AnatomyDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and Processes
Sezary SyndromeMycosis FungoidesLymphoma, T-Cell, CutaneousDermatitis, ExfoliativeSkin NeoplasmsSyndromeReceptors, KIR3DL2Antigens, CD7Receptors, KIR2DL2PhotopheresisDipeptidyl Peptidase 4Lysosomal-Associated Membrane Protein 3Lymphatic DiseasesT-LymphocytesPUVA TherapyPentostatinImmunophenotypingPruritusSkinGene Rearrangement, beta-Chain T-Cell Antigen ReceptorLymphoma, T-CellFlow CytometryNeoplastic Cells, Circulating
MycosisLymphomaMyelodysplasticLymphocytesCTCL2018LeukemicMalignantDiagnosisPatientsClinicalDisordersTypicallyExpressionSkinCasesLymphomaCutaneousMycosis fungoides and the Sezary syndromeErythrodermaSezary's2017Primarily affectinLymphSystemicRefractoryCancerCellsChromosomalRareMolecularGuidelinesStageConditionCommonTreatment
Mycosis12
  • RATIONALE: Lenalidomide may stop the growth of mycosis fungoides/Sezary syndrome by blocking blood flow to the cancer. (stanford.edu)
  • PURPOSE: This phase II trial is studying how well lenalidomide works in treating patients with relapsed mycosis fungoides/Sezary syndrome. (stanford.edu)
  • The immunohistochemical features are very similar to those presented in mycosis fungoides except for the following differences: More monotonous cellular infiltrates (large, clustered atypical pagetoid cells) in Sézary syndrome Sometimes absent epidermotropism Increased lymph node involvement with infiltrates of Sézary syndrome. (wikipedia.org)
  • In one such example, HTS was used to measure the patient-specific TCR sequences in patients with cutaneous T-cell lymphoma (mycosis fungoides and Sezary syndrome) after a non-myeloablative allogeneic transplant. (stanford.edu)
  • While skin cancer can manifest in various forms, this comprehensive guide will focus on four major types: Basal Cell Carcinoma, Cutaneous T-Cell Lymphoma, Mycosis Fungoides, and Sezary Syndrome. (senderrarx.com)
  • Two common subtypes of CTCL include Mycosis Fungoides and Sezary Syndrome. (senderrarx.com)
  • This phase I trial identifies the best dose, possible benefits, and/or side effects of duvelisib in combination with nivolumab in treating patients with stage IIB-IVB mycosis fungoides and Sezary syndrome. (clfoundation.org)
  • Giving duvelisib in combination with nivolumab may work better than giving each of these drugs individually, or treating with the usual approach in patients with mycosis fungoides and Sezary syndrome. (clfoundation.org)
  • Results from a multi-center phase III trial examiniing the safety and efficacy of two doses of denileukin diftitox (Ontak) in patients with biopsy-confirmed CD25 assay-positive cutaneous T-cell lymphoma (CTCL), including both mycosis fungoides and Sezary Syndrome suggest merely that this recombinant protein can outperform a placebo. (lymphomainfo.net)
  • subtypes of cutaneous T-cell lymphoma, SS is a malignant neoplasm originating the most common of which are mycosis from T lymphocytes, which involves the fungoides and Sézary syndrome (SS). (bvsalud.org)
  • Mycosis fungoides and Sézary syndrome are uncommon chronic T-cell non-Hodgkin lymphomas primarily affecting the skin and occasionally the lymph nodes. (msdmanuals.com)
  • Mycosis fungoides and Sézary syndrome are the 2 main types of cutaneous T-cell lymphomas. (msdmanuals.com)
Lymphoma4
  • Sézary disease, or Sézary syndrome, is a type of cutaneous T-cell lymphoma that was first described by Albert Sézary. (wikipedia.org)
  • KIR3DL2 is also a marker for atypical mononuclear (Sezary) cells in the blood of patients with Sezary syndrome, an erythrodermic form of cutaneous T cell lymphoma (11). (rndsystems.com)
  • Begue E, Michel L, Jean-Louis F, Bagot M, Bensussan A (2013) Promoter Hypomethylation and Expression of PLS3 in Human Sezary Lymphoma Cells. (symbiosisonlinepublishing.com)
  • In our practice, hematologic neoplasms are mainly lymphoproliferative syndromes and the most common varieties are non-Burkitt non Hodgkin lymphoma, high grade lymphomas, chronic lymphocytic lymphoma and multiple myeloma. (bvsalud.org)
Myelodysplastic2
  • What is Myelodysplastic Syndrome? (lymphomainfo.net)
  • The question ought to be what are myelodysplastic syndromes (MDS), since this is a group of similar blood and bone marrow diseases that. (lymphomainfo.net)
Lymphocytes1
  • We studied two human lymphocyte cell lines derived from tumor lymphocytes of patients with Sezary syndrome, HuT-78 cells which express PLS3 mRNA and SeAx cells that do not, for methylation status and used a well-established inhibitor of DNA methylation, the nucleoside analog 5-aza-2-deoxycytidine (5-aza-dC), to further determine its effect on PLS3 gene expression in both cell lines. (symbiosisonlinepublishing.com)
CTCL1
  • A molecular feature of Sezary syndrome (SS), the leukemic variant of cutaneous T-cell lymphomas (CTCL), is the abnormal gene expression of PLS3 in 3 out of 4 patients [1-9]. (symbiosisonlinepublishing.com)
20181
  • Il s'agissait d'une étude rétrospective descriptive d'une durée de 2 ans 3 mois allant du 1er janvier 2018 au 31 Mars 2020 portant sur 80 dossiers de malades porteurs d'hémopathies malignes et prise en charge dans le centre. (bvsalud.org)
Leukemic1
  • In some cases, a leukemic phase called Sézary syndrome is characterized by the appearance of malignant T cells with serpentine nuclei in the peripheral blood. (msdmanuals.com)
Malignant1
  • Other malignant conditions such as Sezary syndrome {Horiuchi, 1985} osteogenic sarcoma {Barron, 1992} and transitional cell carcinoma of the urinary bladder {Yaniv, 1994} have been reported. (globale-dermatologie.com)
Diagnosis2
  • The working diagnosis was Sezary syndrome with erythroderma. (cdc.gov)
  • A bone marrow smear was performed, in which 'cerebriform' cells were identified, confirming the diagnosis of Sézary syndrome. (bvsalud.org)
Patients1
  • Le protocole utilisé dans le traitement du myélome multiple a été le VMCD-REV à 76,92% avec pour réponse thérapeutique complète chez 6 patients, 3 réponses partielles et 4 en cours de traitement. (bvsalud.org)
Clinical2
  • In 1986 the clinical picture was compatible with Sezary syndrome. (tau.ac.il)
  • Initial management consisted of en una paciente con topical corticosteroids and oral antihistamines with little clinical response. (bvsalud.org)
Disorders1
  • A remarkable variety of endocrinologic disorders may cause virilization syndromes. (annals.edu.sg)
Typically1
Expression2
  • Low SATB1 expression promotes IL-5 and IL-9 expression in Sezary Syndrome. (nygenome.org)
  • Our results clearly revealed a quantitative relationship between the methylation status of the PLS3 CpG region and PLS3 expression in HuT-78 and SeAx Sezary cell lines. (symbiosisonlinepublishing.com)
Skin1
  • Regarding the epidemiological distribu- skin biopsy of the dorsal and anterior chest tion of this syndrome, it predominates in region. (bvsalud.org)
Cases1
  • In the Western population, there are around 3 cases of Sézary syndrome per 1,000,000 people. (wikipedia.org)
Lymphoma11
  • Sezary syndrome (SS) is a rare form of cutaneous T-cell lymphoma characterized by erythroderma and the presence of Sezary cells in the skin, lymph nodes, and peripheral blood. (nih.gov)
  • Sézary disease, or Sézary syndrome, is a type of cutaneous T-cell lymphoma that was first described by Albert Sézary. (wikipedia.org)
  • Sézary syndrome is an aggressive form of a type of blood cancer called cutaneous T-cell lymphoma. (medlineplus.gov)
  • Although Sézary syndrome is sometimes referred to as a variant of another cutaneous T-cell lymphoma called mycosis fungoides , these two cancers are generally considered separate conditions. (medlineplus.gov)
  • This study will investigate the safety and effectiveness of a modified donor stem cell transplantation procedure for treating advanced mycosis fungoides (MF), a lymphoma primarily affecting the skin, and Sezary syndrome (SS), a leukemic form of the disease. (nih.gov)
  • My mother passed on November 20, 2010 from T-Cell Lymphoma (sezary syndrome). (cancer.org)
  • The Mycosis Fungoides Cooperative Group has been following patients with cutaneous T-cell lymphoma, including mycosis fungoides and the Sezary syndrome variant. (johnshopkins.edu)
  • BACKGROUND: Ultraviolet light (UVL) is a long established treatment for mycosis fungoides (MF) and Sézary syndrome (SS), subtypes of cutaneous T-cell lymphoma (CTCL). (henryford.com)
  • Blood classification and blood response criteria in mycosis fungoides and Sézary syndrome using flow cytometry: recommendations from the EORTC cutaneous lymphoma task force. (cutaneouslymphoma.org)
  • Revisions to the staging and classification of mycosis fungoides and Sezary syndrome: a proposal of the International Society for Cutaneous Lymphomas (ISCL) and the Cutaneous Lymphoma Task Force of the European Organization of Research and Treatment of Cancer (EORTC) .BLOOD. (cutaneouslymphoma.org)
  • Sézary syndrome (SS) is an aggressive leukemic form of Cutaneous T-cell Lymphoma with neoplastic CD4+ T cells present in skin, lymph nodes, and blood. (molepi.nl)
Cutaneous2
Mycosis fungoides and the Sezary syndrome1
Erythroderma4
  • [ 1 ] Sézary syndrome (SS) is a rare CTCL variant closely related to MF and has classically been described as a triad of erythroderma, generalized lymphadenopathy and Sézary cells (atypical neoplastic T lymphocytes with hyperconvoluted cerebriform nuclei) in the skin, blood, and lymph nodes. (medscape.com)
  • People with Sézary syndrome develop a red, severely itchy rash (erythroderma) that covers large portions of their body. (medlineplus.gov)
  • The working diagnosis was Sezary syndrome with erythroderma. (cdc.gov)
  • Mycosis fungoides that is evident as an erythroderma but with too few circulating lymphocytes to warrant a diagnosis of Sézary syndrome is designated erythrodermic mycosis fungoides. (medscape.com)
Sezary's1
  • Evidence is presented for the existence of a "switch" T cell derived from a patient with mycosis fungoides/Sezary's syndrome. (silverchair.com)
20171
  • [ 98 ] , the European Organization for Research and Treatment of Cancer (EORTC) released consensus recommendations for the treatment of mycosis fungoides/Sezary syndrome (MF/SS) in 2017. (medscape.com)
Primarily affectin1
  • Mycosis fungoides and Sézary syndrome are uncommon chronic T-cell non-Hodgkin lymphomas primarily affecting the skin and occasionally the lymph nodes. (msdmanuals.com)
Lymph3
  • The immunohistochemical features are very similar to those presented in mycosis fungoides except for the following differences: More monotonous cellular infiltrates (large, clustered atypical pagetoid cells) in Sézary syndrome Sometimes absent epidermotropism Increased lymph node involvement with infiltrates of Sézary syndrome. (wikipedia.org)
  • People with Sézary syndrome also have enlarged lymph nodes (lymphadenopathy). (medlineplus.gov)
  • peripheral lymphadenopathy, and abnormal hyperchromatic mononuclear (cerebriform) cells in the skin, LYMPH NODES , and peripheral blood (Sezary cells). (bvsalud.org)
Systemic2
  • The systemic treatments used for advanced MF are also used to treat Sezary syndrome. (cancer.org)
  • On Aug. 8, 2018, the Food and Drug Administration approved mogamulizumab-kpkc (Poteligeo, Kyowa Kirin, Inc.) for adult patients with relapsed or refractory mycosis fungoides (MF) or Sézary syndrome (SS) after at least one prior systemic therapy. (fda.gov)
Refractory1
  • This phase II trial studies how well pembrolizumab and interferon gamma-1b work in treating patients with stage IB-IVB mycosis fungoides and Sezary syndrome that has come back (relapsed) or has not responded to previous treatment (refractory). (stanford.edu)
Cancer1
  • RATIONALE: Lenalidomide may stop the growth of mycosis fungoides/Sezary syndrome by blocking blood flow to the cancer. (stanford.edu)
Cells3
  • T Cells in Sézary Syndrome Patients. (nih.gov)
  • Further evidence was obtained using mononuclear cells derived from a patient with immunodeficiency and hyper-IgM, a syndrome characterized by a lack of IgG and IgA secretion. (silverchair.com)
  • The addition of Trac cells to either peripheral blood mononuclear cells or non-T cells from a patient with hyper-IgM syndrome resulted in new secretion of IgG, with a concomitant decrease in IgM secretion, whereas control T cells were not effective in inducing secretion of any isotype other than IgM. (silverchair.com)
Chromosomal1
  • It is unclear whether these alterations play a role in Sézary syndrome, although the tendency to acquire chromosomal abnormalities (chromosomal instability) is a feature of many cancers. (medlineplus.gov)
Rare1
Molecular1
Guidelines1
Stage1
Condition1
  • Some people with Sézary syndrome are less able to control their body temperature than people without the condition. (medlineplus.gov)
Common1
Treatment1