• gene
  • DMRT1 is essential in double dosage for male development in humans, despite its location on an autosome [ 10 ] and its functional activation after Sry , the master sex-determining gene [ 11 ]. (royalsocietypublishing.org)
  • This gene is considered the sex-determining gene in chicken, because among genes that govern sexual development, Dmrt1 resides on the sex chromosomes, acts in a sex-specific pattern in the gonad earliest among those genes, and sex is reversed when Dmrt1 expression is suppressed [ 12 ]. (royalsocietypublishing.org)
  • either
  • Among 34 non-avian reptiles, a convergently evolved pair of amino acids encoded by sequence within exon 2 near the DM-binding domain of Dmrt1 distinguishes species with either type of sex determination. (royalsocietypublishing.org)