OncogenicVectorsPrecursorsLentivirusAccessory ProteinsMatrix proteinsCapsidMembrane ProteinsRetrovirusesRetroviral envelopeSpecificityAntibodiesGene ProductsFamilyGenesGP120StructuralOrthomyxoviridaeTranscriptionParticlesGp41SubfamilyLentiviralInduceMeSHHeterologousSimianMRNACellsReplicationHuman immunSurfactantPhosphorylationMurineAntiviralCellularDefinitionLipidsLSBioKinaseVariantsInterestinglyStrainsTherapeuticVirus
Oncogenic3
- Oncogenic retroviridae proteins are retroviral proteins that have the ability to transform cells. (wikipedia.org)
- Not all retroviral proteins are oncogenic. (wikipedia.org)
- Over-expression, incorporation near oncogenic loci, or the website hosts' response to the protein encoded by retroviral genetics determine the type of disease demonstrated [1]. (siamtech.net)
Vectors4
- Lentiviral (LV) vectors of the Retroviridae family show interesting properties for monogenic gene therapy, since they integrate into the host genome and allow long-lasting gene expression 22 . (nature.com)
- Outcomes We produced retroviral vectors pseudotyped with different gamma and lentiviral Envs on MLV-B and -NB CAs formulated with a green neon proteins (GFP) news reporter. (siamtech.net)
- Lentivirus vectors are derived from the family Retroviridae , a family of enveloped, ssRNA viruses. (alecomm.com)
- Third generation lentiviral vectors currently in use encode no viral proteins, only a few cis-acting sequence elements required for packaging, reverse transcription, and efficient expression. (alecomm.com)
Precursors2
- They are usually synthesized as protein precursors (POLYPROTEINS) and later cleaved into the final viral envelope glycoproteins by a viral protease. (ucdenver.edu)
- The products are usually synthesized as protein precursors or POLYPROTEINS, which are then cleaved by viral proteases to yield the final products. (lookformedical.com)
Lentivirus2
- Directed evolution of retrovirus envelope protein cytoplasmic tails guided by functional incorporation into lentivirus particles. (ucdenver.edu)
- HIV disease is caused by infection with HIV-1 or HIV-2, which are retroviruses in the Retroviridae family, Lentivirus genus. (medscape.com)
Accessory Proteins1
- HIV-1 also has regulatory genes ( tat and rev ) and genes that encode for accessory proteins ( vpu , vpr , vif , and nef ) that are important in viral replication and interaction with the host. (medscape.com)
Matrix proteins2
- The envelope consists of an inner layer of lipids and virus specified proteins also called membrane or matrix proteins. (lookformedical.com)
- The virus' RNA, its associated nucleocapsid proteins, and reverse transcriptase are enveloped by a capsid structure and then by a spherical lipid membrane including env-glyco- (gp41 + gp120), and matrix proteins. (jpt.com)
Capsid4
- Central to both Gag protein arrangements is the capsid (CA) protein, a domain of PrGag, which is cleaved from the precursor to yield a mature Gag protein composed of an N-terminal domain (NTD), a flexible linker region, and a C-terminal domain (CTD). (elsevierpure.com)
- Layers of protein which surround the capsid in animal viruses with tubular nucleocapsids. (lookformedical.com)
- SIV proteins, especially the viral core proteins (i.e., p24, capsid protein), are antigenically related to HIV-I proteins (9). (cdc.gov)
- Some SIV isolates, however, are antigenically more related to HIV-2 than to HIV-I by cross-reactivity of viral capsid and envelope proteins. (cdc.gov)
Membrane Proteins3
- Viral ion channels are short auxiliary membrane proteins with a length of ca. 100 amino acids. (ox.ac.uk)
- This review summarises the current knowledge of these short viral membrane proteins. (ox.ac.uk)
- In addition 34 headings that were formerly under Carrier Proteins, Membrane Proteins or Permeases are now arrayed under Membrane Transport Proteins. (bvsalud.org)
Retroviruses4
- DNA sequences that form the coding region for the viral envelope (env) proteins in retroviruses. (lookformedical.com)
- The retroviruses are enveloped viruses that belong to the viral family Retroviridae. (blog-biosyn.com)
- Retroviruses belong to the family Retroviridae and are ribonucleoprotein (RNP) particles that contain a dimeric RNA genome. (uaeu.ac.ae)
- This review will compare the determinants of gRNA encapsidation among different retroviruses, followed by an examination of our current understanding of the interaction between diverse viral genomes and heterologous proteins, leading to their cross-/co-packaging. (uaeu.ac.ae)
Retroviral envelope3
- Scholars@Duke publication: Transcriptional down-regulation of tumor necrosis factor-alpha gene expression by a synthetic peptide homologous to retroviral envelope protein. (duke.edu)
- We have previously shown that a synthetic peptide (CKS-17) homologous to retroviral envelope protein suppresses the accumulation of superantigen staphylococcal enterotoxin-induced TNF-alpha mRNA in human PBMC and in highly purified human monocytes. (duke.edu)
- The protein encoded by ORF3 is glycosylated and processed, like all retroviral envelope proteins. (johnshopkins.edu)
Specificity1
- The specificity towards RNA packaging requires higher order interactions of the retroviral gRNA with the structural Gag proteins. (uaeu.ac.ae)
Antibodies1
- HIV infection can be diagnosed based on detection of antibodies that are directed against the proteins encoded by the 3 major genes, the detection of the p24 antigen, the viral nucleic acid, and, finally, by means of culturing the virus. (medscape.com)
Gene Products3
- The vpx gene products of human immunodeficiency virus type 2 (HIV-2) and of the closely related simian immunodeficiency viruses from sooty mangabeys (SIVsm) and macaques (SIVmac) comprise a 112-amino-acid virion-associated protein that is critical for efficient virus replication in nondividing cells such as macrophages. (duke.edu)
- Diffusible gene products that act on homologous or heterologous molecules of viral or cellular DNA to regulate the expression of proteins. (bvsalud.org)
- The env genes contain a cis-acting RNA target sequence for the rev protein (= GENE PRODUCTS, REV ), termed the rev-responsive element (RRE). (lookformedical.com)
Family8
- Interestingly, immunity-associated GTPase family M (IRGM), the most targeted protein, was found to interact with the autophagy-associated proteins ATG5, ATG10, MAP1CL3C and SH3GLB1. (sfr-biosciences.fr)
- However, these signature sequences have not so far been extensively investigated amongst orthologous Bcl-2 family proteins. (sfr-biosciences.fr)
- Considering the reliance of female eggs on calcium-dependent proteins and calcium-regulated processes and the exceptional longevity of oocytes in the primate lineage, we propose that this microstructural variation may be an adaptive feature associated with high maternal expression of this Bcl-2 family member. (sfr-biosciences.fr)
- Human immunodeficiency virus (HIV)-1 is a member of the Retroviridae family. (medscape.com)
- The murine leukaemia infections (MLVs) are associates of the gamma-retrovirus genus of the Retroviridae family members. (siamtech.net)
- HIV is part of the genus lentiviridae and family of retroviridae, with its categorization being attributed to its morphology and infection mechanism, respectively. (jpt.com)
- Simian immunodeficiency virus (SIV) belongs to the family Retroviridae (subfamily Lentivirinae) and is closely related to human immunodeficiency virus types 1 and 2 (HIV-1 and HIV-2), the etiologic agents of acquired immunodeficiency syndrome (AIDS). (cdc.gov)
- Ammong the significant changes the names of all genera in the family Retroviridae have been revised. (bvsalud.org)
Genes1
- Some genes no longer code for a protein due to a mutation or error. (rationalwiki.org)
GP1202
- It serves as a precursor for both the HIV ENVELOPE PROTEIN GP120 and the HIV ENVELOPE PROTEIN GP41 . (lookformedical.com)
- Octapeptide sharing sequence homology with HIV envelope protein gp120. (reference.md)
Structural2
- Disruption of the structural and functional features of surfactant protein A by acrolein in cigarette smoke. (lsbio.com)
- Other landmark structural fusion proteins include POL and GAG, which assemble for optimal virion recruitment and spherical particle formation, and regulatory proteins such as NEF, which is required for virus replication and evading the host's defense via downregulation of surface molecules. (jpt.com)
Orthomyxoviridae2
- We have determined the ability of 83 proteins of several families of RNA viruses (Paramyxoviridae, Flaviviridae, Orthomyxoviridae, Retroviridae and Togaviridae), to interact with 44 human autophagy-associated proteins using yeast two-hybrid and bioinformatic analysis. (sfr-biosciences.fr)
- They are found in enveloped viruses from influenza A, influenza B and influenza C (Orthomyxoviridae), and the human immunodeficiency virus type 1 (HIV-1, Retroviridae). (ox.ac.uk)
Transcription2
- Tat protein is a major factor of HIV (human immunodeficiency virus) transcription regulation and has other activities. (crie.ru)
- rRNA synthesis and accumulation occurs rapidly following activation of a conditional MYC-ER allele (coding for a Myc-oestrogen-receptor fusion protein), is resistant to inhibition of Pol II transcription and is markedly reduced by c-MYC RNA interference. (fhcrc.org)
Particles3
- In these strains the protein is found primarily in viral particles. (johnshopkins.edu)
- This piece of DNA can now code for the parts needed to make the virus particles including the proteins needed for the assembly of the virus particle. (blog-biosyn.com)
- During maturation, HIV particles undergo a significant internal morphological reorganization, changing from a roughly spherically symmetric immature particle with a thick protein shell to a mature particle with a thin protein shell and conical core. (bgu.ac.il)
Gp413
- HIV Envelope Protein gp41" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (musc.edu)
- This graph shows the total number of publications written about "HIV Envelope Protein gp41" by people in this website by year, and whether "HIV Envelope Protein gp41" was a major or minor topic of these publications. (musc.edu)
- Below are the most recent publications written about "HIV Envelope Protein gp41" by people in Profiles. (musc.edu)
Subfamily1
- SFTPA1 / Surfactant Protein A is a lung surfactant protein that is a member of a subfamily of C-type lectins called collectins. (lsbio.com)
Lentiviral1
- The deletion of all viral proteins allows the lentiviral backbone to accommodate transgenes of up to 8.5 kb in size. (alecomm.com)
Induce2
- The inhibitory effect of CKS-17 is, however, significantly blocked by a protein synthesis inhibitor cycloheximide, indicating that CKS-17 requires de novo protein synthesis to induce the suppressive activity. (duke.edu)
- Moreover we found that the expression of IRGM-interacting MeV-C, HCV-NS3 or HIV-NEF proteins per se is sufficient to induce autophagy, through an IRGM dependent pathway. (sfr-biosciences.fr)
MeSH1
- The new rules were established with the coordinated efforts of staff from MeSH, NCBI and scientists working in the field of HMG protein research. (bvsalud.org)
Heterologous1
- Analyzing this domain in greater detail, we identified a 26-amino-acid (aa 60 to 85) fragment that was sufficient to mediate the transport of a heterologous protein (green fluorescent protein [GFP]) to the nucleus. (duke.edu)
Simian1
- Scholars@Duke publication: Functional analysis of the simian immunodeficiency virus Vpx protein: identification of packaging determinants and a novel nuclear targeting domain. (duke.edu)
MRNA4
- Taken together, these results suggest that the synthetic retroviral peptide CKS-17 down-regulates TNF-alpha mRNA expression through inhibition of transcriptional activation of the TNF-alpha gene, which requires de novo synthesis of a transcriptional repressor protein(s). (duke.edu)
- After differentiating the mutant and corrected cells into lung organoids, we show expression of SFTPB mRNA during endodermal and organoid differentiation but the protein product only after organoid differentiation. (nature.com)
- Poly(A) binding protein (PABPC1) normally stimulates mRNA translation by interacting with several translation initiation factors bound to the 5'- end of mRNAs. (expasy.org)
- HIV have a +sense RNA that can act as mRNA for protein translation…but in the replication process, it doesn't do that…explain why and describe the pathway it use. (biologyonline.com)
Cells3
- While deletion of the N-terminal extension had no significant functional impact in HeLa cells, our results suggest that the human Bcl2l10 protein evolved a calcium-binding motif in its alpha 5-alpha 6 interhelical region by acquiring critical negatively charged residues. (sfr-biosciences.fr)
- 53:742-750, 1985), in which the 12S E1A protein is required for the complete induction of the cellular DNA replication machinery in the quiescent human epithelial cells in which adenoviruses normally replicate. (cshl.edu)
- The native tropism of HIV-1 is highly restrictive, and so the virus is commonly pseudotyped with Vesicular Stomatitis Virus G protein (VSV-G). VSV-G pseudotyping allows viral entry based on interaction with the LDL-receptor, expressed on all nucleated mammalian cells. (alecomm.com)
Replication2
- During vector production, essential viral proteins are supplied in trans on multiple plasmids to reduce the possibility of successful recombination, while virulence factors nonessential for in vitro replication are omitted entirely. (alecomm.com)
- Tracking these specific proteins in immunity assays allows for accurate separation of viral replication stages. (jpt.com)
Human immun2
- Transmembrane envelope protein of the HUMAN IMMUNODEFICIENCY VIRUS which is encoded by the HIV env gene. (musc.edu)
- External envelope protein of the human immunodeficiency virus which is encoded by the HIV env gene. (lookformedical.com)
Surfactant2
- Surfactant protein B (SFTPB) deficiency is a fatal disease affecting newborn infants. (nature.com)
- This protein plays an essential role in surfactant homeostasis and in the defense against respiratory pathogens. (lsbio.com)
Phosphorylation1
- Among PTMs, protein phosphorylation is the most extensively studied, and its role in signalling transduction is widely accepted, but hundreds of other modifications have been identified to date, and new ones are still under identification. (mdpi.com)
Murine1
- Unexpectedly, a Gly119Glu mutation in the protease enhances retroviral stability in the presence of various wild-type envelope proteins including wild-type amphotropic, ecotropic and 10A1 murine leukemia viruses. (illinois.edu)
Antiviral1
- Preventing the expression of host proteins is also a strategy to counteract the antiviral response. (expasy.org)
Cellular2
- Inhibiting host translation eventually leads to shutoff of host proteins expression and gives viruses transcripts a competitive edge for access to the cellular translation machinery. (expasy.org)
- Although central to autophagy, targeted proteins have also a high number of connections with proteins of other cellular functions. (sfr-biosciences.fr)
Definition1
- Our tailored Peptide ELISA plates are offered as stand alone service for mapping of epitopes and definition of protein interaction sites or as validation assay to confirm results obtained with JPT's peptide microarrays. (jpt.com)
Lipids1
- The encoded protein binds specific carbohydrate moieties found on lipids and on the surface of microorganisms. (lsbio.com)
LSBio1
- This protein carries the LSBio 100% Guarantee. (lsbio.com)
Kinase1
- The biological activities of Cur-Nic and its metal complexes were predicted using the PASS and Swiss Target Prediction online software, respectively, and docking studies with tyrosine-protein kinase SRC were performed using the PyRx software to predict their anticancer activities. (bvsalud.org)
Variants2
- The main goal of the work was to analyze the characteristics of Tat protein in HIV-1 A6 variant, that is, to identify substitutions characteristic for A6 and A1 variants, as well as to compare the frequency of mutations in functionally significant domains in sub-subtype A6 and subtype B. (crie.ru)
- Tat protein of sub-subtype A6 have some characteristics that make it possible to reliably distinguish it from other HIV-1 variants. (crie.ru)
Interestingly1
- Interestingly, two types of hexameric protein arrangements were observed for each virus type. (elsevierpure.com)
Strains1
- The protein is expressed at high levels in fly strains in which gypsy elements are active. (johnshopkins.edu)
Therapeutic1
- Nonstructural HIV proteins can become a promising target of future therapeutic agents and vaccines [ 1-3 ]. (crie.ru)
Virus1
- On the computer virus part, in the past, a one amino acidity (aa) in the California proteins at placement 110 is certainly idea to determine if MLVs are T or D tropic [8,9]. (siamtech.net)