• OBJECTIVES: Foot and ankle involvement is common in rheumatic and musculoskeletal diseases, yet high-quality evidence assessing the effectiveness of treatments for these disorders is lacking. (iwh.on.ca)
  • Epidemiologic studies of rheumatic diseases can be broadly divided into those that describe the occurrence of specific disorders, those that attempt to quantify the role of putative risk factors for disease occurrence, and those that define the outcome and factors associated with it. (ox.ac.uk)
  • It is the most common form of arthritis and one of the most prevalent musculoskeletal disorders worldwide. (nature.com)
  • Weiya Zhang has published over 150 peer-reviewed papers in the past 10 years in epidemiology, clinical trials, systematic reviews and evidence based guidelines in OA, gout and other musculoskeletal disorders. (nottingham.ac.uk)
  • The World Health Organization (WHO) defines musculoskeletal disorders as "health problems of the musculoskeletal system, namely muscles, tendons, bone skeleton, cartilages, ligaments and nerves. (nutraingredients.com)
  • It is well known that the management of musculoskeletal disorders includes both non-pharmacological treatments (physiotherapy and manual therapy) and pharmacological treatments such as non-steroidal anti-inflammatory drugs (NSAIDs) and analgesics. (nutraingredients.com)
  • A recent study published in the international journal BMC Musculoskeletal Disorders involved subjects with shoulder tendinopathy. (nutraingredients.com)
  • Psychological medicine, pain, and musculoskeletal disorders. (bvsalud.org)
  • Clinical trials and observational studies comparing pharmacological, conservative or surgical interventions involving adult participants with any foot or ankle disorder in the following rheumatic and musculoskeletal diseases (RMDs) were eligible for inclusion: rheumatoid arthritis (RA), osteoarthritis (OA), spondyloarthropathies, crystal arthropathies and connective tissue diseases. (iwh.on.ca)
  • Musculoskeletal diseases currently affect approximately 1.5 billion people specifically, osteoarthritis is the most common rheumatic disease . (mpgroup.es)
  • Osteoarthritis (OA) is a degenerative joint disease that leads to pain, stiffness and loss of function. (nature.com)
  • In this Review, Pandey and Bhutani describe the use of single-cell 'omics' technologies to identify cell subpopulations in joint tissues in health and disease, thereby contributing to the construction of joint cell atlases and the identification of pathogenetic cell subpopulations that are potential therapeutic targets for diseases such as osteoarthritis and rheumatoid arthritis. (nature.com)
  • My specific interests are clinical, epidemiologic, and data-intensive research to understand and improve musculoskeletal health and care, particularly osteoarthritis. (shu.ac.uk)
  • The pathway for developing structure modifying drugs for osteoarthritis (OA) has been complicated by the fact that OA is a heterogeneous disease process and by the inability to predict which patients will progressively lose function and develop more joint damage. (oarsi.org)
  • Although osteoarthritis is the most common rheumatic disease, there are a number of other rheumatic diseases that share similar symptoms. (lu.se)
  • Rheumatic musculoskeletal diseases (RMDs) cause impaired function and reduced quality of life and patients with RMDs often require multi-disciplinary team rehabilitation. (rsyd.dk)
  • Rheumatic musculoskeletal diseases (RMDs) are a diverse group of diseases affecting joints and muscles. (rsyd.dk)
  • Getting adequate physical activity is a persistent challenge for many people with rheumatic and musculoskeletal diseases (RMDs). (medpagetoday.com)
  • We are aware that physical activity is associated with lower disease activity, disease progression, and damage, as well as with improved general well-being among patients with RMDs. (medpagetoday.com)
  • The European Parliament Interest Group on Rheumatic and Musculoskeletal Diseases (RMDs) was created in 2009 on the occasion of World Arthritis Day (12 October) and was re-established during the current parliamentary term (2014-2019). (eular.org)
  • In 2017, EULAR launched the Europe-wide campaign entitled 'Don't Delay, Connect Today' with the goal to highlight rheumatic and musculoskeletal diseases (RMDs) as major diseases and a public health concern of pandemic proportions, and that early diagnosis and timely access to treatment can prevent further damage and burden on the individual and society. (eular.org)
  • There are over 200 rheumatic and musculoskeletal diseases, RMDs. (eular.org)
  • Patients may also develop a number of related (e.g. gout) or unrelated rheumatic diseases (e.g. inflammatory arthritis and autoimmune CTDs). (medscape.com)
  • In particular, it is important that rheumatologists are aware of the possibility of the presence of related (e.g. gout) and unrelated rheumatic diseases (e.g. inflammatory arthritis and autoimmune CTDs), because both the prognosis and the treatment may differ significantly. (medscape.com)
  • Gout is an inflammatory rheumatic disease that causes episodes of sudden severe joint pain and swelling of the joint. (lu.se)
  • Pseudogout is similar to gout in the sense that in both disease states , crystals form in the joints creating sudden joint pain. (lu.se)
  • The goal of the NIAMS clinical trial program is to prevent or reduce symptoms and improve outcomes and function in patients with rheumatic, musculoskeletal or skin diseases. (nih.gov)
  • became the Director of the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) in February, 2021. (nih.gov)
  • The IMI research agenda includes an overall section on inflammatory diseases, which includes arthritis and rheumatoid arthritis. (eular.org)
  • For example, flare-ups or increased disease activity in pregnant women with rheumatoid arthritis or inflammatory bowel is associated with a higher risk of adverse pregnancy outcomes, such as preterm birth and low birth weight. (drugs.com)
  • Centers for Disease Control and Prevention. (cdc.gov)
  • Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. (cdc.gov)
  • The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. (cdc.gov)
  • Before joining SHU I worked in the Arthritis Research UK/Versus Arthritis national Primary Care Centre of Excellence at Keele University, designing and undertaking clinical, epidemiologic, and data-intensive research to understand and improve musculoskeletal health and care. (shu.ac.uk)
  • Clinical signs of carditis include cardiomegaly, new onset heart murmur (usually with mitral or aortic valvular disease), pericardial friction rub, pericardial effusion, and congestive heart failure. (cdc.gov)
  • In this regard, this research line explores new pharmacological approaches, either from existing drugs used in clinical practice or from natural active principles Thus, if these compounds show non-toxic anti-inflammatory activity, they could potentially become therapeutic tools to treat musculoskeletal pathologies. (mpgroup.es)
  • The purpose of the Exploratory Clinical Trials Grants Program is to foster clinical trials that will lead to clinically meaningful improvements in prevention, diagnosis, or treatment of these diseases. (nih.gov)
  • Clinical trials in rare diseases where the number of potential study participants is limited. (nih.gov)
  • Through the ACE I developed and participated in numerous clinical trials, testing novel treatments for systemic autoimmune diseases. (rochester.edu)
  • Subsequently, in 2011, OARSI in collaboration with the Foundation for the NIH (FNIH) initiated a 2.5-year study to further explore imaging and biomarkers as predictors of disease progression and clinical outcomes. (oarsi.org)
  • Primary APS is diagnosed in patients demonstrating the clinical and laboratory criteria for the disease without other recognized autoimmune disease. (medscape.com)
  • The key new information is advice for biologic treatment in 'difficult' cases such as those with hepatitis or [HIV] infection," lead author Laura C. Coates, MBChB, PhD, from the Academic Section of Musculoskeletal Disease, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals National Health Service Trust, United Kingdom, told Medscape Medical News . (medscape.com)
  • SARS-CoV-2 Infection and COVID-19 Outcomes in Rheumatic Diseases: A Systematic Literature Review and Meta-Analysis. (nih.gov)
  • Rare Disease PHGKB is an online, continuously updated, searchable database of published scientific literature, CDC and NIH resources, and other information that address the public health impact and translation of genomic and other precision health discoveries into improved health outcomes related to rare diseases. (cdc.gov)
  • The interventions were associated with 20 health outcomes divided into 5 groups: Well-being, Vitality and Quality of Life, Pain, Chronic Noncommunicable Diseases, Infectious Diseases and Noncommunicable Diseases. (bvsalud.org)
  • In total, there were 37 associations between intervention and outcome, the majority (22) with multimodal cupping with TCM and non-TMC of the mixed type and for outcomes in the Pain group (9), Chronic Noncommunicable Diseases (6) and Well-Being, Vitality and Quality of Life (4). (bvsalud.org)
  • Musculoskeletal (MSK) ultrasound is a valuable imaging modality for the practicing rheumatologist and provides an efficient tool with high diagnostic value in the evaluation of patients with musculoskeletal complaints. (the-rheumatologist.org)
  • The following cases demonstrate the usefulness of ultrasound in providing clues to the underlying diagnosis and highlight a case in which this imaging modality was helpful in assessing disease activity in an established RA patient, which altered the patient management. (the-rheumatologist.org)
  • This study aimed to show that access to CQ as a chronic medication for rheumatic and musculoskeletal diseases was limited during the COVID-19 pandemic, and that this resulted in an increased incidence of flares in these patients, affecting their morbidity and potentially leading to mortality. (scielo.org.za)
  • The incidence of acute rheumatic fever is highest in children between the ages of 5 and 15 years. (cdc.gov)
  • The overall goal of this two-year study is to calculate in 21,786 World Trade Center (WTC)-exposed and unexposed firefighters and emergency medical service workers and to estimate the association between intense WTC exposure and Systemic Autoimmune Diseases (SAID). (cdc.gov)
  • To estimate the association between arrival time to the WTC site and new onset systemic autoimmune diseases. (cdc.gov)
  • To estimate the association between months of WTC-related work and new onset systemic autoimmune diseases. (cdc.gov)
  • The aim of the study was to test the association between acute (arrival time at the World Trade Center (WTC) site) and chronic (months of WTC-related work) exposures and new onset systemic autoimmune diseases among firefighters and Emergency Medical Service workers. (cdc.gov)
  • We found prolonged work at the WTC site, independent of acute exposure, was an important predictor of post-9/11 systemic autoimmune diseases. (cdc.gov)
  • 2015. Nested case-control study of selected systemic autoimmune diseases in World Trade Center rescue/recovery workers . (cdc.gov)
  • Mendoza-Pinto C, García-Carrasco M, Cervera R. Role of Infectious Diseases in the Antiphospholipid Syndrome (Including Its Catastrophic Variant). (medscape.com)
  • This state of affairs is understandable and perhaps necessary when one considers that resources are extremely scarce, infectious diseases and trauma often strike persons in their youth or during their most productive years, and treatment for infectious diseases (and to a lesser extent for traumatic injuries) can often be curative with a single-dose low-cost regimen. (who.int)
  • however, nearly 20% will have worse or moderate-to-high disease activity during pregnancy that may require further therapeutic intervention. (medscape.com)
  • OA may be the most common rheumatic disease, but it is not the only disease that causes symptoms such as pain and stiffness of the joints. (lu.se)
  • Caused in almost all cases by autoimmune disease , the result is that the immune system goes awry and begins gradually to destroy the thyroid gland. (diagnose-me.com)
  • Hypothyroidism is usually caused by an autoimmune disease ( Hashimoto's thyroiditis ), but may also be caused by radiation therapy , thyroid surgery, or certain medications. (diagnose-me.com)
  • Dear Colleagues, Many studies have shown that autoimmune diseases disproportionately affect women - nearly 80 percent of those with an autoimmune disease are women. (nih.gov)
  • Caoilfhionn M. Connolly, M.D., from the Johns Hopkins University School of Medicine in Baltimore, and colleagues examined disease flare and postvaccination reactions in 1,377 patients with RMD following two-dose SARS-CoV-2 mRNA vaccination. (physiciansweekly.com)
  • And therefore, there were concerns because of the specificities that there could be certain type of adverse events that would be more common or more worrying among patients with immune mediated disease in general. (hcplive.com)
  • So that was the motivation to create a registry specific for patients with rheumatic diseases. (hcplive.com)
  • One of the concerns was that the vaccines could potentially lead to flares of the inflammatory rheumatic disease, or to certain that there could be certain side effects, especially the ones that are immune mediated that could be more common among patients with rheumatic diseases. (hcplive.com)
  • I guess the key message of the of the results that we'll be presenting, the key takeaway message is that the COVID-19 vaccines are safe in patients with rheumatic diseases. (hcplive.com)
  • The other thing is that the overwhelming majority of our patients, they tolerate the vaccination very well, with rare reports of inflammatory, rheumatic disease flare, and very rare reports of severe adverse events. (hcplive.com)
  • They prevent millions of deaths yearly, and many, many more million deaths will be prevented with COVID-19 vaccines and this includes patients with rheumatic diseases. (hcplive.com)
  • In approximately one-third of patients, acute rheumatic fever follows subclinical streptococcal infections or infections for which medical attention was not sought. (cdc.gov)
  • Interstitial lung disease (ILD) in patients with systemic sclerosis (SSc) is associated with considerable morbidity and mortality. (nature.com)
  • Among patients with at least moderate disease activity in the first trimester, at least 48% had a moderate response during pregnancy, whereas patients with low disease activity in the first trimester reported that their disease activity remained stable during pregnancy. (medscape.com)
  • These patients may need a reminder about the importance of using contraception during therapy with disease-modifying antirheumatic drugs (DMARDs), especially methotrexate, leflunomide, and cyclophosphamide. (medscape.com)
  • Patients with these conditions who do not initiate treatment or discontinue treatment prior to or during pregnancy are more likely to have uncontrolled disease activity. (drugs.com)
  • Rehabilitation goals described by patients with rheumatic and musculoskeletal diseases: content and attainment during the first year after rehabilitation. (uit.no)
  • Manual therapy is a method of treatment used by physiotherapists and physiatrists, involving specialized manual techniques to solve patients' neuro-musculoskeletal dysfunctions. (nutraingredients.com)
  • The key recommendations include new guidance on treating patients with psoriasis who have peripheral arthritis or axial disease. (medscape.com)
  • A total of 83(46.9%) of the patients had appendicitis related diagnosis, 16(9.0%) of the cases resulted from trauma, 25(14.1%) had intestinal obstruction from post-operative bands, 28(15.8%) had intestinal obstruction from colonic tumours and 17(9.6%) had perforated peptic ulcer disease. (bvsalud.org)
  • Musculoskeletal (MSK) complications are common in patients with haemoglobinopathies and may affect the whole of the MSK system, in addition to bone, which is the primary site of the disease. (medscape.com)
  • Treatment of MSK conditions in patients with haemoglobinopathies may be challenging (e.g. bone marrow suppression from disease-modifying agents) and in particular in SCA, steroid therapy (by any route) may precipitate potentially severe vaso-occlusive complications. (medscape.com)
  • Musculoskeletal (MSK) symptoms are common in patients with haemoglobinopathies. (medscape.com)
  • Musculoskeletal involvement is common in patients with haemoglobinopathies. (medscape.com)
  • RA) in patients with haemoglobinopathies and musculoskeletal symptoms. (medscape.com)
  • Other causes of joint pain include inflammation of the bones , muscles, joints, and tendons or in the tissue surrounding the organs in your musculoskeletal system (locomotor system). (lu.se)
  • Cetilar ® ​ Cream assists massage therapy, by helping articulation and movement in cases of joint diseases on an osteoarthritic basis. (nutraingredients.com)
  • The massage can reduce the painful symptomatology at the joint and musculoskeletal level, useful even in cases of sports trauma. (nutraingredients.com)
  • Acute rheumatic fever is a delayed sequela of pharyngitis and skin infections due to Streptococcus pyogenes , which are also called group A Streptococcus (group A strep). (cdc.gov)
  • Acute rheumatic fever is a nonsuppurative, delayed sequela of pharyngitis and skin infections, such as impetigo, due to S. pyogenes . (cdc.gov)
  • Streptococcal pharyngitis typically precedes the onset of acute rheumatic fever by 1 to 5 weeks. (cdc.gov)
  • Acute rheumatic fever is usually characterized by fever and affects multiple organ systems. (cdc.gov)
  • Carditis is the major cardiac manifestation of acute rheumatic fever, occurring in 50% to 70% of first episodes, and is associated with valvulitis. (cdc.gov)
  • Chorea often appears after the other manifestations of acute rheumatic fever. (cdc.gov)
  • It also can appear as the only manifestation of acute rheumatic fever. (cdc.gov)
  • Inadequate or lack of antibiotic treatment of streptococcal pharyngitis increases the risk of someone developing acute rheumatic fever. (cdc.gov)
  • Individuals with a history of acute rheumatic fever have an increased risk of recurrence with subsequent streptococcal pharyngeal infections. (cdc.gov)
  • Acute rheumatic fever is very rare in children 3 years of age and younger in the United States. (cdc.gov)
  • First-onset acute rheumatic fever is rare in adults, although recurrence may occur through adulthood. (cdc.gov)
  • Crowding, such as found in schools, military barracks, and daycare centers, increases the risk of spreading group A strep and thus increases the risk of developing acute rheumatic fever. (cdc.gov)
  • The differential diagnosis of acute rheumatic fever is broad due to the various symptoms of the disease. (cdc.gov)
  • In many countries, health-care systems tend to focus almost exclusively on acute-onset conditions and diseases caused by trauma or infection. (who.int)
  • Typical MSK complications include painful vaso-occlusive disease and osteomyelitis in SCA and reduced BMD in thalassaemia. (medscape.com)
  • Moreover, musculoskeletal conditions and mental health, which are extremely prevalent, tend to attract less attention in all parts of the world because they have low fatality rates. (who.int)
  • While this strategy brings benefits, it overlooks chronic diseases and conditions, such as heart disease and cancer, that rank among the top in terms of global mortality and morbidity. (who.int)
  • A strategy for osteoporosis prevention, which fits well with prevention of other noncommunicable diseases, should accentuate proper nutrition (in this case to include adequate intake of calcium, vitamin D and protein), weight-bearing (aerobic) exercise, maintenance of proper body- mass index, abstinence from tobacco use, and avoidance of excessive alcohol use, and should also stress moderate exposure to sunlight. (who.int)
  • B. Examination by physician A physician performed and recorded the results of a medical examination giving special attention to specified findings related to nutrition, to hearing, to the thyroid gland,and to the cardiovascular, respiratory, neurological and musculoskeletal systems. (cdc.gov)
  • No studies were available regarding cardiovascular, musculoskeletal, renal, dermal or ocular effects in humans after inhalation exposure to tetryl. (cdc.gov)
  • The International Classification of Diseases (ICD-11) includes fibromyalgia in the category of "Chronic widespread pain", code MG30.01. (wikipedia.org)
  • Fibromyalgia is a chronic rheumatic disease that is characterized by widespread muscle pain in the absence of inflammation signs. (nutraingredients.com)
  • Rheumatic Disease Clinics of North America, 22(3),623-637. (bvsalud.org)
  • This event will bring together academics, clinicians and industry to connect over Musculoskeletal Research (MSK) and will follow a workshop format with plenty of opportunity to update MSK research and network with colleagues involved in MSK research. (southampton.ac.uk)
  • Rheumatic or musculoskeletal conditions comprise over 200 diseases and syndromes, which are usually progressive and associated with pain. (vcuhealth.org)
  • Many of these conditions are considered autoimmune diseases, which arise from an abnormal immune response of the body against its own tissues. (vcuhealth.org)
  • The risk may be greater in older adults or if you have heart disease or increased risk for heart disease (for example, due to smoking , family history of heart disease, or conditions such as high blood pressure or diabetes ). (webmd.com)
  • They report barriers such as limited time, motivation, and support for and access to exercise opportunities, in addition to disease-specific barriers (e.g., fatigue, pain, fear of exacerbating disease). (medpagetoday.com)
  • Musculoskeletal pain has an important impact on quality of life. (nutraingredients.com)
  • As many rheumatic diseases share a number of the same symptoms, it is important to receive the correct diagnosis from your healthcare provider to start the right form of treatment. (lu.se)
  • About 30% of all people who suffer from the skin disease psoriasis develop psoriatic arthritis. (lu.se)
  • Psoriatic arthritis is an inflammatory rheumatic disease that mainly affects the small joints in the hands and feet. (lu.se)
  • For many millions of people in Europe the opportunity to design a good life is however severely limited by a chronic disease. (eular.org)
  • So with the introduction of the COVID-19 vaccination programs, there were specific concerns raised by the population with rheumatic diseases because they have either an underlying immune dysfunction or sometimes they're taking drugs that affect the immune system. (hcplive.com)
  • The guidelines do not cover either juvenile idiopathic arthritis or psoriatic disease confined to the skin. (medscape.com)
  • In addition to influencing immune response patterns, many of these alleles are associated with susceptibility to a wide spectrum of autoimmune diseases, making the MHC an essential starting point for anyone wanting to understand the genetics of rheumatic diseases. (musculoskeletalkey.com)
  • He has also worked on the role of the microbiome and infections in development of immune mediated diseases. (rochester.edu)
  • Since the mid-1990's I became interested in investigator-initiated trials of new agents for immune-mediated diseases, most notably one of the very first trials of B cell targeted therapy for autoimmunity (anti-CD20 for SLE). (rochester.edu)
  • The TNF-TNF receptor signalling network has pleiotropic effects that can both promote and protect against immune-mediated diseases. (nature.com)
  • Dr. Kaplan's research focuses on identifying the molecular mechanisms that promote the initiation and perpetuation of perturbed immune responses and the development of organ damage and premature vascular disease in systemic autoimmunity. (nih.gov)
  • Immunoglobulin G4-related disease (IgG4-RD) is a chronic immune-mediated fibroinflammatory disorder that often manifests with tumor-like masses and/or painless enlargement of multiple organs. (msdmanuals.com)
  • in allergic disease, it is thought to have an immune-inhibitory role in preventing anaphylactic reactions to allergens. (msdmanuals.com)
  • The NIAMS Update is a digest on the latest scientific news and resources on diseases of the bones, joints, muscles, and skin. (nih.gov)
  • Exercise is also useful in this context, especially when it is alternated between light aerobic exercise (walking, cycling) and postural exercises or mild muscle strengthening, to help strengthen the musculoskeletal structures. (nutraingredients.com)
  • This type of disease has been found to be the most common cause of reduced mobility. (vcuhealth.org)
  • Hypothyroidism is one of the most common chronic diseases. (diagnose-me.com)
  • The current US Food and Drug (FDA) approval process for structure modifying drugs for OA requires concomitant improvement in a qualified and validated imaging or biochemical marker and improvement in the signs and symptoms of the disease. (oarsi.org)
  • Adherence to therapy in people with rheumatic and musculoskeletal diseases in Italy and the role of the digital health: results of an expert Delphi consensus survey. (bvsalud.org)
  • Integrating enriched longitudinal multi-level data for local population musculoskeletal health intelligence: North Staffordshire & Stoke-on-Trent. (shu.ac.uk)
  • According to the guideline, "HIV or HCV infection should not preclude treatment with anti-TNF therapy, although treatment should only be commenced in those with well-controlled disease and with appropriate monitoring under the care of a hepatologist or HIV specialist. (medscape.com)