• It was originally identified in congenital fibrosarcoma and subsequently found in mammary secretory carcinoma (also termed juvenile breast cancer), mammary analogue secretory carcinoma of salivary glands (also termed MASC or MASCSG), salivary gland-type carcinoma of the thyroid, secretory carcinoma of the skin, congenital fibrosarcoma, congenital mesoblastic nephroma, rare cases of acute myelogenous leukemia, ALK-negative Inflammatory myofibroblastic tumour, cholangiocarcinoma, and radiation-induced papillary thyroid carcinoma. (wikipedia.org)
  • The radiation doses for therapeutic application of such compounds are limited by substantial uptakes in kidneys and salivary glands, with excess doses reportedly leading to radiotoxicity-related adverse effects, such as kidney insufficiency or xenostomia. (tum.de)
  • Sjogren's Syndrome Treatment/Sjogren's syndrome (SS) is an autoimmune disorder caused by the lymphocytic infiltration of exocrine glands resulting in glandular dysfunction, preferentially of the salivary and lacrimal glands [ rx] . (rxharun.com)
  • Sjögren's syndrome is a chronic inflammatory autoimmune disease of unknown origin, attacking, in particular, the tear and salivary glands. (rxharun.com)
  • The infiltrating mononuclear cells, humoral factors such as antibodies and cytokines, or both are hypothesized to cause exocrine gland dysfunction resulting in diminished tear production by the lacrimal glands and diminished saliva production by salivary glands. (rxharun.com)
  • Salivary dysfunction secondary to uptake in salivary glands can be managed with adequate hydration and sucking on candies. (medscape.com)
  • NIS is not only present in well-differentiated thyroid cancers, but is also found in other tissues such as the lacrimal ducts, salivary glands, gastric mucosa, and the lactating mammary gland, which accounts for some of the adverse effects of radioactive iodine ( 131 I) therapy. (touchendocrinology.com)
  • Salivary glands play an important role in our body, keeping moisture in our mouths, helping us to swallow and digest food, and aiding in speech. (lu.se)
  • Dry mouth, or xerostomia, is a group of incurable conditions caused by aging, radiation/chemical exposure, or aberrant inflammation in the salivary glands. (lu.se)
  • AN - do not confuse with SURGICAL STOMATA HN - 2008 BX - Diaphragmatic Stomata BX - Lymphatic Stomata BX - Stomata, Peritoneal FX - Surgical Stomas MH - Von Ebner Glands UI - D054838 MN - A03.556.500.760.906 MN - A10.336.779.906 MN - A14.549.760.906 MS - Small tubulo-alveolar salivary glands located beneath the circumvallate and foliate papillae. (bvsalud.org)
  • Classic anti-cancer strategies aimed at actively killing cancer cells include alkylating agents that generate crosslinks in DNA and trigger repair mechanisms to induce apoptosis, antimetabolites that severely disrupt nucleic acid synthesis, and alkaloids that interfere with microtubule polymerization/depolymerization and halt mitosis 2 . (cancerbiomed.org)
  • Natural static magnetic field-induced apoptosis in liver cancer cell Different cell types require different factors like rotary frequency and treatment time to induce apoptosis. (saferemr.com)
  • TRIM13 inhibited cell proliferation and induced cell apoptosis by regulating NF-κB pathway in non-small-cell lung carcinoma cells. (cancerindex.org)
  • TRIM13-induced NSCLC cell apoptosis was attenuated by a caspase-3 inhibitor Ac-DEVD-CHO, suggesting that TRIM13 induced cell apoptosis partially through a caspase-3-dependent pathway. (cancerindex.org)
  • In the present study, we observed that inactivation of the ERK1/2 signaling pathway using ABT-737 dramatically increased the expression of pro-apoptotic protein Bim via transcriptional and/or posttranslational regulation, in a cell type-dependent manner, inducing mitochondria-mediated apoptosis of human oral cancer cells. (oncotarget.com)
  • Benzydamine HCl for prophylaxis of radiation-induced oral mucositis: results from a multicenter, randomized, double-blind, placebo-controlled clinical trial. (jonnevandermeijden.nl)
  • A male 13-year-old patient with chondroblastic osteosarcoma in the left distal thigh and acute lymphoblastic leukemia undergoing cancer treatment with methotrexate presented with severe oral mucositis. (bvsalud.org)
  • The use of a treatment protocol consisting of a mucositis solution associated with low-level laser therapy effectively resolved a case of severe chemotherapy-induced oral mucositis. (bvsalud.org)
  • The monitoring and treatment of oral mucositis lesions in children and adolescents undergoing chemotherapy are necessary to prevent the patient from suffering from induced comorbidities. (bvsalud.org)
  • Chemotherapy-induced mucositis is one of the most important undesirable side effects of cancer treatment, promoting the worst cases of morbidity, increasing length of hospital stay, and frequently reducing the odds of controlling the tumor and the patient's life expectancy 1 . (bvsalud.org)
  • Moreover, oral mucositis induces pediatric patients to reduce food intake, which affects their nutritional status and makes them less responsive to treatment 4-5 . (bvsalud.org)
  • A brown 13-year-old boy with chondroblastic osteosarcoma in the left distal thigh and acute lymphoblastic leukemia presented with severe oral mucositis (Oral Assessment Guide / OAG)6, namely, ulcerated skin and mucosa in the upper and lower lips ( Figure 1 ), and complaints of pain and much discomfort, especially when talking and eating. (bvsalud.org)
  • La mucositis oral (MO) representa una afección inflamatoria frequente em pacientes oncológicos e uma higiene oral insatisfatória tem frecuente en pacientes con cáncer, y la mala higiene bucal se ha relacionado sido relacionada como fator predisponente para o seu surgimento. (bvsalud.org)
  • for example, intense oral and pharyngeal pain induced by a combination of oral mucositis, oropharyngeal candidiasis, salivary gland hypofunction, and xerostomia frequently lead to dysphagia in cancer patients compromising nutritional intake. (pocketdentistry.com)
  • Differentials for a swelling within the anterior triangle of the neck Multiple: lymph nodes no: Solitary: does it transfer with salivary gland swallowing spasms upper right abdomen [url=https://cfok.org/order/Voveran/]buy voveran 50 mg lowest price[/url]. (ehd.org)
  • In Papers I and Paper III of my thesis, we examined stem cell-derived therapies' potential on two most common conditions of xerostomia, which are acute irradiated and chronic immune dysregulation-caused salivary gland hypofunction. (lu.se)
  • Introduction: Neutropenic enterocolitis (NEC) is a life-threatening complication reported in patients with acute myeloid leukemia (AML) following chemotherapy (CHT). (bvsalud.org)
  • Secondary Myelodysplastic Syndrome, Leukemia and Other Malignancies: The time to development of MDS or acute leukemia ranged from 12 months to 7 years. (drugs.com)
  • Figure 8‐1 Peripheral blood smear from a patient with newly diagnosed acute myelogenous leukemia in blast crisis. (pocketdentistry.com)
  • Acute and/or chronic graft‐versus‐host disease (GVHD) that results from immune‐modulated injury to the patient's tissues can cause clinically significant salivary gland and/or oral mucosal disease. (pocketdentistry.com)
  • Figure 8‐2 Acute leukemia can be considered "naturally metastatic" in that the neoplasm arises within the white blood cell progenitors produced in the bone marrow. (pocketdentistry.com)
  • B) Gingival leukemic infiltrate in newly diagnosed acute myelogenous leukemia patient. (pocketdentistry.com)
  • Acute Lymph Leukemia 19-Feb Myotonic Dystrophy Inguinal Hernia 16-Apr Endometriosis Epidural Hematoma 20-Feb Congest. (ehd.org)
  • Previous studies have reported that chemotherapy and radiation therapy are low effective and have several side effects such as hyposalivation, neutropenia, swallowing disorder, and several neurological difficulties [ 8 , 9 ]. (genominfo.org)
  • Now, instead of needing a diagnosis of brain cancer to enter the Burzynski Clinic, the FDA was requiring that the child first receive standard therapies (chemotherapy and radiation) and have measurable disease. (ouralexander.org)
  • Explained to patient the oral complications of HSCT, chemotherapy, and radiation. (pocketdentistry.com)
  • Clinical scientists continue to observe superior survival of patients treated with combined chemotherapy and radiation approaches, yet the mechanisms behind this synergistic therapeutic approach are not fully understood. (mdanderson.org)
  • Salivary gland carcinoma (SGC) is rare cancer, constituting 6% of neoplasms in the head and neck area. (genominfo.org)
  • Salivary gland carcinoma (SGC) is an uncommon neoplasm, which constitutes approximately 6 percent of cancers in the head and neck region [ 1 , 2 ]. (genominfo.org)
  • Late rectal sequelae following definitive radiation therapy for carcinoma of the uterine cervix: a dosimetric analysis. (uchicago.edu)
  • Modulation of apoptotic response of a radiation-resistant human carcinoma by Pseudomonas exotoxin-chimeric protein. (uchicago.edu)
  • Khouri S, Kotliroff A, Lishner M, Amital H. Imatinib-induced agranulocytosis in a patient with chronic myelogenous leukemia in remission. (jonnevandermeijden.nl)
  • Much debate rages concerning chronic low-dose radiation exposure. (seintl.com)
  • Certainly, the advantages of continued vigilance on chronic low-dose radiation exposure cannot be denied. (seintl.com)
  • Also, the question arises whether or not strict adherence to radiation safety is necessary if no clinically measurable effects arc occurring in chronic low-dose occupationally exposed individuals. (seintl.com)
  • This retrospective or prospective study would be one step in validating whether or not chronic low-dose radiation exposure is the etiological agent for an increase in morbidity and mortality at a younger age. (seintl.com)
  • A fixed duration of venetoclax-rituximab (VenR) resulted in a significant benefit of both PFS and in the attainment of an undetectable minimal residual disease (uMRD) compared with bendamustine-rituximab in relapsed/refractory (R/R) chronic lymphocytic leukemia (CLL) patients. (bvsalud.org)
  • OBJECTIVES: This prospective proof-of-principle study aimed to determine whether [Ga]Ga-Pentixafor uptake, which reflects CXCR4 expression, is higher in the bone marrow of chronic lymphocytic leukemia (CLL) than in other oncological diseases without bone marrow infiltration and can therefore be used for CLL imaging. (tum.de)
  • Tripartite Motif Containing 13 (TRIM13), a member of TRIM proteins, is deleted in multiple tumor types, especially in B-cell chronic lymphocytic leukemia and multiple myeloma. (cancerindex.org)
  • RADIOTHERAPY, ALSO KNOWN as radiation therapy, is a treatment where ionizing x-ray and gamma ray radiation are directed at tumors and used to kill cancer cells. (endalldisease.com)
  • Radiation therapy may provide palliative relief from symptomatic metastases, control recurrent tumors, and prevent recurrence of advanced resected tumors. (medscape.com)
  • Enhancement of replication of genetically engineered herpes simplex viruses by ionizing radiation: a new paradigm for destruction of therapeutically intractable tumors. (uchicago.edu)
  • Radiogenetic therapy: on the interaction of viral therapy and ionizing radiation for improving local control of tumors. (uchicago.edu)
  • In a fasting state, increased glucagon and epinephrine and norepinephrine secretion induce autophagy, and glucocorticoids have also been shown to induce autophagy by stimulating the transcription of autophagy genes such as ATG5, LC3, and Beclin-1 in various tissues 8 . (nature.com)
  • NIR can not cause ionization however have been shown to produce other biological effects, for instance by heating, altering chemical reactions or inducing electrical currents in tissues and cells. (intechopen.com)
  • For each individual patient, calculate the radiation dose estimates to normal organs and tissues per unit activity [D (organ)] of administered dose using data extracted from these 3 images. (guidelinecentral.com)
  • Surprisingly, patients with micropapillary cancer had higher incidence of SPM than counterparts with a larger tumor in radiation group (O/E of 1.40 versus 1.15). (hindawi.com)
  • He explained that the FDA controlled his protocols and it required that Alexander have the tumor return in his brain after using chemo and or radiation. (ouralexander.org)
  • Phase I dose-escalation study of tumor necrosis factor-alpha and concomitant radiation therapy. (uchicago.edu)
  • Tumor necrosis factor alpha (TNF-alpha) gene therapy targeted by ionizing radiation selectively damages tumor vasculature. (uchicago.edu)
  • Decreasing the apoptotic threshold of tumor cells through protein kinase C inhibition and sphingomyelinase activation increases tumor killing by ionizing radiation. (uchicago.edu)
  • Today, up to 60% of cancer patients receive radiotherapy as a part of their treatment regimens 1 and yet most are never fully aware of the risks involved with exposure to ionizing radiation. (endalldisease.com)
  • Compounds that are used in medicine as sources of radiation for radiotherapy and for diagnostic purposes. (lookformedical.com)
  • During my thesis, we evaluated whether cell-derived strategies, in this case, extracellular vesicles (EVs) could be a potential new therapy to repair salivary gland injury and restore function following radiotherapy or in autoimmune diseases. (lu.se)
  • Assessment of oxidant/antioxidant status in saliva of cell phone users No relationship between exposure to radio frequency radiation and changes in the salivary oxidant/antioxidant profile were found. (saferemr.com)
  • My Ph.D. studies have focused on the regeneration of salivary gland, which is an organ that is responsible for the production of saliva in our mouths. (lu.se)
  • Effect on intelligence test score of prenatal exposure to ionizing radiation in Hiroshima and Nagasaki: A comparison of the T65DR and DS86 dosimetry systems. (cdc.gov)
  • and within a few years, ionizing radiation was put to use on cancer patients. (endalldisease.com)
  • The ATM-dependent DNA damage checkpoint plays a pivotal role in cellular response to ionizing radiation. (bioone.org)
  • It takes advantage of a remarkable and unique characteristic of high energy particle beams and how they deposit ionizing radiation as they move through the body. (hopkinsmedicine.org)
  • Combined effects of angiostatin and ionizing radiation in antitumour therapy. (uchicago.edu)
  • Strategies for enhancing viral-based gene therapy using ionizing radiation. (uchicago.edu)
  • Potentiation of the antitumor effect of ionizing radiation by brief concomitant exposures to angiostatin. (uchicago.edu)
  • Another consequence of aging is the accumulation of so-called senescent cells, normal cells that stop dividing, contribute to tissue aging and secrete substances like cytokines that induce inflammation. (qualitycounts.com)
  • Adjust AZEDRA therapeutic doses based on radiation dose estimates results from dosimetry, if needed. (drugs.com)
  • Many of these papers explore potential therapeutic applications of electromagnetic radiation. (saferemr.com)
  • Calculate the estimated critical organ absorbed-dose by multiplying the dosimetry-derived radiation absorbed-dose per unit activity [D (organ)] by weight based therapeutic total activity (Aw). (guidelinecentral.com)
  • Oral complications induced by cancer therapies result from a complex interplay among multiple factors and the recognition of the underlying mechanisms causing oral complications continues to develop. (pocketdentistry.com)
  • Efficient monitoring strategies that include age at the time of thyroid cancer diagnosis, exposure to radiation, gender, and genetic susceptibility may successfully detect SPM earlier in the disease course. (hindawi.com)
  • however, this was not observed in patients who underwent radiation therapy. (hindawi.com)
  • Early-stage, localized disease may be treated with radiation therapy or excision in certain cases. (medscape.com)
  • Dr. Hyder, the individual who would become Alexander s oncologist, explained that radiation was a poor choice of post-surgical therapy. (ouralexander.org)
  • This is especially true in the treatment of young patients with radiation therapy. (mdanderson.org)
  • Proton therapy is a type of advanced radiation treatment. (hopkinsmedicine.org)
  • Current National Comprehensive Cancer Network (NCCN) Clinical Practice Guidelines in Oncology note that proton therapy is an effective and acceptable form of external beam radiation. (hopkinsmedicine.org)
  • Nadir is the lowest ANC after myelosuppressive chemotherapy or radiation therapy. (brainkart.com)
  • The integrity of skin and tissue is at risk in cancer patients be-cause of the effects of chemotherapy, radiation therapy, surgery, and invasive procedures carried out for diagnosis and therapy. (brainkart.com)
  • Radiation therapy with concomitant hydroxyurea and fluorouracil in stage II and III head and neck cancer. (uchicago.edu)
  • Virally directed cytosine deaminase/5-fluorocytosine gene therapy enhances radiation response in human cancer xenografts. (uchicago.edu)
  • Role of gene therapy in radiation oncology. (uchicago.edu)
  • Temporal bone chemodectomas--comparing surgery and radiation therapy. (uchicago.edu)
  • Then, to translate the knowledge from Paper I and III, a new model that could use human samples needed to be found, this is Paper II, in which we developed a bioengineered model for salivary gland disease that can be used to evaluate regeneration and test pharmaceutical trials (like EV therapy). (lu.se)
  • His current clinical/research interests include Diagnosis (Clinical and Microscopic) of Oral Diseases, HPV in Oral Diseases, Oral Cancer, Mucocutaneous Diseases, and Salivary/Oral Stem Cell Biology in co-operation with Laboratory of Molecular Biology, Department of Conservative Dentistry, Periodontology/Preventive Dentistry, Medical University of Hannover, Germany. (jonnevandermeijden.nl)
  • 4 At the peak of popularity in the United States, there were at least 10,000 shoe-fitting x-ray fluoroscopes in use, and despite the massive radiation exposure (equal to more than 1000 chest x-rays) and the significant amount of scatter radiation emitted from these "cancer boxes," the horrifying nature of the technology was largely brushed off by the government and medical community. (endalldisease.com)
  • Upon completion of the combined degree program at the University of Pennsylvania, Dr. Chelsea Pinnix embarked on residency training in Radiation Oncology at the University of Texas MD Anderson Cancer Center. (mdanderson.org)
  • Dr. Pinnix joined the faculty in the Division of Radiation Oncology at MD Anderson Cancer Center in July of 2012. (mdanderson.org)
  • Radiation is a powerful tool in the treatment of lung cancer. (hopkinsmedicine.org)
  • The interaction of 5-fluorouracil, hydroxyurea, and radiation in two human head and neck cancer cell lines. (uchicago.edu)
  • Treatment with systemic of pulmonary reactions, such as bleomycin-induced fibrosis. (ehd.org)
  • Another interest lies in the identification of improved treatment strategies that incorporate radiation in the management of aggressive and refractory lymphomas. (mdanderson.org)
  • SMF has potential for controlling LPS-induced excess neuro-inflammatory response. (saferemr.com)
  • Numerous cancers are thought to be induced from radiation exposure, based on epidemiologic studies involving environmental, medical, and occupational exposures [ 11 - 23 ]. (hindawi.com)
  • Patients with CTD who develop drug-induced ILD may also manifest a variety of histologic patterns in lung biopsy specimens. (medscape.com)
  • Methods: In our study we prospectively enrolled all AML patients admitted in our leukemia unit to receive intensive induction and consolidation chemotherapy and experiencing chemotherapy-induced-neutropenia (CHTN). (bvsalud.org)
  • Inspired by the memory of patients she met during her time as a student studying oral surgery in China, she has spent the past four years researching a regenerative medicine strategy that can be used to repair the function of the salivary gland. (lu.se)
  • For example, the patient with a significant bleeding problem or thrombocytopenia arising as a primary condition or secondary to medication, radiation, or leukemia is best managed in an in-patient environment where replacement of platelets can be provided before the procedure or afterwards if spontaneous bleeding occurs (eg, following a tooth extraction). (medscape.com)
  • Blasting cells with radiation stops them from growing and multiplying, but it also damages every other cell in its path and sets in motion a cascade of negative physiological effects that can persist for multiple generations. (endalldisease.com)
  • Ionizing radiations are extremely high frequency electromagnetic waves (X-rays and gamma rays), which have enough photon energy to produce ionization by breaking the atomic bonds that hold molecules in cells together. (intechopen.com)
  • A static magnetic field attenuates lipopolysaccharide-induced neuro-inflammatory response via IL-6-mediated pathway A static magnetic field had positive effects on survival rate and histological outcomes of LPS-treated mice and decreased IL-6 expression in BV-2 cells by a phenomenon similar to endotoxin tolerance. (saferemr.com)
  • Though the mechanism via which 5 HT, receptor antagonists induce emesis continues to be controversial, evidence from this review displays that, as with cisplatin, a population of 5HT creating cells mediate the emetic effects of 5 HT, receptor antagonists. (gabasignaling.com)
  • Trata-se de um estudo-piloto clínico hygiene oral rigurosa en la prevención de la MO. (bvsalud.org)
  • O clínico piloto aleatorizado, en el que treinta y cinco pacientes fueron asignados grupo-caso foi submetido ao controle de higiene oral associado ao uso en dos grupos. (bvsalud.org)
  • Tomar B. lactis por vía oral podría ayudar a prevenir infecciones de las vías respiratorias, como el resfriado común, en personas sanas. (medlineplus.gov)
  • Tomar B. lactis por vía oral no parece prevenir las caries en los niños pequeños. (medlineplus.gov)
  • En adultos, B. lactis se ha ingerido con mayor frecuencia por vía oral sola o junto con otros probióticos en dosis de hasta 12 500 millones de unidades formadoras de colonias (UFC) al día, durante un máximo de 6 semanas. (medlineplus.gov)
  • In conclusion, we've shown that cisplatin induces dose depejfident emesis during the pigeon as a result of a serotonergic mechanism. (gabasignaling.com)
  • A number of difficulties also stem from limitations of the classical statistical methodology, which requires that chromosome aberration yields be considered as something "fixed" and thus provides a deterministic estimate of radiation dose and associated confidence limits (because an assignment of a probability to an event is based solely on the observed frequency of occurrence of the event). (bioone.org)
  • According to their frequency and energy, electromagnetic waves can be classified as either ionizing radiations or non-ionizing radiations (NIR). (intechopen.com)
  • Radiation would destroy his developing brain, leave him with severe neurological disabilities and reduce his IQ to around 60, which would mean retardation. (ouralexander.org)
  • For the last one-hundred years many studies have reported the deleterious effects of high-dose radiation exposure. (seintl.com)
  • Effect of long-term 50 Hz magnetic field exposure on the micronucleated polychromatic erythrocytes of mice Administration of antioxidant substances with radioprotective capacities known to act through the elimination of free radicals did not diminish the genotoxic effect induced by ELM-MF. (saferemr.com)
  • Also there lire many more publications and journals that devote large sections to studies involving possible health risks associated with radiation. (seintl.com)