Major advances in the treatment of perinatal asphyxial-hypoxic ischemic encephalopathy followed the translation of hypothermia animal studies into successful randomized controlled clinical trials that substantially influenced the current standard of care. (ima.org.il)
Mild total body hypothermia, induced by cooling a baby to 33-34°C for three days after birth, is nowadays a standardized treatment after moderate to severe hypoxic ischemic encephalopathy in full-term and near to fullterm neonates. (wikipedia.org)
Hypoxic ischemic encephalopathy has many causes and is defined essentially as the reduction in the supply of blood or oxygen to a baby's brain before, during, or even after birth. (wikipedia.org)
Recognition of infants with marginal external signs of asphyctic damage at birth, who still develop moderate hypoxic ischemic encephalopathy would be enhanced by finding more reliable bio-markers or physiologic tests accurately predicting the risk for progressive damage. (wikipedia.org)
Perinatal asphyxia, more appropriately known as hypoxic-ischemic encephalopathy (HIE), is characterized by clinical and laboratory evidence of acute or subacute brain injury due to asphyxia. (medscape.com)
Despite the advent of hypothermia therapy for the treatment of hypoxic-ischemic encephalopathy (HIE), treatment options following asphyxia at birth remain limited, particularly in low-resource settings where the incidence of birth asphyxia is highest. (frontiersin.org)
Therapeutic hypothermia2
To present our preliminary experience with the first cases of clinical application of therapeutic hypothermia for PA-HIE [1] in what we believe is the first report on non-experimental hypothermia for PA-HIE from Israel. (ima.org.il)
A 2013 Cochrane review found that therapeutic hypothermia is useful in full term babies with encephalopathy. (wikipedia.org)
Asphyxia1
The fetal sheep asphyxia model also suggests a six-hour window post asphyxia in which hypothermia will have greatest benefit. (wikipedia.org)
Neonatal1
Monitoring of pregnancies, delivery assisted by skillful and qualified personnel, mastery of neonatal resuscitation techniques are good means of prevention. (scirp.org)
Outcome1
We reviewed the medical records, imaging scans, electroencephalograms and outcome data of the six identified asphyxiated newborns who were managed with hypothermia in our services in 2008-2009. (ima.org.il)
Infants1
At present data relate only to full term infants, and all human studies of hypothermia treatment have so far been restricted to infants >36 weeks out of an expected 40 weeks gestation. (wikipedia.org)
Long-term1
None of these programmes have sufficient power to make confident assessments of the long-term effect of hypothermia, however even these underpowered studies give important information on whether the therapeutic effects of cooling are sustained beyond the first two years after birth. (wikipedia.org)
Major1
The périnatal anoxia (PA) is a major health issue in Mali because of its frequency and severity. (scirp.org)
Brain1
There are both more potential side effects on the developing premature with lung disease, and there is more evident protection by hypothermia when a greater volume of complex brain is actively developing. (wikipedia.org)
Neonatal Encephalopathy4
Neonatal encephalopathy is important for its association with significant morbidity and mortality in the newborn period as well as chronic handicapping conditions later in life. (ispub.com)
Recent advances in the pathophysiology of neonatal encephalopathy include the role of increased cytosolic influx of calcium ions, excitatory amino acid neurotransmitters and mediators of inflammation like nitric oxide and free radicals in the disruption of neuronal metabolism thus, resulting in widespread neuronal deaths. (ispub.com)
The role and clinical applicability of these pathophysiological proposals in selecting management options for neonatal encephalopathy are discussed. (ispub.com)
Neonatal encephalopathy (NE), formerly known as Hypoxic - ischaemic encephalopathy (HIE) is a major challenge in newborn care worldwide. (ispub.com)
Cerebral palsy1
The intervention (hypothermia) group had improved scores in mental, psychomotor, and gross motor function and a reduced risk of cerebral palsy. (resus.me)
Moderate2
Mild total body hypothermia, induced by cooling a baby to 33-34°C for three days after birth, is nowadays a standardized treatment after moderate to severe hypoxic ischemic encephalopathy in full-term and near to fullterm neonates. (wikipedia.org)
Recognition of infants with marginal external signs of asphyctic damage at birth, who still develop moderate hypoxic ischemic encephalopathy would be enhanced by finding more reliable bio-markers or physiologic tests accurately predicting the risk for progressive damage. (wikipedia.org)
Therapeutic3
The resuscitation of the asphyxiated infant is followed by a therapeutic window where the infant may appear grossly normal despite an on-going brain damage. (ispub.com)
A 2013 Cochrane review found that therapeutic hypothermia is useful in full term babies with encephalopathy. (wikipedia.org)
None of these programmes have sufficient power to make confident assessments of the long-term effect of hypothermia, however even these underpowered studies give important information on whether the therapeutic effects of cooling are sustained beyond the first two years after birth. (wikipedia.org)
Undertaken2
Studies have been undertaken to determine the effects of hypothermia beyond early childhood. (wikipedia.org)
An RCT of induced hypothermia to 33.5 degrees for 72 hours was undertaken in 625 newborns at least 36 weeks gestation who had evidence of asphyxial encephalopathy. (resus.me)
Effects1
There are both more potential side effects on the developing premature with lung disease, and there is more evident protection by hypothermia when a greater volume of complex brain is actively developing. (wikipedia.org)