Severe chromosome y chromosome microdeletions infertile males oligospermia. Medical search. Frequent questions

An abnormal postcoital test result is observed in 10% of infertile couples. (medscape.com)
Carriers of chromosomal rearrangements have a lower chance of producing normal or balanced gametes due to abnormal segregation of chromosomes at meiosis, which leads to recurrent spontaneous abortions and infertility. (bvsalud.org)
Males with Klinefelter's syndrome have an extra X chromosome, which causes abnormal development of the testicles. (ubbcluj.ro)

Subtelomere FISH for 3q and Yp evidenced that the subtelomeric region of the Y chromosome was found on the terminal region of 3q. (bvsalud.org)
Recently, several recurrent X-chromosome microdeletions (located in subtelomeric region of the long arm) were reported to be associated with male infertility in Spanish and Italian males. (ubbcluj.ro)

Testicular biopsy is indicated in azoospermic men with a normal-sized testis and normal findings on hormonal studies to evaluate for ductal obstruction, to further evaluate idiopathic infertility, and to retrieve sperm. (medscape.com)
There are many causes for oligospermia including: Pre-testicular factors refer to conditions that impede adequate support of the testes and include situations of poor hormonal support and poor general health including: Hypogonadism due to various causes Drugs, alcohol, smoking Strenuous riding (bicycle riding, horseback riding) Medications, including androgens. (wikipedia.org)
In azoospermia, no sperm are present.To determine the causes and establish a treatment plan, additional investigations such hormone tests, chromosomal analysis (Karyotype and Yq microdeletions), and testicular ultrasonography are helpful. (jananamfertility.com)

To identify the position of the SRY gene, FISH using a locus-specific probe was used and showed that the gene had been translocated to chromosome 3. (bvsalud.org)
We previously identified TBC1D21 as a sterility-related RabGAP gene from infertile men. (ubbcluj.ro)
Background Genetic causes of male infertility are hypothesized to involve multiple types of mutations, from single gene defects to complex chromosome rearrangements. (ubbcluj.ro)
The discussion of male infertility focuses on genetic factors impairing spermatogenesis and includes numerical chromosomal anomalies such as Klinefelter syndrome, structural chromosomal anomalies such as Y-chromosome microdeletions, certain single gene mutations, syndromic diseases, and epigenetic mutations. (ubbcluj.ro)

Terms oligospermia, oligozoospermia, and low sperm count refer to semen with a low concentration of sperm and is a common finding in male infertility. (wikipedia.org)
The diagnosis of oligozoospermia requires a work-up via semen analysis (listed in Male infertility). (wikipedia.org)
Offspring of men with severe oligozoospermia or azoospermia have a significantly increased risk of developing cystic fibrosis. (genosalut.com)

Y chromosome infertility is caused by deletions of genes in the AZF regions. (medlineplus.gov)
Most cases of this condition result from new (de novo) deletions on the Y chromosome that occur during formation of sperm cells in an affected individual's father who is not himself infertile. (medlineplus.gov)

These include conditions such as Klinefelter syndrome (47, XXY) and exchanges of genetic material in non-sex chromosomes and are detected by blood tests. (wellinghomeopathy.com)

Multiplex PCR for the commonly deleted genes in the AZFa, AZFb, and AZFc regions of the Y chromosome was performed and indicated the presence of all 3 regions. (bvsalud.org)
While many cases of male-factor infertility can be treated with simple lifestyle interventions, in some cases, the cause is deeper - your genes. (givelegacy.com)
Many genes on the Y chromosome are involved in male sex determination and development. (medlineplus.gov)
In all species, Boule and Dazl are located in single copy on autosomes, while multiple DAZ genes are located on the Y chromosome. (ijbs.com)
In human, an array of four DAZ genes ( DAZ 1-4) is located in two clusters on the Y chromosome and mutations of these genes cause severe oligospermia or azospermia [ 1 ]. (ijbs.com)

Methods: In this study, infertile couples with balanced chromosomal abnormalities undergoing PGT-SR were retrospectively analyzed at a single fertility center from January 2016 to December 2019. (bvsalud.org)
In addition, 2% of men with low counts and 15-20% of men with no sperm counts will harbor chromosomal abnormalities detected by cytogenetic analysis (karyotype). (wellinghomeopathy.com)

Mutations that occur during the reproduction process, when the DNA of both parents is replicated, can lead to infertility in males later in life. (ubbcluj.ro)

hence, the term is used as a synonym of recurrent Definition and causes of infertility Santiago Brugo-Olmedo1, Claudio Chillik, Susana Kopelman CEGYR, Center for Gynecology and Reproduction Studies, Viamonte 1438, Capital Federal (1055), Argentina Infertility in Men and Women Mary Goodman March 15, 2006 Infertility in Males Although men with Cystic Fibrosis still may have a great sex life, the majority of them are infertile. (ubbcluj.ro)

An estimated 15% of couples meet this criterion and are considered infertile, with approximately 35% due to female factors alone, 30% due to male factors alone, 20% due to a combination of female and male factors, and 15% unexplained. (medscape.com)
Preimplantation genetic testing for structural chromosome rearrangements (PGT-SR) is offered to couples who have balanced chromosomal rearrangements in order to select embryos with a balanced karyotype prior to implantation, thereby increasing the chances of pregnancy. (bvsalud.org)
Conclusion: PGT-SR is a useful tool in selecting normal or balanced embryos for transfer in IVF, which could lead to a pregnancy by reducing the chance of miscarriages due to chromosome aneuploidy in couples with balanced chromosomal rearrangements. (bvsalud.org)
Chromosomal and molecular analysis is considered an essential component of the important work-up for individuals with congenital malformations, mental retardation, multiple spontaneous miscarriages, ART failures, or infertile couples. (genetic-center.ir)
Author summary Male sterility affects one in seven couples, and around half of these are the result of male factor disorders. (ubbcluj.ro)
Detection of certain genetic causes of male infertility allows couples to be informed about the potential to transmit genetic abnormalities that may affect the health of offspring. (ubbcluj.ro)

For many decades sperm concentrations of less than 20 million sperm/ml were considered low or oligospermic, recently, however, the WHO reassessed sperm criteria and established a lower reference point, less than 15 million sperm/ml, consistent with the 5th percentile for fertile men. (wikipedia.org)
In cases of sole male-factor infertility, the female partner is fertile, and has properly functioning ovaries, fallopian tubes, and uterus. (givelegacy.com)
Female-factor infertility would be the opposite - a case in which the male partner was fertile, but the female partner had a condition that affected their ability to conceive or carry a pregnancy. (givelegacy.com)
Reference ranges for sperm counts are defined in fertile (not infertile) men. (wellinghomeopathy.com)
But we have no solid evidence for what is the threshold, if any, for the sperm count to exceed in order to allow the male to be fertile [4,5,7]. (infertile.com)

Cytogenetic evaluation was performed by G-banding, C-banding, and FISH using centromeric probes for chromosomes X and Y and showed the presence of a monocentric isochromosome Y with a complex, mosaic karyotype 45,X/46,X,i(Y)(q10)/46,XX/47,XX,i(Y)(q10). (bvsalud.org)

The initial evaluation of the male patient should be rapid, noninvasive, and cost-effective, as nearly 70% of conditions that cause infertility in men can be diagnosed with history, physical examination, and hormonal and semen analysis alone. (medscape.com)

Besides fluorescence in situ hybridization (FISH) for micro deletion syndromes and other indications such as sex selection, identification of marker chromosomes and specific chromosome rearrangements are provided in Genetic Laboratory of Khorasan Razavi institute. (genetic-center.ir)

One study found that the male children of men who used intracytoplasmic sperm injection (ICSI) to conceive were significantly more likely to experience poor semen quality parameters - including lower sperm concentration , sperm count , and motility - compared to male children who were naturally conceived. (givelegacy.com)
Many men conceive without trouble having low sperm counts. (wellinghomeopathy.com)

Missing regions on the Y chromosome (microdeletions) occur in 6% of men with low sperm counts and 15% of men with no sperm counts. (wellinghomeopathy.com)
These cases occur in men with no history of the disorder in their family. (medlineplus.gov)

A number of factors may be involved in the genesis of this condition, including age, infectious agents ( such as Chlamydia trachomatis), Y chromosome microdeletions, mitochondrial changes, environmental pollutants, and "subtle" hormonal changes. (wikipedia.org)
In 2% of men, low sperm counts may be due to hormonal imbalance from prolactinoma. (wellinghomeopathy.com)

Y chromosome infertility occurs in approximately 1 in 2,000 to 1 in 3,000 males of all ethnic groups. (medlineplus.gov)

Men with mild oligospermia (semen concentration of 15 million to 20 million sperm/ml) were studied for an association of sperm DNA damage with life style factors. (wikipedia.org)
Some men with Y chromosome infertility who have mild to moderate oligospermia may eventually father a child naturally. (medlineplus.gov)

In males, decreased general health status appears to be associated with impaired male reproductive health. (medscape.com)
Many causes of genetic male infertility can be overcome with assisted reproductive technology (ART) , or fertility treatments. (givelegacy.com)
When men with Y chromosome infertility do father children, either naturally or with the aid of assisted reproductive technologies, they pass the genetic changes on the Y chromosome to all their sons. (medlineplus.gov)

Male-factor infertility and genetics: Is male infertility inherited? (givelegacy.com)
In general, the impact of genetics on male fertility is not fully understood. (givelegacy.com)
Genetics may contribute to anywhere from 15-60% of male-factor infertility. (givelegacy.com)
So while other male fertility factors like age , diet, lifestyle , and hormones may be common, genetics is sometimes a factor or even the sole cause of male-factor infertility. (givelegacy.com)
One sign that male-factor infertility may involve genetics: There is some evidence that men who are infertile are more likely to have sons who are infertile, as well. (givelegacy.com)

Causes of infertility in men can be categorized as obstructive or nonobstructive. (medscape.com)
A complete exome analysis to analyse the causes of infertility in women and men. (genosalut.com)

As a result, the sons will also have Y chromosome infertility. (medlineplus.gov)

In a number of situations direct medical or surgical intervention can improve the sperm concentration, examples are use of FSH in men with pituitary hypogonadism, antibiotics in case of infections, or operative corrections of a hydrocele, varicocele, or vas deferens obstruction. (wikipedia.org)

It found no significant relation between oligospermia and being underweight. (wikipedia.org)
Increasingly, genetic abnormalities are being found in men with severe oligospermia. (wellinghomeopathy.com)

Experts estimate about one-third of infertility cases are male-factor infertility, one-third are female-factor infertility, and the final third involve factors related to both partners, or are unexplained. (givelegacy.com)
Male Infertility Causes - More than 90% of male infertility cases are due to low sperm counts, poor sperm quality, or both. (ubbcluj.ro)

Read on to learn about the genetic causes of male-factor infertility, and the different types of genetic infertility. (givelegacy.com)
At Genosalut we analyse the genetic causes of male infertility and female infertility. (genosalut.com)
Despite this, many genetic causes of male infertility remain unknown, even though it is recognised that rates of genetic abnormalities are likely to be increased among men requiring ART. (ubbcluj.ro)

There are many factors, including genetic factors, that affect the fertility of women and men. (genosalut.com)

In more severe cases IVF, or IVF - ICSI is done and is often the best option, specifically if time is a factor or fertility problems coexist on the female side. (wikipedia.org)
There are a few known, but rare genetic conditions that affect male fertility or cause male-factor infertility. (givelegacy.com)
What is male-factor infertility? (givelegacy.com)
Male-factor infertility refers to difficulty conceiving that's primarily caused by issues with the sperm's inability to fertilize the egg. (givelegacy.com)
A number of conditions could contribute to male-factor infertility, including low sperm count or poor sperm motility . (givelegacy.com)
Since ICSI is a treatment that helps overcome male-factor fertility issues, such as oligospermia (low sperm count), it's possible that those same male fertility issues may be genetically passed down to male offspring. (givelegacy.com)

The importance of genetic testing in infertile patients and the need for genetic counselling to prevent the transmission of the defect are emphasized. (bvsalud.org)
Information about genetic abnormalities in infertile patients can be particularly useful for disease classification and monitoring, as well as diagnosis and treatment strategy decision. (genetic-center.ir)
Infertile patients cannot afford to wait for treatment while their eggs get older. (infertile.com)

A review in 2013 came to the result that oligospermia and azoospermia are significantly associated with being overweight (odds ratio 1.1), obese (odds ratio 1.3) and morbidly obese (odds ratio 2.0), but the cause of this is unknown. (wikipedia.org)

In most cases of oligospermia including its idiopathic form there is no direct medical or surgical intervention agreed to be effective. (wikipedia.org)
The use of carnitine showed some promise in a controlled trial in selected cases of male infertility improving sperm quality and further studies are needed. (wikipedia.org)
This condition accounts for about 13 percent of cases of azoospermia and 5 percent of severe oligospermia. (medlineplus.gov)
This has a general effect on health and in some cases it can have a direct impact on male fertility. (hickeysolution.com)
It is divided into roughly 60% Non-obstructive Azoospermia (NOA) cases and 40% Obstructive Azoospermia cases (OA).Non-Obstructive Azoospermia (NOA) is a medical disorder in which spermatogenesis fails and a man is unable to make sperm. (jananamfertility.com)

Men with Y chromosome infertility do not have any other signs or symptoms related to the condition. (medlineplus.gov)

Welling Homeopathy Treatment offers speciality Homeopathic medicines for the treatment of Oligospermia helping men to father a child at the earliest. (wellinghomeopathy.com)

Approximately 9% of men in the US have reported seeking advice, testing, or treatment for infertility . (givelegacy.com)

Causes of male infertility - UpToDate Causes of male infertility Endocrine and systemic disorders (hypogonadotropic hypogonadism) Congenital disorders Congenital GnRH deficiency (Kallmann syndrome) Iron overload syndromes Multiorgan genetic disorders (Prader-Willi syndrome, Laurence-Moon-Biedl syndrome, familial cerebellar ataxia) Low sperm count (oligospermia) A malfunctioning immune system. (ubbcluj.ro)

Oligospermia is a male fertility issue defined as a low sperm concentration in the ejaculate. (wellinghomeopathy.com)

DAZ family proteins are located in the nucleus and/or in the cytoplasm of male and female germ cells at different developmental stages throughout the gametogenesis. (ijbs.com)
Combining with other proteins, DAZ family members play a crucial role in male and female gametogenesis conserved throughout the evolution. (ijbs.com)

Infertility in men can result from deficiencies in sperm formation, concentration, or transportation. (medscape.com)
As a result, either few sperm develop or sperm do not develop at all, leading to Y chromosome infertility. (medlineplus.gov)

Infertile men may have deficiencies in sperm formation, concentration (eg, oligospermia [too few sperm], azoospermia [no sperm in the ejaculate]), or transportation. (medscape.com)

Cytogenetics refers to the microscopic analysis of chromosomes and/or genetic materials in individual cells. (genetic-center.ir)

Y chromosome infertility is a condition that affects the production of sperm and causes male infertility, which means it is difficult or impossible for affected men to father children. (medlineplus.gov)

Precocious puberty, defined as the onset of puberty before age 9 years in males, may be the sign of a serious underlying endocrinologic disorder. (medscape.com)

The initial step in the evaluation of an infertile male is to obtain a thorough medical and urologic history. (medscape.com)
Am. Diagnosing male infertility problems usually involves: General physical examination and medical history. (ubbcluj.ro)

Thus, an appropriate male evaluation may allow the couple to better understand the basis of their infertility and to obtain genetic counseling when appropriate. (ubbcluj.ro)

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Organisms2

Diseases30

Chemicals and Drugs12

Analytical, Diagnostic and Therapeutic Techniques and Equipment22

Psychiatry and Psychology1

Phenomena and Processes107

Information Science3

Health Care1

Abnormal3

Subtelomeric region2

Testicular3

Gene4

Oligozoospermia3

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Klinefelter1

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Genetics5

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