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GlycosaminoglycansChondroitin SulfatesDermatan SulfateHeparitin SulfateHeparinChondroitinHyaluronic AcidSulfatesMucopolysaccharidosesProteoglycansKeratan SulfateChondroitinases and Chondroitin LyasesHeparin LyaseElectrophoresis, Cellulose AcetateUronic AcidsMucopolysaccharidosis IDisaccharidesChondroitin LyasesHyaluronoglucosaminidasePolysaccharide-LyasesChondroitin ABC LyaseIduronic AcidGlucosamineHeparin Cofactor IIHeparan Sulfate ProteoglycansHexosaminesNitrous AcidMucopolysaccharidosis IIAlcian BlueExtracellular MatrixChloratesSulfur RadioisotopesRenal Tubular Transport, Inborn ErrorsN-Acetylgalactosamine-4-SulfataseSulfuric AcidsCartilageUridine Diphosphate Glucose DehydrogenaseMucopolysaccharidosis IVGlucuronidaseChromatography, GelGlycocalyxCollagenSulfotransferasesIduronidaseCartilage, ArticularCattleCells, CulturedChromatography, Ion ExchangeChondroitin Sulfate ProteoglycansGlycomicsGlycosidesSepharoseOligosaccharidesProtein BindingElectrophoresisCHO CellsCricetinaeCarbohydrate SequenceOculocerebrorenal SyndromeMucopolysaccharidosis VIIIduronate SulfataseMucopolysaccharidosis VIExtracellular Matrix ProteinsSulfatasesBinding SitesSilver ProteinsKineticsCarbohydrate ConformationFibroblastsSurface Plasmon ResonanceChromatography, PaperPolysaccharidesMonosaccharidesXyloseMucopolysaccharidosis IIISkinMolecular Sequence DataCell LineChromatography, AffinityGlycoproteinsAggrecansHymecromoneSyndecansMolecular WeightChromatographyRecombinant ProteinsCorneaPronaseArylsulfatasesFibrocartilageAmino Acid SequenceBiglycanPentosan Sulfuric PolyesterDecorinGlucuronatesFibronectinsComb and WattlesGlycoside HydrolasesSyndecan-4Virus Attachment
GAGsProteoglycansHeparanExtracellular matrixProteinsProteoglycanHeparinMucopolysaccharidesIduronic acidCollagenCellularKeratanHyaluronicMicroenvironmentBiochemicalEndothelialBiomoleculesTissuesBiologicalSulfationRegulationProteinAminoTissueCellsCritical rolesMelanomaMetabolic disordersPlayCrucial rolesPossible rolesVascularWoundPlaysBiology
GAGs18
  • Importantly, cell-associated and tumor microenvironment glycosaminoglycans (GAGs)/proteoglycan (PG) content and distribution are markedly altered during tumor pathogenesis and progression. (hindawi.com)
  • Free glycosaminoglycans (GAGs) and proteoglycan- (PG-) containing GAGs, key effectors of cell surface, pericellular and extracellular microenvironments, perform multiple functions in cancer by virtue of their coded structure and their ability to interact with both ligands and receptors that regulate cancer growth [ 1 - 4 ]. (hindawi.com)
  • Glycosaminoglycans (GAGs) comprise a class of linear, negatively charged polysaccharides composed of repeating disaccharide units of acetylated hexosamines (N-acetyl-galactosamine in the case of chondroitin sulphate and dermatan sulfate or N-acetyl-glucosamine in the case of heparin sulphate and heparin) and mainly of uronic acids (d-glucuronic acid or l-iduronic acid) being sulfated at various positions. (hindawi.com)
  • Glycosaminoglycans (GAGs) are essential functional components of the extracellular matrix (ECM). (degruyter.com)
  • Glycosaminoglycans (GAGs) are multifunctional polysaccharides of the extracellular matrix (ECM) responsible for ECM hydration and binding of cations and proteins due to their negative charge. (degruyter.com)
  • Glycosaminoglycans (GAGs) or mucopolysaccharides are long, linear polysaccharides consisting of repeating disaccharide units (i.e. two-sugar units). (wikipedia.org)
  • Pr Bourgault's team is studying how the interactions of natively disordered peptidic hormones with glycosaminoglycans (GAGs) modulate their conformation ensemble and biological function. (uqam.ca)
  • Discover which therapies are expected to grab the major mucopolysaccharidosis market share @ Mucopolysaccharidosis Market Report Mucopolysaccharidosis Overview Mucopolysaccharidosis (MPS) refers to a group of inherited metabolic disorders characterized by the accumulation of glycosaminoglycans (GAGs) within cells throughout the body. (cbinsights.com)
  • The effects of chemokines are modulated by several means, including binding to G-protein coupled receptors (GPCRs), binding to glycosaminoglycans (GAGs), and through post-translational modifications (PTMs). (utmb.edu)
  • Glycosaminoglycans (GAGs) are linear mucopolysaccharides with repeating disaccharide units. (biomedcentral.com)
  • Glycosaminoglycans (GAGs) are a class of long linear anionic periodic polysaccharides. (bvsalud.org)
  • Recognition and binding of regulatory proteins to glycosaminoglycans (GAGs) from the extracellular matrix is a process of high biological importance. (bvsalud.org)
  • Hyaluronic acid belongs to a family of molecules known as glycosaminoglycans or GAGs for short. (sapienskinseattle.com)
  • Glycosaminoglycans (GAGs) have therapeutic potential in areas ranging from angiogenesis, inflammation, hemostasis and cancer. (rpi.edu)
  • The complex sulfation motifs of heparan sulfate glycosaminoglycans (HS GAGs) play critical roles in many important biological processes. (rpi.edu)
  • Glycosaminoglycans (GAGs) are a group of natural substances found in and around the cells of cartilage, joints, tendons and organs that contribute to normal joint function. (tailblazerslegacy.com)
  • Mucopolysaccaridoses (MPS) are group of genetic disease characterized by a deficiency of lysosomal enzymes responsible for the hydrolysis of glycosaminoglycans (GAGs), whose manifold biological roles resulting in a variety of clinical manifestations in patients presenting with MPS. (scientiacme.org)
  • Generally, the main ECM components are proteins and complex polymeric carbohydrates belonging to a class of glycosaminoglycans (GAGs). (jcmnh.org)
Proteoglycans9
  • Proteoglycans, which are protein core + glycosaminoglycan composites, contribute vital structural properties to vessel extracellular matrix and have important regulatory roles vis-à-vis vascular cells. (navbo.org)
  • Proteoglycans are comprised of a core protein and one or more covalently attached glycosaminoglycan (GAG) chains. (openbiochemistryjournal.com)
  • Proteoglycans are complex macromolecules comprised of a core protein and one or more covalently attached glycosaminoglycans (GAG) chains so that structurally they are both proteins and carbohydrates. (openbiochemistryjournal.com)
  • 13. Tzanakakis G., Kovalszky I., Heldin P., Nikitovic D. Proteoglycans/glycosaminoglycans: from basic research to clinical practice. (uoc.gr)
  • This review examines the roles of HS-proteoglycans (HS-PGs) in general, and, in particular, perlecan and syndecan as representative examples and their interactive ligands, which regulate physiological processes and cellular behavior in health and disease. (bvsalud.org)
  • Changes in glycosaminoglycans and related proteoglycans in intrinsically aged human skin in vivo. (sapienskinseattle.com)
  • Here, we present a molecular understanding of netrin-1 mediated interactions with glycosaminoglycan chains of diverse heparan sulfate proteoglycans (HSPGs) and short heparin oligosaccharides. (diamond.ac.uk)
  • GHK-Cu acts directly on fibroblasts to increase the production of collagen, elastin, proteoglycans, glycosaminoglycans, and decorin, all of which play vital roles in tissue maintenance and repair. (tringali-health.com)
  • Proteoglycans (PGs) are proteins with glycosaminoglycan (GAG) chains, such as chondroitin sulfate (CS) or heparan sulfate (HS), attached to serine residues. (scilifelab.se)
Heparan6
  • Glycosaminoglycans are major components of stroma, including hyaluronan and heparan sulfate. (biomedcentral.com)
  • Kure S, Yoshie O: A syngeneic monoclonal antibody to murine Meth-A sarcoma (HepSS-1) recognizes heparan sulfate glycosaminoglycan (HS-GAG): cell density and transformation dependent alteration in cell surface HS-GAG defined by HepSS-1. (exbio.cz)
  • Kure S, Yoshie O, Aso H: Metastatic potential of murine B16 melanoma correlates with reduced surface heparan sulfate glycosaminoglycan. (exbio.cz)
  • Mii Y, Yamamoto T, Takada R, Mizumoto S, Matsuyama M, Yamada S, Takada S, Taira M: Roles of two types of heparan sulfate clusters in Wnt distribution and signaling in Xenopus. (exbio.cz)
  • Physiological concentrations of fucoidan effectively stimulated ECM deposition of proteins, presented by collagen types I and IV, and glycosaminoglycans, presented by heparan sulfate and hyaluronic acid, by AoSMC and DFB in manner and extent comparable to corresponding actions of ascorbic acid. (jcmnh.org)
  • Their protein backbones are linked to different glycosaminoglycans, such as dermatan-, chondroitin-, keratan- or heparan sulphate. (lu.se)
Extracellular matrix1
Proteins2
  • This review summarizes the unique immune-modulatory aspects of hRSV infection that are associated with the roles performed by viral proteins in intracellular immune signaling, their interactions with the host immune system, and their possible implications for disease pathology. (fortunejournals.com)
  • The mapping of GAG modifications of proteins in endocrine cells may thus assist us in delineating possible roles of PGs in endocrine cellular physiology. (scilifelab.se)
Proteoglycan1
Heparin2
  • These functions are mediated principally by four fibroblast growth factor receptors (FGFRs), members of the receptor tyrosine kinase family, with heparin glycosaminoglycan as an important cofactor. (eur.nl)
  • Heparin, as a glycosaminoglycan, is known for its anticoagulant and antithrombotic properties for several decades. (bvsalud.org)
Mucopolysaccharides1
  • These are are complex, long-chain polysaccharide compounds (mucopolysaccharides) with important roles in cell growth, differentiation, morphogenesis, cell migration and bacterial/viral infections . (sapienskinseattle.com)
Iduronic acid2
  • Inhibition of iduronic acid biosynthesis by ebselen reduces glycosaminoglycan accumulation in mucopolysaccharidosis type I fibroblasts. (uu.se)
  • Glycosaminoglycans are polymers of forms of glucose (glucosamine, glucuronic acid, iduronic acid) suggesting that glycosaminoglycan synthesis may compete with the glucose needs of the developing fetus. (biomedcentral.com)
Collagen1
  • Glycosaminoglycan, CaG can strengthen ECM by increasing activity of TIMP-2 and adhesion activity on collagen known to inhibit changes of ECM, leading to tumor cell invasion and progression. (biomedcentral.com)
Cellular4
  • Glycosaminoglycans: from "cellular glue" to novel therapeutical agents. (uoc.gr)
  • Platelet-endothelial cell adhesion molecule-1 (CD31)-mediated cellular aggregation involves cell surface glycosaminoglycans. (ejohg.com)
  • Decorin has also been shown to play additional roles in the regulation of cellular responses to GROWTH FACTORS . (nih.gov)
  • Netrin-1 is a bifunctional chemotropic guidance cue that plays key roles in diverse cellular processes including axon pathfinding, cell migration, adhesion, differentiation, and survival. (diamond.ac.uk)
Keratan1
  • The repeating two-sugar unit consists of a uronic sugar and an amino sugar, except in the case of the sulfated glycosaminoglycan keratan, where, in place of the uronic sugar there is a galactose unit. (wikipedia.org)
Hyaluronic1
Microenvironment1
  • By combining chemical biology, biophysics and biochemistry, we aim at elucidating the roles of the microenvironment and the (transient) interactome on the kinetics and pathway of amyloidogenesis and at developing (bio)chemical approaches to control the assembly of IAPP and LC. (uqam.ca)
Biochemical1
  • 1) Yamada S, Sugahara K, Ozbek S. Evolution of glycosaminoglycans: Comparative biochemical study. (sapienskinseattle.com)
Endothelial1
  • 10 ] reviewed the composition and functions of the endothelial glycocalyx, and strengthened the roles of the glycocalyx in human diseases including diabetes, ischemia/reperfusion, and atherosclerosis. (jbiomed.com)
Biomolecules2
  • Peptides are important biomolecules that play key biological roles by acting as hormones, neurotransmitters, antibiotics and/or growth factors. (uqam.ca)
  • Targeting this glycosaminoglycan complex biomolecules might be a novel therapeutic strategy to treat disorders such as cancers, neurodegenerative diseases, and infections associated with receptor for advanced glycation end-products (RAGE) containing disaccharide units (CS-E) [ 2 ]. (biomedcentral.com)
Tissues3
  • These complex sugars play crucial roles in maintaining healthy tissues and organs. (cbinsights.com)
  • Hyaluronidases and heparanases are present within placental tissues, and likely play roles in modification of stromal components to facilitate fold development. (biomedcentral.com)
  • It's a glycosaminoglycan (also called a mucopolysaccharide), a type of complex polysaccharide found in most tissues that play important biological roles - like the one HA does in wound healing. (mynewa.com)
Biological1
  • In addition to the aforementioned, acidic polysaccharides-specifically sulfated glycosaminoglycans-whose presence has been shown by using electrophoretic and chromatographic methods in Eisenia andrei [ 13 ] also fulfil important biological functions. (hindawi.com)
Sulfation1
  • Glycosaminoglycans vary greatly in molecular mass, disaccharide structure, and sulfation. (wikipedia.org)
Regulation1
  • 6,8 There are many other roles, such as free radical scavenging, and regulation of gene expression. (optimsm.com)
Protein1
  • The protein contains a single glycosaminoglycan chain and is similar in structure to BIGLYCAN . (nih.gov)
Amino1
  • Tyrosine is also a constituent of amino sugars (glycosaminoglycans), special compounds which have important roles throughout the body. (foodsco.net)
Tissue1
  • Decreased production of long chain glycosaminoglycans (GAG's) with an increase in shorter chain Gag's, resulting in dehydration of tissue and loss of membrane function. (life-enthusiast.com)
Cells3
  • The objective of this study was to evaluate the anti-cancer effect of insect-derived polymer dung beetle glycosaminoglycan (GAG) after intraperitoneally injecting it to melanoma mice induced by B16F10 cells. (biomedcentral.com)
  • In addition, treatment with N-glycans derived from theses glycosaminoglycan increased activities of TIMP-2 in HMVEC cells pretreated with TNF-alpha and in melanoma cells, suggesting that they had anti-inflammatory and anticancer activities. (biomedcentral.com)
  • In this context, the different staining patterns observed in epidermal mucous cells hinted at their functional roles with respect to production of mucus with different physical properties. (hindawi.com)
Critical roles1
  • 3,7 In the liver, sulfur plays two critical roles. (optimsm.com)
Melanoma1
  • Mice with induced melanoma were then treated with Catharsius molossus (dung beetle) GAG (CaG) at 5 mg/kg for 8 weeks to investigate its anti-cancer effects compared to bumblebee ( Bombus ignitus ) queen glycosaminoglycan (IQG) and Huechys sanguinea glycosaminoglycan (HEG). (biomedcentral.com)
Metabolic disorders1
  • Mucopolysaccharidoses are a group of metabolic disorders in which abnormal accumulations of glycosaminoglycans occur due to enzyme deficiencies. (wikipedia.org)
Play1
  • Plant cell walls encompass the majority of terrestrial biomass and play many important environmental and economic roles [ 1 ]. (biomedcentral.com)
Crucial roles1
Possible roles1
  • CONCLUSIONS: The altered expression patterns of glypican and syndecan-1 and -4 in chronic ulcers reflect their possible roles during inflammation and cell proliferation. (lu.se)
Vascular3
  • The presentation will review their roles in vascular function and pathology illustrated by recent work for our laboratory. (navbo.org)
  • New roles for an old molecule in platelet and vascular biology. (ejohg.com)
  • 5 ] focused on the roles of the glycocalyx in cancer and vascular diseases such as atherosclerosis, stroke, hypertension, kidney disease and sepsis. (jbiomed.com)
Wound1
Plays2
  • Dr. George is also a principal in Cellese, where he plays several roles. (barefacedtruth.com)
  • Calcium plays many other roles in your pet's body including muscle contraction, nerve transmission, and proper blood clotting. (tailblazerslegacy.com)
Biology1
  • He has served the American Society for Matrix Biology in many roles, including organizing its 2014 biennial conference and chaired the 2013 Gordon Research Conference on Matrix Metalloproteinases. (navbo.org)