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Silver SulfadiazineSulfadiazineSilverOcclusive DressingsSilver CompoundsAnti-Infective Agents, LocalBurnsSkin CreamOintmentsWound InfectionSilver NitrateAdministration, TopicalChitosanWound HealingSilver StainingBupivacaineAntiprotozoal AgentsDrug CarriersCoccidiostatsPyrimethamineAtovaquoneToxoplasmosis, AnimalPseudomonas aeruginosaToxoplasmaToxoplasmosis, CerebralStaphylococcus aureus
SilvadeneCovered with silver sulfadiazine creamCreamCentral venous caOintmentNitrateSulfonamide antibioticCommercially availableSulfonamidesAntibioticGrape seed exColloidalDressingsBurnsChlorhexidineWound HealingTopicallyIonsPediatricBacterialSlightly solubleTreatmentWoundsAdultInfectionOccurAntimicrobial silverCompoundsAntiseptic and disinfectantConcentrationBroad spectrumPreventionEffectivenessTopical applicationNanoparticlesSulfadiazine'sOrganismsMedicinesAmounts of silverStudiesBody surfFormWater
Silvadene4
  • SILVADENE Cream 1% is a soft, white, water-miscible cream containing the antimicrobial agent silver sulfadiazine in micronized form. (druglib.com)
  • Pediatric patients were randomly assigned to treatment with either Silva- Sorb Gel (Medline Industries, Munedelein, IL) or Silvadene silver sulfadiazine cream (King Pharmaceuticals, Bristol, TN) for up to 21 days or to the point of full reepithelialization of the wound. (gosouthernmd.com)
  • Pilot in vitro studies demonstrated that nystatin combined with Silvadene (silver sulfadiazine 1% [Marion Laboratories, Inc., Kansas City Mo. (utmb.edu)
  • For those who do not have an allergy to sulfa, a silver sulfadiazine cream such as Silvadene can be prescribed, Gladstone says. (usms.org)
Covered with silver sulfadiazine cream1
Cream24
Central venous ca1
  • Background Use of chlorhexidine and silver sulfadiazine-impregnated (CSS) central venous catheters (CVCs) has not been shown to decrease the catheter-related bloodstream infection rate in an ICU. (usuhs.edu)
Ointment3
  • Mother's milk for group 1, ethyl alcohol for group 2, and silver sulfadiazine ointment for group 3 were applied to the umbilical stump three hours after birth and continued every eight hours until two days after umbilical cord separation. (archive.org)
  • All studies except one showed faster wound closure by the application of silver sulfadiazine ointment. (bvsalud.org)
  • Took to the vet and they gave some silver sulfadiazine ointment for daily application and 10 ceftazidime injections to be given every 3 days. (beardeddragon.org)
Nitrate10
Sulfonamide antibiotic2
Commercially available2
  • Catheters impregnated with chlorhexidine-silver sulfadiazine are commercially available. (cdc.gov)
  • Use of chlorhexidine-silver sulfadiazine-impregnated catheters has been associated with serious anaphylactoid reactions in Japan ( 16 ), and these catheters are not commercially available in that country. (cdc.gov)
Sulfonamides1
Antibiotic3
  • Before the overuse of pharmaceutical antibiotics, which resulted in antibiotic-resistant bacteria, silver was used in surgical and burn injury applications during the late 19th and early 20th centuries. (utopiasilver.com)
  • Historically, there's no evidence that bacteria can adapt to silver to develop a resistance to silver's antibiotic properties. (utopiasilver.com)
  • The inside scoop on colloidal silver -- the world's most powerful natural antibiotic! (blogspot.com)
Grape seed ex1
  • In this study, a double-layered nanofibrous mat containing grape seed extract (GSE) and silver sulfadiazine (SSD) was fabricated. (lu.se)
Colloidal5
  • But antimicrobial silver has been used successfully for over 2,000 years, and modern-day products like electrically generated colloidal silver have been used successfully against infections and related diseases for over 110 years. (blogspot.com)
  • So the next time someone challenges you over colloidal silver, calling it "quackery" and demanding to know "Where's all of the peer-reviewed clinical studies? (blogspot.com)
  • So, the next time someone challenges you over colloidal silver by saying "Where's all of the peer-reviewed clinical studies? (blogspot.com)
  • And to my knowledge, there's never been a death from oral or topical colloidal silver usage in its entire 110 year history, in spite of the fact that tens of millions of people worldwide now use it. (blogspot.com)
  • The modern versions of colloidal silver (oligodynamic silver) are shown to have little or no toxicity. (blogspot.com)
Dressings4
  • CONCLUSION: Silver mesh dressings is one of the choices for pressure ulcer treatment with good healing rate, minimal care and lower overall cost. (druglib.com)
  • Technologic advances shown to reduce the risk for these infections include a catheter hub containing an iodinated alcohol solution, short-term chlorhexidine-silver sulfadiazine-impregnated catheters, minocycline-rifampin-impregnated catheters, and chlorhexidine-impregnated spong dressings. (cdc.gov)
  • This use of silver in surgical gauze dressings and bandages to dress open wounds and burns was quite successful at preventing bacterial infections that hindered the healing process or created serious complications. (utopiasilver.com)
  • Historically, various silver salts were used to soak gauze dressings for burns. (utopiasilver.com)
Burns8
  • Silver sulfadiazine is an antimicrobial agent that is FDA approved for the treatment of wound sepsis in patients with second and third degree burns . (wikidoc.org)
  • A prospective, randomized trial of acticoat versus silver sulfadiazine in the treatment of partial-thickness burns: Which method is less painful? (arizona.edu)
  • Patients with partial-thickness burns that required only topical wound care were assigned randomly to treatment with Acticoat® (Smith and Nephew USA, Largo, FL) or silver sulfadiazine (AgSD). (arizona.edu)
  • Dive into the research topics of 'A prospective, randomized trial of acticoat versus silver sulfadiazine in the treatment of partial-thickness burns: Which method is less painful? (arizona.edu)
  • In children with 13 % body surface area burns, the urinary sulfadiazine concentration was 31.8 mg/L. (bcmedequip.com)
  • Leukopenia has been reported following the use of silver sulfadiazine, especially patients with large area burns. (bcmedequip.com)
  • Oral hypoglycemic agents and Phenytoin In patients with large area burns where serum sulfadiazine levels may approach therapeutic levels, the action of oral hypoglycemic agents and Phenytoin may be potentiated and it is recommended that blood levels be monitored. (bcmedequip.com)
  • 3. Barret JP, Dziewulski P, Ramzy PI, Wolf SE, Desai MH, Herndon DN Biobrane versus 1% silver sulfadiazine in second-degree pediatric burns. (webmedcentral.com)
Chlorhexidine6
  • 11 days ( 6 - 14 ), the incidence of catheter-related bloodstream infections was reduced by using chlorhexidine-silver sulfadiazine-impregnated catheters (RR 0.4, confidence interval [CI] 0.2-0.8) ( 4 ). (cdc.gov)
  • Published studies of chlorhexidine-silver sulfadiazine-impregnated catheters were performed with catheters impregnated extraluminally. (cdc.gov)
  • However, the U.S. Food and Drug Administration (FDA) has recently approved the use of catheters impregnated intraluminally with chlorhexidine, in addition to chlorhexidine-silver sulfadiazine extraluminal impregnation. (cdc.gov)
  • However, in vitro studies of Pseudomonas stutzeri exposed to slowly increasing concentrations of chlorhexidine, in the absence of silver sulfadiazine, have demonstrated the development of resistance to chlorhexidine and associated resistance to several classes of therapeutic antimicrobial agents ( 17 ). (cdc.gov)
  • In a prospective, randomized clinical trial of catheters in place for an average of 6 to 7 days, minocycline-rifampin-impregnated catheters were associated with lower incidence of infection than chlorhexidine-silver sulfadiazine-impregnated catheters (RR 0.1, CI 0-0.6) ( 18 ). (cdc.gov)
  • The active ingredients of the minocycline-rifampin-impregnated catheters were on the extraluminal and intraluminal surfaces of the device, whereas the active ingredients of the chlorhexidine-silver sulfadiazine-impregnated catheters were only on the extraluminal surface. (cdc.gov)
Wound Healing3
  • Drugs releasing silver in ionic forms are known to get neutralized in biological fluids and upon long-term use may cause cosmetic abnormality, e.g., argyria and delayed wound healing. (nih.gov)
  • Conclusions and Clinical Relevance- In conclusion, L. plantarum gel therapy improved wound healing and resulted in better outcomes after severe burn injury in diabetic rats compared with the silver sulfadiazine treatment. (ivsajournals.com)
  • 11 Silver sulfadiazine (SSD) is the gold standard therapy in topical burn treatment, 12 but due to its adverse effects, bacterial resistance and its ineffectiveness on the healing process, scientists are still searching for alternative compounds that can enhance the wound healing process. (ivsajournals.com)
Topically2
  • Sensitization to topically applied silver sulfadiazine is rarely predicted or proven by patch testing. (bcmedequip.com)
  • Although replaced by pharmaceutical antibiotics during WW II until the 1960s, renewed interest in silver for topically treating burn treatments has since surfaced. (utopiasilver.com)
Ions3
  • Silver sulfadiazine works by releasing silver ions, which have antibacterial properties and can kill a wide range of bacteria . (differencebetween.io)
  • Newer topical treatments such as SilvaSorb Gel (Medline Industries) have been developed to address the potential side effects of SSD, while maintaining rapid healing, increasing ease in application, ability to reduce bioburden, and improving patient comfort.3 SilvaSorb Gel is an amorphous, biocompatible hydrogel with a unique Micro- Lattice structure in which the scaffolding stabilizes the silver ions. (gosouthernmd.com)
  • Nanosilver particles time-release silver ions over a longer period, increasing the wound surface area in contact with the silver and the duration of that contact. (utopiasilver.com)
Pediatric1
Bacterial2
  • Silver Sulfadiazine is a topical antibacterial medication that is commonly used to prevent and treat bacterial infections in burn wounds. (differencebetween.io)
  • The National Institutes of Health study referenced above states that silver has a 6,000-year history as a bacterial disinfectant. (utopiasilver.com)
Slightly soluble1
  • Silver sulfadiazine is a light-stable white powder, very slightly soluble in water and most organic solvents, but readily soluble in nitric acid and concentrated ammonia solutions. (bcmedequip.com)
Treatment6
  • If allergic reactions attributable to treatment with silver sulfadiazine occur, continuation of therapy must be weighed against the potential hazards of the particular allergic reaction . (wikidoc.org)
  • Newborns from birth were randomized to either: 1) mother's milk group, 2) alcohol group, 3) silver sulfadiazine group, and 4) control (no treatment) group. (archive.org)
  • Patients were allocated into 2 groups receiving treatment with either topical silver sulfadiazine plus EGF or silver zinc sulfadiazine. (druglib.com)
  • Silver is an effective antimicrobial agent with low toxicity, which is important especially in the treatment of burn wounds where transient bacteremia is prevalent and its fast control is essential. (nih.gov)
  • Most recently, silver nanoparticles began taking over topical burn treatment application materials with even greater success and fewer complications. (utopiasilver.com)
  • Silver compounds have been used as medicine since the late 1800's and have been used as a treatment against infections by hundreds of thousands of individuals in the United States. (blogspot.com)
Wounds1
Adult2
Infection4
  • Prevalence of pin-site infection: the comparison between silver sulfadiazine and dry dressing among open tibial fracture patients. (druglib.com)
  • As new devices incorporating silver into their infection-prevention design are surfacing rapidly, an up-to-the-minute tally is nearly impossible. (utopiasilver.com)
  • Whereas … other products have emerged with antibacterial properties, silver remains a reasonable addition to the armamentarium against infection and with relatively few side effects. (utopiasilver.com)
  • There is evidence that silver is a natural critical component of our immune system and that low tissue levels associated with dietary deficiency may result in a relatively weakened immune system, making one more prone to infection. (blogspot.com)
Occur1
  • If you are exposed to a hazardous substance such as silver, several factors will determine whether harmful health effects will occur and what the type and severity of those health effects will be. (cdc.gov)
Antimicrobial silver2
  • Ambrosio AM. Evaluation of an antimicrobial silver foam dressing for use with V.A.C. therapy: Morphological, mechanical, and antimicrobial properties. (utopiasilver.com)
  • The bottom line is that antimicrobial silver has worked wonders against infections and related diseases for thousands of years (see History of the Medical Use of Silver ). (blogspot.com)
Compounds7
  • Silver could be found at hazardous waste sites in the form of these compounds mixed with soil and/or water. (cdc.gov)
  • Therefore, these silver compounds will be the main topic of this profile. (cdc.gov)
  • Throughout the profile, the various silver compounds will at times be referred to simply as silver. (cdc.gov)
  • Photographers use silver compounds to make photographs. (cdc.gov)
  • Rain washes silver compounds out of many soils so that it eventually moves into the groundwater. (cdc.gov)
  • Over time it may change from the form first released, to metallic silver, and then back to the same or other compounds. (cdc.gov)
  • Skin contact and breathing in air containing silver compounds also occurs in the workplace. (cdc.gov)
Antiseptic and disinfectant2
  • The antiseptic and disinfectant power of silver has impacted many areas of mainstream medical instruments and other non-medical commercial applications. (utopiasilver.com)
  • Almost none of these silver antiseptic and disinfectant applications are considered controversial, they're even FDA approved! (utopiasilver.com)
Concentration1
  • The antibacterial spectrum of S-gel was found to be comparable to that of a commercial formulation of silver sulfadiazine, albeit at a 30-fold less silver concentration. (nih.gov)
Broad spectrum1
  • Given its broad spectrum activity, efficacy and lower costs, the search for newer and superior silver based antimicrobial agents is necessary. (nih.gov)
Prevention1
Effectiveness2
  • PURPOSE: This study aimed to evaluate the effectiveness of topical silver sulfadiazine (SSD) in preventing acute radiation dermatitis in women receiving radiotherapy for breast cancer. (druglib.com)
  • But the lack of understanding the science about silver in no way changed the fact of that minerals effectiveness. (utopiasilver.com)
Topical application1
  • The purpose of this study was to compare the effect of topical application of human milk, ethyl alcohol 96%, and silver sulfadiazine on umbilical cord separation time in newborn infants. (archive.org)
Nanoparticles3
  • Among the various options available, silver nanoparticles have been the focus of increasing interest and are being heralded as an excellent candidate for therapeutic purposes. (nih.gov)
  • This report gives an account of our work on development of an antimicrobial gel formulation containing silver nanoparticles (SNP) in the size range of 7-20 nm synthesized by a proprietary biostabilization process. (nih.gov)
  • These results clearly indicate that silver nanoparticles could provide a safer alternative to conventional antimicrobial agents in the form of a topical antimicrobial formulation. (nih.gov)
Sulfadiazine's1
  • The mechanism of silver sulfadiazine's antibacterial action has not been fully elucidated. (bcmedequip.com)
Organisms1
Medicines1
  • Other sources of exposure include the use of silver in medicines, and in activities such as jewelry-making, soldering, and photography. (cdc.gov)
Amounts of silver2
  • Trace amounts of silver are in the bodies of all humans and animals. (blogspot.com)
  • The natural wearing down of silver-bearing rocks and soil by the wind and rain also releases large amounts of silver into the environment. (cdc.gov)
Studies2
  • RESULTS: The review found 100 studies in PubMed, Web of Science and other search engines. (bvsalud.org)
  • Studies observed and cited in this review have also discovered a silver releasing foam agent to be effective at reducing lower leg or venous ulceration and bed sores. (utopiasilver.com)
Body surf1
Form3
  • Silver is rare but occurs naturally in the environment as a soft, "silver" colored metal Because silver is an element, there are no manmade sources of silver People make jewelry, silverware, electronic equipment, and dental fillings with silver in its metallic form. (cdc.gov)
  • Silver is stable and remains in the environment in one form or another until it is taken out again by people. (cdc.gov)
  • Because silver is an element, it does not break down, but it can change its form by combining with other substances. (cdc.gov)
Water3
  • Silver that is released into the environment may be carried long distances in air and water. (cdc.gov)
  • Most people are exposed daily to very low levels of silver mainly in food and drinking water, and less in air. (cdc.gov)
  • The silver in these sources is at least partially due to naturally occurring silver in water and soil. (cdc.gov)