• Rsks are serine/threonine kinases and are activated by the MAPK/ERK pathway. (wikipedia.org)
  • Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1. (wuxibiortus.com)
  • The 90-kDa ribosomal S6 kinase (Rsk) is a family constituted by four isoforms (Rsk1-4) of serine/threonine kinases broadly expressed in the brain that regulate important cellular functions, including cell survival [ 1 ]. (biomedcentral.com)
  • Is involved in cell cycle regulation by phosphorylating the CDK inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents its translocation to the nucleus and inhibition of G1 progression. (wuxibiortus.com)
  • In molecular biology, ribosomal s6 kinase (rsk) is a family of protein kinases involved in signal transduction. (wikipedia.org)
  • The main distinguishing feature between p90rsk and p70rsk is that the 90 kDa family contain two non-identical kinase domains, while the 70 kDa family contain only one kinase domain. (wikipedia.org)
  • The 90-kDa ribosomal S6 kinase (Rsk) family is involved in cell survival. (biomedcentral.com)
  • Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function. (wuxibiortus.com)
  • Here, we analyzed the protein levels, activity and role of Rsk in in vivo and in vitro HD models. (biomedcentral.com)
  • There are two subfamilies of rsk, p90rsk, also known as MAPK-activated protein kinase-1 (MAPKAP-K1), and p70rsk, also known as S6-H1 Kinase or simply S6 Kinase. (wikipedia.org)
  • Rsks are serine/threonine kinases and are activated by the MAPK/ERK pathway. (wikipedia.org)
  • Mitogen-activated protein kinases (MAPK) promote MAPK-activated protein kinase activation. (rcsb.org)
  • The main distinguishing feature between p90rsk and p70rsk is that the 90 kDa family contain two non-identical kinase domains, while the 70 kDa family contain only one kinase domain. (wikipedia.org)
  • The Ca(2+)-dependent binding of S100B to the calcium/calmodulin-dependent protein kinase (CaMK)-type domain of RSK1 is reminiscent of the better known binding of calmodulin to CaMKII. (rcsb.org)
  • Although S100B-RSK1 and the calmodulin-CAMKII system are clearly distinct functionally, they demonstrate how unrelated intracellular Ca(2+)-binding proteins could influence the activity of the CaMK domain-containing protein kinases. (rcsb.org)
  • The chemical reactivity of Cys-SSH is thought to be involved in the catalytic activity of particular proteins via protein polysulfidation, the formation of -S-(S)n-H on their reactive cysteine residues. (bvsalud.org)