Sequence analysis terminal avian proteins. Medical search. Frequent questions

Lin YP , Shaw M , Gregory V , Cameron K , Lim W , Klimov A , Avian-to-human transmission of H9N2 subtype influenza A viruses: relationship between H9N2 and H5N1 human isolates. (cdc.gov)
Cocirculation of avian H9N2 and contemporary "human" H3N2 influenza A viruses in pigs in southeastern China: potential for genetic reassortment? (cdc.gov)
RNA viruses may escape acquired humoral and cellular immune responses by mutations in protective antigenic epitopes (e.g., avian influenza viruses), while accessory nonstructural proteins or multifunctional structural proteins interfere with the interferon system (e.g. (imperial.ac.uk)
The Qinghai-like Clade 2.2 virus was found to possess a high genetic relationship with viruses isolated from other countries on the migratory flyway of wild birds 4 , suggesting that the migration of wild birds played an important role in circulating H5N1 HPAIV viruses between the different avian populations. (nature.com)
The unique property of some avian H10 viruses, particularly the ability to cause severe disease in mink without prior adaptation, enabled our study. (biomedcentral.com)
Coupled with previous experimental data and genetic characterization here we tried to investigate the possible influence of different genes on the virulence of these H10 avian influenza viruses in mink. (biomedcentral.com)
Phylogenetic analysis revealed a close relationship between the viruses studied. (biomedcentral.com)
Our study also showed that there are no genetic differences in receptor specificity or the cleavability of the haemagglutinin proteins of these viruses regardless of whether they are of low or high pathogenicity in mink. (biomedcentral.com)
The ON mapping showed a close genomic relationship between the mink isolate (A/Mink/Sweden/3900/84) and the concomitant avian H10N4 viruses from fowl (A/fowl/Hampshire/378/85) and mallard (A/mallard/Gloucestershire/374/85) respectively, and a weaker genomic relationship with the H10 prototype [ 7 ] virus (A/chicken/Germany/N/49) [ 4 ]. (biomedcentral.com)
Here, we performed a time-resolved phylogenetic analysis of 129 HA sequences representing all 1891 available H5N8 viruses collected from 2010 to 2020. (mdpi.com)
Understanding and predicting host tropism of influenza proteins lay an important foundation for future work in constructing computation models capable of directly predicting interspecies transmission of influenza viruses. (springer.com)
A large number of influenza A viruses naturally reside in avian species where they constantly circulate and evolve. (springer.com)
Avain Influenza (AI) is a highly contagious disease caused by type A influenza viruses which have negative-sense, single-stranded genomes that encode at least ten proteins including two surface glycoproteins [haemagglutinin (HA) and neuraminidase (NA)], nucleoprotein (NP), three polymerase proteins [polymerase basic (PB1), (PB2) and polymerase acidic (PA)], two matrix (M1 and M2) proteins and two non-structural (NS1 and NS2) proteins. (scialert.net)
Some avian H9 viruses have acquired receptor binding characteristics typical of human strains, increasing the potential for reassortment in both human and pig respiratory tracts ( Suzuki, 2005 ). (scialert.net)
However, for these avian (av) viruses to efficiently replicate in mammalian cells, host adaptation of the viral polymerase is necessary. (nature.com)
Human infections with avian H7N9 subtype influenza viruses are a major public health concern and vaccines against H7N9 are urgently needed for pandemic preparedness. (nature.com)
In addition to seasonally occurring human infections, zoonotic infections caused by avian influenza A viruses are a major public health concern and pose a pandemic threat. (nature.com)
In addition, highly pathogenic avian influenza (HPAI) H7N9 viruses emerged that featured a polybasic cleavage site in the hemagglutinin (HA) and were lethal for poultry 7 , 8 . (nature.com)
This has led to a growing concern regarding the pandemic potential of the highly pathogenic avian influenza H5N1 viruses. (justia.com)
Interferon-induced transmembrane proteins (IFITMs) are antiviral factors that act uniquely and early in viral replication cycles to restrict the entry of a diverse range of primarily enveloped viruses into cells ( 1 ). (life-science-alliance.org)
As their name suggests, IFITMs are membrane proteins, allowing them to police the cell surface and endocytic membranes that viruses must cross to invade cells. (life-science-alliance.org)
In influenza A viruses there are 8 segments of RNA coding for eight viral proteins and two non-structural proteins. (csiropedia.csiro.au)
In addition, since the gene encoding the A56 protein is non-essential, it can be used as an insertion point for foreign genes and has been deleted in some viruses that are in clinical development as oncolytic agents. (microbiologyresearch.org)

A total of 17,376 protein-coding genes were predicted and their functions were annotated. (biomedcentral.com)
The number of 1:1 orthologous genes that were predicted to have undergone positive selection in the Hainan Partridge was 504 and some environmental adaptation related categories, such as response to ultraviolet radiation were represented in GO distribution analysis. (biomedcentral.com)
Phylogenetic analysis HA and NA genes showed that they share a common ancestor Qa/HK/G1/97 isolate which had contributed internal genes of H5N1 virus. (scialert.net)
In this study, we characterized HA and NA genes and proteins of 5 Iranian isolate which have been isolated from Commercial broiler chicken in the Iran between 2008 and 2009. (scialert.net)
Some MHC-linked genes encode proteins that interact with MHC molecules. (biomedcentral.com)
With about 18,500 protein-coding genes, the platypus is quite normal in that regard (the human, chimp, cat, chicken, nematode, and sea anemone genomes have approximately the same number of genes). (creation.com)
Bioinformatic and comparative genomic analyses allowed us to identify genes encoding three candidate antibacterial effectors located within SPI-6 and two candidate effectors located within SPI-19. (frontiersin.org)
Of note, the genes encoding these effectors and immunity proteins are widely distributed in Salmonella genomes, suggesting a relevant role in interbacterial competition and virulence. (frontiersin.org)
Gene ontology category and KEGG analysis suggested that 216 upregulated genes in MZ-2 were annotated by 70 GO assignments, 242 upregulated genes were associated with 188 signal pathways, while 321 upregulated genes in MZ-3 were annotated by 56 GO assignments, 322 upregulated genes were associated with 168 signal pathways. (biomedcentral.com)
The molecular functions of upregulated genes in MZ-2 were mainly enriched for protein degradation and amino acid metabolism. (biomedcentral.com)
As opposed to other styles of muscles dystrophy, where mutations take place in genes encoding structural protein, calpainopathy was the initial reported kind of dystrophy predetermined by mutations within a gene encoding a proteolytic enzyme. (exposed-skin-care.net)

In this paper, ARS scientists collaborated with scientists at the Gyeongsang National University in South Korea to clone and study biological function of important duck cytokine, IL-17 which is involved in the control of host innate immunity to many viral diseases such as avian influenza. (usda.gov)
Up to the present, systematically assessing viral protein antigenicity and/or determining the immunorelevant domain(s) of viral proteins during serological testing for CAV infection has never been performed. (biomedcentral.com)
The expression, production and antigenic characterization of CAV viral proteins such as VP1, VP2 and VP3, and their use in the development of diagnostic kit would be useful for CAV infection prevention. (biomedcentral.com)
Three CAV viral proteins VP1, VP2 and VP3 was separately cloned and expressed in recombinant E. coli . (biomedcentral.com)
This is the first report to systematically assess the antigenic characteristics of CAV viral proteins for sero-diagnosis purposes. (biomedcentral.com)
Nonstructural protein 5 (Nsp5) is the main protease of SARS-CoV-2 that cleaves viral polyproteins into individual polypeptides necessary for viral replication. (elifesciences.org)
The A56 protein is capable of binding two viral proteins, a serine protease inhibitor (K2) and the vaccinia virus complement control protein (VCP), and anchoring them to the surface of infected cells. (microbiologyresearch.org)
LXGG sequence is recognized by viral and cellular deubiquitinating enzymes. (microbiologyresearch.org)

There are at least 16 species in genus Arborophila and no genome sequence is available. (biomedcentral.com)
Development of logical control strategy against many infectious diseases of poultry and other avian species critically depends on the availability of immunological knowledge and reagents that can be used in basic and applied research. (usda.gov)
Further studies in immunological function of these cytokines will provide enhanced insights on their role in mediating innate immunity in avian species. (usda.gov)
Yet when some avian strains do acquire the ability to overcome species barrier, they might become adapted to humans, replicating efficiently and causing diseases, leading to potential pandemic. (springer.com)
Avian MHC organization is of particular interest because the chicken Gallus gallus , the avian species with the best characterized MHC, possesses a highly streamlined minimal essential MHC, which is linked to resistance against specific pathogens. (biomedcentral.com)
The zebra finch MHC differs markedly from that of the chicken, the only other bird species with a complete genome sequence. (biomedcentral.com)
RNA species obtained from clonal lines of avian sarcoma and from avian leukosis virus. (wikidata.org)
Mycoplasma gallisepticum causes chronic respiratory disease in chickens and other avian species. (biomedcentral.com)
Chlamydia (C.) psittaci , the causative agent of avian chlamydiosis and human psittacosis, is a genetically heterogeneous species. (biomedcentral.com)
Following clean-up, reassembly and polishing of poorly assembled genomes from public databases, phylogenetic analyses using C. psittaci whole-genome sequence alignment revealed four major clades within this species. (biomedcentral.com)
A parallel study, conducted with CDC, is examining the distribution and number of mosquito species in relation to land cover, weather conditions, and avian deaths. (cdc.gov)

To carry out the further antigenic characterization of the immunorelevant domains of the VP2 and VP3 proteins, five recombinant VP2 subunit proteins (VP2-435N, VP2-396N, VP2-345N, VP2-171C and VP2-318C) and three recombinant VP3 subunit proteins (VP3-123N, VP3-246M, VP3-366C), spanning the defined regions of VP2 and VP3 were separately produced by an E. coli expression system. (biomedcentral.com)
Characterization of a 105,000 molecular weight gag-related phosphoprotein from cells transformed by the defective avian sarcoma virus PRCII. (wikidata.org)
Characterization of protein kinase activity associated with the transforming gene product of Fujinami sarcoma virus. (wikidata.org)

Sequence analysis of this genomic DNA fragment revealed that the 2.6-kb c-erbB transcript is produced by alternative processing. (elsevierpure.com)
Adam Felsenfeld, director of the Large-Scale Sequencing Program at the US National Human Genome Research Institute, exemplifies the evolutionists' response to the platypus genome sequence: 'I find it fascinating that genomic features of what are now two separate lineages can coexist in the genome of a single organism. (creation.com)
Identification of domains under low sequence identity conditions and lack of structural homologues acquire a crucial importance especially at the genomic scale. (biomedcentral.com)
Domain assignment to the protein sequences has paramount importance in the post genomic era. (biomedcentral.com)

Through alternative splicing of the fetal exon and other alternative exons in the N-terminal variable region, the expression of fsTnT during mammalian and avian development undergoes a high molecular to low molecular weight isoform switch in both fast and slow fiber dominant skeletal muscles. (wikipedia.org)
The switch of high to low molecular weight splice forms occurs in avian leg muscles during post hatching development similar to that in developing mammalian skeletal muscles. (wikipedia.org)
The encoded protein, predicted to consisted of 169 amino acids, displayed a molecular weight of 18.8 kDa, a 29 residue NH2-terminal signal peptide, a single potential N-linked glycosylation site, and 6 cysteine residues conserved with mammalian IL-17s. (usda.gov)
Duck IL-17 shared 84% amino acid sequence identity to the previously described chicken IL-17 (chIL-17) and 36-47% to mammalian homologues and the open reading frame 13 of Herpesvirus saimiri (HVS 13). (usda.gov)

The causative agent behind this outbreak was identified as H5N1 highly pathogenic avian influenza virus (HPAIV). (nature.com)
Most influenza strains evolve exclusively in the large reservoir of water birds, but some highly pathogenic avian strains (e.g. (nature.com)
Neutralizing monoclonal antibodies (MAbs), particularly those having cross-clade neutralizing activity, play a critical role in immunoprotection against various influenza A virus (IAV) infections, particularly those caused by the highly pathogenic avian influenza H5N1 virus and any future unpredictable virus strains. (justia.com)

Genetic and phylogenetic analyses revealed that this Sanmenxia H5N1 virus was a novel reassortant, possessing a Clade 2.3.2.1c HA gene and a H9N2-derived PB2 gene. (nature.com)
Similar to H5N1 strains, this further affirms the potential of avian influenza strains capable of directly infecting human, causing severe illnesses. (springer.com)
Disclosed herein are neutralizing monoclonal antibodies (MAbs) specific for the surface hemagglutinin (HA) protein of the influenza H5N1 strain. (justia.com)
Avian influenza (H5N1) is rare in humans in developed countries. (medscape.com)

It is characterised by an ability to constantly change its two surface proteins - haemagglutinin and neuraminidase - allowing the virus to cause successive epidemics every one or two years or more serious pandemics at irregular intervals. (csiropedia.csiro.au)
The sequence data was used also by Don Wiley (Harvard University) and colleagues in their landmark determination of the 3D structure of the influenza virus haemagglutinin, published in Nature in 1981. (csiropedia.csiro.au)
Influenza virus is a pleomorphic, enveloped virus with two coat proteins on its surface, the haemagglutinin (HA) and the neuraminidase (NA). (csiropedia.csiro.au)
While originally characterized as a haemagglutinin protein, A56 has other functions as well. (microbiologyresearch.org)

Sequence analysis revealed that the 3′ end of one cDNA clone diverged from the known sequence of the extracellular ligand-binding domain (LBD) of the full-length receptor. (elsevierpure.com)
Translation of this 2.6-kb transcript would produce a secreted, truncated receptor molecule which contains the amino-terminal three-fourths of the extracellular LBD of the native receptor. (elsevierpure.com)
Alternative splicing of the avian trkB receptor generates an extracellular deletion (ED) isoform missing 11 amino acids from the neurotrophin-binding domain of the full-length (FL) receptor. (jneurosci.org)
Two of these differ in the presence of juxtamembrane extracellular sequences which regulate the ability of TACE (TNF-alpha converting enzyme) to proteolytically cleave ErbB4 from the cell surface. (bio-techne.com)
In the poster section, Joanna Shisler (University of Illinois at Urbana-Champaign [UIUC], Urbana) reported that the modified virus, Ankara, activates nuclear factor κB through the mitogen-activated protein kinase, extracellular signal–regulated kinase (MEK)/extracellular signal–regulated kinase (ERK) pathway, possibly facilitating the host immune response. (cdc.gov)

The whole genome of Hainan Partridge was de novo sequenced (with shotgun approach on the Illumina 2000 platform) and assembled. (biomedcentral.com)
A whole genome shotgun approach on the Illumina 2000 platform was performed to sequence the genome. (biomedcentral.com)
Here, we demonstrate that this method can be scaled up for whole genome analysis, by taking Mycoplasma gallisepticum genome as a specific example. (biomedcentral.com)
To assess whether there are genetic markers associated with host tropism we comparatively analyzed whole-genome sequences of 61 C. psittaci strains, 47 of which carrying a 7.6-kbp plasmid. (biomedcentral.com)

Domain commonly found in eukaryotic signalling proteins. (embl.de)
The Type VI Secretion System (T6SS) is a multiprotein device that has emerged as an important fitness and virulence factor for many Gram-negative bacteria through the injection of effector proteins into prokaryotic or eukaryotic cells via a contractile mechanism. (frontiersin.org)
While some effector proteins specifically target bacterial or eukaryotic cells, others can target both types of cells (trans-kingdom effectors). (frontiersin.org)
IFITMs belong to the CD225/pfam04505 or "dispanin" protein superfamily ( http://pfam.xfam.org/family/PF04505 ) ( 3 ) that contains more than 2,000 members, including both prokaryotic and eukaryotic proteins, all of which encode a conserved CD225 protein domain. (life-science-alliance.org)

We used NMR to determine conformational ensembles of E627 and K627 forms of 627-NLS of PB2 in complex with avian and human ANP32A. (nature.com)
Dynamic and conformational switching in proteins. (rochester.edu)
From CD experiments at different SDS concentrations, an alpha-helix/beta-sheet conformational transition was only observed in the blocked PrP[Ac-106-126-NH2] sequence. (cnr.it)

RNA-Seq analysis revealed that more severe disease in line W was associated with significant up-regulation of pathways involved in inflammation, cytoskeletal regulation by Rho GTPases, nicotinic acetylcholine receptor signaling, and Wnt signaling in the bursa compared to line 15I. (imperial.ac.uk)
At least four major transcripts are produced by the avian c-erbB/epidermal growth factor receptor gene. (elsevierpure.com)
Ser/Thr protein kinases such as the Akt/Rac family, the beta-adrenergic receptor kinases, the mu isoform of PKC and the trypanosomal NrkA family. (embl.de)

Butt KM , Smith GJ , Chen H , Zhang LJ , Leung YH , Xu KM , Human infection with an avian H9N2 influenza A virus in Hong Kong in 2003. (cdc.gov)

A host transcription regulator ANP32A, comprising a long C-terminal intrinsically disordered domain (IDD), is responsible for this adaptation. (nature.com)
We have extended our studies to encompass intrinsically disordered proteins, and are using the sequences of those proteins as an added resource in the study of folding and stability in proteins. (rochester.edu)

To provide genome-scale insights into the vulnerable Hainan Partridge, facilitate comparative studies of avian genomics and further the development of genetic tools for Hainan Partridge research and conservation, we sequenced the genome of the Hainan Partridge. (biomedcentral.com)
OBJECTIVE: To carry out combined genetic analysis on two patients suspected for Burkitt lymphoma to facilitate their diagnosis and treatment. (bvsalud.org)
Genetic structure, transforming sequence, and gene product of avian sarcoma virus UR1. (wikidata.org)

C/EBP homologous protein (CHOP), also known as growth arrest and DNA damage-inducible protein 153 (GADD153), belongs to the CCAAT/enhancer-binding protein (C/EBP) family. (bvsalud.org)
Serological analyses demonstrated that homologous hemagglutination inhibition and microneutralization antibody titers were detectable in the ferrets after the first immunization with the AS03-adjuvanted vaccines that were further boosted by the second immunization. (nature.com)
Sequence-, structure-, and dynamics-based comparisons of structurally homologous CheY-like proteins. (rochester.edu)

Sequence homology and protein epitope allosteric similarity data suggest that TnT gene was originated by duplication of a TnI-like ancestor gene and fsTnT was the first TnT emerged. (wikipedia.org)
Rat and human AICARFT/IMPCHase cDNAs show 84 and 91% homology at the nucleotide and amino acid sequence level, respectively. (embl-heidelberg.de)
A 10-amino acid sequence within the COOH-terminal portion of human AICARFT/IMPCHase has some degree of homology to a previously noted "folate binding site. (embl-heidelberg.de)
Pleckstrin homology (PH) domains are small modular domains that occur in a large variety of proteins. (embl.de)

The outbreak of severe respiratory disease in mink ( Mustela vison) in 1984 was linked to an avian influenza virus of subtype H10N4. (biomedcentral.com)
In addition, an avian H7N2 virus caused an outbreak in cats in an animal shelter in New York that led to one human case 11 . (nature.com)
In related work, presented at the poster session, Marylin Ruiz (UIUC, Urbana) reported the efforts of the College of Veterinary Medicine Geographic Information System and Spatial Analysis Laboratory, in collaboration with the Illinois Department of Public Health, and the Illinois Department of Agriculture in the mapping and analysis of the WNV outbreak in Illinois. (cdc.gov)

We have recently shown that it is possible to enhance prediction of domains in the unassigned regions by 25% through indirect connections in the class III adenylyl cyclase domain containing proteins [ 10 ]. (biomedcentral.com)

Mouse protein citron, a putative rho/rac effector that binds to the GTP-bound forms of rho and rac. (embl.de)
This is based on several pieces of evidence: MYC induces CR2 expression in both proliferating and arrested cells and in the absence of protein synthesis, binds the CR2 promoter and transactivates CR2 in an E-box-dependent manner. (bvsalud.org)

Differences in pathogenicity and virulence in mink between these strains could be related to clear amino acid differences in the non structural 1 (NS1) protein. (biomedcentral.com)
Protein domains are the structural, functional and evolutionary units of proteins. (biomedcentral.com)
Homolog detection using global sequence properties suggests an alternate view of structural encoding in protein sequences. (rochester.edu)
nevertheless, recent studies have got exposed a fresh potential function for CAPN3 being a structural proteins (23,24). (exposed-skin-care.net)
Furthermore, the deleterious aftereffect of missense mutations can occur not merely from immediate disruption of CAPN3 function(s), but additionally from disruption from the protein's structural integrity, that could affect its intra or intermolecular protein lead and interactions to decreased stability or altered localization. (exposed-skin-care.net)

With the emergence of non-human H9N2 isolates with avian characteristics, it is important to study the H9N2 isolates from avian hosts in addition to those obtained from humans for pandemic influenza understanding and preparedness. (scialert.net)

In addition, features from all 11 proteins were used to construct a combined model to predict host tropism of influenza virus strains. (springer.com)
When used together as a host tropism prediction system, zoonotic strains could potentially be identified based on different protein prediction results. (springer.com)
Proteins expression for every group of vectors was examined in five strains of 1 Shot BL21 Star (DE3) (ThermoFisher), Arctic Express (Stratagene), Origami B(DE3) (Novagen), SHuffle T7(New England BioLabs), and SHuffle K12 competent AB1010 cell signaling cells (New England BioLabs). (immune-source.com)
Virus strains are named according to influenza virus type, the place where first isolated, the isolate number and the year of isolation as well as the nature of the two surface proteins. (csiropedia.csiro.au)

Avian influenza polymerase undergoes host adaptation in order to efficiently replicate in human cells. (nature.com)
Human ANP32A IDD lacks a 33 residue insertion compared to avian ANP32A, and this deletion restricts avian influenza polymerase activity. (nature.com)
The docking analyses predicted the compounds targeting PA or PB2 interacted with enzyme active sites to abolish endonuclease or cap-binding activity of the polymerase, whereas the compound targeting the PA-PB1 interaction likely induced configurational changes that impeded polymerase assembly. (hku.hk)
Hepatitis E virus (HEV) ORF1 protein (pORF1) contains methyltransferase (MetT), papain-like cysteine protease (PCP), RNA helicase (Hel) and RNA-dependent RNA polymerase (RdRp) domains. (microbiologyresearch.org)

The human and avian purH cDNAs are 75 and 81% similar on the nucleotide and amino acid sequence level, respectively. (embl-heidelberg.de)
Nucleotide sequence analysis of five representative isolates confirmed that all isolates possessed one type of amino acid motif (R-S-S-R/GL) at cleavage site of HA, Deduced amino acid sequences showed the presence of L226 (234 in H9 numbering) in all five Iranian isolates which indicates a preference to binding of α (2-6) sialic acid receptors. (scialert.net)
Regulators of small G-proteins like guanine nucleotide releasing factor GNRP (Ras-GRF) (which contains 2 PH domains), guanine nucleotide exchange proteins like vav, dbl, SoS and Saccharomyces cerevisiae CDC24, GTPase activating proteins like rasGAP and BEM2/IPL2, and the human break point cluster protein bcr. (embl.de)

Pleckstrin, the protein where this domain was first detected, is the major substrate of protein kinase C in platelets. (embl.de)
Tyrosine-specific protein kinase activity associated with p105 of avian sarcoma virus PRCII. (wikidata.org)

Avian influenza virus was isolated from poultry farms with history of respiratory illness and increased mortality. (scialert.net)

In the period from 1975 to 1983, CSIRO scientists Colin Ward, Theo Dopheide, Gerry Both and Merilyn Sleigh achieved international recognition for their work on the amino acid and gene sequences of numerous influenza virus haemagglutinins. (csiropedia.csiro.au)

Northern analysis identified a 2.8-kb AICARFT/IMPCHase mRNA and the level of the AICARFT/IMPCHase transcripts increased markedly at 24 h after partial (70%) hepatectomy. (embl-heidelberg.de)
In this study, at the mRNA and/or protein level, the expression patterns were similar for renal FXYD12 and NKA in the two medakas. (ijbs.com)

In 2013, an avian H7N9 virus strain emerged in China that caused hundreds of human infections. (nature.com)

Current hepatitis C virus (HCV) testing guidance recommends a two-step testing sequence for diagnosis of HCV infection. (cdc.gov)
We performed bioinformatics analysis on a virus genome from a patient with 2019-nCoV infection and compared it with other related coronavirus genomes. (hku.hk)
HA is the major coat protein (~95% of the total) and is responsible for cell attachment and infection by a membrane fusion process. (csiropedia.csiro.au)
The reason for this is not a poor immune response, rather it is the fact that the influenza virus continues to change its coat proteins so that the new infecting variants are no longer recognised and destroyed by the immune response generated against the earlier infection. (csiropedia.csiro.au)

The phylogenetic analysis indicated that the Hainan Partridge possessed a basal phylogenetic position in Phasianidae and it was most likely derived from a common ancestor approximately 36.8 million years ago (Mya). (biomedcentral.com)
Phylogenetic analysis of vertebrate IFITMs indicates that IFITM1 , IFITM2 , and IFITM3 group with murine ifitm6 and ifitm7 in a clade of immunity-related IFITMs (IR-IFITMs), with IFITM5 and IFITM10 falling as separate lineages ( 2 ). (life-science-alliance.org)

The vaccinia virus A56 protein was one of the earliest-described poxvirus proteins with an identifiable activity. (microbiologyresearch.org)
He also showed that double-stranded (ds)RNA- and ZDNA binding proteins had a role in poxvirus pathogenesis. (cdc.gov)

Each P exon encodes a pentapeptide AHH(A/E)A. The Tx segment of adult fsTnT in avian orders of Galliformes and Craciformes contains 7-9 H(A/E)AAH repeats that possess high affinity binding to transition metal ions Cu(II), Ni(II), Zn(II) and Co(II). (wikipedia.org)

Cytoskeletal proteins such as dynamin (see IPR001401 ), Caenorhabditis elegans kinesin-like protein unc-104 (see IPR001752 ), spectrin beta-chain, syntrophin (2 PH domains) and S. cerevisiae nuclear migration protein NUM1. (embl.de)

Host interferon-induced transmembrane proteins (IFITMs) are broad-spectrum antiviral restriction factors. (life-science-alliance.org)

Combined with the clinical features and pathological characteristics, the two patients were finally diagnosed with Burkitt lymphoma, which was confirmed by targeted capture next generation sequencing. (bvsalud.org)
Here, we describe strategies used in several approaches to optimize scorpion AMPs, addressing their primary sequence, biotechnological potential, and characteristics that should be considered when developing an AMP derived from scorpion venoms. (frontiersin.org)
Combining these data with information about avian migratory patterns, landscape characteristics, and weather conditions, over space and time, will provide the foundation for developing spatial analytical and forecasting models to assess the risk for human illness. (cdc.gov)

We report here the cloning and sequencing of the cDNA, purification, steady state kinetic analysis, and truncation mapping studies of the human 5-aminoimidazole- 4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (AICARFT/IMPCHase). (embl-heidelberg.de)
The prediction models were trained on influenza protein sequences isolated from both avian and human samples, which were transformed into amino acid physicochemical properties feature vectors. (springer.com)
From the prediction models constructed, all achieved high prediction performance, indicating clear distinctions in both avian and human proteins. (springer.com)
Human cells infected with SARS-CoV-2 exhibit a decrease in TRMT1 protein levels and TRMT1-catalyzed tRNA modifications, consistent with TRMT1 cleavage and inactivation by Nsp5. (elifesciences.org)
Purification of individual SARS-CoV-2 proteins from human cells have identified a potential interaction between a catalytic-inactive version of Nsp5 with human tRNA methyltransferase 1 (TRMT1) ( Gordon et al , 2020b ). (elifesciences.org)
Two peptide fragments, corresponding to the amino acid residues 106-126 (PrP[Ac-106-126-NH2]) and 106-114 (PrP[Ac-106-114-NH2]) of the human prion protein have been synthesised in the acetylated and amide form at their N- and C-termini, respectively. (cnr.it)
Expression and Purification of Human Bcl-2 Residues 1-218 of the Bcl-2 gene (UniProt entry "type":"entrez-protein","attrs":"text":"P10415″,"term_id":"231632″P10415) were optimized for expression in (GeneArt, Life Technologies) and cloned into a pET28a vector with an N-terminal His6-MBP solubility tag with a TEV cleavage site to remove the tag. (immune-source.com)
Chlamydia (C.) psittaci is known as the etiological agent of avian chlamydiosis and human psittacosis [ 1 ]. (biomedcentral.com)

Each antibacterial effector gene is located upstream of a gene encoding a hypothetic immunity protein, thus conforming an effector/immunity (E/I) module. (frontiersin.org)

Proteins containing only a single amino terminal CH domain. (embl.de)

The results of these ELISAs using truncated recombinant VP2 and VP3 subunit proteins as coating antigen showed that VP2-345N, VP2-396N and VP3-246M gave good immunoreactivity with CAV-positive chicken sera compared to the other subunit proteins. (biomedcentral.com)

Missense mutations in PRPF31 have previously been shown to cause reduced protein solubility, suggesting insufficiency of functional protein as the disease mechanism. (molvis.org)
The RP11 missense mutations exert their pathology mainly via a mechanism based on protein insufficiency due to protein insolubility, but there is also a minor direct negative effect on function. (molvis.org)
Their data showed conclusively that the emergence of new influenza virus epidemics was associated with the accumulation of point mutations in the virus coat proteins. (csiropedia.csiro.au)

Several influenza proteins have been shown to be major determinants in host tropism. (springer.com)
In this study, computational models for 11 influenza proteins have been constructed using the machine learning algorithm random forest for prediction of host tropism. (springer.com)
0.916) capable of determining host tropism of individual influenza proteins. (springer.com)

The protein produced by the rat cDNA using pET-expression system catalysed the penultimate and final steps of de novo purine biosynthesis. (embl-heidelberg.de)

Nsp5 cleaves TRMT1 at a specific position that matches the consensus sequence of SARS-CoV-2 polyprotein cleavage sites, and a single mutation within the sequence inhibits Nsp5-dependent proteolysis of TRMT1. (elifesciences.org)
the Golden Gate technique.31 All N-terminal tags had been accompanied by two protease cleavage sites (i.electronic. (immune-source.com)
The crystal structure of calpain 2 was solved in both holoenzyme and apo- state governments, providing home elevators the potential system of activation, that involves autocatalytic cleavage of the N-terminal pro-peptide ahead of substrate cleavage (6,7). (exposed-skin-care.net)
ORF1 sequence analysis showed two consensus LXGG cleavage sites at 664 and 1205. (microbiologyresearch.org)

Because this strange creature defies easy categorization, perhaps it would be easier to discuss its evolutionary origin if they could sequence the platypus genome (its full complement of hereditary information carried on its DNA). (creation.com)
Due to high evolutionary divergence, it is not always possible to identify distantly related protein domains by sequence search techniques. (biomedcentral.com)

MetT-PCP carried out deISGylation of the ISG15-conjugated cellular proteins, suggesting a possible role in combating cellular antiviral pathways. (microbiologyresearch.org)

Sequence determinants of protein architecture. (rochester.edu)

The sequencing of the zebra finch Taeniopygia guttata genome, in combination with targeted bacterial artificial chromosome (BAC) sequencing, has allowed us to characterize an MHC from a highly divergent and diverse avian lineage, the passerines. (biomedcentral.com)

Actin binding domains present in duplicate at the N-termini of spectrin-like proteins (including dystrophin, alpha-actinin). (embl.de)
A number of actin-binding proteins, including spectrin, alpha-actinin and fimbrin, contain a 250 amino acid stretch called the actin binding domain (ABD). (embl.de)

We are interested in computational studies of protein folding and dynamics, and particularly in the information about protein physics which is available through bioinformatic studies. (rochester.edu)
In recent work we developed the first bioinformatic representation of protein dynamics, and are currently using this tool, in combination with earlier studies of the static physical properties of amino acid sequences, to elucidate basic mechanisms of protein folding. (rochester.edu)
In earlier work, we have applied novel bioinformatic methods to the comparison of protein sequences and protein structures, and used the resulting data to address problems at the foundations of bioinformatics. (rochester.edu)

Experimental and/or computational methods can be used to identify domains in the given protein sequence. (biomedcentral.com)

Anatomy5

Organisms3

Chemicals and Drugs38

Analytical, Diagnostic and Therapeutic Techniques and Equipment25

Phenomena and Processes58

Disciplines and Occupations1

Information Science4

Health Care4

Viruses23

Genes11

Viral8

Species11

Characterization3

Genomic4

Mammalian4

Highly pathogenic3

H5N14

Haemagglutinin4

Extracellular5

Whole genome4

Eukaryotic4

Conformational3

Receptor3

Hong Kong1

Intrinsically disordered2

Genetic3

Homologous3

Homology4

Outbreak3

Domain-containi1

Binds2

Structural5

H9N21

Strains4

Polymerase4

Nucleotide3

Kinase2

Poultry1

Gene Sequences1

MRNA2

Infections1

Infection4

Phylogenetic analysis2

Poxvirus2

Encodes1

Cytoskeletal1

Transmembrane1

Characteristics3

Human8

Antibacterial1

Amino-terminal1

Antigen1

Mutations3

Host tropism3

Novo1

Cleavage4

Evolutionary2

Antiviral1

Determinants1

Divergent1

Spectrin2

Bioinformatic3

Computational1