Sensitivity organ specificity. Medical search. Frequent questions

The high specificity and level of sensitivity of the ICP-MS analysis enables the accurate dedication of low-abundance Pt and La [below parts per trillium (ppt)] in the native biological samples. (sciencepop.org)
Salivary anti-H. pylori antibody positivity showed low sensitivity (36.6%) and high specificity (75.8%) in CLD patients. (who.int)
Combined analysis of GAD65 and ICA512(IA-2) autoantibodies in organ and non-organ specific autoimmune diseases confers high specificity for insulin- dependent diabetes mellitus. (cdc.gov)

However, this approach limits the sensitivity of tr-DNA due to the masking effect of a high amount of DNA from the urogenital tract cells. (wikipedia.org)

Additionally, prenatal diagnosis and organ transplantation monitoring are other potential applications. (wikipedia.org)
Many studies indicate a high sensitivity and specificity for US in the diagnosis of appendicitis. (springer.com)
The aim of this study is to analyse whether examination with a HCU device is a rapid and reliable alternative to contrast-enhanced multidetector CT (MDCT) scans in diagnosis of free intra-abdominal fluid and organ lacerations in major trauma patients. (uni-regensburg.de)
In major trauma patients, examination with HCU according to the 'focused assessment with sonography for trauma' principles for the diagnosis of organ lacerations and free intra-abdominal fluid is a reliable and rapid alternative to MDCT scans and can help save precious time in emergency situations, and should, additionally, be evaluated in the pre-clinical workflow. (uni-regensburg.de)
PURPOSE Hypertension is the most common diagnosis in ambulatory care, yet little evidence exists regarding recommended screening intervals or the sensitivity and specificity of a routine office-based blood pressure measurement, the most common screening test. (annfammed.org)
Performing IL-6 and C-reactive protein on day 0, together with either TNFα on day 1 or C-reactive protein on day 2, showed the best overall sensitivity (98%) and specificity (91%) for the diagnosis of late onset infection. (bmj.com)
Diagnosis of organ transplant rejection relies upon biopsy approaches to confirm alloreactive T cell infiltration in the graft. (jci.org)
The diagnosis of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis is based on the presence of ANCA, clinical symptoms, and a biopsy of the frequently affected organs such as the kidneys and nasal mucosa or the lungs (which are infrequently affected). (medicinenet.com)
This variability makes early disease especially difficult to diagnose, and delayed diagnosis can lead to organ damage and is associated with increased mortality. (the-rheumatologist.org)
In many cases, diagnosis occurs because clinicians focus on the presence of a few high-yield clinical and immunologic symptoms, such as a malar rash in an individual with anti-DNA autoantibodies, that can be used in routine practice to clinically diagnose patients with SLE with high sensitivity and specificity. (the-rheumatologist.org)

These tests also must have sufficient specificity to protect patients with false-positive results from unwarranted diagnostic evaluations. (aafp.org)
Without quick action, patients developing DILI may progress to multi-organ failure and potentially death. (pharmexec.com)
solid organ transplant (SOT) recipients had significantly higher fungal loads than patients with hematological malignancies. (ntnu.no)
This microorganism can cause severe pneumonia in susceptible hosts, including patients with cancer and autoimmune diseases and people undergoing solid organ transplantation. (ntnu.no)
Specifically, low loads of microorganisms are sufficient to cause infection in patients with blood cancer compared to those in solid organ recipients. (ntnu.no)
We still don't know why patients with ANCA vasculitis experience damage to different organs or body parts. (medicinenet.com)
uNGAL levels were correlated with the severity of illness and organ failure in critically ill patients. (biomedcentral.com)
The design of the present study required the selection of patients at risk for organ dysfunction. (biomedcentral.com)
This CUBIC ( c orrelation between u rinary bi omarker and organ failure in c ritically ill patients) study was a prospective observational study. (biomedcentral.com)
The validity of these measures was compared with Campylobacter-like organ- ism analysis (gold standard) performed on patients requiring gastric biopsy. (who.int)
Sensitivity and specificity of salivary rently, managing chronically-ill patients tests have indicted that saliva could be with hepatic disease is a challenge for den- useful as a non-invasive technique for de- tal practitioners. (who.int)

Infectious disease transmission through organ and tissue transplantation has been associated with severe complications in recipients. (cdc.gov)
Determination of donor-derived infectious risk associated with organ and tissue transplantation is challenging and limited by availability and performance characteristics of current donor epidemiologic screening (e.g., questionnaire) and laboratory testing tools. (cdc.gov)
The exact risk for infection associated with organ or tissue transplantation is unknown but is related to multiple factors, including epidemiology of specific infectious exposures, tissue tropism of the organism, and transmissibility of potential pathogens through transplantation. (cdc.gov)
Transplantation of organs and tissues is increasing ( Figure ). (cdc.gov)
In an attempt to prevent donor-derived infections in transplantation, organ and tissue donors are evaluated to identify those that might be more likely to harbor transmissible pathogens. (cdc.gov)

Generally, an increase in urine volume collected enhances the sensitivity and specificity of quantification. (wikipedia.org)
The primary aim of this study was to determine, in a group of women without advanced pelvic organ prolapse and with or without a uterus, (1) whether successful incontinence pessary fitting can be predicted by specific pelvic organ prolapse quantification (POPQ) measurements [8] and (2) whether POPQ measures predict pessary size. (researchgate.net)

Introduction and hypothesis The aim of the study was to determine whether successful incontinence pessary fitting or pessary size can be predicted by specific POPQ measurements in women without advanced pelvic organ prolapse. (researchgate.net)
vaginal pessary has been used for centuries as a conservative treatment of pelvic organ prolapse [1] and more recently for stress urinary incontinence [2 - 4]. (researchgate.net)
Pelvic organ prolapse (POP) and urinary incontinence (UI) are common conditions affecting many adult women today. (medscape.com)
Pelvic organ prolapse is the abnormal descent or herniation of the pelvic organs from their normal attachment sites or their normal position in the pelvis. (medscape.com)
Pelvic organ prolapse and its consequences have been reported since 2000 BC. (medscape.com)
Hippocrates described numerous nonsurgical treatments for pelvic organ prolapse. (medscape.com)
From the early 1800s through the turn of the century, various surgical approaches have been described to correct pelvic organ prolapse. (medscape.com)
Pelvic organ prolapse is a defect of a specific vaginal segment characterized by descent of the vagina and associated pelvic organ. (medscape.com)
In the most severe case (complete pelvic organ prolapse), the pelvic organ protrudes completely through the genital hiatus. (medscape.com)
The exact prevalence of pelvic organ prolapse is difficult to determine. (medscape.com)
A study by Handa et al suggests that vaginal birth and operative vaginal birth increase an individual's risk for urinary incontinence and pelvic organ prolapse 5-10 years after delivery when compared with cesarean delivery without labor. (medscape.com)
Therefore, multiparous women are at particular risk for pelvic organ prolapse. (medscape.com)
[ 5 ] A thorough evaluation and definition of all support defects is of critical importance because most women with pelvic organ prolapse have multiple defects. (medscape.com)
In a 1999 study of Swedish women aged 20-59 years, Samuelsson and colleagues found that, although signs of pelvic organ prolapse are frequently observed, the condition seldom causes symptoms. (medscape.com)

The diaphragm is a double-domed musculotendinous partition between the thoracic and abdominal organs and is composed of the central tendinous area and the peripheral muscular area. (medscape.com)
It lacks ionising radiation, allows dynamic visualisation of the abdominal organs and is of lower cost compared with computed tomography (CT). (springer.com)

Uveitis can result in blurry vision and an extreme sensitivity to light (photophobia). (medlineplus.gov)

After an increase in serum levels of the free chains, the protein deposits in organs, causing significant dysfunction . (medscape.com)
Systemic amyloidosis is a group of rare disorders characterized by the abnormal buildup of misfolded proteins in various tissues, leading to progressive organ dysfunction and death. (phrmafoundation.org)
Neutrophil to lymphocyte (NLR) and mean platelet volume (MPV) are simple biomarkers of inflammation that can be measured in routine hematological examination which role in predicting organ dysfunction remain unclear. (paediatricaindonesiana.org)
Organ dysfunction was identified using qSOFA score more than 2 points. (paediatricaindonesiana.org)
Surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children. (paediatricaindonesiana.org)

Introduction of a better cell isolation method and a secondary mAb significantly improves the FCXM sensitivity and specificity resulting in better correlation with the solid-phase HLA antibody assays. (atcmeetingabstracts.com)

Antineutrophil cytoplasmic antibody (ANCA) vasculitis can result in various symptoms depending on the organ or body part affected. (medicinenet.com)

We're about to go to a multisite clinical trial for a diagnostic that we believe has about 85% sensitivity and specificity for Stage II ovarian cancer," says McDade. (drugdiscoverytrends.com)

Standardization Program (DASP, 2000, 2002, 2003), organized by WHO, the data were: 76-100% sensitivity, 90-100% specificity (100% specificity 3 times), and 100% validity for GAD65 autoantibodies (3). (cdc.gov)

Intrathoracic herniation of abdominal solid organs appears as mushroom-shaped, homogeneous opacities in the thorax. (medscape.com)
On CT scans, herniation of an organ or omental fat may be visible through an abrupt discontinuity in the diaphragm. (medscape.com)

11 The sensitivity and specificity of the qPCR test and virus isolation is high during the acute phase of disease. (veterinaryirelandjournal.com)

Point-of-care ultrasound (POCUS) has well-documented, multi-organ system applications. (acep.org)
[ 15 , 16 ] We have developed and refined a rapid multi-organ exam, dubbed "triple scan" (TS), composed of abbreviated echocardiography, lung ultrasound (US) and IVC exam, which can easily be performed by EPs at the bedside of the acutely dyspneic patient. (medscape.com)

We assess whether drug sensitivity in cancer cell lines is able to discriminate tissue specificity. (nih.gov)
Prostate-specific membrane antigen (PSMA)-ligand PET/CT or PET/MRI provides high sensitivity and specificity for prostate cancer staging ( 1 ). (snmjournals.org)
The classic organ systems are influenced by ters DNA repair or causes genomic mutation theory of cancer no longer mechanistic events associated with instability, (4) induces epigenetic fully encompasses the mechanistic cancer induction. (who.int)

Although regulatory requirements and risk-benefit considerations for evaluating organ and tissue donors differ, the fundamental process for donor screening and testing, and the challenges faced in prospectively assessing the risk for donor-derived infection, are similar for organ and tissue donors. (cdc.gov)
Our third study showed that when all VEGFRs receptors are deleted, the organ-specificity and -sensitivity differ in different vascular beds. (helsinki.fi)

HA has also been labeled with radioactive isotopes including 99mTc 3 111 125 and 11C to track its biodistribution with relatively high detection level of sensitivity and specificity [17-21]. (sciencepop.org)

The initial pilot focuses on kidney safety biomarkers that have the potential to significantly improve the development of new therapies by detecting kidney injury with greater sensitivity and specificity. (c-path.org)
In the future, C-Path plans to work on other organ safety biomarkers, including liver, skeletal muscle, vascular, and pancreatic injury biomarkers. (c-path.org)
ED providers experienced with POCUS showed equivalent or better sensitivity and specificity when diagnosing certain pathologies compared to laboratory biomarkers or evaluation by expert consultants. (acep.org)

These clusters included infection transmitted to recipients of vascularized organs or tissues such as bone, tendon, skin, or corneas. (cdc.gov)

Duck is one of the most sensitive animals to AFB 1 , and severe economic losses are caused by duck AFB 1 poisoning every year, but the exact mechanism of this high sensitivity is still unclear. (hindawi.com)

Sensitivity and specificity of some ucfDNA applications are comparable to other standards in liquid biopsy. (wikipedia.org)

These microengineered culture systems combine organ-specific cell types, tissue-specific extracellular matrix, and biophysical forces to mimic in vivo microenvironments. (pharmexec.com)
Multiple studies have shown that cells grown in Organ-Chips closely mimic in vivo cells both in behavior and in gene expression profiles 9-12 . (pharmexec.com)

Common methods and standards for evaluating potential donors of organs and tissues are needed to facilitate effective data collection for assessing the risk for infectious disease transmission. (cdc.gov)

We compared vital signs, PaO 2 /F I O 2 , serum C-reactive protein (CRP) levels, acute physiology and chronic health evaluation (APACHE) II score, sequential organ failure assessment (SOFA) score, and uNGAL levels between the sepsis group and the esophagectomy group. (biomedcentral.com)

The symptoms can vary depending on the organs affected, and may include fatigue, weight loss, and swelling. (phrmafoundation.org)
Symptoms vary with the organ infected. (msdmanuals.com)
Others have more severe symptoms affecting various parts of the body, including the eyes and the vital organs. (medlineplus.gov)

In this work, we identify and characterize OX40 as a surrogate biomarker for alloreactive T cells in organ transplant rejection and monitor its expression by utilizing immunoPET. (jci.org)

Organisms seen by Gram stain yielded a sensitivity of 96.6%, specificity of 88.9%, positive predictive value of 97.7% and negative predictive value of 84.2% when used to predict positive culture results for bacterial wound infection. (who.int)
The sensitivity, specificity, positive and negative predictive values for each test and combination of tests for predicting systemic infection were also determined. (bmj.com)
IL-6 had the highest sensitivity (89%) and negative predictive value (91%) for detecting late onset infection on day 0. (bmj.com)

We anticipate that these MPL-compatible OS composite resins will pave the path towards production of soft, bioactive, and conductive microstructures for various applications in the emerging fields of flexible bioelectronics, biosensors, nanoelectronics, organ-on-chips, and immune cell therapies. (techbriefs.com)

For instance Melendez-Alafort labeled a HA-paclitaxel conjugate with 99mTc to evaluate its biodistribution through four different administration routes by measuring gamma-ray activity in organs and conducting gamma ray image analysis [22]. (sciencepop.org)

Sagittal, coronal, and 3-dimensional reformation of CT scans may improve sensitivity. (medscape.com)
I'm referring also to inter-modality consensus to enable comparison and matching of reports generated from scans of the same organ by different modalities, e.g. (pharmaceuticalintelligence.com)

CONCLUSION A limited annual screening strategy for hypertension can improve specificity without sacrificing sensitivity when compared with routine screening at every visit in previously normotensive adults. (annfammed.org)
1 Yet there is little evidence to recommend a screening interval 2 or to define the sensitivity and specificity of the most common screening test, a routine office-based blood pressure measurement performed by manual sphygmomanometry. (annfammed.org)

Then, we investigated whether uNGAL is associated with the severity of illness and organ failure, and whether uNGAL is a reliable screening test for AKI. (biomedcentral.com)

The sensitivity of the currently licensed EIA tests is 99% or greater when performed under optimal laboratory conditions. (cdc.gov)

We hypothesize that a more limited annual screening strategy may increase specificity while maintaining sensitivity. (annfammed.org)
To further increase the specificity of the testing process, laboratories must use a supplemental test--most often the Western blot test--to validate repeatedly reactive EIA results. (cdc.gov)

Organ-on-a-Chip technology has been proven to predict DILI with a higher rate of confidence than traditional in vitro methods and animals. (pharmexec.com)
The biosensor offered a highly sensitive glucose sensing platform with nearly 10-fold higher sensitivity compared to previous glucose biosensors. (techbriefs.com)
Higher sensitivity was observed in the FCXM performed with EasySep as compared to Ficoll. (atcmeetingabstracts.com)

Screening tests require high sensitivity to detect early-stage disease. (aafp.org)
The use of serial and multiple markers in the first 48 hours further enhanced the sensitivity and specificity of these tests. (bmj.com)
The specificity of the currently licensed EIA tests is approximately 99% when repeatedly reactive tests are considered. (cdc.gov)

Les micro-organismes mis en évidence par coloration de Gram ont donné une sensibilité de 96,6 %, une spécificité de 88,9 %, une valeur prédictive positive de 97,7 % et une valeur prédictive négative de 84,2 % lorsqu'ils étaient utilisés pour prévoir les résultats de culture positifs pour les infections bactériennes des plaies. (who.int)

The primary outcome measure was the TBR, which was obtained by normalizing to the omentum (in 106 lesions) or other solid organs (27 lesions). (cancernetwork.com)

15 and the necessity of a MDCT scan (standard of reference) were enrolled prospectively to this study, and additionally examined with a HCU, according to 'focused assessment with sonography for trauma' principles for the assessment of organ lacerations and free intra-abdominal fluid. (uni-regensburg.de)

To truly evaluate the potential of Organ-Chips, a large study was needed. (pharmexec.com)

With the exception of prostate-specific antigen (PSA), tumor markers do not have sufficient sensitivity or specificity for use in screening. (aafp.org)
It is suggested to perform ANCA testing through indirect immunofluorescence and antigen-specific enzyme-linked immunosorbent assays, both of which have excellent sensitivity (about 99 percent) and good specificity (approximately 70 percent). (medicinenet.com)

Placenta Placenta A highly vascularized mammalian fetal-maternal organ and major site of transport of oxygen, nutrients, and fetal waste products. (lecturio.com)

No statistically significant difference in sensitivity existed between the 2 methods. (annfammed.org)
The current diagnostic methods have limitations in terms of sensitivity and specificity and are technically difficult to interpret. (phrmafoundation.org)

In addition, this biosensor exhibited excellent specificity and high reproducibility. (techbriefs.com)

Many studies had previously suggested that Organ-Chips may be superior to conventional preclinical models when predicting drug toxicity 13,14 . (pharmexec.com)
However, the limited scale of these studies left some doubt about the robustness of Organ-Chips. (pharmexec.com)

Anatomy2

Analytical, Diagnostic and Therapeutic Techniques and Equipment1

Phenomena and Processes4

Information Science1

Health Care1

High specificity3

Masking effe1

Diagnosis10

Patients11

Transplantation5

Quantification2

Pelvic organ pr14

Abdominal organs2

Extreme Sensitivity1

Dysfunction5

Correlation1

Antibody1

Ovarian1

Validity1

Herniation2

Isolation1

Multi-organ2

Cancer3

Differ2

Detection1

Biomarkers3

Recipients1

Unclear1

Biopsy1

Vivo2

Tissues1

Sepsis1

Symptoms3

Transplant1

Infection3

Therapies1

Gamma1

Scans2

Routine2

Screening test1

Laboratory1

Increase2

Higher3

Tests3

Positive1

Solid1

Assessment1

Potential1

Specific2

Major1

Methods2

Excellent1

Studies2