Rituximab autoimmune disease purpura thrombocytopenic. Medical search. Frequent questions

Adult chronic immune thrombocytopenic purpura (chronic ITP) is an autoimmune disorder in which patients produce anti-platelet antibodies that destroy their platelets leading to a low blood platelet count (thrombocytopenia) that may produce bruising or excessive bleeding. (ndtv.com)
The diagnosis is one of exclusion and other causes like drug-induced thrombocytopenia, Immune thrombocytopenia associated with other diseases like collagen vascular disease, lymphoproliferative disorders and infections need to be excluded. (ndtv.com)
Reported that between 10% and 23% of patients who have autoimmune hemolytic anemia, will also have thrombocytopenia and thus Evans syndrome. (standardofcare.com)
Differential diagnosis of immune thrombocytopenia (ITP), thrombotic thrombocytopenic purpura (TTP), and disseminated intravascular coagulation (DIC). (medscape.com)
What is immune thrombocytopenia purpura? (carenity.co.uk)
Evans syndrome is the presence of simultaneous or sequential direct Coombs-positive autoimmune hemolytic anemia (AIHA) in conjunction with immune-mediated thrombocytopenia, with no known underlying etiology. (medscape.com)
Signs of thrombocytopenia include purpura, petechiae, and ecchymoses. (medscape.com)
Rituximab, a chimeric CD20 monoclonal antibody that causes depletion of B cells, shows short-term treatment efficacy in 40% to 60% of immune thrombocytopenia (ITP) patients. (ashpublications.org)
Immune thrombocytopenia (formerly known as idiopathic thrombocytopenic purpura) is a medical term for an autoimmune disorder (immune) causing a shortage of platelets (thrombocytopenia) and bruising (purpura). (itpsupport.org.uk)
Immune Thrombocytopenia (An autoimmune disorder (Immune) causing a shortage of small cells in the blood known as platelets (Thrombocytopenic) Formerly known as Idiopathic (of unknown origin) Thrombocytopenic Purpura (bruising). (itpsupport.org.uk)
The importance of recognizing the oral manifestations of thrombocytopenia is highlighted here, since the oral cavity is a frequent site of hemorrhage and could be the only manifestation of the disease. (bvsalud.org)
The goal of this clinical study is to evaluate povetacicept (ALPN-303) in adults with autoimmune cytopenias of immune thrombocytopenia, autoimmune hemolytic anemia, and cold agglutinin disease to determine if povetacicept is safe and potentially beneficial in treating these diseases. (pbi.org.au)
BACKGROUND: Thrombotic thrombocytopenic purpura (TTP) is a rare and life-threatening thrombotic microangiopathy characterized by microangiopathic hemolytic anemia, severe thrombocytopenia, and organ ischemia. (bvsalud.org)
Due to hemolytic anemia, thrombocytopenia, and schistocytosis, thrombotic thrombocytopenic purpura-hemolytic uremic syndrome was suspected and plasma exchange therapy was initiated immediately. (biomedcentral.com)
Werlhof's disease , also as Werlhof disease and Immune thrombocytopenia known to be an autoimmune disease. (healthandmedicineinfo.com)
Amgen today announced that the U.S. Food and Drug Administration (FDA) approved Amgen's Supplemental Biologics License Application (sBLA) for Nplate® (romiplostim) to include new data in its U.S. prescribing information showing sustained platelet responses in adults with immune thrombocytopenia (ITP), a rare, serious autoimmune disease characterized by low platelet counts. (pdsa.org)

It is used for non-Hodgkin lymphoma, chronic lymphocytic leukemia (in non-geriatric patients), rheumatoid arthritis, granulomatosis with polyangiitis, idiopathic thrombocytopenic purpura, pemphigus vulgaris, myasthenia gravis and Epstein-Barr virus-positive mucocutaneous ulcers. (wikipedia.org)
The diagnosis is made by confirming hemolytic anemia and idiopathic thrombocytopenic purpura, but also a positive direct antiglobulin test (DAT) and an absence of any known underlying etiology. (standardofcare.com)
Autoimmune hemolytic anemia (AIHA) can be idiopathic or secondary to many disease processes, including illness, rheumatologic conditions, drug publicity, and lymphoproliferative disorders. (forgetmenotinitiative.org)
She also experienced a history of idiopathic thrombocytopenic purpura (ITP) approximately two decades prior to her current demonstration. (forgetmenotinitiative.org)
Since no clinical symptoms/laboratory findings indicated a malignant or specific autoimmune-mediated disorder, the diagnosis made was thrombotic thrombocytopenic purpura-hemolytic uremic syndrome due to idiopathic combined, autoantibody-mediated ADAMTS-13/factor H deficiency. (biomedcentral.com)

Targeted diseases include type 1 diabetes , rheumatoid arthritis , Inflammatory bowel disease (IBD), cancer , chronic and viral diseases . (wikimili.com)
[7] The modified version of TRX1, designated MTRX1011A, is being developed for the treatment of autoimmune diseases, which may include rheumatoid arthritis, cutaneous lupus erythematosus (CLE), multiple sclerosis (MS), and systemic lupus erythematosus (SLE). (wikimili.com)
Primary Sjögren syndrome occurs in the absence of another underlying rheumatic disorder, whereas secondary Sjögren syndrome is associated with another underlying rheumatic disease, such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), or scleroderma. (medscape.com)
To treat rheumatoid arthritis, inflammatory bowel disease, and multiple sclerosis. (genestarbio.com.tw)
No, unlike autoimmune diseases such as rheumatoid arthritis and m ultiple s clerosis it is not a progressive disease, but the risk of bleeding is present from the day the disease develops. (itpsupport.org.uk)
Rheumatoid Arthritis (RA) Rheumatoid arthritis is a chronic systemic autoimmune disease that primarily involves the joints. (merckmanuals.com)
Simultaneous development of cutaneous vasculitis and an autoimmune bullous skin disease during anti-TNF therapy for rheumatoid arthritis: a case report and review of the literature. (kyoto-u.ac.jp)

ADAMTS13 activity in thrombotic thrombocytopenic purpura-hemolytic uremic syndrome: relation to presenting features and clinical outcomes in a prospective cohort of 142 patients. (medscape.com)
Thrombotic thrombocytopenic purpura-hemolytic uremic syndrome is a life-threatening condition with various etiopathogeneses. (biomedcentral.com)

Rituximab is a chimeric monoclonal antibody against the protein CD20, which is primarily found on the surface of immune system B cells. (wikipedia.org)
These tissue-deposited immune complexes activate complements, which lead to the clinical manifestation of the disease (eg, inflammatory changes in the renal glomeruli and in the skin). (medscape.com)
The company was focused on discovering and developing new therapies designed to treat patients by reprogramming the immune system, allowing for long-term remission of immune-related diseases after a short course of therapy. (wikimili.com)
The disease is caused when normal proteins located on the platelet surface act as antigens and stimulate the immune system to produce autoantibody. (ndtv.com)
There is no universally effective treatment for chronic refractory immune thrombocytopenic purpura (ITP). (ndtv.com)
COVID-19 has been associated with different inflammatory and auto-immune diseases. (unipr.it)
In addition to HUS, the differential diagnosis also includes immune thrombocytopenic purpura (ITP) and disseminated intravascular coagulation (DIC), two entities with very different modes of therapy (see the image below). (medscape.com)
Joly BS, Roose E, Coppo P, Vanhoorelbeke K, Veyradier A. ADAMTS13 conformation is closed in non-immune acquired thrombotic thrombocytopenic purpura of unidentified pathophysiology. (medscape.com)
The absence of high quality evidence for basic clinical dilemmas in immune thrombocytopenic purpura (ITP) underlines the need for contemporary guidelines relevant to the local treatment context. (mja.com.au)
Local guidelines are needed to assist clinicians treating immune thrombocytopenic purpura (ITP) in Australia and New Zealand. (mja.com.au)
Autoimmune Disorders An autoimmune disorder is a malfunction of the body's immune system that causes the body to attack its own tissues. (msdmanuals.com)
Rituximab (Rituxan, Truxima), can also be used to inhibit the immune response which targets the platelets. (carenity.co.uk)
ITP is an autoimmune disease in which the immune system mistakes the platelets as being foreign and destroys them. (itpsupport.org.uk)
Additional blood tests may be taken at this time to exclude rare clotting or immune diseases that can mimic ITP. (itpsupport.org.uk)
Treatments, which are currently aimed at suppressing or confusing the immune system, all have their dangers and drawbacks, only temporarily raise the platelet count, but do not cure the disease. (itpsupport.org.uk)
Classic immunosuppressants remain the most beneficial and widely used drugs for immune-mediated neuromuscular diseases. (medlink.com)
Most patients with immune-mediated neuromuscular diseases experience improvement of symptoms and quality-of-life measures with appropriate treatment. (medlink.com)
Several specific therapies have emerged as potential treatments for immune-mediated neuromuscular diseases. (medlink.com)
Biological agents have emerged as effective therapies for patients with treatment-resistant immune-mediated neuromuscular diseases. (medlink.com)
One picture is coming into better focus, however, which suggests that an immune-triggered, complement-mediated thrombotic microangiopathy (TMA) is surprisingly common in patients with coronavirus disease 19 (COVID-19). (nature.com)
These agents are thought to re-educate [1] the immune system to a level that the recurrent autoimmune inflammation of ocular tissues are prevented. (aao.org)
Werlhof's disease belongs to the group of autoimmune diseases: The immune system forms antibodies against the body's own blood platelets, the thrombocytes. (healthandmedicineinfo.com)
Chronic Granulomatous Disease , autoimmune diseases Autoimmune diseases Disorders that are characterized by the production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides. (lecturio.com)
Immune Thrombocytopenic Purpura (ITP), is an autoimmune disease that is characterized by a low level of platelets, a blood component essential for clotting. (thekachetlife.com)
In brief, I was diagnosed with CLL in 2005, an aggressive variant, and within a year, I was in a world of trouble with single-digit platelets from a rare and, in my case, difficult-to-treat autoimmune complication (immune thrombocytopenic purpura or ITP) that resulted in multiple hospitalizations, an urgent splenectomy, and massive internal bleeding. (blogspot.com)

100 × 10 9 /L. Corticosteroids are recommended as the first-line treatment, splenectomy is recommended as the second-line treatment, and thrombopoietin receptor agonists (TPO-RAs) and rituximab are recommended as the third-line treatments for ITP in Japanese ITP treatment guidelines. (biomedcentral.com)
Therefore, in this study, the cost-effectiveness of adding rituximab treatment to the existing treatments indicated for ITP in Japan, namely splenectomy and the TPO-RA romiplostim, was investigated based on the scenario that rituximab is eligible for reimbursement in Japan as a treatment for ITP. (biomedcentral.com)
The analyzed treatment order consisted of three patterns: splenectomy-romiplostim (sequence 1), splenectomy-romiplostim-rituximab (sequence 2), and splenectomy-rituximab-romiplostim (sequence 3). (biomedcentral.com)
Treatment is by corticosteroids, i.v. gamma globulins, rituximab or splenectomy. (ndtv.com)
Options with the most robust evidence include splenectomy, rituximab and thrombopoietin receptor agonists. (mja.com.au)
The researchers recommend that children diagnosed with Evans Syndrome be tested for ALPS, because there are different treatment approaches for the two diseases and a splenectomy or rituximab may be harmful to ALPS patients. (pdsa.org)

In patients with major organ involvement, such as lymphocytic interstitial lung disease, consider therapy with steroids and immunosuppressive agents, such as cyclophosphamide. (medscape.com)
Fludarabine-containing regimens include FCR (fludarabine, cyclophosphamide, and rituximab) and FR (fludarabine and rituximab). (medscape.com)
The PCR (pentostatin, cyclophosphamide, and rituximab) regimen is given every 21 d with growth factor support and ID prophylaxis. (medscape.com)
Methods We treated two patients with severe life-threatening AAV with renal and pulmonary manifestation despite induction therapy with rituximab and cyclophosphamide with four to eight doses of 1800 mg daratumumab. (bmj.com)
In this study, we analyzed the outcome of 84 patients at 3 years of follow-up after first-line treatment with fludarabine, cyclophosphamide and rituximab (FCR) induction followed by 36 months of rituximab maintenance thearpy. (haematologica.org)
As per protocol, 15 patients (17.8%), who achieved a complete response and undetectable peripheral blood and BM residual disease after four courses of induction, were allowed to stop fludarabine and cyclophosphamide and complete two additional courses of rituximab and continue with maintenance therapy for 18 cycles. (haematologica.org)
This study is to assess the change in disease activity of epcoritamab when combined with intravenous and oral rituximab, cyclophosphamide, doxorubicin hydrochloride, vincristine, and prednisone (R-CHOP) or R-CHOP in adult participants with diffuse large b-cell lymphoma. (pbi.org.au)

Rituximab, sold under the brand name Rituxan among others, is a monoclonal antibody medication used to treat certain autoimmune diseases and types of cancer. (wikipedia.org)
Rituximab is a chimeric monoclonal antibody targeted against CD20 which is a surface antigen present on B cells. (wikipedia.org)
Among the biologic therapies, the greatest experience in primary Sjögren syndrome is with rituximab, an anti-CD20 (which is expressed on B-cell precursors) monoclonal antibody. (medscape.com)
Rituximab is a monoclonal antibody which has high specificity for CD20 and it is used to treat certain autoimmune diseases and types of cancer. (eaglebio.com)
Tolerx's lead product candidate, otelixizumab , also known as TRX4, is a novel monoclonal antibody being developed for the treatment of autoimmune type 1 diabetes and other autoimmune diseases. (wikimili.com)
New therapies used in these diseases, including biological agents (monoclonal antibodies or recombinant proteins), are also reviewed. (medlink.com)

began on corticosteroids and every week rituximab. (forgetmenotinitiative.org)
30 × 10 9 /L), at least 3 weeks after high-dose (≥1 mg/kg) corticosteroids, who were randomized between 3 rituximab dosing schemes, that is, 2 or 4 once-weekly standard 375 mg/m 2 doses and a twice-weekly 750 mg/m 2 regimen. (ashpublications.org)
Corticosteroids may suppress clinical signs of infection and allow diseases such as septicaemia or tuberculosis to reach an advanced stage before being recognised. (obaid.info)
Treatment of severe, ongoing, active disease requires corticosteroids and immunosuppressants. (merckmanuals.com)

To treat relapsed or refractory mycosis fungoides and Sézary disease. (genestarbio.com.tw)
This study is to compare the efficacy of zanubrutinib plus obinutuzumab versus lenalidomide plus rituximab (R^2) in participants with relapsed/refractory (R/R) follicular lymphoma (FL). (pbi.org.au)

To make an accurate diagnosis, the clinician must recognize the similarity between thrombotic thrombocytopenic purpura (TTP) and hemolytic-uremic syndrome (HUS). (medscape.com)
Diagnosis of thrombotic thrombocytopenic purpura (TTP) was established based on PLASMIC score, and he was successfully treated with intravenous (IV) Methylprednisolone, therapeutic plasma exchange and IV Rituximab. (bvsalud.org)

Reports of widespread thromboses and disseminated intravascular coagulation (DIC) in patients with coronavirus disease 19 (COVID-19) have been rapidly increasing in number. (nature.com)

Originally, the disease was named for Friedrich Wegener who discussed the disorder in 1936 [2]. (rheumres.org)
aTTP is a rare, life-threatening autoimmune blood disorder causing excessive blood clot formation and impaired oxygen transport to vital organs. (sanofi.com)
Thrombotic thrombocytopenic purpura (TTP) is a serious disorder that involves the formation of small blood clots throughout the body that block the flow of blood to vital organs such as the brain, heart, and kidneys. (msdmanuals.com)
Thrombotic thrombocytopenic purpura (TTP) is a rare disorder in which many small blood clots (thrombi) form suddenly throughout the body. (msdmanuals.com)
What triggers an autoimmune disorder is not known. (msdmanuals.com)
Acquired hemophilia A (AHA) is a rare autoimmune bleeding disorder caused by circulating autoantibodies (inhibitor) directed against coagulation factor VIII (FVIII). (journalmc.org)
Systemic lupus erythematosus is a chronic, multisystem, inflammatory disorder of autoimmune etiology, occurring predominantly in young women. (merckmanuals.com)

Antibodies to Rituximab are pre-coated onto microwells. (eaglebio.com)
An autoimmune disease in which an individual's antibodies attack their own red blood cells and platelets. (standardofcare.com)
In the setting up of solid tumors, both a warm or frosty antibody autoimmune hemolytic Rabbit polyclonal to NOTCH1 anemia (CAIHA) are feasible, though warm antibodies are more prevalent 2. (forgetmenotinitiative.org)
Ferrari S, Mudde GC, Rieger M, Veyradier A, Kremer Hovinga JA, Scheiflinger F. IgG-subclass distribution of anti-ADAMTS13 antibodies in patients with acquired thrombotic thrombocytopenic purpura. (medscape.com)
Therapeutic antibodies are widely used for the treatment of diseases, including cancer and autoimmunity. (genestarbio.com.tw)
Here, however, we show absent levels of platelet-bound antibodies to be associated with refractoriness to rituximab. (ashpublications.org)
In Werlhof's disease, the number of platelets decreases significantly because the blood platelets that are overloaded with antibodies are broken down too quickly in the spleen. (healthandmedicineinfo.com)
The disease is generally categorized as warm or cold, depending on the thermal reactivity of the autoantibodies Autoantibodies Antibodies that react with self-antigens (autoantigens) of the organism that produced them. (lecturio.com)

Thrombotic thrombocytopenic purpura and the atypical hemolytic uremic syndrome: an update. (medscape.com)

Regardless of the cause, platelet disorders typically manifest with petechiae, purpura, and bleeding of the mucous membranes 3 . (bvsalud.org)
Hence, primary hemostatic disorders are characterized by prolonged bleeding time, and the characteristic physical examination findings are petechiae and purpura. (medscape.com)

Ninety percent of patients with adult-onset ITP have chronic disease, and the male-to-female ratio is 1:2. (biomedcentral.com)
Sanofi's goal is to fundamentally redefine the management of these rare and often chronic blood disorders and the company has launched innovative treatments for patients with limited options in cold agglutinin disease (CAD) and acquired thrombotic thrombocytopenic purpura (aTTP). (sanofi.com)
Immunosuppressants are used to suppress rejection in organ transplant recipients and to treat a variety of chronic inflammatory and autoimmune diseases. (obaid.info)
Organ Transplant Rejection, Prevention of Cardiac Transplant Rejection, Prevention of Kidney Transplant Rejection, Prevention of Liver Transplant Rejection, Graft Versus Host Disease, Prevention of Graft Versus Host Disease, Prevention of Lung Transplant Rejection, Pure Red Cell Aplasia associated with Chronic Lymphocytic Leukemia. (obaid.info)
Patients with chronic liver disease often have low platelets and need surgery. (pdsa.org)
It has been postulated that monitoring measurable residual disease (MRD) could be used as a surrogate marker of progression-free survival (PFS) in chronic lymphocytic leukemia (CLL) patients after treatment with immunochemotherapy regimens. (haematologica.org)
As in many other chronic diseases, the prevalence of fibromyalgia is increased, which may cause diagnostic confusion in patients with periarticular and generalized pain and fatigue. (merckmanuals.com)
After a year, Werlhof's disease becomes chronic. (healthandmedicineinfo.com)
Screening for autoimmune (anti-nuclear antibody, anti-extractable nuclear antigen, anti-double-stranded DNA), lupus anticoagulant studies, and chronic infectious diseases also resulted negative. (drpaulalexander.com)

More recently, rituximab has been introduced in the therapeutic approach to nephrotic syndrome and, based on clinical trials, its use was limited to patients having proven sensitivity to steroids and cyclosporine. (racetab.org)
These pre-clinical candidates may be developed for the treatment of cancer and viral diseases. (wikimili.com)
Guidance for the treatment of patients in clinical remission but with persistent severe ADAMTS13 deficiency who fail to respond to rituximab remains unclear. (elsevierpure.com)
10%) and presence of autoantibodies during clinical remissions despite immunosuppressive therapy with rituximab, bortezomib and azathioprine. (elsevierpure.com)
While in a clinical remission, he was diagnosed with Crohn's disease and initially treated with adalimumab. (elsevierpure.com)
The following data was collected from the patients' files: age at onset of disease, gender, disease duration, clinical and laboratory features, and types of treatment. (rheumres.org)
After clinical evaluation, 74 patients went into rituximab maintenance and the primary endpoint was assessed in the final analysis at 3 years of follow-up. (haematologica.org)
This article will review the clinical presentation and pathologic hallmarks of TMA involving the kidney, and the disease-specific mechanisms that contribute to the endothelial injury that characterizes TMA lesions. (bvsalud.org)
The clinical picture of Werlhof's disease is correspondingly diverse. (healthandmedicineinfo.com)

Long-term safety and efficacy findings from the post-HERCULES trial (NCT02878603), a three-year prospective follow-up study for patients with acquired thrombotic thrombocytopenic purpura (aTTP) who completed the Phase 3 HERCULES trial (NCT02553317), will also be presented in an oral presentation at EHA 2022 (abstract #S294). (sanofi.com)

Samples and standards are pipetted into microwells and human Rituximab present in the sample are bound by the capture antibody. (eaglebio.com)
Then, a HRP (horseradish peroxidase) conjugated anti-Rituximab antibody is pipetted and incubated. (eaglebio.com)
Lymphoproliferative disorders, which includes persistent lymphocytic leukemia (CLL), Hodgkin's disease, non-Hodgkin's lymphoma, and Waldenstr?m's macroglobulinemia, will be the most common factors behind secondary situations of warm antibody autoimmune hemolytic anemia (WAIHA) 1. (forgetmenotinitiative.org)
One emerging treatment option for several antibody-mediated autoimmune diseases is the anti-CD38 antibody daratumumab, which depletes autoantibody-secreting plasma cells. (bmj.com)

Epidemiology and pathophysiology of adulthood-onset thrombotic microangiopathy with severe ADAMTS13 deficiency (thrombotic thrombocytopenic purpura): a cross-sectional analysis of the French national registry for thrombotic microangiopathy. (medscape.com)

In a new study, the patients in this category who used eltrombopag (Promacta), a pill that stimulates the bone marrow to make more platelets, needed fewer platelet transfusions than the liver disease surgery patients who did not take the drug. (pdsa.org)
In Werlhof's disease, there is a sharp decrease in blood platelets (thrombocytes). (healthandmedicineinfo.com)
It was not until 1883 that it was diagnosed that the signs of the disease were generated by a decrease in blood platelets. (healthandmedicineinfo.com)
A characteristic of the disease is that the body mistakenly attacks its own platelets, which leads to their rapid breakdown. (healthandmedicineinfo.com)
If the cause of the bleeding is the lack of platelets, it is called thrombocytopenic purpura. (healthandmedicineinfo.com)

3 Unfortunately, the treatment efficacy of rituximab so far cannot be predicted. (ashpublications.org)
A phase 1b open-label study to assess the safety, efficacy, pharmacokinetics, and pharmacodynamics of Povetacicept in subjects with autoimmune cytopenias (RUBY-4). (pbi.org.au)

Current treatment options are discussed for the most frequent of these diseases: inflammatory neuropathies, myasthenia gravis, and inflammatory myopathies. (medlink.com)
The neuromuscular disorders treated with immunotherapies encompass a large and heterogeneous group of diseases, including the inflammatory neuropathies, neuromuscular junction diseases, and inflammatory myopathies. (medlink.com)

The patient had no history of bleeding, clotting, or other autoimmune disorders. (drpaulalexander.com)

Prior to starting the first rituximab dose and subsequently for 10 weeks, weekly EDTA-anticoagulated blood sampling was requested to assess the presence of platelet-associated immunoglobulin G (IgG) and IgM autoantibodies by the direct platelet immunofluorescence test (PIFT) and the eluate-(indirect) PIFT, as described previously. (ashpublications.org)
We report a 39-year-old single female who presented to emergency department with sudden onset gross hematuria 10 days following her first dose of Pfizer-BioNTech severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA (coronavirus disease 2019 (COVID-19)) vaccine. (journalmc.org)

[ 84 ] In a randomized, placebo-controlled, parallel-group study of 120 patients with primary Sjögren syndrome, treatment with rituximab did not alleviate disease activity or symptoms at week 24, although it did alleviate some symptoms at weeks 6 and 16. (medscape.com)
Secondary Sjögren syndrome is diagnosed when, in the presence of a connective-tissue disease, symptoms of oral or ocular dryness exist in addition to criterion 3, 4, or 5, above. (medscape.com)
The symptoms of Purpura are visible on your skin. (my.id)

Major advances have been made with respect to the pathophysiology of primary TMA entities, with the subsequent development of novel diagnostic tools and lifesaving therapies for diseases like thrombotic thrombocytopenic purpura and complement-mediated TMA. (bvsalud.org)

Autoimmune thrombotic thrombocytopenic purpura (aTTP) is caused by autoantibodies to the von Willebrand Factor cleaving enzyme, ADAMTS13. (elsevierpure.com)

Anti-B-cell strategies, particularly rituximab, have a promising effect in the treatment of patients with severe extraglandular manifestations of Sjögren syndrome. (medscape.com)
Rituximab appears promising in the treatment of vasculitis and intravenous immunoglobulin (IVIG)-dependent ataxic neuropathy. (medscape.com)
However, in Japan, rituximab is not eligible for reimbursement for the treatment of ITP. (biomedcentral.com)
Adding rituximab to standard treatment for ITP (sequences 2-3) is less costly and marginally more effective than standard therapy in adults. (biomedcentral.com)
According to the study results, if rituximab is reimbursed for the treatment of ITP in Japan, medical expenses are expected to decline. (biomedcentral.com)
Rituximab has shown promise in the treatment of severe extraglandular manifestations (eg, vasculitis, cryoglobulinemia, peripheral neuropathy). (medscape.com)
Some patients recover spontaneously (within first few weeks) while about 5-10% have stable disease, with a platelet count of 30-100,000/ml, which may persist for months to years rarely requiring treatment. (ndtv.com)
The patient needed 14 plasma exchanges, treatment with steroids, rituximab and caplacizumab and 18 days of mechanical ventilation. (unipr.it)
Caplacizumab Treatment for Acquired Thrombotic Thrombocytopenic Purpura. (medscape.com)
ISTH guidelines for treatment of thrombotic thrombocytopenic purpura. (medscape.com)
Beyond the platelet count, the decision to treat is affected by individual bleeding risk, disease stage, side effects of treatment, concomitant medications, and patient preference. (mja.com.au)
Updated consensus statement on biological agents for the treatment of rheumatic diseases, 2007. (spr-journal.ru)
Bone-marrow transplantation, prevention and treatment of graft-versus-host disease, adult and child over 3 months 3-5 mg/kg daily by intravenous infusion over 2-6 hours from day before transplantation to 2 weeks postoperatively (or 12.5-15 mg/kg daily by mouth) then 12.5 mg/kg daily by mouth for 3-6 months then tailed off. (obaid.info)
In this Perspective article, we review the theory and evidence for a disease model of complement-mediated TMA and important implications for treatment. (nature.com)
Diagnostic approach and both empirical and disease-specific treatment strategies will be discussed, along with the potential role for emerging targeted disease-specific therapies. (bvsalud.org)
The disease requires extensive medical treatment and therapy. (healthandmedicineinfo.com)
Visceral disseminated varicella zoster virus infection after rituximab treatment for granulomatosis with polyangiitis. (kyoto-u.ac.jp)

Patients with severe autoimmune thrombotic thrombocytopenic purpura (TTP) experience acute hematologic emergencies during disease flares and a lifelong threat for relapse. (nih.gov)

We then calculated the theoretical cost to the hospital of initiating rituximab in the inpatient setting for both initial TTP and relapse TTP cohorts, with the hypothesis that preventing sufficient future TTP admissions offsets the cost of initiating rituximab in all patients with TTP. (nih.gov)
Patients with RA associated with Sjögren syndrome likely require other disease-modifying agents. (medscape.com)
Reports on the use of rituximab in patients with primary Sjögren syndrome have emerged in the literature. (medscape.com)
In a prospective study of 78 patients with primary Sjögren syndrome treated with rituximab, significant improvement in extraglandular manifestations was reported, as measured by EULAR [European League Against Rheumatism] Sjögren Syndrome Disease Activity Index (ESSDAI) (disease activity score) and overall good tolerance reported. (medscape.com)
About 50% of patients with Sjögren syndrome have cutaneous findings, such as dry skin (xeroderma), palpable and nonpalpable purpura, and/or urticaria. (medscape.com)
Patients must be monitored carefully for the potential development of lymphoma, as the risk for this disease is significantly higher than in the general population. (medscape.com)
Inhibition of Complement C1s With Sutimlimab in Patients With Cold Agglutinin Disease (CAD): 2-Year Follow-Up From The CARDINAL Study. (sanofi.com)
[ 5 ] Teachey et al demonstrated that more than half (58%) of the patients with Evans syndrome might have autoimmune lymphoproliferative syndrome (ALPS), a novel finding with potentially important therapeutic implications. (medscape.com)
1 , 2 Our recently published multicenter randomized open-label phase 2 trial comparing 3 rituximab dosing schemes showed 50% responses in 138 ITP patients. (ashpublications.org)
Thirty-seven patients (44%) did not have detectable residual disease in the BM prior to maintenance therapy. (haematologica.org)
Interestingly, 29 patients with detectable residual disease in the BM after induction no longer had detectable disease in the BM following maintenance therapy. (haematologica.org)
After a median followup of 6.30 years, the median overall survival (OS) and PFS had not been reached in patients with either undetectable or detectable residual disease in the BM, who had achieved a complete response at the time of starting maintenance therapy. (haematologica.org)
These data show that, compared to historic controls, patients treated with FCR followed by rituximab maintenance have high-quality responses with fewer relapses and improved OS. (haematologica.org)
Without therapy approximately 90% of all patients die from the disease. (biomedcentral.com)
This approval will provide patients the opportunity to receive Nplate earlier in the course of their disease, potentially reducing their need for prolonged steroid use. (pdsa.org)
Multiple sclerosis (MS) patients may also be at risk of the disease and its complications depending on the medication they are taking. (drnasermoghadasi.com)
In this study, we evaluated a large population of patients with MS with different disease modifying drugs to show if any of them increases the risk. (drnasermoghadasi.com)
11. Naser Moghadasi A. One Aspect of Coronavirus disease (COVID-19) Outbreak in Iran: High Anxiety among MS Patients . (drnasermoghadasi.com)

[ 86 , 87 ] Results from the AIR registry (French) indicated that rituximab appears to be effective in cryoglobulinemia or vasculitis-related peripheral nervous system involvement in primary Sjögren syndrome. (medscape.com)
Granulomatosis with polyangiitis is the third most common type of vasculitis in Iran after Behcet's disease and cutaneous leukocytoclastic angiitis [6]. (rheumres.org)
A concomitant case of pathologically proven IgG4-related disease and ANCA-associated vasculitis: case report. (kyoto-u.ac.jp)

It has a marked antitumour effect in acute lymphoblastic leukaemia, Hodgkin's disease, and the non-Hodgkin lymphomas. (obaid.info)

The cause of TTP is often unknown, but some people develop it after taking certain drugs (including quinine , cyclosporine , and mitomycin C), after certain types of intestinal infection, during pregnancy, or rarely as an inherited disease. (msdmanuals.com)
A reduction in platelet number or function can occur through a variety of mechanisms, including autoimmune destruction, spleen sequestration, bone marrow infiltration by tumor cells, infection (e.g. dengue fever), and adverse drug reaction. (bvsalud.org)

Two cases of autoimmune and secondary pulmonary alveolar proteinosis during immunosuppressive therapy in dermatomyositis with interstitial lung disease. (kyoto-u.ac.jp)

Hepatitis A, B, and C are all viral diseases that can cause liver damage. (autolama.sk)
Acquired thrombotic thrombocytopenic purpura (TTP) is an autoimmune disease that can be triggered by different events, including viral infections. (unipr.it)

Rare manifestations included autoimmune hemolytic anemia, thrombotic thrombocytopenic purpura, digital gangrene, and deep vein thrombosis (each in 1 patient). (rheumres.org)
Common manifestations may include arthralgias and arthritis, Raynaud syndrome, malar and other rashes, pleuritis or pericarditis, renal or central nervous system involvement, and autoimmune cytopenias. (merckmanuals.com)
Furthermore, we underline how the potential risk of not recognizing disease manifestations promptly, together with specific coagulation alterations, could significantly affect the patient's outcome. (drpaulalexander.com)

The etiology is diverse and includes infections Infections Invasion of the host organism by microorganisms or their toxins or by parasites that can cause pathological conditions or diseases. (lecturio.com)

Rituximab, in addition to steroids and therapeutic plasma exchange (TPE), has been shown to mitigate relapse risk. (nih.gov)

She was discharged after a many week admission on a steroid taper and with a plan for her to total four weekly doses of rituximab. (forgetmenotinitiative.org)

The time course of rituximab sequelae and rapid response to therapy prompts some considerations on possible mechanisms. (racetab.org)
Bone marrow (BM) MRD analysis was performed after the last planned induction course and every 6 months in cases with detectable residual disease during the 36 months of maintenance therapy. (haematologica.org)
long-term dependence on steroid therapy, if more than 5-10mg/day of prednisolone is required to keep the disease in control- steroid-sparing IMT is indicated. (aao.org)
While plasma exchange therapy was continued, rituximab was given once weekly for four consecutive weeks. (biomedcentral.com)

Studies have shown that Werlhof's disease often has to be diagnosed after infections and / or pregnancy. (healthandmedicineinfo.com)

True, there are advantages to starting some therapies earlier when the disease burden is low. (blogspot.com)

Of 45 children diagnosed with Evans Syndrome, 21 were found to have autoimmune lymphoproliferative syndrome (ALPS) instead, report researchers from data gathered from 22 institutions. (pdsa.org)
Seif AE et al, "Identifying autoimmune lymphoproliferative syndrome in children with Evans syndrome: a multi-institutional study. (pdsa.org)

To treat autoimmune diseases and B cell malignancies. (genestarbio.com.tw)

Anatomy13

Organisms7

Diseases71

Chemicals and Drugs68

Analytical, Diagnostic and Therapeutic Techniques and Equipment42

Phenomena and Processes18

Disciplines and Occupations1

Information Science3

Health Care11

Geographicals1

Thrombocytopenia16

Idiopathic5

Rheumatoid arthritis7

Thrombotic thrombocytopenic purpura-h2

Immune25

Splenectomy6

Cyclophosphamide7

Monoclonal6

Corticosteroids4

Refractory2

Diagnosis2

Disseminated intravascul1

Disorder7

Antibodies8

Hemolytic uremic s1

Petechiae2

Chronic9

Clinical9

Abstract1

Antibody4

Deficiency1

Platelets5

Efficacy2

Inflammatory2

Disorders1

Dose2

Symptoms3

Pathophysiology1

Caused by autoantibodies1

Treatment17

Severe1

Patients18

Vasculitis3

Acute1

Infection2

Immunosuppressive therapy1

Viral2

Manifestations3

Etiology1

Steroids1

Doses1

Therapy4

Pregnancy1

Therapies1

Syndrome2

Malignancies1