• The anticancer effects of selenium differ depending on which form is used. (zrtlab.com)
  • Adverse effects of selenium intake are seen above 1500 µg/day, with "selenosis" and DNA damage occurring above 3000 µg/day [9] [10] . (zrtlab.com)
  • This has been postulated to be due to the antioxidant effects of selenium, since the inflammatory response to critical illness leads to massive production of free radicals. (humannaturellc.com)
  • An observed association between low selenium status and an increased risk of prostate cancer led to studies of selenium supplementation in an effort to mitigate risk. (zrtlab.com)
  • Supplementation with selenium-enriched yeast in the Nutritional Prevention of Cancer (NPC) trial reduced the incidence of prostate cancer by 52-65%, but the Selenium and Vitamin E Cancer Prevention Trial (SELECT) used selenomethionine supplements with or without vitamin E and was discontinued after 5.5 years when no benefit was seen in terms of prostate cancer risk reduction. (zrtlab.com)
  • Remarkably, dietary selenium supplementation elevated facultative incorporation into UCP1, elevated energy expenditure through thermogenic adipose tissue, and protected against obesity. (nih.gov)
  • Brazil nuts are commonly used as a form of selenium supplementation, but it isn't commonly known that the level of selenium in Brazil nuts is highly variable. (zrtlab.com)
  • The supplementation of selenium has also been studiedin the critically ill population. (humannaturellc.com)
  • There is mixed evidence as to whether supplementing with selenium can help reduce the risk of cancer: It may only help those deficient in selenium, while it may be potentially harmful for others (see What It Does ). (consumerlab.com)
  • Eating foods grown in selenium-deficient soils, or having a prior infection by a selenium-encoding pathogen are factors which promote susceptibility to HIV infection and ultimately AIDS. (life-enthusiast.com)
  • The genetic code of HIV includes a viral requirement for selenium, therefore HIV generally appears to restrict infection to individuals who are deficient in this trace element. (life-enthusiast.com)
  • This is either because of a diet deficient in selenium, or prior infection by other selenium-encoding pathogens. (life-enthusiast.com)
  • In one study, mice fed on a selenium deficient diet developed hyperinsulinaemia and had decreased insulin sensitivity. (interclinical.com.au)
  • People deficient in selenium have an increased risk of cancer. (tahomaclinicblog.com)
  • In other words, when you're deficient in selenium (which most people are)-you may have a slowed metabolism. (myersdetox.com)
  • Because of its chemical similarity to sulfur and stronger nucleophilicity and acidity, selenium is an extremely efficient catalyst of reactions between sulfur and oxygen. (usda.gov)
  • Cellular selenocysteines, where sulfur is replaced with selenium, exhibit enhanced reactivity with ROS. (nih.gov)
  • A non-metallic, group 16 element, selenium is a member of the oxygen family, which includes sulfur and tellurium. (globalhealing.com)
  • In this manuscript, we evaluated thirty eight accessions of broccoli germplasm for their capacity to accumulate selenium and for their responses to selenate treatment in terms of organic selenium species production, essential micronutrient accumulation, glucosinolate synthesis, total antioxidant content, and selenium/sulfur gene expression. (usda.gov)
  • The objective of this study was to determine the distribution of total selenium (Se) and of the proportion of total Se comprised as the selenized amino acids selenomethionine (SeMet) and selenocysteine (SeCys) within the post mortem tissues of lambs that were fed high dose selenized enriched yeast (SY), derived from a specific strain of Saccharomyces cerevisae CNCM (Collection Nationale de Culture de Micro-organism) I-3060. (reading.ac.uk)
  • Selenium is differentially distributed in the body, with some tissues, such as the brain and the testes, acquiring a higher percentage of the total selenium content than others, particularly in times of selenium deficiency. (interclinical.com.au)
  • Hydride generation techniques that rely on selenium to be in an inorganic form would have underestimated total selenium in extracts given that these species have different reactivities with borohydride. (edu.au)
  • Methylselenocysteine (also known as Se-methyl-selenocysteine) and its derivative gamma-glutamyl Se-methylselenocysteine are metabolic products of selenocysteine that are the predominant form of selenium in plants of the allium (onions, garlic) and brassica (cruciferous vegetables, e.g., broccoli, cabbage) families. (zrtlab.com)
  • Selenate is the predominant form of selenium in shellfish and vegetables (other than the allium and brassica families) grown in seleniferous soil. (zrtlab.com)
  • Our results provide new information for the effects of selenate treatment on selenium accumulation in broccoli accessions and on plant nutrient synthesis in general. (usda.gov)
  • Se-methyl-L-selenocysteine ​​is a bioavailable form of selenium. (vitaminer.nu)
  • Animals fed a highly bioavailable source of organic selenium are able to maintain their antioxidant status during challenging situations, supporting their resistance to stress (e.g. during period of increased stress such as heat stress, weaning, transportation, etc. (lallemandanimalnutrition.com)
  • Selenocysteine was the predominant selenized amino acid in glandular tissues, such the liver and kidney. (reading.ac.uk)
  • Dive into the research topics of 'Decomposition of three common selenium species found in animal tissues using microwave digestion with nitric acid and ICP-MS'. Together they form a unique fingerprint. (edu.au)
  • Decomposition of three common selenium species found in animal tissues using microwave digestion with nitric acid and ICP-MS . Microchemical Journal , 126 , 92-95. (edu.au)
  • Cypress Systems supplies SelenoExcell, a yeast-based ingredient, while Sabinsa supplies several selenium ingredients including its SelenoSelect branded form of L-selenomethionine. (nutraingredients.com)
  • "In principle and in reality the yeast functions just like a plant taking selenium out of the soil and storing it in its protein structure," ​ Willis said. (nutraingredients.com)
  • Only trace amounts of selenium are needed and deficiency is rare in the U.S. and Canada due to selenium occurring in foods such as grains and meats, but is more prevalent in countries with low levels of selenium in soil (see From Food ). (consumerlab.com)
  • Selenium deficiency may induce exudative diathesis (ED) in broiler chick, and this damage is closely related to oxidative damage. (oncotarget.com)
  • The aim of the present study was to clarify the LncRNA expression profile in broiler veins and filter and verify the LncRNAs related to oxidative damage of ED. This study established an ED model induced by selenium deficiency and presented the expression and characterization of LncRNAs in normal and ED samples. (oncotarget.com)
  • Of all the elements, selenium has one of the narrowest ranges between dietary deficiency and toxic levels. (interclinical.com.au)
  • Even a moderate deficiency of selenium can have long term consequences since it may increase the risk of diseases associated with aging. (interclinical.com.au)
  • Failure to prevent oxidative breakdown can explain the oxidative damage to haemoglobin and possibly the wide variety of degenerative conditions that occur in selenium deficiency. (interclinical.com.au)
  • [ 3 ] Nuts , seeds, beans, and some vegetables are rich in selenium, but you can also take this essential micronutrient supplementally when your diet falls short. (globalhealing.com)
  • The daily requirement for selenium is just 55 micrograms (mcg) for most adults and a bit higher for women who are pregnant or lactating. (consumerlab.com)
  • vitamin E is included in some supplements because its antioxidant effects are synergistic with selenium. (zrtlab.com)
  • Selenium and vitamin E both play important roles in the detoxification of peroxides and free radicals. (humannaturellc.com)
  • The market started to loose steam, sources say, following of the unblinding of the SELECT cancer trial, which concluded that it could find no benefit in prostate cancer risk reduction with selenium in concert with vitamin E. That trial, which used the L-selenomethionine ingredient, did not find a cancer-reducing benefit for that form of selenium or of the form of vitamin E used it the trial. (nutraingredients.com)
  • "The halting of the SELECT trial (use of L-selenomethionine and Vitamin E for Prostate cancer) midway through due to lack of benefit must have been responsible for dampened growth even though it is still a matter of polemics which one of the constituents, Selenium or Vitamin E, that did not yield the desired benefit," ​ Nagabhushanam Kalyanam, Sabinsa's president of reseach and development told NutraIngredients-USA. (nutraingredients.com)
  • This week I'll be addressing three more nutrients that are beneficial for skin health: vitamin E, pantothenic acid (vitamin B5), and selenium. (chriskresser.com)
  • 3 ) Vitamin E may also play a synergistic role with selenium in improving glutathione levels in the body, further increasing antioxidant activity. (chriskresser.com)
  • vitamin A is very toxic, selenium is a heavy metal, iodine must not be taken with thyroid problems, salt is very dangerous to good health, there is nothing worse than eating cholesterol , that supplementing with vitamin E and with antioxidants increases mortality, and that menopausal women must all take 1.2g of calcium carbonate daily. (funmeddev.com)
  • Patients with chronic inflammation typically have lower selenium status than those who are healthy. (interclinical.com.au)
  • [ 12 ] People with asthma may have lower selenium levels in their blood, though it is not clear if this is a cause of asthma or an effect of the condition. (globalhealing.com)
  • In enzymology, a L-seryl-tRNASec selenium transferase (EC 2.9.1.1) is an enzyme that catalyzes the chemical reaction L-seryl-tRNASec + selenophosphate ⇌ {\displaystyle \rightleftharpoons } L-selenocysteinyl-tRNASec + phosphate Thus, the two substrates of this enzyme are L-seryl-tRNASec and selenophosphate, whereas its two products are L-selenocysteinyl-tRNASec and phosphate. (wikipedia.org)
  • This enzyme belongs to the family of transferases, specifically those transferring selenium-containing groups selenotransferases. (wikipedia.org)
  • The systematic name of this enzyme class is selenophosphate:L-seryl-tRNASec selenium transferase. (wikipedia.org)
  • The SEPSECS gene encodes O-phosphoseryl-tRNA:selenocysteinyl-tRNA synthase (SepSecS), the final enzyme that catalyzes the Sep-tRNA to Sec-tRNA conversion, which is used in the synthesis of selenocysteine ( 1 , 2 ). (frontiersin.org)
  • An additional action of selenium is its integral part of the enzyme type 1 iodothyronine deiodinase, which catalyzes the deiodination of the iodothyronines. (humannaturellc.com)
  • Another selenium-containing enzyme called iodothyronine deiodinase converts the thyroid hormone thyroxine (T4) to the more actively used triiodothyronine (T3) by removing one iodine ion. (globalhealing.com)
  • We need selenocysteine as it plays a critical role in the structure of the active site of the enzyme, which means that portion of the protein involved in the biochemical reaction that the enzyme requires to be effective. (funmeddev.com)
  • [ 8 ] On the skin, selenium - usually in the form of selenium sulfide (SeS 2 ) - resists the growth of harmful fungus species. (globalhealing.com)
  • However, only few studies have investigated the genotypic variation of crop species in accumulating selenium and its effect on other metabolite accumulation. (usda.gov)
  • Selenium content depends on the region in which the tree is grown, the pH of the soil, and can vary from nut to nut in a single batch or between trees [2] . (zrtlab.com)
  • Selenium in any form, whether from food or supplements, organic or inorganic, is utilized by the body for selenoprotein synthesis after first being metabolized to hydrogen selenide, the cellular storage form of selenium. (zrtlab.com)
  • Among supplements which passed testing, we identified our Top Pick , providing a highly absorbable form of selenium at low cost. (consumerlab.com)
  • Make sure you're choosing the best selenium supplements approved in our tests! (consumerlab.com)
  • You will get results for 10 selenium supplements selected by ConsumerLab.com and two others that passed testing in the voluntary Quality Certification Program. (consumerlab.com)
  • Get the details in the Concerns and Cautions section of our Selenium Supplements Review. (consumerlab.com)
  • Because other foods, beverages, and supplements provide selenium on top of Brazil nuts, it is best to measure total daily selenium intake. (zrtlab.com)
  • Scientific studies found that when asthmatics took selenium supplements, they experienced fewer asthma symptoms than those taking a placebo. (globalhealing.com)
  • Brazil nuts are well known for their high concentration of selenium. (zrtlab.com)
  • In a single study, Brazil nut selenium concentration ranged from 0.03 to 512 µg/g, a substantial difference [4] . (zrtlab.com)
  • At the highest concentration, a single serving of Brazil nuts (around 6 whole nuts) could result in a selenium intake of 14515 µg, much higher than the recommended daily amount (RDA) of 55 µg [5] . (zrtlab.com)
  • As trimethylselenonium ion is not degraded, this may lead to the formation of volatile dimethyselenide or dimethyldiselenide during hydride generation and an overestimation of selenium concentration. (edu.au)
  • It is even more abundant in Brazil, hence the huge selenium concentration found in Brazil nuts. (funmeddev.com)
  • The present study was conducted to investigate the effects of 5 and 10 mg L -1 concentrations of selenium nanoparticles (SeNPs) and 50 mg L -1 ancymidol (ANC) on physiological and biochemical characteristics of S. rebaudiana colonized by the root endophytic fungus Piriformospora indica at vegetative and initial flowering stages. (ac.ir)
  • While o ptimal selenium levels are imperative for proper thyroid function , abnormally high selenium intake can be toxic - causing gastrointestinal disturbances, changes in nails and hair, weakness, convulsions and decreased cognitive function. (zrtlab.com)
  • selenium decreases levels of eltrombopag by inhibition of GI absorption. (medscape.com)
  • Higher levels of selenium intake in the range of 200-300 µg/day are believed to be effective in the prevention of certain types of cancer such as lung, colon and prostate [7] [8] . (zrtlab.com)
  • Brazil nuts, therefore, increase plasma selenium levels and antioxidant production in this human population. (zrtlab.com)
  • If you are planning on supplementing with Brazil nuts, it is highly recommended that you test your urine selenium levels to determine if safe levels of selenium are being consumed. (zrtlab.com)
  • Serum selenium levels of 75-85 µg/L were associated with the lowest prevalence of ARC. (aaem.pl)
  • Due to a confirmed association between serum selenium levels and age-related cataract, low serum selenium levels may constitute a potential risk factor of age-related cataract. (aaem.pl)
  • It has been noted that in critical illness, selenium levels decline. (humannaturellc.com)
  • In a recent study, selenium was measured in patients suffering from IBD revealing that levels were significantly lower than in controls. (interclinical.com.au)
  • [ 12 ] Either way, making you have adequate selenium levels can support lung health . (globalhealing.com)
  • This is the ONLY form of selenium that raises levels of selenium quickly. (myersdetox.com)
  • Levels of several health-promoting minerals, including selenium, have been shown to be high among some of the world's longest-living people. (healthlandcenter.com)
  • Exploiting genotypic variation is likely to be effective in providing information for breeding varieties with high levels of selenium along with other health beneficial compounds. (usda.gov)
  • Transcriptional regulation of adenosine 5'-phosphosulfate sulfurylase and selenocysteine Se-methyltransferase gene expression might contribute to the different levels of Se accumulation in broccoli. (usda.gov)
  • It is the predominant form of selenium in Brazil nuts, cereals, legumes, and fish. (zrtlab.com)
  • The discovery of broad diversity in broccoli germplasm provides the opportunity to breed broccoli cultivars that simultaneously accumulate selenium and other health benefit compounds. (usda.gov)
  • Selenium helps convert T4 to T3 by removing one iodine molecule through the selenium-containing iodothyronine deiodinase molecule. (globalhealing.com)
  • Although an essential nutrient, very high intake of selenium can cause hair to fall out, and a recent case report highlighted the need to consider how much selenium one gets from foods before supplementing with selenium. (consumerlab.com)
  • Foods fortified with selenium have been advocated as functional foods. (usda.gov)
  • Biotics Research's Aqueous Selenium is a source of supplemental selenium in a liquid form, with each drop supplying 95 mcg of elemental selenium, an essential trace mineral providing anti-oxidant activity. (humannaturellc.com)
  • Even though the L-selenomethionine form of selenium took a blow with the SELECT trial news, newer research has been more promising, Sabinsa's Kalyanam said. (nutraingredients.com)
  • Fortunately, this form of selenium helps to detox mercury found in the thyroid and repairs the DNA damage metal toxicity creates. (myersdetox.com)
  • Selenium (Se) is a trace mineral that supports your body in many ways. (globalhealing.com)
  • Selenium is critical for the endocrine system, especially the thyroid gland , which affects metabolism, as well as heart, brain, and muscle function. (globalhealing.com)
  • Selenium plays an important role in metabolism because it is part of an amino acid called selenocysteine. (funmeddev.com)
  • The Institute of Medicine's Food and Nutrition Board set a recommended dietary allowance of 55 µg selenium/day for adults with a tolerable upper intake level of 400 µg selenium/day [6] . (zrtlab.com)
  • Due to the large variation of selenium in Brazil nuts, it is difficult to determine if Brazil nuts are providing inadequate, adequate, or excessive intake. (zrtlab.com)
  • Selenium is important for proper immune and thyroid function. (consumerlab.com)
  • Additionally, as selenium is a semiconductor and photoelectrically active, it has more advanced applications such as xerography and solar cell assembly. (sigmaaldrich.com)
  • In addition to being an essential nutrient in the body, selenium is a semiconductor, which means it can transfer electrical energy, but not quite as well as conductors, like metals. (globalhealing.com)
  • A balance of nutrients is required by our bodies to maintain good health, and selenium (Se) is an important one that often gets overlooked. (zrtlab.com)
  • Karaküçük S, Ertugrul Mirza G, Faruk Ekinciler O, Saraymen R, Karaküçük I, Ustdal M. Selenium concentrations in serum, lens and aqueous humour of patients with senile cataract. (aaem.pl)
  • Selenium is a naturally occurring metalloid element that is essential to both humans and animal in trace amounts. (interclinical.com.au)
  • I am, unfortunately, of an age to remember selenium rectifier stacks and even copper oxide rectifiers and have often heard of the stench when a selenium rectifier fails but it is something I have never experienced. (thenakedscientists.com)
  • Why Are Brazil Nuts High in Selenium? (zrtlab.com)
  • The amount of selenium in Brazil nuts is highly variable. (zrtlab.com)
  • According to the USDA, there is 96 µg of selenium per Brazil nut and 544 µg of selenium per serving [3] . (zrtlab.com)
  • In a New Zealand study, 59 adults were separated into three groups, receiving either Brazil nuts (2 nuts a day or an estimated 100 µg selenium/day), selenomethionine tablets (100 µg selenium/day), or placebo tablets (no selenium) for 3 months [12] . (zrtlab.com)
  • How Much Selenium Am I Getting from Brazil Nuts? (zrtlab.com)
  • Measuring the selenium content of Brazil nuts is complex and requires extensive digestion in the lab and time-consuming analytical procedures. (zrtlab.com)
  • This is one reason why selenium sulfide is an active ingredient in certain dandruff and anti-itch shampoos, conditioners, lotions, and creams. (globalhealing.com)