Loading...


  • genes
  • The incidence of schizophrenic children of 2 schizophrenic parents is less than 50% → - This means either several genes are involved or that having a "schizophrenia gene" imparts a susceptibility to develop the disorder, the disease itself being triggered by other factors. (coursehero.com)
  • One hypothesis is that CNV events cause disease by affecting genes with specific brain functions. (plos.org)
  • Accepted 6 July 2011 Large collaborative Genome-wide Association studies of schizophrenia have identified genes and genomic regions that are associated with the disorder at highly stringent levels of statistical significance. (docme.ru)
  • The early studies of Darvasi were aimed to develop experimental and computational strategies for the identification of genes affecting complex traits. (wikipedia.org)
  • More recently, he was part of a large international consortium that discovered over 100 genes affecting schizophrenia (published in Nature 2014). (wikipedia.org)
  • paranoid schizophrenia
  • Joanne Verbanic / Founder of Schizophrenics Anonymous / 1970 diagnosed with paranoid schizophrenia / 1985 with Mental Health Association in Michigan Founded Schizophrenics Anonymous / Motivated to erase stigma / "The stigma is harder to deal with than the illness itself. (wikipedia.org)
  • hypothesis
  • Such timings, coupled with evidence of cerebral asymmetry deficits in schizophrenia, and evidence that asymmetry development and neural tube closure represent concurrent fourth-embryonic-week processes both sensitive to oxidant stress, led us to the hypothesis that pro-oxidant sunlight actions capable of affecting the mother's blood could result in a peri-June peak of inhibition and a peri-December peak of facilitation of both processes. (biomedsearch.com)
  • They claim these results are consistent with the glutamate hypothesis of schizophrenia, which proposes that dysfunction in this neurotransmitter system leads to abnormal neural activity underlying this disorder. (wikipedia.org)
  • Such a disruption would be consistent with the GABA hypothesis of schizophrenia, which states that dysfunctional GABAergic inhibition may disrupt neural activity in subjects with this disorder, and this in turn may lead to visual processing abnormalities. (wikipedia.org)
  • This led to the dopamine hypothesis of schizophrenia. (wikipedia.org)
  • occurs
  • While it is claimed that schizophrenia occurs at similar rates worldwide, its prevalence and incidence varies across the world, within countries, and at the local and neighborhood level. (wikipedia.org)
  • In fact, the first onset of schizophrenia for men occurs around the ages of 20 to 25, while in women the first onset generally occurs between the ages of 25 to 30 years. (wikipedia.org)
  • However, it has also been noted that in women a second peak in schizophrenia occurs at the ages of 40 to 45. (wikipedia.org)
  • It is unclear if the phenomenon called "thought blocking", where a talking person suddenly becomes silent for a few seconds to minutes, occurs in schizophrenia. (wikipedia.org)
  • incidences
  • Mutations of DISC1 ( disrupted in schizophrenia 1 ), a gene involved in regulation of neuronal migration during development, have been found in families w/ high incidences of schizophrenia. (coursehero.com)
  • In longitudinal studies begun in the 1930s and ending in the 1980s, Manfred Bleuler (Eugen's son) found the incidences of catastrophic schizophrenia had declined significantly since his father's study. (wikipedia.org)
  • Transcranial
  • A Review of the Effects of Transcranial Direct Current Stimulation for the Treatment of Hallucinations in Patients With Schizophrenia. (bioportfolio.com)
  • The cortical area MT (medial temporal cortex, also known as V5) plays a significant role in motion processing, and deactivation of this region using Transcranial magnetic stimulation can affect perception of motion. (wikipedia.org)
  • researchers
  • To this end, the researchers examined the data available on almost 2,000 people with schizophrenia , comparing them with data on more than 2,300 healthy controls. (medicalnewstoday.com)
  • A group of researchers from the University of Maryland's School of Medicine discovered a relationship between stress in a man's life and the likelihood of his future children developing schizophrenia or other mental illnesses. (emaxhealth.com)
  • Researchers blinded as to patients' race found that African-American subjects were more than twice as likely (odds ratio 2.7) to be diagnosed with schizophrenia spectrum than white subjects. (psychnews.org)
  • onset
  • Schizophrenia is diagnosed 1.4 times more frequently in males than females, and typically appears earlier in men-the peak ages of onset are 20-28 years for males and 26-32 years for females. (wikipedia.org)
  • However, using broad criteria for diagnosing schizophrenia shows that males have a bimodal age of onset, with peaks at 21.4 years and 39.2 years old, while females have a trimodal age of onset with peaks at 22.4, 36.6, and 61.5 years old. (wikipedia.org)
  • Gender differences have been observed in the age of onset of schizophrenia. (wikipedia.org)
  • Doctors Lindamer, Lohr, Harris, and Jeste conducted a study to determine age of onset of schizophrenia in which they examined gender differences in 194 patients ranging in age from 35 to 97. (wikipedia.org)
  • abnormalities
  • The specificity of many visual processing abnormalities in schizophrenia is still an area of active debate within the scientific community. (wikipedia.org)
  • Subjects with schizophrenia have shown abnormalities in perceptual judgments of motion, speed and direction, with deficits in these judgments generally being reported. (wikipedia.org)
  • NPAS1 and NPAS3-deficient mice display behavioral abnormalities typical to the animal models of schizophrenia. (wikipedia.org)
  • diagnosis
  • By using precise methods in its diagnosis and a large, representative population, schizophrenia seems to occur with relative consistency over time during the last half-century. (wikipedia.org)
  • Shortly before forming SA, Verbanic had publicly disclosed her diagnosis and had discussed her illness on national television programs in an effort to challenge the stigma associated with schizophrenia by educating the public. (wikipedia.org)
  • Humans
  • These results emphasise the importance of getting the majority of your exposure to moderate or higher intensity light during the morning and provide further support that changes to environmental light exposure in humans may affect body weight regulation," says study co-author Ivy N. Cheung. (scmp.com)
  • Disrupted in schizophrenia 1 is a protein that in humans is encoded by the DISC1 gene. (wikipedia.org)
  • Their findings were shown to affect chronic pain in humans as well. (wikipedia.org)
  • loci
  • mRNA INTRODUCTION Genome-wide association studies (GWAS) of schizophrenia have identified a small number of loci at which variants are associated with the disorder at a level considered genome-wide significant (GWS) [Dudbridge and Gusnanto, (docme.ru)
  • found
  • In the largest study of its kind to date, 160 scientists from 27 institutions worldwide set out to examine how schizophrenia affects the brain's white matter, which is the fatty substance found in the deep tissues of the brain. (medicalnewstoday.com)
  • The study found that the brain's entire communication system - and not just isolated areas - seems to be disrupted in schizophrenia. (medicalnewstoday.com)
  • However, two brain areas were found to be affected more than others. (medicalnewstoday.com)
  • The abnormal communication patterns found in schizophrenia present in multiple ways, but the most common are dysfunction in two types of brain chemical systems: glutamate and dopamine. (leafly.com)
  • One meta-analysis reviewed 19 studies published between 1988 and 2013 and found a strong association between vitamin D deficiency and schizophrenia. (greatplainslaboratory.com)
  • One review including a total of 437,710 individuals with schizophrenia found that most individuals were born in January and February. (greatplainslaboratory.com)
  • In a study measuring adults' reactions to stress and how it affects their bodies, they found that adults who fail to maintain positive moods such as cheerfulness or calm when faced with the minor stressors of everyday life appear to have elevated levels of inflammation. (scmp.com)
  • In 2000, the World Health Organization found the prevalence and incidence of schizophrenia to be roughly similar around the world, with age-standardized prevalence per 100,000 ranging from 343 in Africa to 544 in Japan and Oceania for men and from 378 in Africa to 527 in Southeastern Europe for women. (wikipedia.org)
  • The LOD for the chromosome 1 translocation and identification of schizophrenia alone in the Scottish family was found to be 3.6. (wikipedia.org)
  • They also found that estrogen is effective for relieving schizophrenia in both male and female rats. (wikipedia.org)
  • Disruption of NPAS3 was found in one family affected by schizophrenia and NPAS3 gene is thought to be associated with psychiatric illness and learning disability. (wikipedia.org)
  • disorder
  • In the authors' words, schizophrenia may be "a disorder of global brain structural connectivity. (medicalnewstoday.com)
  • We can definitively say for the first time that schizophrenia is a disorder where white matter wiring is frayed throughout the brain. (medicalnewstoday.com)
  • Contrary to popular misunderstanding, schizophrenia is is not the same as multiple personality disorder. (webmd.com)
  • The effect held even after controlling for the presence or absence of serious affective disorder. (psychnews.org)
  • Schizophrenia does not imply a "split personality" or "dissociative identity disorder" - conditions with which it is often confused in public perception. (wikipedia.org)
  • SARDAA promotes recovery for persons with schizophrenia and related disorders and envisions a future in which every person with a schizophrenia-related disorder will have the opportunity to recover and live a life free from stigma and discrimination. (wikipedia.org)
  • one's
  • Not only does this affect one's ability to see or touch the other person that they are communicating with, but is also affects one feeling of psychological closeness that one person has for the other. (wikipedia.org)
  • relatively
  • We conclude that association between schizophrenia and TCF4 is not mediated by a relatively common nonsynonymous variant, or by a variant that alters mRNA expression as measured in adult human brain. (docme.ru)
  • illnesses
  • The organization describes the program's purpose as helping participants to learn about schizophrenia, "restore dignity and sense of purpose," obtain "fellowship, positive support, and companionship," improve their attitudes about their lives and their illnesses, and take "positive steps towards recovery. (wikipedia.org)
  • perception
  • There is evidence that schizophrenia affects perception of contrast and motion, control of eye movements, detection of visual contours, and recognition of faces or facial expressions. (wikipedia.org)
  • Perception of contrast is affected by the temporal frequency and spatial frequency properties of a stimulus, and the sensitivity to contrast in sine wave stimuli is characterized by the Contrast sensitivity function. (wikipedia.org)
  • Inhibition of motion perception by the addition of a surround stimulus has also been examined in schizophrenia, with one group finding evidence both of impaired motion perception and weaker perceptual suppression effects in schizophrenia. (wikipedia.org)
  • However, another recent report has disputed this finding, instead showing evidence consistent with stronger surround influence on motion perception in schizophrenia. (wikipedia.org)
  • Evidence
  • There is some evidence that it affects the variance in IQ test findings among identical twins, that is, monochorionic identical twins display less IQ variance one from another than do dichorionic identical twins. (wikipedia.org)
  • There is weak evidence that monozygotic twins sharing a placenta have a higher concordance rate for schizophrenia than monozygotic twins with separate placentas. (wikipedia.org)
  • conditions
  • The main purpose of OHP research is to understand how working conditions affect worker health, use that knowledge to design interventions to protect and improve worker health, and evaluate the effectiveness of such interventions. (wikipedia.org)
  • site
  • Recently published in the journal Aging, the study led by Kristoffer Valerie, Ph.D., discovered that certain BRCA1 mutations affecting the BRCA1 C-terminal (BRCT) binding site resulted in excessive DNA repair, or hyper-recombination, which may contribute to the development of breast and ovarian cancers. (medicalxpress.com)
  • Only the site where the infection has first come into contact with the skin is affected. (wikipedia.org)
  • blood
  • However, only the association between the insecticide and the standard repellent produced a synergistic effect that inhibited the mosquito from taking its blood feed. (bio-medicine.org)
  • THC is converted rapidly to 11-hydroxy-THC, which is also pharmacologically active, so the drug effect outlasts measurable THC levels in blood. (wikipedia.org)