Sarcoma growth epithelioid cells. Medical search. Frequent questions

Generally speaking, epithelioid sarcoma has a high rate of relapse after initial treatment and tends to recur locally (at or near the original tumor site). (wikipedia.org)
Epithelioid sarcoma is a slow-growing and relatively painless tumor, often resulting in a lengthy period of time between presentation and diagnosis. (wikipedia.org)
SMARCB1 is a core protein subunit of the 15 subunit SWI/SNF (or BAF) complex involved in regulating the nucleosome architecture of our genome and has been shown to be a potent tumor suppressor gene, meaning that its primary role is to control cell division and to even halt division under appropriate circumstances (i.e. signals to over-replicate). (wikipedia.org)
As this tumor suppressor is commonly inactivated in epithelioid sarcoma, cell division can fail to appropriately halt, resulting in unregulated cellular growth and the formation of cancer tumors. (wikipedia.org)
This is a critical pathway in angiogenesis, a process that cancer cells use to form new blood vessels, which provide necessary elements to the tumor for tumor survival. (wikipedia.org)
The differential diagnosis of a malignant effusion is accordingly broad, especially for the small round blue cell tumors that includes not only mesenchymal tumors, but also non-mesenchymal tumors, such as neuroblastoma and Wilms tumor. (cytojournal.com)
Background Loss of function of fumarate hydratase (FH), the mitochondrial tumor suppressor and tricarboxylic acid (TCA) cycle enzyme, is associated with a highly malignant form of papillary and collecting duct renal cell malignancy. (immune-source.com)
Histopathologic study of the surgical piece revealed a malignant mesenchymal tumor of high cellular density arrayed in sheets and adopting different patterns in which fusiform, epithelioid, highly collagenized, and myxoid areas alternated. (isciii.es)
Immunohistochemistry showed tumor cells with extensive and diffuse positivity to muscular actin (HHF 35) and negativity to desmin and osteocalcin. (isciii.es)
Osteogenic sarcoma, or osteosarcoma, is the most frequent primary bone tumor (17 to 21%) in people younger than 40 years, affecting the mandible and maxilla in approximately 6.5% of cases. (isciii.es)
Poorly differentiated synovial sarcoma is a rare soft tissue tumor. (unipa.it)
Moreover, the negligible positivity for Bax and caspase 3 suggested that the minor role of programmed cell death could be one of the causes of the aggressive behaviour of this tumor. (unipa.it)
As has often been the case, hematologic malignancies have led the way in the introduction of this new generation of therapeutics-perhaps because of easy access to tumor samples for pharmacodynamics, and the narrow spectrum of cells of origin. (cancernetwork.com)
e The pattern listed is for the spindled cell component of the tumor. (basicmedicalkey.com)
The tumor consists of sex cord-like and mesenchymal differentiation with various possible components, including Sertoli-like tubules, nested granulosa-like architecture, retiform growth, lipidized cells, Leydig-like cells, stromal cells with infiltrative growth, and solid sheets of smooth muscle-like cells. (cedars-sinai.edu)
Perivascular epithelioid cell tumor (PEComa) occurring in the female genital tract are rare, and typically found in the uterine corpus. (biomedcentral.com)
Upon immunohistochemistry (IHC), the tumor cells were positive for HMB45 and TFE3, focally positive for MelanA, while negative for muscle marker. (biomedcentral.com)
The cytologic characteristics of the tumor can provide sufficient clues for PEComa diagnosis, which includes loosely cohesive, epithelioid morphology with abundant clear or eosinophilic cytoplasm, low-grade nuclear atypia, cytoplasmic melanin pigments. (biomedcentral.com)
SWI/SNF‑related, matrix‑associated, actin‑dependent regulator of chromatin, subfamily a, member 4 (SMARCA4)‑deficient non‑small cell lung cancer (dNSCLC) is a rare malignant tumor that originates in the lungs. (spandidos-publications.com)
Biopsy of the tumor showed solid flaky, nest‑like infiltrating growth. (spandidos-publications.com)
Epithelioid sarcoma (ES) is a rare, malignant soft tissue tumor. (logicalimages.com)
Tazverik (tazemetostat) binds to and inhibits EZH2, resulting in decreased tri-methylation of H3K27, and potentially leading to inhibition of cell proliferation and tumor growth ( PMID: 23620515 ). (jax.org)
TAZVERIK ® 's potential for broad applicability and favorable safety profile may provide further inhibition of tumor growth and metastasis when used in combination therapy. (businesswire.com)
Clear cell sarcoma (CCS) is an anaplastic tumor consisting of cells derived from melanoblasts not forming melanin in the skin, but rather mitotic changes more consistent with malignant melanoma in subcutaneous tissue, tendons and aponeuroses. (faoj.org)
Clear cell sarcoma (CCS) is an indolent tumor of unknown histogenesis involving subcutaneous tissue, tendon and aponeurosis. (faoj.org)
Although the tumor is rare and histologically resembles melanoma, it more closely resembles soft tissue sarcoma in that it has a high propensity to lymph node metastasis. (faoj.org)
Table 1 Clear cell sarcoma (CCS) often meets four of the five criteria of malignant melanoma with asymmetry, border irregularity, diameter enlargement, and evolving changes of the tumor. (faoj.org)
Soft tissue sarcoma (STS) is a relatively rare malignant tumor of the extremities and trunk, occurring predominantly in middle-aged and older adults. (iiarjournals.org)
While various risk factors have been reported for distant metastases that significantly affect the prognosis of soft tissue sarcoma ( 12 - 17 ), risk factors for the appearance of distant metastases early after treatment of the primary tumor have not been investigated. (iiarjournals.org)
The basis for the name synovial cell sarcoma was the similarity between cells of this tumor and primitive synoviocytes. (medscape.com)
In fact, there is a histologic resemblance between the neural cells of malignant peripherical nerve sheath tumor (MPNST) and the cells of synovial sarcoma. (medscape.com)
Approximately 800 new cases occur in the United States each year, and this tumor represents around 5-10% of all soft-tissue sarcomas. (medscape.com)
Synovial sarcoma is the third most common soft-tissue tumor in adolescents and young adults. (medscape.com)
This is especially true in the case of mutant tumor DNA derived "driver" and "drug-resistant" alleles that are present in the circulating cell-free tumor DNA (cfDNA) in the peripheral blood circulation of GIST patients. (biomedcentral.com)

Synovial sarcoma is a malignant soft-tissue neoplasm that most commonly affects the extremities near to, but not in continuity with, large joints. (medscape.com)
The histogenesis of synovial sarcoma is unknown. (medscape.com)
Synovial sarcomas have been described in many anatomic sites. (medscape.com)
Overlapping lung and pleural involvement in individual cases has given rise to the more inclusive term "pleuropulmonary" synovial sarcoma. (medscape.com)
Synovial sarcomas encompass both biphasic (epithelial and spindle cell components) and monophasic (purely spindle cell) variants. (medscape.com)
The possibility that poorly differentiated synovial sarcoma could be calretinin-positive was a new data, to our knowledge, and it could be of some importance in diagnostic pathology. (unipa.it)
These data also suggest that the reduction of apoptotic phenomena in poorly differentiated synovial sarcoma could be considered one of the major mechanisms of tumoral growth. (unipa.it)
Synovial sarcoma is a rare type of cancer that tends to arise near large joints, particularly the knee, in young adults. (suratoncologycentre.in)
Synovial sarcoma (also referred to as synovial cell sarcoma) is one of the most common soft-tissue tumors in adolescents and young patients, with approximately one third of cases occurring in the first two decades of life. (medscape.com)
Adjuvant chemotherapy and neoadjuvant chemotherapy have been proposed for patients with metastatic soft-tissue sarcomas, but chemotherapy in the treatment of synovial sarcoma has been controversial. (medscape.com)
The origin of synovial sarcoma is unclear. (medscape.com)
Its name notwithstanding, this sarcoma is not associated with synovial joints. (medscape.com)
Synovial sarcoma is characterized by a specific chromosomal translocation, t(X;18)(p11;q11). (medscape.com)
The incidence of synovial sarcoma has been estimated to be 2.75 per 100,000. (medscape.com)
Synovial sarcoma has been reported to be particularly likely to metastasize. (medscape.com)

VEGF (vascular endothelial growth factor) is often over-expressed in epithelioid sarcoma. (wikipedia.org)
The neoplasm had an infiltrative growth pattern, but there was no vascular invasion. (turkjpath.org)
Some vascular tumours preferentially affect the hand, such as pyogenic granulomas or spindle cell haemangiomas associated with Maffucci syndrome. (springer.com)
1 Angiosarcomas are one subtype of soft-tissue sarcoma of vascular origin. (jhoponline.com)
My translational interests and contributions have spanned blood/lymphatic vascular endothelial cell biology and pathobiology in vitro and in vivo, hepatosplanchnic lymphatic/microcirculatory physiology, small animal models, in vivo lymphatic imaging, thoracic duct lymph drainage, lymphogenous cancer spread, and genomics/proteomics of lymphedema-angiodysplasia syndromes in man and experimental models, including defects, deficiency, and overexpression of human and murine lymphangio- gene-sis genes and their syndromic/phenotypic manifestations. (arizona.edu)

Cutaneous angiosarcoma is another sarcoma subtype that may respond to immunotherapy. (jhoponline.com)
Cutaneous angiosarcoma represents less than 1% of all soft-tissue sarcomas. (jhoponline.com)

While most tumors metastatic to the serous membranes are of epithelial origin, cytologists should be aware that non-epithelial neoplasms can also cause malignant effusions including sarcomas, melanomas, germ cell tumors, and, more rarely, brain tumors. (cytojournal.com)
Common non-epithelial neoplasms that may cause malignant effusions include malignant melanoma, sarcomas, and other neoplasms including germ cell tumors [ Figure 1 ]. (cytojournal.com)
These malignant tumors are also known as sarcomas. (hope-amc.com)
Here, in Part I, we describe areas where major inroads were initially achieved by targeting angiogenesis (central to the biology of renal cell carcinoma and hepatocellular cancer) and by unraveling pathways in the heterogeneous tumors of mesenchymal origin-spurred by the identification of c-Kit-activating mutations in gastrointestinal stromal tumors (GIST) and the regressions that ensued when tumors harboring these mutations were exposed to the tyrosine kinase inhibitor imatinib (Gleevec). (cancernetwork.com)
Fibroblastic or myofibroblastic tumors make up the majority of soft tissue tumors of the aerodigestive tract and range from nonneoplastic or benign proliferations (fibromas) to high-grade malignancies (undifferentiated high-grade pleomorphic sarcomas). (basicmedicalkey.com)
UTROSCT lacks FOXL2 and DICER1 mutations, which are found in granulosa cell tumors and Sertoli Leydig cell tumors of the ovary, respectively. (cedars-sinai.edu)
Tumors were uniformly well circumscribed and typically contrast enhancing with solid and cystic growth. (aku.edu)
Tumors with EWSR1-CREB1 fusions more often featured stellate/spindle cell morphology, mucin-rich stroma, and hemangioma-like vasculature compared to tumors with EWSR1-ATF1 fusions that most often featured sheets of epithelioid cells with mucin-poor collagenous stroma. (aku.edu)
Perivascular epithelioid cell tumors (PEComas) are a rare group of mesenchymal neoplasms characterized by the presence of histologically and immunohistochemically distinctive perivascular epithelioid cells [ 1 ], which can occur in any part of the body. (biomedcentral.com)
HUTCHMED plans to develop and seek approval for TAZVERIK ® in various hematological and solid tumors, including ES, FL and diffuse large b-cell lymphoma ("DLBCL") in its Territory. (businesswire.com)
Meningiomas , as defined by the World Health Organization (WHO), are "meningothelial (arachnoid) cell neoplasms, typically attached to the inner surface of the dura mater," and these tumors fall into WHO grades I, II, and III. (medscape.com)
Resolving the Pathogenesis of Anaplastic Wilms Tumors through Spatial Mapping of Cancer Cell Evolution. (lu.se)
Schwannomas are rare benign tumors of the nerve sheath that originate from the Schwann cells of the peripheral nerve and have a broad anatomic distribution that includes superficial tissues, deep tissues, including the central nervous system, and the gastrointestinal system. (jocr.co.in)
Biphasic tumors, containing both epithelial and spindle cell components, express the SYT-SSX1 transcript, whereas monophasic tumors with only a spindle cell component may express either transcript. (medscape.com)
Research into the oncogenic mechanisms of GISTs has found that these tumors frequently contain activating gene mutations in either platelet-derived growth factor receptor A ( PDGFRA ) or a receptor tyrosine protein associated with a mast cell growth factor receptor encoded by the KIT gene. (biomedcentral.com)
Whether these lesions develop as a result of vessel invasion by one or several endometrial tumors, or whether they are formed by a proliferation of smooth muscle cells within the vessel wall is still debated. (5y1.org)
The lack of claudin-4 expression in ovarian small cell carcinomas of hypercalcemic type suggests that these tumors may be better regarded as sarcomas rather than carcinomas. (cusabio.cn)
Malignant peripheral nerve sheath tumors (MPNSTs) are one of the rarest soft-tissue sarcomas with a prevalence of 0.001% in the general population. (surgicalneurologyint.com)
In lymphomas I have conducted studies in rare aggressive primary cutaneous tumors such as gamma/delta T cell lymphoma (expanding the description of the epidermotropic variant) as well as more indolent entities such as lymphomatoid papulosis (type D) and CD4-positive small to medium size T cell lymphoproliferative disorders. (mdanderson.org)

Distinct round nucleoli were visible in some cells (Fig. 1 C), notably with numerous melanin pigments in the cytoplasm (Fig. 1 D). The primary diagnosis was atypical cells which were suspected to be melanoma. (biomedcentral.com)
Traditionally, it has been considered to be part of the nodular melanoma spectrum, however, it may also arise from the acrolentiginous, superficial spreading and lentigo maligna types, displaying a growth pattern restricted to the papillary dermis [6]. (studyres.com)

In one case study, a patient with advanced metastatic vulvar epithelioid sarcoma showed a partial resolution of both lung and pleural metastases when pazopanib was administered, whereas all other therapies had failed MET (mesenchymal to epithelial transition) is another biological pathway that is likely involved in the development and progression of epithelioid sarcoma. (wikipedia.org)
As malignant cells have a tendency to round up in body fluids these non-epithelial neoplasms can therefore mimic reactive mesothelial cells and metastatic adenocarcinoma. (cytojournal.com)
Tazverik (tazemetostat) is FDA approved for use in patients aged 16 years and older with metastatic or locally advanced epithelioid sarcoma not eligible for complete resection, and in adult patients with relapsed or refractory follicular lymphoma (R/R FL) harboring an EZH2 mutation after 2 prior therapies, and in patients with R/R FL without treatment options (FDA.gov). (jax.org)

Histologically, epithelioid sarcoma forms nodules with central necrosis surrounded by bland, polygonal cells with eosinophilic cytoplasm and peripheral spindling. (wikipedia.org)
The results showed that MTNR1A and MTNR1B were expressed in all tissues of the Tibetan sheep HPTA, and both were co-expressed in the cytoplasm of epididymis basal and halo cells located at common sites of the epididymis basement membrane, forming an immune barrier. (bvsalud.org)
Microscopically, some loosely cohesive epithelioid cells were uniform with abundant clear cytoplasm, showing predominantly round or oval nuclei with finely stippled chromatin. (biomedcentral.com)
Distinct round nucleoli were visible in some cells, notably with numerous melanin pigments in the cytoplasm. (biomedcentral.com)
Microscopically, we observed some loosely cohesive atypical cells arranged in single or clusters and sheets, which exhibited epithelioid morphology with abundant clear cytoplasm. (biomedcentral.com)
The cell block section showed single or clusters of medium-sized epithelioid cells in a background of fibrinoid fluid, with abundant clear or granular eosinophilic cytoplasm. (biomedcentral.com)
All MLAs exhibited architectural diversity, compactly aggregated small tubules, eosinophilic intraluminal secretions, overlapped and angulated nuclei, scant cytoplasm, and presence of spindle cells. (iiarjournals.org)
Rare cases have been reported in the pelvis, vulva, penis, and spine.Histologically, epithelioid sarcoma forms nodules with central necrosis surrounded by bland, polygonal cells with eosinophilic cytoplasm and peripheral spindling. (studyres.com)
The melanocytes are epithelioid and/or spindle-shaped, and contain moderate to large amounts of amphophilic or ground-glass cytoplasm. (atlasgeneticsoncology.org)
2B-C) Lesion is composed of fascicles and nests of epithelioid and spindle-shaped melanocytes with moderate amounts of amphophilic cytoplasm. (atlasgeneticsoncology.org)

UTROSCT also lacks JAZF1 and PHF1 rearrangements, which is helpful in differentiating UTROSCT from low grade endometrial stromal sarcoma. (cedars-sinai.edu)
In the differential diagnosis of UTROSCT, we considered ESTSCLE, low-grade endometrial stromal sarcoma, epithelioid leiomyoma, and endometrioid carcinoma with sex-cord-like elements. (turkjpath.org)

Background/Aim: Distant metastasis has a strong influence on prognosis in patients with soft tissue sarcoma (STS). (iiarjournals.org)
The SARC028 clinical trial showed that immunotherapy with a programmed cell death 1 (PD-1) and PD ligand 1 (PD-L1) inhibitor can result in responses in patients with soft-tissue sarcoma, particularly in patients with undifferentiated pleomorphic sarcoma and dedifferentiated liposarcoma. (jhoponline.com)

[ 4 , 5 ] are small perivascular nodules that are histologically and ultrastructurally identical to meningothelial cells of the CNS. (medscape.com)
Histologically, all of them showed horncyst surrounded by basophilic cells showing Trichilemmal keratinisation, except for one case where there was no horn cyst formation. (studyres.com)
Large cell neuroendocrine carcinoma (LCNEC) is now recognized as a histologically high grade non small cell carcinoma showing histopathological features of neuroendocrine differentiation as well as immunohistochemical neuroendocrine markers. (ersjournals.com)

SFTs of the pleura are localized mesenchymal neoplasms composed of fibroblastlike cells believed to arise from the subpleural connective tissue. (medscape.com)
Background: Perivascular epithelioid cell tumours (PEComas) are mesenchymal neoplasms with variable biological behaviour, ranging from benign to extremely aggressive diseases able to metastasize. (fortuneonline.org)
It should be noted that the vast majority of neoplasms of the upper aerodigestive tract are epithelial and that some of these can show a spindle cell phenotype, e.g., spindle cell or sarcomatoid carcinoma and myoepitheliomas. (basicmedicalkey.com)
Meningiomas , as defined by the 2016 World Health Organization (WHO), are "a group of mostly benign, slow-growing neoplasms that most likely derive from the meningothelial cells of the arachnoid layer. (medscape.com)
I continue to work on a variety of infectious diseases and immune disorders (e.g., inflammatory bowel disease, AIDS, Kaposi sarcoma, tuberculosis, filariasis, congenital/hereditary lymphatic system syndromes, opportunistic infections/neoplasms) and direct an internationally recognized Lymphedema-Angiodysplasia clinic. (arizona.edu)

Epithelioid sarcoma also demonstrates lymphatic spread (in 22-48% of cases), and metastasis (in 21-63% of cases). (wikipedia.org)

Liposarcoma can occur in fat cells in any part of the body, but most cases occur in the muscles of the limbs or in the abdomen. (suratoncologycentre.in)

We studied a case arising in the pleural cavity of a young subject, characterised by the presence of spindle cell, small cell, and large epithelioid cell areas. (unipa.it)
3B-C) Lesion is composed of large epithelioid and oval cells admixed with abundant collagenous stroma. (atlasgeneticsoncology.org)

UHGPS, undifferentiated high-grade pleomorphic sarcoma. (basicmedicalkey.com)

Dermatofibrosarcoma protuberans (DFSP) is a very rare type of skin cancer that begins in connective tissue cells in the middle layer of your skin (dermis). (suratoncologycentre.in)

DSRCT is composed of small cells with round hyperchromatic nuclei and a dense fibrous or spindle cell stroma. (medscape.com)
The epithelioid cells were uniform and approximately the same size as the parabasal cells (Fig. 1 A&B), showing predominantly round or oval nuclei with finely stippled chromatin. (biomedcentral.com)
A few spindled nuclei and melanin pigments were also identified (Fig. 2 A). IHC demonstrated that the epithelioid cells were positive for HMB45 andTFE3 (Fig. 2 B&C), focally positive for Melan-A, while negative for S-100, SOX-10, AE1/AE3, EMA, Desmin, SMA, H-caldesmon. (biomedcentral.com)
Osteocytes were trapped inside these trabeculae, which contained osteoclast-like multinucleated cells and voluminous pavement cells with hyperchromatic nuclei, sometimes interpreted as osteoblasts. (bvsalud.org)

Microscopic evaluation showed anastomosing cords, trabeculae, nests, and tubules of epithelial-like cells found in a fibroblastic stroma (Figure 1 ). (turkjpath.org)
Anastomosing cords, trabeculae, nests and tubules of epithelial-like cells were lying in a fibroblastic stroma. (turkjpath.org)

Developmental lesions such as heterotopia of meningothelial cells in the scalp are believed to be the origin of meningiomas under the scalp and skin of the head. (medscape.com)
The tumours (lesions) of Kaposi's sarcoma typically appear as painless purplish spots on the legs, feet or face. (suratoncologycentre.in)
In severe Kaposi's sarcoma, lesions may develop in the digestive tract and lungs. (suratoncologycentre.in)
In addition of the categories of squamous dysplasia and carcinoma in situ , two additional lesions were added to the group of pre-invasive lesions: atypical adenomatous hyperplasia (AAH) and diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH). (ersjournals.com)
Most lesions consist of a central zone of smooth muscle cells and blend with the surrounding dermal collagen and adjacent pilar muscle. (5y1.org)
Maturation" in the context of melanocytic lesions means (1) the cells get smaller with depth, (2) cells are less mitotic with depth. (librepathology.org)

2004). Less common are histologic variants such as desmoplastic/sclerosing, angiomatoid, myxoid and plexiform Spitz nevi (Lyon, 2010), and pigmented spindle cell nevus (Ferrara et al. (atlasgeneticsoncology.org)

The large cell carcinoma class has been enriched with several variants, including the LCNEC and the basaloid carcinoma, both with a dismal prognosis. (ersjournals.com)

Solitary fibrous tumours are rare growths of soft tissue cells that can form nearly anywhere in the body. (suratoncologycentre.in)

Epithelioid sarcoma typically contains chromosome 22q11.2 mutations or deletions and 8q gains, particularly i(8) (>q10). (wikipedia.org)
All except one MLA harbored activating Kirsten rat sarcoma viral oncogene homolog mutations. (iiarjournals.org)
The identification of genetic aberrations in proto-oncogenes that drive the growth of GISTs is critical for improving the efficacy of cancer therapy by matching targeted drugs to specific mutations. (biomedcentral.com)
GISTs are characterized by mutations in a receptor tyrosine protein (encoded by the KIT gene) associated with a mast cell growth factor receptor or in the gene encoding platelet-derived growth factor receptor A ( PDGFRA ). (biomedcentral.com)

A non-cancerous (benign) soft tissue tumour is a growth that does not spread (metastasize) to other parts of the body. (cancer.ca)
As compared to the previous edition, changes include a better definition of pre-invasive lesion, a reclassification of adenocarcinoma, the description of two new tumour types as variants of large cell carcinoma, large cell neuroendocrine carcinoma (LCNEC) and basaloid carcinoma, and a new class called pleomorphic carcinoma. (ersjournals.com)

Histology shows nests of nevus cells that would positively express the following immunohistochemical markers: S100, Melan A (MART-1), SOX10, and HMB45. (medscape.com)

expression of claudin-4 is highly specific for true epithelial differentiation and may be useful to distinguish SWI/SNF complex-deficient undifferentiated carcinomas from sarcomas with epithelioid morphology. (cusabio.cn)

Diverse growth patterns make it difficult to distinguish uterine MLA from more commonly encountered histological types of endometrial carcinoma, including endometrial endometrioid carcinoma (EC) ( 10 ), serous carcinoma (SC), and carcinosarcoma (CS). (iiarjournals.org)

Two courses of four weekly infusions of rituximab with or without interferon-2a: final results from a randomized phase III study in symptomatic indolent B-cell lymphomas. (cancercentrum.se)

The stromal cells had mild pleomorphism and no necrosis. (turkjpath.org)
The specimens of soft tissue sarcoma were classified using the French Federation of Cancer Center Sarcoma Group system (FNCLCC), which includes the mitotic index, necrosis extension, and histological differentiation ( 15 ). (iiarjournals.org)

f Kaposi sarcoma. (basicmedicalkey.com)

The purpose of this study was to compare between the histochemical characteristics and the expression of epidermal growth factor (EGF) and it's receptor (EGFR) in the submandibular gland (SMG) of adult yaks and yellow cattle. (bvsalud.org)
It occurs more frequently in male smokers, and the epidermal growth factor receptor ( EGFR ) gene is often mutation‑free. (spandidos-publications.com)

Typically, epithelioid sarcoma starts as a small firm growth or lump that's painless. (suratoncologycentre.in)
[3] This is typically facilitated via use of a liquid, semi-solid, or solid growth medium , such as broth or agar . (wikipedia.org)

The CPAM type 4 lesion, with its large and often thick-walled cysts lined with alveolar lining cells, may be confused with the cysts of type I pleuropulmonary blastoma, although its cyst walls contain subepithelial foci of rhabdomyosarcoma, almost exclusively underlying stretches of cuboidal-to-columnar epithelium, rather than the alveolar cell epithelium of CPAM type 4. (ersjournals.com)

Islands of basophilic cells show peripheral pallisading. (studyres.com)

Epithelioid (superficial) or spindled (deep). (librepathology.org)

Epithelioid sarcoma most commonly strikes young adults, yet no age group is immune. (wikipedia.org)
Although meningiomas commonly arise in locations where meningothelial cells are found, the embryonic origin of intraventricular and pulmonary meningiomas are intriguing. (medscape.com)
Tissue culture commonly refers to the culture of animal cells and tissues, with the more specific term plant tissue culture being used for plants. (wikipedia.org)

In 1907 the zoologist Ross Granville Harrison demonstrated the growth of frog embryonic cells that would give rise to nerve cells in a medium of clotted lymph . (wikipedia.org)

Imbruvica (ibrutinib) is a selective, irreversible inhibitor of Bruton's tyrosine kinase (BTK), which promotes apoptosis and inhibits B-cell mediated signaling pathways, and has additional activity against ERBB2 (HER2) and EGFR ( PMID: 20615965 , PMID: 21422473 , PMID: 27678331 ). (jax.org)

The CPAM type 1 lesion has been noted to contain clusters of mucogenic cells in ∼35% of cases, and these clusters are thought to predispose the patient to the development of BAC. (ersjournals.com)

These genetic aberrations lead to constitutive activation of these growth factor receptors and concomitant abnormal cellular proliferation, which leads to the development of GIST. (biomedcentral.com)

An NGS panel for sarcoma gene fusions was negative for gene rearrangements. (cedars-sinai.edu)

Prominent nucleoli can be observed in some cells. (biomedcentral.com)

Anatomy62

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Chemicals and Drugs58

Analytical, Diagnostic and Therapeutic Techniques and Equipment31

Phenomena and Processes41

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Tumor34

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Tumors19

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Metastatic3

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Patients with soft tissue2

Histologically3

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