugar-aldehyde derivative of twenty amino acids that is extensively distributed on the surfaces of animal and plant cells and in their body secretions. (cabio.com)
Description: SIGLEC6 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 563 amino acids (27-347a.a.) and having a molecular mass of 62.6kDa (Molecular size on SDS-PAGE will appear at approximately 70-100kDa). (therabio.org)
SIGLEC6 is expressed with a 239 amino acids hIgG-His tag at C-Terminus and purified by proprietary chromatographic techniques. (therabio.org)

We performed single-molecule force spectroscopy (SMFS) to investigate the rupture force required to break individual and multiple bonds formed between synthetic sialic acid (SA) receptors and the two principal spike proteins of the influenza A virus (H3N2): hemagglutinin (H3) and neuraminidase (N2). (fu-berlin.de)
Avian or human influenza A viruses bind preferentially to avian- or human -type sialic acid receptors, respectively, indicating that receptor tropism is an important factor for determining the viral host range . (bvsalud.org)
In this study, we established a novel system using MDCK cells with avian- or human -type sialic acid receptors and with both sialic acid receptors knocked out (KO). (bvsalud.org)
In this study, we established a novel system using a set of genetically engineered MDCK cells with knocked out sialic acid receptors to biologically evaluate the receptor tropism for influenza A viruses . (bvsalud.org)
Recently, we determined the crystal structure of the extracellular region of P110 and demonstrated its binding to sialic acid receptors 6 . (nature.com)
It interacts with SIALIC ACIDS and mediates signaling from B-CELL ANTIGEN RECEPTORS. (bvsalud.org)

Sialic acids are commonly part of glycoproteins, glycolipids or gangliosides, where they decorate the end of sugar chains at the surface of cells or soluble proteins. (wikipedia.org)
Sialin moves a molecule called free sialic acid, which is produced when certain proteins and fats are broken down, out of the lysosomes to other parts of the cell. (medlineplus.gov)
512. Quantification of Multivalent Interactions between Sialic Acid and Influenza A Virus Spike Proteins by Single-Molecule Force Spectroscopy. (fu-berlin.de)
By interacting with other proteins, sialic acid participates in adhesion between cells and between cells and matrix, thereby regulating tissue formation and maintenance. (cabio.com)

These enzymes can be used for chemoenzymatic synthesis of sialic acid derivatives. (wikipedia.org)
This project aims to increase our fundamental understanding of the roles of bacterial Sias in host-pathogen interactions, and to characterize biosynthetic pathways and enzymes involved in sialic acid synthesis. (uit.no)
Sialic acid biosynthetic and modifying enzymes will be tested for their potential use in chemoenzymatic synthesis to create modified Sias with useful properties, for example antiviral compounds. (uit.no)
Synthesis and application of sialic acid-containing building blocks for glycopeptide libraries. (ku.dk)

This disorder is generally classified into one of three forms: infantile free sialic acid storage disease, Salla disease, and intermediate severe Salla disease. (medlineplus.gov)
Infantile free sialic acid storage disease (ISSD) is the most severe form of this disorder. (medlineplus.gov)
Free sialic acid means that the sialic acid is not attached (bound) to other molecules. (medlineplus.gov)
SLC17A5 gene mutations that reduce or eliminate sialin activity result in a buildup of free sialic acid in the lysosomes. (medlineplus.gov)
Adams D, Wasserstein M. Free Sialic Acid Storage Disorders. (medlineplus.gov)
Free sialic acid can be detected in fibroblasts and amnion cells. (medicinelearners.com)
Four members of an extended consanguineous Bedouin family presented with different phenotypic variants of an autosomal recessive lysosomal free sialic acid storage disease. (bgu.ac.il)
One affected individual had congenital ascites followed by rapid clinical deterioration and death, a presentation concordant with the clinical course of infantile free sialic acid storage disorder. (bgu.ac.il)
Diagnosis of free sialic acid storage disease was based on clinical findings, histology, and biochemical assays of sialic acid. (bgu.ac.il)

More than 50 kinds of sialic acid are known, all of which can be obtained from a molecule of neuraminic acid by substituting its amino group or one of its hydroxyl groups. (wikipedia.org)
The sialic acid family includes many derivatives of the nine-carbon sugar neuraminic acid, but these acids rarely appear free in nature. (wikipedia.org)
The term sialic acid includes derivatives of neuraminic acid that are N- or O-acetylated. (medicinelearners.com)
Characteristic of the sialic acid storage disease, which is also referred to as neuraminic acid storage disease, is a functional restriction or a total loss of function of the transport protein sialin. (medicinelearners.com)
Life expectancy in the infantile form of neuraminic acid storage disease is usually just a few years. (medicinelearners.com)
Although deaminated neuraminic acid exists in both vertebrates and microorganisms, it is known to be abundant in lower vertebrates (Proudfoot 2009). (interesjournals.org)

Sialic acid residues are present in the mucin glycoproteins of mucus. (wikipedia.org)
Differential involvement of cell surface sialic acid residues in wheat germ agglutinin binding to parental and wheat germ agglutinin-resistant Chinese hamster ovary cells. (rupress.org)
Expression of sialic acids on virulent yeast forms of P. brasiliensis (3.7 X 10(6) residues per cell) may inhibit fungal phagocytosis during early infection, when the immunological response is still being built up. (unifesp.br)
Outbreaks of highly pathogenic avian influenza (HPAI), acid residues into the HA0 cleavage site (5). (cdc.gov)
Kidney cell monolayers were pretreated with 100 units of neuraminidase to remove sialic-acid residues and then treated with chromium or manganese particles and a viral inducer. (cdc.gov)
The receptivity and interaction of cell membrane bound sialic-acid residues with metal particles are involved in the cellular protective responses to chromium and manganese particles. (cdc.gov)

Sialic acid-rich oligosaccharides on the glycoconjugates (glycolipids, glycoproteins, proteoglycans) found on surface membranes help keep water at the surface of cells[citation needed]. (wikipedia.org)
On cell surfaces, sialic acid is typically found in glycoproteins and glycolipids, forming modifications known as glycosylation. (cabio.com)
Sialic acids are usually found at the terminals of glycoproteins and glycolipids, in capsular and tissue polysialic acids, in bacterial lipooligosaccharides/polysaccharides, and in other forms that determine their significance in biology (Olusegun et al. (interesjournals.org)

A bacterial enzyme with sialic acid mutarotase activity, NanM, that is able to rapidly equilibrate solutions of sialic acid to the resting equilibrium position of around 90% beta/10% alpha has been discovered. (wikipedia.org)
In bacterial systems, sialic acids can be also biosynthesized by an aldolase. (wikipedia.org)
A functional sialic acid transporter is essential for the uptake and utilization of sialic acid in a range of pathogenic bacteria, and developing new inhibitors that target these transporters is a valid mechanism for inhibiting bacterial growth. (instem.res.in)
We are presently mainly working on the biosynthesis of glycosaminoglycans and bacterial sialic acid uptake mechanisms. (lu.se)

Neuraminidase treatment of cell monolayers and sialic-acid pretreatment of chromium and manganese particles abolished the adverse effects of the metal particles on viral interferon induction. (cdc.gov)

In contrast to other animals, humans are genetically unable to produce the sialic acid variant N-glycolylneuraminic acid (Neu5Gc). (wikipedia.org)
The N-glycoylneuraminic acid (NGNA) standard is a quantitative standard of NIST-F and USP traceable Neu5Gc monosaccharide. (qa-bio.com)

Sialic acids (Sias) are carbohydrates with immensely important roles in biological, pathological and immunological processes. (uit.no)
to α2,3-linked sialic acids (SIAs) compared to a closely related avian H7N9 virus from 2008. (uu.nl)

Sialic acid plays an essential function in biological processes, and its mechanisms are involved in crucial biological processes such as cell signaling, cell adhesion, and receptor activation. (cabio.com)
Sialic acid is a major determinant of carbohydrate-receptor interactions in many systems pertinent to human health and disease. (johnshopkins.edu)
Functional regulation of the lymphatic hyaluronan receptor (LYVE-1) by terminal sialic acid. (ox.ac.uk)
Siglec-14 is a sialic acid-recognizing activatory receptor found on certain immune cells types that is undergoing concerted evolution with the gene for Siglec-5 (an inhibitory receptor) via ongoing gene conversion of exons encoding amino-terminal V-set lg-like domains. (anthropogeny.org)
Discovery of Siglec-14, a novel sialic acid receptor undergoing concerted evolution with Siglec-5 in primates. (anthropogeny.org)
Influenza A Virus Agnostic Receptor Tropism Revealed Using a Novel Biological System with Terminal Sialic Acid Knockout Cells. (bvsalud.org)
When we examined the replication of human and avian influenza viruses in these KO cells , we observed unique viral receptor tropism that could not be detected using a conventional solid-phase sialylglycan binding assay, which directly assesses physical binding between the virus and sialic acids . (bvsalud.org)
These data indicate that a panel of sialic acid receptor KO cells could be a useful tool for determining the biological receptor tropism of influenza A viruses . (bvsalud.org)
It was found previously that EKC-causing Ads use sialic acid as a cellular receptor and demonstrated that soluble, sialic acid-containing molecules can prevent infection. (lu.se)

An infantile and an adult form of the lysosomal sialic acid storage disease are known. (medicinelearners.com)
Of the two forms, infantile sialic acid storage disease is the one with the less favorable prognosis. (medicinelearners.com)

Sialic acid is a crucial molecule for cellular recognition and signaling due to its chemical properties. (cabio.com)
As an essential bioactive molecule, sialic acid possesses complex and diverse structures and chemical properties, and performs a variety of crucial functions in living organisms. (cabio.com)
SiaT is shown to be electrogenic, and transport is dependent upon more than one Na ion for every sialic acid molecule. (instem.res.in)

The molecular structures of these sialic acids contain a variety of functional groups, enabling them to perform a variety of functions in organisms. (cabio.com)

Sialic acid in the form of polysialic acid is an unusual posttranslational modification that occurs on the neural cell adhesion molecules (NCAMs). (wikipedia.org)
Sialic acids are essential molecules with a wide range of structural variations. (interesjournals.org)
The result is that the two molecules have similar binding properties for sialic acids. (anthropogeny.org)
It appears that this may be the ancestral condition, and that the human molecules have restored the arginine residue required for sialic acid recognition. (anthropogeny.org)

It is not known how this buildup, or the disruption of other possible functions of sialin in the brain, causes the specific signs and symptoms of sialic acid storage disease. (medlineplus.gov)
Sialic acid storage disease is a very rare, genetically determined lysosomal storage disease in which the protein sialin is incorrectly encoded. (medicinelearners.com)
Sialin is a transmembrane protein that normally clears the lysosome of monosaccharides such as sialic acid, which result from the enzymatic breakdown of glycoproteins and other substances. (medicinelearners.com)
The reduced functionality of the sialin leads to an accumulation of sialic acid in the lysosomes, i.e. to sialic acid storage disease. (medicinelearners.com)
Normally, the sialic acids are transported out of the lysosome through the membrane of the lysosome with the help of the anion transport protein sialin. (medicinelearners.com)
A mutation in exon 8 of the SLC17A5 gene, replacing glycine with glutamic acid at position 328 of the sialin protein. (bgu.ac.il)

Commensal and pathogenic bacteria can use host-derived sialic acids for a competitive advantage, but require a functional sialic acid transporter to import the sugar into the cell. (instem.res.in)

Several enzymes involved in the metabolism of different sialic acids have been produced and functionally characterized by various biochemical and biophysical methods, and three dimentional structures are determined. (uit.no)
Although it is accepted by the metabolism as a building block, it does not have the ability to eject the sialic acid through the lysosomal membrane. (medicinelearners.com)

The alpha-anomer is the form that is found when sialic acid is bound to glycans. (wikipedia.org)
Aim: To compare and correlate serum level of total sialic acid (TSA) and lipid bound sialic acid (LSA) in oral Squamous cell carcinoma and potentially malignant condition with normal healthy subjects. (journalcra.com)
Methods: Total sialic acid (TSA) and Lipid bound sialic acid (LSA) determination was carried out in patients included in study along with 30 healthy individuals without any systemic disease. (journalcra.com)

Approximately 20 mutations that cause sialic acid storage disease have been identified in the SLC17A5 gene. (medlineplus.gov)
The WHO Collaborating Center for Influenza Reference and Research at the Centers for Disease Control and Prevention in Atlanta, with input from many influenza subject matter experts from around the world, has developed an inventory of amino acid mutations in H5N1 viruses that is intended to be used by the influenza surveillance and research community as a tool to inform the influenza knowledge base for surveillance and public health preparedness. (cdc.gov)

Sialic acid is a class of natural carbohydrate compounds widely present in biological systems, and plays a very important biological function in physiological processes such as cell differentiation, maturation, and intercellular interactions. (peptidepowders.com)

Sialic acids are building blocks of glycoproteins, glycosaminoglycans and other substances and are released through their enzymatic degradation within special lysosomes. (medicinelearners.com)
The sialic acids produced in the lysosomes can be smuggled out of the lysosomes, resulting in an excessive accumulation of sialic acids in the lysosomes. (medicinelearners.com)

Particularly, we aim to assess the performance of this platform for the separation of isomeric glycoconjugates due to the type of sialic acid linkage, at the intact glycoprotein, glycopeptide and glycan level. (whiterose.ac.uk)
Paracoccidioides brasiliensis, the agent of paracoccidioidomycosis, when grown in a synthetic medium, expresses at the cell surface of both yeast and mycelial forms acidic glycoconjugates containing N-acetylneuraminic acid units. (unifesp.br)
Mammalian cell surfaces are decorated with complex glycoconjugates that terminate with negatively charged sialic acids. (instem.res.in)

Sialic acids are found widely distributed in animal tissues and related forms are found to a lesser extent in other organisms like in some micro-algae, bacteria and archaea. (wikipedia.org)

For it to become active to enter in the oligosaccharide biosynthesis process of the cell, a monophosphate nucleoside is added, which comes from a cytidine triphosphate, turning sialic acid into cytidine monophosphate-sialic acid (CMP-sialic acid). (wikipedia.org)
Our results indicate that, unlike UDP-GlcNAc 2-epimerase, which promotes biosynthesis of sialic acid, GlcNAc 2-epimerase can serve a catabolic role, diverting metabolic flux away from the sialic acid pathway. (johnshopkins.edu)

Although this modification is critical in both health and disease, the regulation and dysregulation of these enzymes and thus α-2,6-linked sialic acid are poorly understood. (medicineinnovates.com)
They applied the new assay to analyze the regulation of ST6GAL1 and ST6GAL2, the enzymes underlying α-2,6-sialic acid. (medicineinnovates.com)

Sialic acid storage disease is an inherited disorder that primarily affects the nervous system. (medlineplus.gov)
People with sialic acid storage disease have signs and symptoms that may vary widely in severity. (medlineplus.gov)
Sialic acid storage disease is a very rare disorder. (medlineplus.gov)
In people affected by sialic acid storage disease, an increased concentration of sialic acid in the urine is symptomatic and an increased rate of excretion of polysaccharides. (medicinelearners.com)
In severe cases of sialic acid storage disease, bone malformations, ascites ( abdominal dropsy ), severe movement disorders, spastic cramps and severe mental disabilities become noticeable soon after birth. (medicinelearners.com)
In most cases, sialic acid storage disease can be recognized and diagnosed before birth. (medicinelearners.com)

This enzyme uses for example a mannose derivative as a substrate, inserting three carbons from pyruvate into the resulting sialic acid structure. (wikipedia.org)

The microneme adhesive repeat (MAR) domain of T. gondii MIC1 (TgMIC1) recognizes sialic acid (Sia), a key determinant on the host cell surface for invasion by this pathogen. (unl.pt)

This quantitative glycopeptide standard was developed for use during the sialic acid or monosaccharide release and labeling process. (qa-bio.com)

Section 2:Functions and Mechanisms of Sialic Acid in Biological Processes. (cabio.com)
What are the sialic acid's mechanisms of action in biological processes? (cabio.com)
thus, the mechanisms that control intracellular ManNAc levels are important regulators of sialic acid production. (johnshopkins.edu)

Evaluation of ion mobility for the separation of glycoconjugate isomers due to different types of sialic acid linkage, at the intact glycoprotein, glycopeptide and glycan level. (whiterose.ac.uk)

Recent experiments have demonstrated the presence of sialic acid in the cancer-secreted extracellular matrix. (wikipedia.org)

Click below to download this free supplement and discover how Agilent's new kit can help you to reduce sample prep time, minimise transfer steps for increased quantification accuracy and improve sialic acid release. (drugtargetreview.com)

In recent years, the infant nutrition and functional food markets have paid increasing attention to sialic acid, a significant bioactive ingredient. (cabio.com)

The main functions of sialic acid are to improve the memory and intelligence of infants and young children, anti-senile dementia, anti-recognition and improve intestinal absorption of vitamins and minerals, antibacterial detoxification and antiviral, inhibit white blood cell adhesion and anti-inflammatory, improve human immunity, etc. (meetsupplement.com)
Sialic acid, a significant sugar-aldehyde compound, is involved in a variety of biological processes, including cell recognition, signal transduction, and immune regulation. (cabio.com)
α-2,6-Linked sialic acids on galactose drive cancer development and metastasis, immunological recognition, and microglial phagocytosis. (medicineinnovates.com)
In many cancers, α-2,6-linked sialic acids are overexpressed, and dysregulation of this glycan is emerging as a crucial part of cancer formation, metastasis, and immune recognition. (medicineinnovates.com)

The presence of sialic acid in dairy products substantially promotes infant and young child growth and immune function development. (cabio.com)
Possible selection pressures include the interaction with sialic acid-expressing pathogens and general control of innate immune responses. (anthropogeny.org)

The exterior of cell surfaces express a dense layer of glycans which are often terminated by sialic acid (SA). (csuohio.edu)

The addition of sialic acid to infant milk powder is essential to ensure the normal growth and development of infants, to help the baby's memory form a more stable structural basis, and to strengthen the development of the nervous system. (peptidepowders.com)

There is a broad interest in the development of nanoparticles (NPs) carrying on their surface carbohydrates such as sialic acids. (unimore.it)

Today, the largest market for sialic acid is for use in the production of anti-viral drugs, but the largest future demand will most likely be as a nutritional additive, in particular to infant milk formulas, and for cosmeceutical and pharmaceutical applications. (uit.no)
The H5N1 Inventory is an inclusive compilation of amino acid changes and/or motifs identified within each viral protein that affect one or more biological properties, provided in broad categories. (cdc.gov)

This overexpression of sialic acid on surfaces creates a negative charge on cell membranes. (wikipedia.org)
Increased erythrocyte membrane sialic acid was found to adversely affect cell deformability. (iospress.com)
Sialic acid is also involved in cell adhesion and migration, playing a crucial regulatory function in cell motility and tissue formation. (cabio.com)
Sialic acid is crucial for cell signaling. (cabio.com)
Sialic acid is also essential for cell adhesion. (cabio.com)

The Sodium Sialic Acid Symporter From Has Altered Substrate Specificity. (instem.res.in)

Anatomy9

Organisms13

Diseases4

Chemicals and Drugs82

Analytical, Diagnostic and Therapeutic Techniques and Equipment13

Phenomena and Processes18

Disciplines and Occupations3

Information Science3

Lectin6

Form of sialic acid st2

Forms of sialic acid st2

Importance of sialic acids2

Neu5Ac8

Amino acids3

Receptors6

Proteins4

Synthesis4

Free sialic acid9

Neuraminic acid6

Residues6

Glycolipids3

Bacterial4

Neuraminidase1

Neu5Gc2

Sias2

Receptor9

Infantile2

Molecule3

Molecular1

Molecules4

Sialin6

Transporter1

Metabolism2

Bound3

Mutations2

Intercellular interactions1

Lysosomes2

Glycoconjugates3

Bacteria1

Biosynthesis2

Enzymes2

Storage disease6

Pyruvate1

Determinant1

Monosaccharide1

Mechanisms3

Glycopeptide1

Extracellular1

Quantification1

Functional1

Recognition4

Immune2

Glycans1

Structural1

Carbohydrates1

Viral2

Cell5

Specificity1