• 1989
  • From 1989 through 1991 in the United States, the average annual number of hospital discharge diagnoses in patients with diabetes exceeded 100,000 for diabetic ketoacidosis, 4,500 for diabetic coma, 10,800 for diabetic hyperosmolar nonketotic coma and 18,800 for acidosis. (aafp.org)
  • A total of 1,441 volunteers with type 1 diabetes were recruited from 29 medical centers in the United States and Canada between 1983 and 1989, and were followed up until 1993. (wikipedia.org)
  • METHODS
  • RESEARCH DESIGN AND METHODS -We conducted a randomized 1-year feasibility trial comparing CSII with continuing MDIs in preschool children with a history of type 1 diabetes for at least 6 months' duration. (diabetesjournals.org)
  • Several registers have reported improved glycaemic control over time, 4 , 5 and it has been proposed that benchmarking activity, consisting of actively identifying problems and adopting systematic improvement methods (including reporting of results by centre), has contributed to improving patient outcomes. (mja.com.au)
  • RESEARCH DESIGN AND METHODS We searched The Cochrane Library, MEDLINE, Embase, Science Citation Index Expanded, Social Sciences Citation Index, PsycINFO, and CINAHL from inception until 1 October 2014. (diabetesjournals.org)
  • RESEARCH DESIGN AND METHODS Blinded, 3-7 day CGM profiles were obtained in 16 short-term T1D patients (age 8-18 years, T1D duration 6-52 weeks) who had peak C-peptide levels ranging from 0.46 to 1.96 nmol/L during a mixed-meal tolerance test. (diabetesjournals.org)
  • Before the advent of inexpensive molecular methods, yeasts that were isolated from infected patients were often called Candida without clear evidence of relationship to other Candida species. (wikipedia.org)
  • clinical
  • Intensified treatment and education of type 1 diabetes as clinical routine. (uni-hamburg.de)
  • Exclusion criteria were a clinical requirement for strict blood pressure control or β-blockade, severe vascular disease, severe concurrent illness or illness precluding β-blocker use, pregnancy, or unwillingness to participate. (acpjc.org)
  • Main outcomes were a first diabetes-related nonfatal or fatal predefined clinical end point, deaths related to diabetes, and all-cause mortality. (acpjc.org)
  • Large population-based diabetes registers in several countries have collated data on glycaemic control, management and clinical outcomes for young people with diabetes, facilitating the international benchmarking of paediatric diabetes centres. (mja.com.au)
  • While a number of paediatric diabetes centres with established clinical databases have reported clinical outcomes for younger patients over recent decades, 7 - 10 there has been no national surveillance of glycaemic control or the management of diabetes in young people. (mja.com.au)
  • Hyperglycemic hyperosmolarity is part of a clinical spectrum of severe hyperglycemic disorders ranging from pure hyperglycemic hyperosmolarity without ketosis to diabetic ketoacidosis, with significant overlap in the middle. (aafp.org)
  • The clinical spectrum of severe hyperglycemic disorders ranges from hyperglycemic hyperosmolarity without ketosis to full-blown diabetic ketoacidosis, with considerable overlap in the middle (i.e., approximately one fifth to one third of patients with otherwise classic diabetic ketoacidosis also have hyperglycemic hyperosmolarity). (aafp.org)
  • In addition, clinical background factors were considered when studying the frequency of HLA types. (bmj.com)
  • the American Diabetes Association says, "Prediabetes should not be viewed as a clinical entity in its own right but rather as an increased risk for diabetes and cardiovascular disease (CVD). (wikipedia.org)
  • Blinded CGM results in this group of participants with short-term T1D were compared with results of blinded CGM profiles obtained by the Juvenile Diabetes Research Foundation (JDRF) CGM Randomized Clinical Trial study group. (diabetesjournals.org)
  • Autoantibodies against the 65 kD isoform of glutamate decarboxylase (GADA) at the onset of clinical diabetes increased the risk of DR 15 years later, relative risk 1.12 for each 100 WHO units/ml, [95% CI 1.02 to 1. (pubmedcentralcanada.ca)
  • In this study we hypothesize that autoimmune processes resulting from HLA genotype and the relationship of these genes with islet autoantibody status and residual C-peptide production at the clinical onset of diabetes are associated with the risk of DR 15 years later. (pubmedcentralcanada.ca)
  • The review of Ozempic® is based on the SUSTAIN programme, a global clinical development programme that comprises eight phase 3a trials, encompassing more than 8,000 adults with type 2 diabetes. (wikipedia.org)
  • treatment
  • Rationale for the use of insulin therapy alone as the pharmacological treatment of type 2 diabetes mellitus. (uni-hamburg.de)
  • or systolic pressure ≥ 160 mm Hg, diastolic pressure ≥ 90 mm Hg, or both in patients not receiving antihypertensive treatment) who had been recruited to the U.K. Prospective Diabetes Study (UKPDS). (acpjc.org)
  • Patients were stratified for presence or absence of previous hypertensive treatment. (acpjc.org)
  • Many patients with type 2 diabetes will eventually need to have insulin added to their treatment regimens because of β-cell failure. (acpjc.org)
  • All were receiving treatment at Tokyo Women's Medical University Diabetes Center. (bmj.com)
  • This theoretical phenomenon was named after Michael Somogyi, a Hungarian-born professor of biochemistry at the Washington University and Jewish Hospital of St. Louis, who prepared the first insulin treatment given to a child with diabetes in the USA in October 1922. (wikipedia.org)
  • The Edmonton Protocol is a method of implantation of pancreatic islets for the treatment of type 1 diabetes mellitus, specifically "brittle" type 1 diabetics prone to hypoglycemic unawareness. (wikipedia.org)
  • This study aimed to identify the usefulness and safety of the bariatric surgery for obese patients with type 2 diabetes compared with medical treatment in regards of diabetes remission, standards of HbA1c, FBG, high-density lipoprotein and triglycerides, dose of hypoglycemic, antihypertensive, lipid-lowering medicine, weight loss, and adverse events, respectively. (hindawi.com)
  • To investigate the possibility that glucagon-like peptide-1 (7-36)-amide (GLP-1) receptor agonism may influence axonal structure and function through neuroprotection neurotrophic support, effects of GLP-1 and its long acting analog, Exendin-4 (Ex4) treatment on pyridoxine-induced peripheral neuropathy were examined in rats using behavioral and morphometric techniques. (scribd.com)
  • Our findings suggest a potential role for these peptides in the treatment of neuropathies, including that associated with type II diabetes mellitus. (scribd.com)
  • Ozempic® (semaglutide) is a once-weekly analogue of human glucagon-like peptide-1 (GLP-1) that has been developed for the treatment of type 2 diabetes. (wikipedia.org)
  • Octreotide has also been used off-label for the treatment of severe, refractory diarrhea from other causes. (wikipedia.org)
  • This type of continuous treatment is in contrast to traditional multiple daily injections (MDI) that use slower-acting insulin. (wikipedia.org)
  • Between the two studies, the treatment of people with diabetes was significantly changed. (wikipedia.org)
  • Changes were subsequently made in the eligibility criteria for the full-scale trial to exclude anyone with this very common short-term complication of diabetes treatment, which also raises questions about exactly how "random" the selection process really was. (wikipedia.org)
  • symptoms
  • Infection can result in a wide variety of symptoms ranging from mild respiratory illness (common cold), hand, foot and mouth disease, acute hemorrhagic conjunctivitis, aseptic meningitis, myocarditis, severe neonatal sepsis-like disease, and acute flaccid paralysis. (wikipedia.org)
  • It develops more insidiously than diabetic ketoacidosis and is frequently associated with central nervous system signs and symptoms (the most profound of which is coma), as well as severe fluid depletion and impairment of renal function. (aafp.org)
  • Prediabetes is the precursor stage before diabetes mellitus in which not all of the symptoms required to diagnose diabetes are present, but blood sugar is abnormally high. (wikipedia.org)
  • Patients should monitor for signs and symptoms of type 2 diabetes mellitus. (wikipedia.org)
  • Sometimes a person with diabetes will experience the Somogyi rebound when awake and notice symptoms of the initial low blood sugar or symptoms of the rebound. (wikipedia.org)
  • A commonly used "number" to define the lower limit of normal glucose is 70 mg/dl (3.9 mmol/l), though in someone with diabetes, hypoglycemic symptoms can sometimes occur at higher glucose levels, or may fail to occur at lower. (wikipedia.org)
  • Symptoms and effects can be mild, moderate or severe, depending on how low the glucose falls and a variety of other factors. (wikipedia.org)
  • Over 85% of people that carry the mutation in mitochondrial DNA at position 3243 present symptoms of diabetes. (wikipedia.org)
  • islet
  • A webpage maintained by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) of the U.S. National Institutes of Health (NIH) indicates that the Collaborative Islet Transplant Registry's 2010 annual report presented data on 571 patients who received pancreatic islet allo-transplants between 1999 and 2009. (wikipedia.org)
  • 1] The major problem limiting islet transplantation therapy for type 1 diabetic individuals is the lack of organ donors. (wikipedia.org)
  • "Since 2000, Several hundred people have received islet transplants, by a year after transplant, 50 - 68% of patients do not need to receive additional insulin, but by five years after the procedure, fewer than 10% of total patients are free of daily insulin supplementation. (wikipedia.org)
  • Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. (wikipedia.org)
  • Islet cell autoantibodies, insulinoma-antigen 2 autoantibodies, residual C-peptide and the type 1 diabetes associated haplotypes DQ2, DQ8 and DQ6 were not associated with DR. (pubmedcentralcanada.ca)
  • pump
  • The pump operates with a single AAA battery and uses a piston-plunger pump to infuse a programmed amount of insulin into the patient through a length of tubing. (wikipedia.org)
  • So any change in basal or bolus is patient-driven by programming the pump using the Bolus WizardTM. (wikipedia.org)
  • organs
  • Systemic infections of the bloodstream and major organs (candidemia or invasive candidiasis), particularly in immunocompromised patients, affect over 90,000 people a year in the U.S. The genome of several Candida species has been sequenced. (wikipedia.org)
  • In debilitated or immunocompromised patients, or if introduced intravenously, candidiasis may become a systemic disease producing abscess, thrombophlebitis, endocarditis, or infections of the eyes or other organs. (wikipedia.org)
  • Naturally, the most metabolically active organs in the patient will be affected by this ATP deficiency. (wikipedia.org)
  • Microencapsulation is a valuable technique for local, regional and oral delivery of therapeutic products as it can be implanted into numerous tissue types and organs. (wikipedia.org)
  • prevalence
  • 1 The prevalence of diabetes mellitus in the United States has increased substantially during the past 25 years, 2 with 1.9 million new cases diagnosed in adults aged 20 years or older in 2010 alone. (jaoa.org)
  • Intervention
  • Hereditary or inherited disease a type of genetic disease caused by mutation that is hereditary (and can run in families) Iatrogenic disease A disease condition caused by medical intervention. (wikipedia.org)
  • episodes
  • In other models of brain damage, such as ischemic stroke, brief, mild episodes of antecedent brain ischemia has been shown to cause a beneficial adaptation that protects the brain against a subsequent episode of more severe ischemia (a phenomena known as ischemic preconditioning) ( 17 ). (diabetesjournals.org)
  • 1996
  • 1996). GLP-1 has been shown to possess the ability to mediate central nervous system effects relating to satiety (Turton et al. (scribd.com)
  • secretion
  • Recent studies have established that GLP-1 and Ex4, have multiple synergistic effects on glucose-dependent insulin secretion pathways of pancreatic β-cells and on neural plasticity. (scribd.com)