• From the studies identified in this way, we selected only observational trials, randomized control trials (RCTs), and meta-analysis. (hindawi.com)
  • Randomized controlled trials (RCTs), if interventions based on IT, performed in primary care and outcomes reported on medication safety. (oegam.at)
  • Out of 3918 studies retrieved, 10 RCTs met the inclusion criteria. (oegam.at)
  • A total of 29 studies [15 randomised controlled trials (RCTs) and 14 cohort studies] were included. (bvsalud.org)
  • the National Lung Screening Trial (NLST, N = 53,454) and Nederlands-Leuvens Longkanker Screenings Onderzoek (NELSON, N = 15,792) were the largest RCTs. (uspreventiveservicestaskforce.org)
  • Patellar tendinopathy was studied in 2 RCTs, one did not show a significant difference and the other showed superior improvement compared to controls. (springeropen.com)
  • For individuals who have non-neurogenic urinary dysfunction including overactive bladder and have failed behavioral and pharmacologic therapy who receive an initial course of PTNS, the evidence includes randomized sham-controlled trials, randomized controlled trials (RCTs) with an active comparator, and systematic reviews. (southcarolinablues.com)
  • The Sham Effectiveness in Treatment of Overactive Bladder Symptoms (SUmiT) and the Overactive Bladder Innovative Therapy (OrBIT) trials are 2 key industry-sponsored RCTs. (southcarolinablues.com)
  • eligible study designs are experimental studies (randomized controlled trials (RCTs), quasi-RCTs, non-RCTs), non-experimental studies (interrupted time series, controlled before-and-after studies), and cohort studies. (biomedcentral.com)
  • We included all randomized controlled trials (RCTs) describing the use of NSAIDs in the treatment of endometriosis in women of all ages. (qxmd.com)
  • We selected only in vitro research, randomized controlled trials (RCTs) or clinical trials. (espalibrary.eu)
  • RCTs and clinical trials revealed, after BT, a reduction in circulating levels of pro-inflammatory molecules, such as TNF-α, IL-1β, and C-reactive protein, and an increase in anti-inflammatory molecules such as the IGF-1 growth factor especially in musculoskeletal diseases. (espalibrary.eu)
  • Recently, also clinical trials and Randomized Controlled Trials (RCTs) have been developed to study the effects of BT on the human immune system. (espalibrary.eu)
  • This is a review article not intended to meet the full range of criteria required for a systematic review. (hindawi.com)
  • Conducting a systematic review of reviews highlights the usefulness of bringing together a summary of reviews in one place, where there is more than one review on an important topic. (biomedcentral.com)
  • These reviews are likely to be of variable quality and scope, with more than one systematic review on important topics. (biomedcentral.com)
  • A logical and appropriate next step is to conduct a systematic review of reviews of the topic under consideration, allowing the findings of separate reviews to be compared and contrasted, thereby providing clinical decision makers with the evidence they need. (biomedcentral.com)
  • Systematic reviews that included these and other published trials have found short-term reductions in voiding dysfunction with PTNS. (southcarolinablues.com)
  • MEDLINE added a "publication type" term for "randomized controlled trial" in 1991 and a MESH subset "systematic review" in 2001. (wikipedia.org)
  • review: is a systematic search for all available studies to answer a particular question - A systematic review seeks to identify, collate, and systematically summarize all empirical evidence on a specific research topic, using explicit, systematic, transparent, and replicable methods that are designed to minimize bias. (slideshare.net)
  • Is there already an existing systematic review on the topic? (slideshare.net)
  • To support evidence-based clinical guidelines on erythropoietin use for anemia in oncology, we conducted systematic reviews of controlled trials on four patient groups. (cancernetwork.com)
  • Just over half of the studies were found to have a low risk of selection bias, that is, studies adjusting for systematic differences in prognosis or treatment responsiveness between the groups, and similarly, 60% had a low risk of detection bias, that is, studies considered systematic differences in the ways the outcomes were measured and detected. (cochrane.org)
  • They conducted a systematic review and meta-analysis of Medline/PubMed, Web of Science, and Cochrane Library databases on September 27, 2021 (with no language restriction) that revealed 14 clinical trials that met analysis criteria. (dermatologyadvisor.com)
  • Study limitations include a shortage of randomized controlled trials and failure to perform clinical trial selection according to accepted principles for systematic reviews. (dermatologyadvisor.com)
  • A retrospective cohort of women diagnosed with invasive, nonmetastatic breast cancer and potentially eligible for these clinical trials was used. (nih.gov)
  • Procalcitonin levels predict bacteremia in patients with community-acquired pneumonia: a prospective cohort trial. (jamanetwork.com)
  • We included randomized controlled trials, cohort studies, case-control studies and other non-randomized intervention studies with an estimate of the effect of exposure to long work ing hours (41-48, 49-54 and ≥ 55 h/week), compared with exposure to standard work ing hours (35-40 h/week), on depression (prevalence, incidence and/or mortality). (cdc.gov)
  • Results: Twenty-two studies (all cohort studies) met the inclusion criteria, comprising a total of 109,906 participants (51,324 females) in 32 countries (as one study included multiple countries) in three WHO regions (Americas, Europe and Western Pacific). (cdc.gov)
  • Sociodemographic characteristics, symptoms of SARS-CoV-2 infection (assessed with the Centers for Disease Control and Prevention [CDC] Person Under Investigation Symptom List), and symptoms of post-infectious syndromes (ie, fatigue, sleep quality, muscle/joint pains, unrefreshing sleep, and dizziness/fainting, assessed with CDC Short Symptom Screener for myalgic encephalomyelitis/chronic fatigue syndrome) were assessed at baseline and 3 months via electronic surveys sent via text or email. (cdc.gov)
  • AHRQ establishes contracts with theEvidence-based Practice Centers to develop evidence reports and technologyassessments on clinical topics that are common, expensive, and/or significantfor the Medicare and Medicaid populations. (cancernetwork.com)
  • More detailed information onthe Evidence-based Practice Centers program, the topic nomination process, andthe list of centers is available at http://www.ahrq.gov/clinic/epcix/htm . (cancernetwork.com)
  • The opinions expressed by authors contributing to this journal do not necessarily reflect the opinions of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. (cdc.gov)
  • As a result of dependence upon higher brain centers, certain lesions or diseases of the brain (eg, stroke, cancer, dementia) can result in a loss of voluntary control of the normal micturition reflex as well as symptoms such as urinary urgency. (medscape.com)
  • In 2010, the Centers for Disease Control and Prevention reported that 25.6 million, or 11.3%, of US adults aged 20 or older had diagnosed or undiagnosed diabetes (1). (cdc.gov)
  • I'm Loretta Jackson Brown and I'm representing the Clinician Outreach and Communication Activity, COCA, with the Emergency Risk and Communication Branch at the Centers for Disease Control and Prevention. (cdc.gov)
  • Dr. Tauben would like to disclose that his employer, the University of Washington, received a contract payment from the Centers for Disease Control and Prevention. (cdc.gov)
  • She is the Deputy Associate Director for Science in the Division of Unintentional Injury Prevention and Control at the Centers for Disease Control and Prevention. (cdc.gov)
  • The second presenter Dr. Deborah Dowell is Senior Medical Advisor for the Division of Unintentional Injury Prevention at the Centers for Disease Control and Prevention. (cdc.gov)
  • The objective of this document is to guide the editorial and scientific quality requirements required of Brazilian journals indexed in LILACS, sustainably strengthening the development of this collection, and to serve as a guide for LILACS editors and cooperative centers responsible for the selection and insertion of scientific and technical quality production published in their countries and institutions. (bvsalud.org)
  • BIREME coordinates the management of the LILACS index at the regional level, and since October 1992, each country of the Latin American and Caribbean Health Sciences Information System, through the National Coordinating Centers (CCN), is responsible for the selection of national journals. (bvsalud.org)
  • ATSDR received considerable assistance in this work from the Cardiovascular Diseases Branch of the Centers for Disease Control & Prevention (CDC). (cdc.gov)
  • This article reviews current data that shapes guidelines regarding patient selection for SLNB in melanoma and highlights areas where performing this procedure remains controversial. (medscape.com)
  • [ 16-20 ] This article is intended to offer a concise review of the current literature that forms the basis for current guidelines regarding patient selection for SLNB, recognizing that the data that shapes these guidelines are in a state of constant flux. (medscape.com)
  • A sample was constructed to include participants from each trial who appeared to meet eligibility criteria and be appropriate candidates for the other trial's interventions. (nih.gov)
  • Direct comparisons of results from separate trials of lifestyle and pharmacologic interventions are compromised by marked differences in enrolled cohorts. (nih.gov)
  • WHO urges Member States as well as international, regional and national health institutions to regularly report on AMR status to serve as an evidence base for informing strategies and devising efficient preventive and control interventions. (who.int)
  • To systematically analyze the random controlled trials testing interventions to research informed consent process. (biomedcentral.com)
  • 39 out of 1523 articles fulfilled review criteria (2.6%), with a total of 54 interventions. (biomedcentral.com)
  • Deprescribing interventions take many forms, including reviews of medications by clinical pharmacists, identifying medications based on established criteria or lists (e.g. (ahrq.gov)
  • Clinical trial recruitment can be impeded by eligibility criteria being too numerous or too restrictive. (nih.gov)
  • This study's principal objective was to determine whether a specific category of eligibility criteria could be identified as a major barrier to patient enrollment. (nih.gov)
  • All eligibility criteria were sorted into the following categories: definition of disease, precision, safety, ethical and legal, or administrative. (nih.gov)
  • Proportions of cases with 'not met' eligibility criteria were assessed for each category in each trial. (nih.gov)
  • All other subcategories of eligibility criteria assessed were 'not met' by less than 15% of patients. (nih.gov)
  • Many eligibility criteria were considered 'nonevaluable' because the information evaluated would have required additional procedures not performed as part of the general practice. (nih.gov)
  • The subjects from the study population are not precluded from entry in a trial because of stringent eligibility criteria. (nih.gov)
  • Eligibility criteria should reflect as much as possible the whole population to whom the treatment will be offered, with the exception of drugs targeting a specific receptor or pathway where only a subpopulation is hypothesized to benefit from the therapy. (nih.gov)
  • No records identified in ClinicalTrials met the eligibility criteria. (ugeskriftet.dk)
  • Eligibility criteria for study selection Randomized clinical trials comparing antenatal corticosteroids with placebo or no treatment in women with a singleton pregnancy at ≥34 weeks' gestation. (bmj.com)
  • Study appraisal and synthesis methods: At least two review authors independently screened titles and abstracts against the eligibility criteria at a first stage and full texts of potentially eligible records at a second stage, followed by extraction of data from qualifying studies. (cdc.gov)
  • NCIC CTG MA.27 had the highest proportion of 'not met' subcategory due to an inclusion criterion requiring participation to two companion studies. (nih.gov)
  • So, to see how AA stacks up against other common alcohol misuse treatments the team analyzed 27 studies on the topic, representing 10,565 study participants. (inverse.com)
  • In October 2014, we performed a comprehensive literature search in the bibliographic database "Pubmed," looking at studies discussing the following topics: "hypovitaminosis D and physical performance: observational studies," "can vitamin D supplementation improve muscle function? (hindawi.com)
  • In studies regarding frailty, the terminology of frailty should have been defined by objective criteria. (hindawi.com)
  • Finally, we did not include the totality of studies meeting the above criteria, in order to prevent redundancies. (hindawi.com)
  • Methodological challenges and possible solutions are described within the context of (i) sources, (ii) study selection, (iii) quality assessment (i.e. the extent of searching undertaken for the reviews, description of study selection and inclusion criteria, comparability of included studies, assessment of publication bias and assessment of heterogeneity), (iv) presentation of results, and (v) implications for practice and research. (biomedcentral.com)
  • RESULTS: Twenty studies met our pre-defined selection criteria. (hivevidence.org)
  • Among the rotator cuff studies, 4 comparative studies claimed that cell therapy is a more efficient treatment with a lower retear rate and pain level compared to the control group. (springeropen.com)
  • Two independent examiners analyzed the titles, abstracts and full texts, considering the following study inclusion criteria: studies of pulmonary function in up to 5-year-old children diagnosed with BPD in the neonatal period. (bvsalud.org)
  • The SUmiT and OrBIT trials each included extension studies that followed individuals who responded to the initial course of PTNS and continued to receive periodic maintenance therapy. (southcarolinablues.com)
  • The authors reported a subset of available observational studies, and the selection criteria were unclear. (dangerousdrugs.us)
  • and 29% for miscellaneous.Multiple sources of variation existed between included studies: control processes, the presence of a human proctor, real vs. simulated protocol, and assessment formats. (biomedcentral.com)
  • However, due to the absence of continuous quantitative measurements and the lack of a non-musical sound control group in most studies, the identification of the specific impact of music on DOC patients remains challenging. (frontiersin.org)
  • CRRM was shown to reduce the incidence of contralateral breast cancer (CBC), but there is insufficient evidence that CRRM improves survival, and studies that control for multiple variables that can affect results are recommended. (cochrane.org)
  • We searched electronic academic databases for potentially relevant records from published and unpublished studies, including the WHO International Clinical Trial Registers Platform, Medline, PubMed, EMBASE, Web of Science, CISDOC and PsycInfo. (cdc.gov)
  • Selection criteria: Randomized Controlled Trials (RCT), Controlled Before-After studies (CBA) and Interrupted Time-Series studies (ITS) evaluating engineering controls, administrative controls, personal hearing protection devices, and hearing surveillance were included. (cdc.gov)
  • Case studies of engineering controls were collected. (cdc.gov)
  • Better quality studies and better implementation of noise control measures and HPDs is needed. (cdc.gov)
  • That's why doing such a trial would be completely unethical and we have to rely on the accumulated knowledge from epidemiological studies to determine whether vaccines are causing adverse outcomes. (scienceblogs.com)
  • The 16 studies included various study designs, including 9 randomized controlled trials, and settings, including academic-affiliated primary care practices and private practices. (cdc.gov)
  • BIREME coordinates LILACS's International Journal Selection Committee, which endorses the titles selected by the National Selection Committees, periodically evaluates the titles indexed in LILACS, and promotes studies on Latin American and Caribbean scientific production. (bvsalud.org)
  • The characteristics of participants projected to be jointly eligible for both trials continued to reflect differences between trials according to factors likely linked to retention, adherence, and study outcomes. (nih.gov)
  • Individual meetings of the Methods, Outcomes and Topics subcommittees were held from 8:30 - 9:30 am, allowing the subcommittee chairs and members to finalize recommendations and presentations for the full Working Group. (cdc.gov)
  • The WG recognized that outcomes would need to be selected from the list for each topic, that literature would probably not be available for many of these domains, and that some outcomes would be less critical for recommendations. (cdc.gov)
  • 2016). Since early 2017, a DFG-funded (LU 660/9-1) randomized controlled trial evaluating the effects of personalized treatment prediction and personalized treatment adjustment on treatment outcomes has been ongoing. (uni-trier.de)
  • The research group (Lutz) participated in the SMART Tournament (Stratified Medicine Approaches foR Treatment Selection (SMART) - Mental Health Prediction Tournament), a scientific competition to determine the best method for predicting treatment outcomes and the optimal allocation of patients to different treatment conditions (funded by UK Wellcome Trust). (uni-trier.de)
  • Crossover trials were analysed using the inverse variance method in RevMan to calculate the odds ratio for binary outcomes. (qxmd.com)
  • Adult patients with this disease who are not receiving tube or parenteral nutrition are being recruited for a randomized, double-blind, placebo-controlled, phase 2 study of ponsegromab (from Pfizer), a monoclonal antibody directed against GDF15. (medscape.com)
  • Goldberg commented that with the placebo-controlled design, participants will have a 50:50 chance of receiving the experimental drug at the start. (medscape.com)
  • As I mentioned the last time I discussed this, years ago (and sometimes even now ) antivaccinations would call for an actual randomized, double-blind, placebo-controlled "vaxed versus unvaxed" clinical trial. (scienceblogs.com)
  • The initial search yielded 14,849 publications, with 10 of them o s t e r H o F meeting the inclusion criteria. (bvsalud.org)
  • Even within the subsets of participants who appear to be eligible and appropriate candidates for trials of both modes of intervention, differences remained. (nih.gov)
  • We included participants exposed to a traumatic event as specified in the PTSD diagnostic criteria of the Diagnostic and Statistical Manual of Mental Disorders (DSM) versions DSM-3, DSM-4 and DSM-5 and the International Classification of Diseases (ICD) versions ICD-10 or ICD-11. (ugeskriftet.dk)
  • For approximately 15 months, participants in the control arm will receive nivolumab plus standard chemotherapy every 2 weeks or every 3 weeks. (medscape.com)
  • Unlike the rest of the participants, P1 did not report strong experiences of pain control generalized into her everyday life. (researchgate.net)
  • All patients were randomly assigned to three groups: an intervention group (music therapy group, n = 5), a control group (familial auditory stimulation group, n = 5), and a standard care group (no sound stimulation group, n = 5). (frontiersin.org)
  • Regarding cardiovascular risk stratification, both the intervention (26 %) and the control (6 %) groups shifted to the lower-risk class. (bvsalud.org)
  • One hundred forty-eight seventh-grade students and their teachers participated in a 10-day intervention on learning to solve ratio and proportion word problems, with classrooms randomly assigned to SBI or a control condition. (ed.gov)
  • We searched the Cochrane Menstrual Disorders and Subfertility Group Trials Register (April 2008) published in the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library), MEDLINE (1966 to April 2008), EMBASE (1980 to April 2008), and the reference lists from relevant publications. (qxmd.com)
  • Subsequently, the following filters were applied: Randomized Controlled Trial, Adult: 19-44 years, Middle Aged: 45-64 years and Aged: 65+ years. (ugeskriftet.dk)
  • This article reviews the literature that helps frame those guidelines, with specific focus on results from the MSLT-I, as this is currently the only randomized controlled trial comparing wide local excision (WLE) and SLNB with WLE and observation in the treatment of melanoma. (medscape.com)
  • The SMART Tournament results were presented at the Treatment Selection Idea Lab conference in London in June 2018. (uni-trier.de)
  • When ask to comment on this study, Richard Goldberg, MD, professor emeritus at West Virginia University Cancer Institute, said, "The domvanalimab and zimberelimab combination with chemotherapy has shown promising results in trials performed with patients who have advanced lung cancer. (medscape.com)
  • Results Six trials, including 5698 singleton pregnancies, were analyzed. (bmj.com)
  • First, substantial underdiagnosis of ODD and CD in this study population might be due to selection biases and affect our results. (psychiatrist.com)
  • Following an established REL Pacific research protocol, we conducted a web-based search for methodologically rigorous resources related to the effect of teaching meta-cognitive strategies to students to build their comprehension (see Methods section for search terms and resource selection criteria). (ed.gov)
  • A total of 985 patient-trials were evaluated, defined as the experimental unit since one patient could be eligible to more than one trial. (nih.gov)
  • Has this course been offered as Selected Topics/Experimental Topics course? (usf.edu)
  • What is/are the most important specific endpoint(s) you are comparing between the control group and the experimental group? (scienceblogs.com)
  • ineligibility was primarily due to better glycemic control or no early history of cardiovascular disease. (nih.gov)
  • In this selected population, tighter glycemic control, as measured by the HbA1c, is associated with an increased risk of a motor vehicle crash. (plos.org)
  • It is common for driver licensing authorities to require evidence that a diabetic person's condition is well controlled before they issue a driving license. (plos.org)
  • No Proceed with one if sufficient evidence has emerged on the topic Yes No need No A new review is warranted Yes Yes No need Is existing review sufficiently comprehensive and exhaustive of the topic in terms of databases searched, any language restrictions or other restrictions? (slideshare.net)
  • In concept, evaluating the literature is closely related to the recent emphasis on evidence-based medicine, a topic that has a number of excellent reviews in the literature and on the Internet. (medscape.com)
  • Finally, formal ways have been developed to measure the quality of evidence for a particular clinical topic. (medscape.com)
  • Articles were considered eligible if they included subjects with AS before surgery and compared a chosen method with either a control or a comparison group (using another method). (bvsalud.org)
  • People with one of these illnesses who have not received systemic treatment for advanced disease are eligible for a randomized, open-label, phase 3 clinical trial of a combination of domvanalimab, zimberelimab, and standard chemotherapy. (medscape.com)
  • This is an attractive trial for eligible patients. (medscape.com)
  • However, decision makers are increasingly faced by a plethora of such reviews and these are likely to be of variable quality and scope, with more than one review of important topics. (biomedcentral.com)
  • the WG discussed the process and criteria for reviews with Dr. Bradley from CDC and Dr. Randhawa from AHRQ. (cdc.gov)
  • In the breast cancer clinical trials evaluated for the present study, no criterion precluding recruitment was shared by many or all trials and no specific eligibility criterion was consistently the reason for patients' ineligibility. (nih.gov)
  • The forest plot depicts the Peto odds ratios (ORs) with 95% confidence intervals (CIs), comparing patients treated in the PCT and control groups in different trials and clinical settings. (jamanetwork.com)
  • Many other areas of active research on this topic are ongoing, including investigations into improved selection criteria for patients undergoing SLNB based on features of the primary tumor, refinements in histopathologic and molecular evaluation of the sentinel node (SN), the prognostic importance of positive non-SNs and quality of life following the procedure, to name a few. (medscape.com)
  • The study was not randomized, neither patients nor treating doctors were blinded, and patients were briefed about the "risk of depressive relapse associated with discontinuation of antidepressant therapy. (dangerousdrugs.us)
  • However, due to ethical and practical concerns, it is impossible to carry out a longitudinal randomized controlled trial with 2 arms of volunteers (one for good drug compliance and the other for poor drug compliance) to determine the impact of drug adherence on ODD/CD among patients with ADHD. (psychiatrist.com)
  • PubMed and Google Scholar were searched from 1997 up to June 2020, with search criteria including terms related to BT and immune system. (espalibrary.eu)
  • To approve cell therapy for tendon diseases, randomized clinical trials are required with a large sample size and long-term follow-ups. (springeropen.com)
  • Around 8% of the US population has diabetes, a group of diseases in which the body cannot control levels of glucose (sugar) in the blood. (plos.org)
  • Remember: Clinical equipoise means that there must be genuine uncertainty over which group in a clinical trial is receiving the superior treatment, and there is no doubt that leaving one group of children unvaccinated leaves them susceptible to vaccine-preventable diseases and thus does them harm. (scienceblogs.com)
  • 3 , 4 ] They can be characterized as exploratory projects that methodically map the available literature on a certain topic. (lww.com)
  • Many specific reasons exist why an emergency physician might review the literature on a particular topic. (medscape.com)
  • LILACS - Latin American and Caribbean Health Sciences Literature is a regional index that establishes the bibliographic control of scientific and technical literature in Health Sciences produced and published in Latin American and Caribbean countries. (bvsalud.org)
  • COCA is excited to partner with CDC's National Center for Injury Prevention and Control to offer this call series on CDC Guidelines for Prescribing Opioids for Chronic pain. (cdc.gov)
  • No controlled study has been performed on elbow tendinopathies, but 5 case series demonstrated the effectiveness of cell injection in elbow tendon disorders. (springeropen.com)
  • The next meeting of the "Treatment Selection Idea Lab" will take place at the University of Trier in 2021. (uni-trier.de)
  • LILACS Brazil's evaluation and permanence criteria are compatible with LILACS regional criteria and were discussed and approved at a meeting of the LILACS Brazil Journal Evaluation and Selection Committee in March 2021 and have taken effect in July 2021. (bvsalud.org)
  • The primary cause for both selection bias and detection bias was not controlling for all major confounding factors, e.g., risk factors or having bilateral risk-reducing salpingo-oophorectomy (BRRSO - surgery to remove fallopian tubes and ovaries) in the subject and control groups. (cochrane.org)
  • Therefore, since it is a global public health problem involving several sectors, it also requires a global solution in the context of the One Health approach to achieve adequate control through the prevention, reduction, and mitigation of drug-resistant infections. (who.int)
  • For Achilles tendinopathies, only one randomized controlled trial (RCT) found that both cell therapy and control groups showed significant pain reduction and functional improvement with no statistical differences at the 6 months follow-up, but the cell therapy group had improved faster at earlier follow-ups. (springeropen.com)
  • In an additional, small sham-controlled trial, a 50% reduction in urge incontinent episodes was attained in 71% of the PTNS group compared with 0% in the sham group. (southcarolinablues.com)
  • Neither of the sham-controlled trials found that active stimulation was superior to sham for achieving the primary outcome, at least a 50% reduction in mean weekly fecal incontinence episodes. (southcarolinablues.com)
  • The mean HbA1c was lower for those in a crash than controls (7.4% versus 7.9%, unpaired t -test, p = 0.019), equal to a 26% increase in the relative risk of a crash for each 1% reduction in HbA1c (odds ratio = 1.26, 95% confidence interval 1.03-1.54). (plos.org)
  • Prolonged periods of high blood sugar levels can damage eyesight and nerves throughout the body, resulting in pain, tingling, and reduction of feeling or muscle control. (plos.org)
  • The Action for Health in Diabetes (Look AHEAD) and The Action to Control Cardiovascular Risk in Diabetes (ACCORD) trials enrolled 5145 and 10,251 adults with type 2 diabetes, respectively. (nih.gov)
  • The largest, highest quality study was the double-blind, sham-controlled SUmiT trial, which reported a statistically significant benefit of PTNS versus sham at 12 weeks. (southcarolinablues.com)
  • Use of nationwide naturalistic data is the best alternative way to investigate this research topic. (psychiatrist.com)
  • To our knowledge, no randomized controlled trial has examined whether paroxetine treats depression during pregnancy more effectively than placebo, psychotherapy, or alternative treatment/therapy. (dangerousdrugs.us)
  • [ 9 ] These filters allow readers to choose not only the clinical study topic but also whether the interest is in etiology, diagnosis, therapy, prognosis, or clinical prediction. (medscape.com)
  • Comparing findings from separate trials is necessary to choose among treatment options, however differences among study cohorts may impede these comparisons. (nih.gov)
  • The larger sham-controlled randomized trial did find a significantly greater decrease in the absolute number of weekly incontinence episodes in the active treatment group, but the overall trial findings did not suggest the superiority of PTNS over sham treatment. (southcarolinablues.com)
  • We included randomised clinical trials evaluating the outcome of a trauma-focused psychotherapy, cognitive behavioural therapy (CBT), prolonged exposure therapy (PE), cognitive processing therapy, eye movement desensitisation and reprocessing (EMDR), or narrative exposure therapy or stress management compared with treatment by sertraline, paroxetine, fluoxetine or venlafaxine, or combinations of these, to reduce PTSD symptoms in adults. (ugeskriftet.dk)
  • Optimal treatment for clinically localized melanoma requires surgical control of the primary site and accurate staging of the regional nodal basin with sentinel lymph node biopsy (SLNB). (medscape.com)
  • It can lead to serious complications and premature death, but suitable treatment can control the disease and lower the risk of complications. (plos.org)
  • N = 1,927) demonstrated reduced odds of transfusion after erythropoietin, but higher-quality trials reported smaller odds reductions. (cancernetwork.com)
  • Type 1 diabetes occurs when the body's immune system prevents the production of insulin, the hormone that controls blood glucose. (plos.org)
  • A lower reading is considered an indicator of good diabetic control, but conversely, a blood glucose level that is too low can cause hypoglycemia. (plos.org)
  • Improving medication safety has become a major topic in all clinical settings. (oegam.at)
  • New Trials in Non-CRC GI Cancers: Could Your Patient Benefit? (medscape.com)
  • One can even control the sensitivity or specificity of the search. (medscape.com)
  • Draft inclusion and exclusion criteria will be established and pilot tested amongst the team. (biomedcentral.com)
  • ACCORD tests pharmacological therapies for control of glycemia, hyperlipidemia, and hypertension. (nih.gov)
  • Randomized controlled design is the gold standard for examining causal inference between these 2 events. (psychiatrist.com)
  • Incidence of major cardiovascular disease events is the primary outcome for both trials. (nih.gov)
  • It is possible that selection bias in terms of healthier, younger women being recommended for or choosing CRRM produces better overall survival numbers for CRRM. (cochrane.org)
  • We studied the association between glycosylated hemoglobin (HbA1c) and the risk of a motor vehicle crash using a population-based case control analysis. (plos.org)
  • 2 , 3 The low comorbidity rate in our study may be attributed to the case-recruitment criteria. (psychiatrist.com)