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Schistosoma mansoniHelminthsSchistosomaSchistosoma haematobiumSchistosomiasis mansoniHelminthiasisAntigens, HelminthSchistosomiasisAntigensHelminthiasis, AnimalAntibodies, HelminthSchistosomiasis japonicaParasite Egg CountBiomphalariaPraziquantelAnthelminticsSchistosomiasis haematobiaHelminth ProteinsTherapy with HelminthsAntigens, BacterialIntestinal Diseases, ParasiticAntigens, NeoplasmAntigens, SurfaceDNA, HelminthTrichurisAncylostomatoideaAntigens, ViralOxamniquineSnailsLiver Diseases, ParasiticHost-Parasite InteractionsBulinusFecesGranulomaAntigens, ProtozoanOvumNematospiroides dubiusNematode InfectionsStrongylida InfectionsAntigens, Polyomavirus TransformingGenome, HelminthAlbendazoleHLA AntigensParasitologyCercariaAntigens, CDCestodaAntigens, FungalDisease VectorsMice, Inbred BALB CImmunoglobulin GH-2 AntigensLung Diseases, ParasiticAntigens, CD15Fasciola hepaticaMolecular Sequence DataTh2 CellsEnzyme-Linked Immunosorbent AssayProtozoan InfectionsAntibodies, MonoclonalCarcinoembryonic AntigenFilarioideaCote d'IvoireAntigens, Viral, TumorCross ReactionsEpitopesEchinostomaTrematodaCestode InfectionsVaccinesHLA-DR AntigensReceptors, Antigen, T-CellImmunoglobulin ET-LymphocytesEgyptAntiplatyhelmintic AgentsPrevalenceHistocompatibility AntigensAmino Acid SequenceNecator americanusProliferating Cell Nuclear AntigenMice, Inbred C57BLHistocompatibility Antigens Class IIPhilippinesProstate-Specific AntigenLymphocyte ActivationO AntigensNippostrongylusReceptors, Antigen, B-CellParasitic DiseasesFilariasisImmunizationLife Cycle StagesNeuroschistosomiasisEndemic DiseasesBrazilCytokinesBuffaloesAntigens, Tumor-Associated, CarbohydrateSpleen
InfectionSoil-transmitted helminthsHaematobiumSchistosomiasisParasiticInfectionsCathodic antigenParasitesMekongiAntibodiesJaponicumStrongyloidesDetectionSpeciesSolubleMorbidityHematobiumGranuloma formationVaccineAPCsGenomesCoinfectionTrichurisNecatorAntibodyHypersensitivityResponsesStoolNeglected tropicalInflammationOccurMiceDiagnosis2016InterleukinLife cyclesVivoBiologyCanisOrganImmune systemBrazilDiagnostics
Infection21
  • BACKGROUND: The Kato-Katz (KK) stool smear is the standard test for the diagnosis of Schistosoma mansoni infection, but suffers from low sensitivity when infections intensities are moderate to low. (gwu.edu)
  • Infection status was also determined by the CCA-ICT and infection exposure by antibody ELISA (enzyme-linked immunosorbent assay) to S. mansoni soluble egg antigen (SEA) and soluble (adult) worm antigen preparation (SWAP). (gwu.edu)
  • Maternal decidual CD8+ T cells must integrate the antithetical demands of providing immunity to infection while maintaining immune tolerance for fetal and placental antigens. (bvsalud.org)
  • To understand the basis of this protection, we explored the nature of the immune response in the brown rat to infection by Schistosoma mansoni. (bvsalud.org)
  • Schistosomiasis and infection by soil-transmitted helminths are some of the world's most prevalent neglected tropical diseases. (biomedcentral.com)
  • We built a spatial CRF to estimate infection risks for Ascaris lumbricoides , Trichuris trichiura , hookworms ( Ancylostoma duodenale and Necator americanus ) and Schistosoma mansoni using data from a national survey of Rwandan schoolchildren. (biomedcentral.com)
  • The most common human diseases are caused by soil-transmitted helminths (STHs) causing ascariasis, trichuriasis and hookworm infection (necatoriasis, ancylostomiasis), followed by schistosomiasis and lymphatic filariasis [ 1 ]. (biomedcentral.com)
  • Studies have shown strong associations between schistosoma infection and schistosoma-induced cytokine profiles [ 6 ]. (hindawi.com)
  • 8 ] speculated that IL-10 is important in regulating the human immune response to Schistosoma mansoni infection and that it is the main cytokine that plays part in the control of morbidity. (hindawi.com)
  • Consequently, Th2-mediated responses are thought to be selectively advantageous to the human host in S. mansoni infection and perhaps other helminth infections [ 13 ]. (hindawi.com)
  • The main objective of this study was to assess the prevalence and risk factors associated with Schistosoma (S.) mansoni infection among PSAC from Panamasso village, western Burkina Faso. (researchsquare.com)
  • Urine samples were subjected to a point-of-care circulating cathodic antigen (POC-CCA) cassette test and a centrifugation method to check for both S. mansoni and S. haematobium infection, respectively. (researchsquare.com)
  • Here, we show that retinal dehydrogenases (Raldh), required for the synthesis of RA, are induced during a retinoid-dependent type-2 immune response elicited by Schistosoma mansoni infection, but not during a retinoid-independent anti-viral immune response. (prolekarniky.cz)
  • However, the importance of RA in the generation of T H 2 responses during helminth infection is not well characterized and the population of cells responsible for RA synthesis in this setting has not been identified. (prolekarniky.cz)
  • Before hepatitis B vaccination, refugees and V93s of all ages are tested for hepatitis B virus infection by using hepatitis B surface antigen (HBsAg), where available. (cdc.gov)
  • Loss of MTA1 results in aberrant cytokine expression, and we now speculate that, after helminth parasite infection, aberrant cytokine expression is disadvantageous for the establishment of infection and/or a productive parasitism. (plasignaling.com)
  • Infection with flukes (trematodes) of the genus SCHISTOSOMA. (lookformedical.com)
  • Performance of the point-of-care circulating cathodic antigen (POC-CCA) urine cassette test for follow-up after treatment of S. mansoni infection in Eritrean refugees. (unibas.ch)
  • Comparison of novel and standard diagnostic tools for the detection of Schistosoma mekongi infection in Lao People's Democratic Republic and Cambodia. (unibas.ch)
  • T. gondii infection induces a shift toward a Th1-type immune response while suppressing a helminth-specific Th2 immune response, paving the way for developing novel vaccines and more efficient control strategies. (ac.ir)
  • Immune responses to helminth infection. (ac.ir)
Soil-transmitted helminths2
Haematobium4
Schistosomiasis6
  • As an alternative, the urine-based diagnosis of schistosomiasis mansoni via the circulating cathodic antigen immuno-chromatographic test (CCA-ICT) has been extensively evaluated in Africa with the conclusion that it may replace the KK test in areas where prevalences are moderate or high. (gwu.edu)
  • For schistosomiasis, Th2 responses with the production of IgE antibodies against a restricted range of adult worm antigens are associated with protection against reinfection after chemotherapy. (hindawi.com)
  • Schistosoma mansoni is one of the causative agents of intestinal schistosomiasis and Plasmodium falciparum is the major causative agent of malaria. (scirp.org)
  • Schistosomiasis caused by Schistosoma mansoni. (lookformedical.com)
  • Use of multi antigen vaccine candidates against schistosomiasis old concept and insistent necessity hpv vaccine for cancer cervix Dysbiosis antibiotics cancer genetic environmental, virus papiloma humano genotipo 45 papilloma follicolare tiroide. (stamincasaliga1.ro)
  • Papillary thyroid cancer treatment algorithm kako se otkriti paraziti u schistosomiasis vaccine development, cancer antigen benign colorectal cancer under Snail Fever, Possible New Treatments aggressive cancer prostate Cancer utero schistosomiasis vaccine development sintomas hpv warts reddit, virus papiloma en boca association between human papillomavirus and prostate cancer a meta-analysis. (stamincasaliga1.ro)
Parasitic6
  • More than half of the world's population is at risk of infections through parasitic worms (helminths). (swisstph.ch)
  • In the developing world, over 207 million people are infected with parasitic Schistosoma worms. (cdc.gov)
  • IL-4 and immuno-modulation are hallmarks of parasitic infections, my laboratory broadly focuses on using the helminth parasite Schistosoma mansoni as a tool to understand both, the consequences of IL-4 induced immuno-modulation, and the complex interplay between B, T, and stromal cells necessary to develop an optimal T and B cell memory response. (utah.edu)
  • This review summarises the historical advances in functional genomics in parasitic helminths and highlights pending limitations that will need to be overcome to deploy transgenesis tools. (biomedcentral.com)
  • Schistosoma mansoni and Plasmodium falciparum are co-endemic in Uganda and are the leading parasitic causes of public health problems across sub-Saharan Africa. (scirp.org)
  • Parasitic infections due to protozoa and helminths are responsible for substantial morbidity and mortality worldwide. (merckmanuals.com)
Infections11
  • Many people suffer from multiple species of helminth infections. (swisstph.ch)
  • Acknowledging this contribution in 2014, the World Health Organization (WHO) has nominated Swiss TPH as a WHO Collaborating Centre for Epidemiology and Control of Helminth Infections. (swisstph.ch)
  • Multivariate approaches can be instrumental in the global effort to reduce and eventually eliminate neglected helminth infections in developing countries. (biomedcentral.com)
  • Helminth infections impact the health of hundreds of millions of persons globally and also cause important economic losses in livestock farming. (biomedcentral.com)
  • Globally, helminth infections have been estimated to have resulted in approximately 14 million disability-adjusted life years (DALYs) lost yearly during the last decade [ 1 ]. (biomedcentral.com)
  • Despite all attempts, most vaccines against helminth infections remain trapped in early-stage development or are undergoing pre-clinical evaluation, and no human anti-helminth vaccine has yet been approved for widespread use [ 7 , 10 ]. (biomedcentral.com)
  • Notwithstanding, the marked complexity as well as the limitations in availability and access to samples still represent a great handicap for basic research on helminth infections [ 11 ]. (biomedcentral.com)
  • Helminth infections are typically linked with Th2-dependent responses leading to IgE production and eosinophilia. (hindawi.com)
  • Specifically, AAMφ are an inducible source of RA synthesis during helminth infections and T H 2 responses that may be important in regulating immune responses. (prolekarniky.cz)
  • 2009) Low Sensitivity of the Formol-Ethyl Acetate Sedimentation Concentration Technique in Low-Intensity Schistosoma japonicum Infections. (moam.info)
  • The sedimentation technique processes a relatively large stool sample and is thus theoretically more sensitive than alternative techniques in low-intensity helminth infections. (moam.info)
Cathodic antigen3
  • point-of-care circulating cathodic antigen (POC-CCA) urine cassette test for S. mansoni, etc. (swisstph.ch)
  • Kato Katz thick smears and circulating cathodic antigen tests were performed for S. mansoni screening, whereas thick and thin blood smear techniques were performed for P. falciparum screening. (scirp.org)
  • Although a positive S. mansoni point-of-care circulating cathodic antigen (POC-CCA) test result was obtained from 8.6% (95% CI 5.7-12.8%) of the samples, no intermediate host snails of S. mansoni were found, and the relevance of S. mansoni remains uncertain. (biomedcentral.com)
Parasites4
Mekongi1
Antibodies2
Japonicum6
  • Characterization of Schistosoma japonicum egg antigens / by Wilfred Uy Tiu. (who.int)
  • Schistosoma japonicum--pathogenicity. (who.int)
  • of Sj23LHDGST bivalent antigen from Schistosoma japonicum and. (moam.info)
  • Nov 17, 2012 - Molecular cloning and characterization of Schistosoma japonicum aldose reductase. (moam.info)
  • study of the hatching biology of Schistosoma japonicum. (moam.info)
  • Abstract Background: The endemic countries are in a diagnostic dilemma concerning Schistosoma japonicum with increasing difficulties in diagnosing the infected individuals. (moam.info)
Strongyloides1
  • High antifilarial IgG titers to microfilariae often result in cross reactivity with other nonfilarial helminth antigens, such as Strongyloides and Schistosoma antigens, as demonstrated in reported cases. (wikipedia.org)
Detection3
  • Schistosoma mansoni is one of the most widespread species, and its routine diag- nosis is based on microscopic detection of parasite eggs in stool samples. (cdc.gov)
  • Testing may be performed by stool O&P examination, although stool antigen detection testing is easier to perform and has comparable sensitivity. (refugeehealthta.org)
  • Evaluation of the diagnostic performance of recombinant antigen B1 for detection of cystic echinococcosis using lateral flow dipstick test. (unibas.ch)
Species1
  • This could be indicative of host-specific evolution of antigens in different species of schistosomes, a factor that should be considered carefully when developing vaccine targets. (sruc.ac.uk)
Soluble1
  • Immune responses to products secreted by the eggs (soluble egg antigens, SEA) result in the formation of granulomas that are composed of macrophages, eosinophils, lymphocytes, and fibroblasts [ 17 ]. (hindawi.com)
Morbidity2
  • The pharmaceutical industry, the World Health Organization (WHO) and the scientific community all recognise reduction of helminth-related morbidity as a global priority and work to identify regions in need of anthelmintics [ 14 ]. (biomedcentral.com)
  • Individuals in whom Th2 responses against egg antigens predominate show less severe egg-associated morbidity than those where Th1 responses predominate. (hindawi.com)
Hematobium1
  • Schistosoma hematobium associated with squamous cell carcinoma of the urinary bladder and the liver flukes Opisthorchis and Chlonorchis associated with cholangiocarcinoma of the bile duct. (eg.net)
Granuloma formation1
  • Embolization of microfilariae or eggs, which degenerate and expose antigens to the local immune system, leads to granuloma formation. (medscape.com)
Vaccine1
APCs2
  • Ligation of MHC-I/peptide complexes presented by antigen-presenting cells (APCs), triggers the recruitment of lymphocyte-specific protein tyrosine kinase (Lck), which leads to lymphokine production, motility and cytotoxic T lymphocyte (CTL) activation. (thermofisher.com)
  • Homeostatic Raldh expression in immune cells is well described in gut-associated lymphoid tissues (GALT) [7] - [11] , where RA synthesis by antigen presenting cells (APCs) contributes to the recruitment and function of local lymphocyte populations. (prolekarniky.cz)
Genomes1
  • The rapid development of new sequencing platforms, such as Roche 454 sequencing system (Roche Diagnostics) and Illumina sequencing platforms (Illumina, Inc.) offered 1000-fold increase in throughput over the Sanger sequencing technology and supported the progressive publication of more helminth genomes [ 11 ]. (biomedcentral.com)
Coinfection1
  • Coinfection in mice with Schistosoma manson i reduces mortality induced by Toxocari canis and prevents Plasmodium -associated brain lesions and, on the contrary, promotes replication of Leishmania and enhances susceptibility to tuberculosis. (histoweb.com)
Trichuris1
Necator1
  • For example, a phase 1 clinical trial using ultraviolet-attenuated Necator americanus larvae elicited an antigen-specific humoral and cellular immune response that resulted in reduced larval output in vaccinated participants [ 8 ]. (biomedcentral.com)
Antibody4
  • Secretory / excretory antigens stimulate production of antibody from B lymphocytes and eosinophil stimulation promoter from T lymphocytes. (slideshare.net)
  • Antibody opsonises helminth larva, eosinophils degranulate around it and kill it. (slideshare.net)
  • Trypanosoma antigens stimulate antibody production. (slideshare.net)
  • First, oral tolerance is never absolute (complete), that is, parenteral immunization of tolerant animals with the tolerated antigen may induce antibody formation at levels inversely proportional to the ingested (tolerizing) dose of the antigen, but, this antibody formation can no longer be boostered by further parenteral immunizations [ 6 ]. (hindawi.com)
Hypersensitivity3
  • Type 4 hypersensitivity: antigen stimulates T lymphocytes to produce interferon gamma. (slideshare.net)
  • The pathogenesis of Loeffler syndrome is unknown but presumably reflects a hypersensitivity response to an ingested or inhaled antigen from food, medication, or an infectious agent. (medscape.com)
  • Furthermore, parenteral re-exposure to a tolerated antigen has systemic effects on the migration of leucocytes and bone-marrow eosinopoiesis [ 11 ], blocks delayed-type hypersensitivity (DTH) reactions triggered by keyhole limpet haemocyanin (KLH) and paw oedema triggered by carragenan [ 12 ]. (hindawi.com)
Responses3
  • The Jensen laboratory is focused on antigen processing and presentation and the role of classical and nonclassical histocompatibility (MHC) molecules in regulating immune responses. (utah.edu)
  • Thus, the local immunological milieu in tissue compartments forms the nature and magnitude of the host responses, i.e., frequencies of regulatory T cells (Tregs) vs. T-helper 17 (Th17) cells, amount of pro-inflammatory cytokines vs. anti-inflammatory cytokines, extent of neutrophilia and antigen-presenting-cell (APC) activation, among others. (frontiersin.org)
  • Second, parenteral reexposure to a tolerated antigen blocks the initiation of immune responses to a second unrelated antigen-the effect we have named "indirect effect of oral tolerance" [ 7 , 8 ] and is also known as "bystander suppression" [ 3 , 9 ]. (hindawi.com)
Stool2
  • Is PCR the Next Reference Standard for the Diagnosis of Schistosoma in Stool? (cdc.gov)
  • Therefore, it is recommended that confirmation testing with E. histolytica stool antigen testing be performed prior to treatment when E. histolytica cysts are reported. (refugeehealthta.org)
Neglected tropical1
  • Moreover, it can be comple- mented with other (multiplex real-time) PCRs to detect a wider range of helminths and thus enhance effectiveness of current integrated control and elimination strategies for neglected tropical diseases. (cdc.gov)
Inflammation2
  • His Interleukin 4 research is multidisciplinary, relying on both Inflammation and Antigen-presenting cell. (research.com)
  • All of his Immunology and Antigen, T cell, Interleukin 4, Inflammation and Heligmosomoides polygyrus investigations are sub-components of the entire Immunology study. (research.com)
Occur1
  • The inhibitory indirect effects of oral tolerance does not require the simultaneous injection of the tolerated protein and the second antigen: it is still present 72 h after an injection of the tolerated antigen, but does not occur if the tolerated protein is injected after the second antigen [ 10 ]. (hindawi.com)
Mice2
  • Herein, we show that i.p. injection of OVA + Al(OH) 3 minutes before i.v. injection of Schistosoma mansoni eggs into OVA tolerant mice blocked the increase of pulmonary granulomas. (hindawi.com)
  • Schistosoma mansoni eggs injected into the tail vein of mice are transported into the lung tissue via the pulmonary arteries where they become trapped within the lung parenchyma [ 22 , 23 ]. (hindawi.com)
Diagnosis1
  • Methodological limitations as well as the low attention given to the study of helminths have impacted biological research and, thus, the procurement of accurate diagnosis and effective treatments. (biomedcentral.com)
20161
  • 2016). The helminth T2 RNase ω1 promotes metabolic homeostasis in an IL-33 and group 2 innate lymphoid cell-dependent mechanism. (tcd.ie)
Interleukin2
Life cycles1
  • The discovery of helminth life cycles. (unibas.ch)
Vivo2
  • His study in Cell biology is interdisciplinary in nature, drawing from both Cellular differentiation, CD40, Th2 response, Antigen-presenting cell and In vivo. (research.com)
  • His Antigen research includes themes of Cell, In vitro, Cellular differentiation, In vivo and Heligmosomoides polygyrus. (research.com)
Biology6
  • Understanding the biology of helminths using genomic and proteomic approaches could contribute to advances in understanding host-helminth interactions and lead to new vaccines, drugs and diagnostics. (biomedcentral.com)
  • This step relies on the availability of well-curated genomic, transcriptomic and proteomic databases, as well as on a detailed knowledge of helminth biology. (biomedcentral.com)
  • Progress in helminth biology research has gone hand in hand with the advances in techniques for genome sequencing and proteome characterisation. (biomedcentral.com)
  • His research integrates issues of Cell, Dendritic cell, Antigen, Th2 response and CD40 in his study of Cell biology. (research.com)
  • Immunology, Cell biology, Immune system, Schistosoma mansoni and Dendritic cell are his primary areas of study. (research.com)
  • The Cell biology study combines topics in areas such as Cell growth, Dendritic cell, Antigen, Chemokine and Circadian rhythm. (research.com)
Canis1
  • involucra animales de compañía caninos y felinos, como también perros y gatos sin hogar ( Canis familiaris y Felis catus , respectivamente), que diseminan los huevos del parásito en sus heces al medio ambiente. (scielo.org.co)
Organ2
  • The foundation of my research centers around neonatal tolerance to organ specific antigens and microbiota. (utah.edu)
  • Helminths are multicellular and have complex organ systems. (merckmanuals.com)
Immune system1
  • Andrew S. MacDonald has included themes like Helminths, Downregulation and upregulation, Disease and Effector in his Immune system study. (research.com)
Brazil1
Diagnostics1
  • Work primarily contributed by the Unit Diagnostics and the Group Helminths and Health . (swisstph.ch)