• It is a member of the scavenger receptor superfamily found on T cells, thymocytes, B cell subsets, chronic B lymphocytic leukemia (B-CLL), and peripheral blood dendritic cells. (biolegend.com)
  • CD5 modulates T and B cell receptor signaling, thymocyte maturation, and T-B cell interactions upon binding to ligands such as CD72. (biolegend.com)
  • CD5 Antigen-like (CD5L), also known as Sp alpha, is a secreted protein that is a member of the SCSR (scavenger receptor cysteine rich) superfamily. (rndsystems.com)
  • It is a type I membrane glycoprotein whose extracellular region contains three scavenger receptor cysteine-rich (SRCR) domains. (exbio.cz)
  • CD5 modulates signaling through the antigen-specific receptor complex (TCR and BCR). (exbio.cz)
  • CD5 may serve as a dual receptor, giving either stimulatory or inhibitory signals depending both on the cell type and development stage. (exbio.cz)
  • Cloning of a novel bacteria-binding receptor structurally related to scavenger receptors and expressed in a subset of macrophages. (embl.de)
  • The results suggest that the novel protein is a macrophage-specific membrane receptor with a role in host defense, as it shows postnatal expression in macrophages, which are considered responsible for the binding of bacterial antigens and phagocytosis. (embl.de)
  • Studies utilizing cloned native and mutant forms of the scavenger receptor have provided insights into the structural basis for their function. (embl.de)
  • CD6, also known as T12, is a member of the scavenger receptor superfamily found on T and B cell subsets, thymocytes, and acute lymphocytic leukemia cells (ALL). (exbio.cz)
  • Three-dimensional solution structure and conformational plasticity of the N-terminal scavenger receptor cysteine-rich domain of human CD5. (ox.ac.uk)
  • The lymphocyte receptor CD5 influences cell activation by modifying the strength of the intracellular response initiated by antigen engagement. (ox.ac.uk)
  • Regulation through CD5 involves the interaction of one or more of its three scavenger receptor cysteine-rich domains present in the extracellular region. (ox.ac.uk)
  • The eCD5d1m structure is similar to other members of the scavenger receptor cysteine-rich superfamily, but the position of the lone alpha helix differs due to interactions with the unique N-terminal region of the domain. (ox.ac.uk)
  • CD5 is a counter-receptor for CD72 and plays a role in the T-B cell interaction. (thermofisher.com)
  • This gene encodes a member of the scavenger receptor cysteine-rich (SRCR) superfamily. (arigobio.cn)
  • CD6 is a type 1 transmembrane glycoprotein belonging to the scavenger receptor cysteine-rich family. (hcdm.org)
  • 1 Its extracellular region contains 3 scavenger receptor cysteine-rich domains. (hcdm.org)
  • Martínez-Florensa M, Consuegra-Fernández M, Martínez VG, Cañadas O, Armiger-Borràs N, Bonet-Roselló L, Farrán A, Vila J, Casals C, Lozano F. Targeting of key pathogenic factors from gram-positive bacteria by the soluble ectodomain of the scavenger-like lymphocyte receptor CD6. (hcdm.org)
  • The mouse monoclonal antibody CRIS1 reacts with an extracellular epitope of CD5, a 67kDa single-chain transmembrane glycoprotein expressed on mature T lymphocytes, most of thymocytes and B lymphocytes subset (B-1a lymphocytes). (exbio.cz)
  • Nitrocellulose membrane was probed with 2 µg/ml of mouse anti-CD5 monoclonal antibody followed by IRDye800-conjugated anti-mouse secondary antibody. (exbio.cz)
  • In other words, if the antigen-antibody reaction is compared to a "key-and-lock" model, natural antibodies found in human secretions act as "passe-partout" keys to offer a background protection against most pathogens, food antigens and microbes, before the antigen-specific response can develop [ 4 ]. (biomedcentral.com)
  • The following product was used in this experiment: CD5 Monoclonal Antibody (53-7.3), NovaFluor™ Red 725, eBioscience™ from Thermo Fisher Scientific, catalog # M026T03R05, RRID AB_2926168. (thermofisher.com)
  • C57BL/6 mouse splenocytes were unstained (left) or stained with 0.2 µg of CD5 Monoclonal Antibody, NovaFluor Red 725 (Product # M026T03R05) (right). (thermofisher.com)
  • Description: The 53-7.3 monoclonal antibody reacts with mouse CD5, a 67 kDa protein expressed by a majority of thymocytes, mature T cells and a subset of B cells. (thermofisher.com)
  • Western blot: 10 µg of Jurkat cell lysate stained with ARG66751 anti-CD5 antibody [SQab20184] at 1:1000 dilution. (arigobio.cn)
  • The tissue section was stained with ARG66751 anti-CD5 antibody [SQab20184] at 18°C - 25°C for 30 minutes. (arigobio.cn)
  • Mouse anti Rat CD5 antibody, clone OX-19 recognizes the rat CD5 cell surface antigen, a 69kD glycoprotein expressed by T cells, thymocytes and a subset of B cells. (bio-rad-antibodies.com)
  • Mouse anti Rat CD5 antibody, clone OX-19 is routinely tested in flow cytometry on rat splenocytes. (bio-rad-antibodies.com)
  • CD5 is the phenotypic marker of a B cell subpopulation involved in the production of autoreactive antibodies. (exbio.cz)
  • Western blotting analysis of human CD5 using mouse monoclonal antibodies MEM-32, CRIS1, and L17F12 on laurylmaltoside lysates of Jurkat cells and of K562 cells (negative control) under non-reducing conditions. (exbio.cz)
  • Human serum usually contains natural IgG, IgM and IgA antibodies, generated independently of any exposure to foreign antigens or vaccines or elicited in the course of infectious or autoimmune diseases. (biomedcentral.com)
  • B-1 cells are found in peritoneal and pleural cavities where they provide first-line defence through antibodies able to bind polysaccharide antigens and repeated motifs that are typically found in microbial cell walls and macromolecules [ 2 , 3 ]. (biomedcentral.com)
  • Several functions have been proposed for natural antibodies, including a first-line role in the defense against infections, a scavenger-like activity to apoptosis by-products and a turn-off, regulative role in the maintenance of immune homeostasis [ 7 , 14 ]. (biomedcentral.com)
  • The extracellular domain of CD6 is significantly related to the extracellular domain of the human and mouse T cell antigen CD5, the cysteine-rich domain of the bovine and mouse type I macrophage scavenger receptor, the extracellular domain of the sea urchin spermatozoa protein that crosslinks the egg peptide speract, the mammalian complement factor 1, and the human lung tumor antigen L3. (embl.de)
  • The CD5 is a signal transducing molecule whose cytoplasmic tail is devoid of any intrinsic catalytic activity. (exbio.cz)
  • Macrophage scavenger receptors. (embl.de)
  • Macrophage scavenger receptors are integral membrane proteins whose ability to bind and degrade modified LDL has implicated them in the process of atherosclerotic foam cell formation. (embl.de)
  • they may also play other roles in immune regulation and homeostasis, through their ability to bind host antigens, surface molecules and receptors. (biomedcentral.com)
  • Freedman AS, Freeman G, Whitman J, Segil J, Daley J, Levine H, Nadler LM: Expression and regulation of CD5 on in vitro activated human B cells. (exbio.cz)
  • Castro MA, Nunes RJ, Oliveira MI, Tavares PA, Simões C, Parnes JR, Moreira A, Carmo AM. OX52 is the rat homologue of CD6: evidence for an effector function in the regulation of CD5 phosphorylation. (hcdm.org)
  • Human peripheral blood lymphocytes were stained with purified CD5 (UCHT2) (solid line) or purified mouse IgG1, κ (dashed line), followed by anti-mouse IgG PE. (biolegend.com)
  • BST2 bone marrow stromal cell antigen 2 (Tetherin): Candida albicans enhanced the production of the CCR5-interacting chemokines CCL3, CCL4, and CCL5, and stimulates the production of interferon-a and the restriction factors APOBEC3G, APOBEC3F, and tetherin (BST2) in macrophages Rodriguez et al, 2013 . (polygenicpathways.co.uk)
  • CD5 crosslinking induces extracellular Ca++ mobilization, tyrosine phosphorylation of intracellular proteins and DAG production. (exbio.cz)
  • CD5 is expressed on all mature T-lymphocytes, most of thymocytes, subset of B-lymphocytes and on many T-cell leukemias and lymphomas. (exbio.cz)
  • The expression of CD5 by a small subset of B cells characterizes a developmentally and functionally distinct lineage of B cells called B-1 cells. (thermofisher.com)
  • CD5 antigen-like is a protein that in humans is encoded by the CD5L gene. (wikipedia.org)
  • CD5L/Sp alpha exhibits a high degree of homology with the extracellular regions of CD5 and CD6, exhibiting three SCSR domains. (rndsystems.com)
  • Herpes virus infections induce loss of CD5 expression in the expanded CD8+ human T cells. (exbio.cz)
  • Human CD6 antigen purified by immunoaffinity chromatography from HBP-ALL cells followed by preparative SDS-PAGE of non-boiled non-reduced sample (excised piece of gel corresponding to the 100 kDa zone). (exbio.cz)
  • Here, we present the 3D solution structure of a non-glycosylated double mutant of the N-terminal domain of human CD5 expressed in Escherichia coli (eCD5d1m), which has enhanced solubility compared to the non-glycosylated wild-type (eCD5d1). (ox.ac.uk)
  • CD5 is a 67 kDa human T-lymphocyte single-chain transmembrane glycoprotein. (thermofisher.com)
  • Recombinant full length protein of Human CD5 (extracellular). (arigobio.cn)
  • Figure B. RPE conjugated Mouse anti Rat MHC-I ( MCA156PE ) and FITC conjugated Mouse anti Rat CD5 ( MCA52F ). (bio-rad-antibodies.com)
  • Gimferrer I, Farnós M, Calvo M, Mittelbrunn M, Enrich C, Sánchez-Madrid F, Vives J, Lozano F. The accessory molecules CD5 and CD6 associate on the membrane of lymphoid T cells. (hcdm.org)
  • CD5 is a 67 kD single chain type I glycoprotein also known as Leu-1, Ly-1 and T1. (biolegend.com)
  • The availability of an experimentally tractable form of CD5d1, together with its 3D structure, provides new tools for further investigation of its function within intact CD5. (ox.ac.uk)
  • CD6 may exert some its functions via association with CD5, probably by fine-tuning CD5 signaling. (exbio.cz)
  • 8. The accessory molecules CD5 and CD6 associate on the membrane of lymphoid T cells. (nih.gov)
  • they may also play additional roles in immune rules and homeostasis through their ability to bind sponsor antigens surface molecules and Polygalacic acid receptors. (acancerjourney.info)
  • B-1a cells become turned on in response to antigens arousal [10] and will directly generate antibodies with no involvement of T-helper cells while B-1b cells may take component Polygalacic acid in adaptive immunity by giving a specialized kind of IgM storage cells [11-13]. (acancerjourney.info)
  • 2. The ectodomains of the lymphocyte scavenger receptors CD5 and CD6 interact with tegumental antigens from Echinococcus granulosus sensu lato and protect mice against secondary cystic echinococcosis. (nih.gov)
  • 3. Soluble CD5 and CD6: Lymphocytic Class I Scavenger Receptors as Immunotherapeutic Agents. (nih.gov)
  • 5. Genomic organization of the human CD5 gene. (nih.gov)
  • CD5 antigen-like is a protein that in humans is encoded by the CD5L gene. (wikipedia.org)
  • 3. transfecting tumor cell-associated antigen-encoding gene into DC [ 10 - 13 ]. (aging-us.com)
  • 90K, also known as galectin 3 binding protein, LGALS3BP, Mac-2-binding protein, has recently been identified as a tumor-associated antigen and a promising immunotherapy target. (aging-us.com)
  • Liau et al showed a clinical phase I trial of DC vaccines from patients' peripheral blood pulsed GBM antigen peptides successfully extended mean OS to 23.4 months [ 9 ]. (aging-us.com)
  • 19. Role of the CD6 glycoprotein in antigen-specific and autoreactive responses of cloned human T lymphocytes. (nih.gov)
  • 10. Molecular linkage of the mouse CD5 and CD6 genes. (nih.gov)
  • 11. A sequence conserved between CD5 and CD6 binds an FERM domain and exerts a restraint on T-cell activation. (nih.gov)
  • Human serum usually contains natural IgG, IgM and IgA antibodies, generated independently of any exposure to foreign antigens or vaccines or elicited in the course of infectious or autoimmune diseases. (biomedcentral.com)
  • To improve the tumor-killing efficiency, a combination of tumor-specific antigen and apoptotic GBM tumor cell lysate was pulsed DC to improve the effect of immunotherapy. (aging-us.com)
  • B-1 cells are found in peritoneal and pleural cavities where they provide first-line defence through antibodies able to bind polysaccharide antigens and repeated motifs that are typically found in microbial cell walls and macromolecules [ 2 , 3 ]. (biomedcentral.com)
  • The level of surface CD5 expression is developmentally regulated in the thymus, starting with low levels on CD4-CD8- thymocytes and increasing as they mature to CD4+CD8+ then CD4+CD8- or CD4-CD8+ thymocytes. (bdbiosciences.com)
  • In other words if the antigen-antibody reaction is compared to a "key-and-lock" model natural antibodies found in human secretions act as "passe-partout" keys to offer a background safety against most pathogens food antigens and microbes before the antigen-specific response can develop [4]. (acancerjourney.info)
  • Several functions have been proposed for natural antibodies, including a first-line role in the defense against infections, a scavenger-like activity to apoptosis by-products and a turn-off, regulative role in the maintenance of immune homeostasis [ 7 , 14 ]. (biomedcentral.com)
  • HCFs obtained from three different host species all were highly useful for immunoblotting, and sera from 19 (95%) of 20 CE patients equally recognized the antigen B subunit (approximately 8 kDa). (nih.gov)