• With the purpose of studying the influence of prolonged phyisical exercise causing myocardial lesion and disqualifying horses in endurance competitions, 87 blood samples were collected from adult Arabian and crossbred horses, to determine the serum concentration of the isoenzyme MB (CKMB), the serum activity of creatine kinase (CK), and the CKMB/CK index. (usp.br)
  • Procedures -Records were retrieved from a database containing results of serum samples tested for acetylcholine receptor antibodies. (avma.org)
  • By starch gel and paper electrophoresis the normal serum alkaline phosphatase isoenzyme is shown to be rarely present in hepatic bile. (bmj.com)
  • The normal serum level is the result of two factors, the rate of release of the enzyme from the tissues, principally liver and bone, and the rate of inactivation of the enzymes in the serum and body protein pool. (bmj.com)
  • In liver disease the increase in serum levels is a result of increased liberation of the enzyme from the sinusoidal surface of the liver cell and of regurgitation of the biliary isoenzyme back into the serum. (bmj.com)
  • Myocardial I/R injury may induce cell apoptosis and autophagy by activating oxidative stress and upregulating inflammatory mediators, ultimately resulting in irreversible fibrotic damage ( 3 ). (spandidos-publications.com)
  • To examine superoxide dismutase isoenzyme gene expression in peripheral blood mononuclear cells of patients on hemodialysis and to determine the associations between superoxide dismutase isoenzyme gene expression, oxidative stress, and non-enzymatic antioxidative protection. (balkanmedicaljournal.org)
  • The superoxide dismutase isoenzyme gene is expressed at a higher rate in patients with end-stage renal failure, probably due to increased oxidative stress and attenuated antioxidative defense. (balkanmedicaljournal.org)
  • Zafirlukast is a weak inhibitor of CYP3A4, an isoenzyme partially responsible for the metabolism of dihydrocodeine. (pdr.net)
  • Hydrocodone is a CYP3A4 substrate, and coadministration with CYP3A4 inhibitors like zafirlukast can increase hydrocodone exposure resulting in increased or prolonged opioid effects including fatal respiratory depression, particularly when an inhibitor is added to a stable dose of hydrocodone. (pdr.net)
  • DxD primarily metabolized by the liver via CYP3A4 isoenzyme. (unboundmedicine.com)
  • Strong or moderate CYP2C19 inhibitors may increase mavacamten systemic exposure, resulting in heart failure due to systolic dysfunction. (medscape.com)
  • As a result, the new prescribing information for colchicine warns that concomitant use of P-glycoprotein or strong cytochrome P 450 isoenzyme 3A4 inhibitors is contraindicated in patients with renal or hepatic impairment receiving therapy. (medscape.com)
  • A distinct form of osteopetrosis occurs in association with renal tubular acidosis and cerebral calcification due to carbonic anhydrase isoenzyme II deficiency. (medscape.com)
  • Mg deficiency changes the isoenzyme pattern of reactive oxygen species" by RENGİN ÖZGÜR UZİLDAY, BARIŞ UZİLDAY et al. (tubitak.gov.tr)
  • The aim of this work was to investigate changes in isoenzyme patterns of enzymes related to reactive oxygen species (ROS) detoxification such as superoxide dismutase (SOD), catalase (CAT), peroxidase (POX), ascorbate peroxidase (APX), glutathione reductase (GR), and glutathione-S-transferase (GST) in cotton under Mg deficiency. (tubitak.gov.tr)
  • For example, a new Cu/ZnSOD isoenzyme was induced in plants treated with 0 μM Mg. Cotton plants adapt to Mg deficiency by changing the intensity of existing isoenzymes or inducing new ones. (tubitak.gov.tr)
  • Two of these are due to the deficiency of the heterodimeric (α-β), "A" isoenzyme of lysosomal β-hexosaminidase (HexA). (nih.gov)
  • The third form results from a deficiency of the GM2 activator protein (GM2AP), a substrate-specific cofactor for HexA. (nih.gov)
  • The creatine phosphokinase (CPK) isoenzymes test measures the different forms of CPK in the blood. (adam.com)
  • The value for the isoenzyme of creatine kinase with muscle and blood subunits is most specific, but it may be falsely elevated in persons with myopathy, hypothyroidism, renal failure, or skeletal muscle injury. (medscape.com)
  • And defects in the PYCR1 gene can lead to the abnormality of mitochondrial membrane potential, which results in mitochondrial network disruption and the apoptosis rate increasing during oxidation [ 12 - 15 ]. (jcancer.org)
  • X-linked hypophosphatemic rickets and autosomal recessive hypophosphatemic rickets are the result of mutations in PHEX (a phosphate-regulating gene with homologies to endopeptidases on the X chromosome) and dentin matrix protein 1 ( DMP1 ), respectively. (medscape.com)
  • Acetaminophen has been associated with cases of acute liver failure, at times resulting in liver transplant and death. (nih.gov)
  • The action of neuraminidase demonstrates that β-globulin isoenzymes of liver and bone are not identical. (bmj.com)
  • A less sensitive biomarker of hepatotoxicity than aminotransferases is the liver isoenzyme. (ganeshdiagnostic.com)
  • These conditions may result in failure of osteoid calcification (rickets) in children because of a disruption in the pathway of either vitamin D or phosphate metabolism. (medscape.com)
  • Finally, a genetic absence of the receptor for calcitriol results in deficient calcification. (medscape.com)
  • Factors that can affect test results include cardiac catheterization , intramuscular injections, recent surgery, and vigorous and prolonged exercise or immobilization. (adam.com)
  • Fire-police officer dies as a result of a cardiac arrest at the scene of a motor vehicle accident - Pennsylvania. (cdc.gov)
  • The defect in bone turnover characteristically results in skeletal fragility despite increased bone mass, and it may also cause hematopoietic insufficiency, disturbed tooth eruption, nerve entrapment syndromes, and growth impairment. (medscape.com)
  • Several diseases can result in disorders of bone mineralization, which can be defined as the process by which osteoid becomes calcified. (medscape.com)
  • 1998). However, the chronic inhalation study with mice resulted in statisti- cally significantly increased incidences of bronchioloalveolar tumors in both male and female mice at the end of 2 yr, but not after 12 or 18 mo (Cruzan et al. (cdc.gov)
  • In the field of epidemiology, erythrocyte pain may develop from either primary, resulting from myeloproliferative disorder or secondary, resulting from a hemoglobinopathy, chronic hypoxia, malignancy, or dysregulated erythropoietin production. (frontiersin.org)
  • Moderate) Concomitant use of dihydrocodeine with zafirlukast may increase dihydrocodeine plasma concentrations, resulting in greater metabolism by CYP2D6, increased dihydromorphine concentrations, and prolonged opioid adverse reactions, including hypotension, respiratory depression, profound sedation, coma, and death. (pdr.net)
  • If zafirlukast is discontinued, hydrocodone plasma concentrations will decrease resulting in reduced efficacy of the opioid and potential withdrawal syndrome in a patient who has developed physical dependence to hydrocodone. (pdr.net)
  • CYP) 3A4 isoenzyme consciousness, breathing problems, overdose decision to publish, or preparation of the manuscript. (cydiablog.com)
  • The LDH fraction 1 isoenzyme is primarily released by the heart, but it also may come from the kidneys, stomach, pancreas, and red blood cells. (medscape.com)
  • High levels of more than one isoenzyme may indicate more than one cause of tissue damage. (healthline.com)
  • Superoxide dismutase isoenzyme messenger ribonucleic acid levels were determined by real-time polymerase chain reaction. (balkanmedicaljournal.org)
  • The plasma total antioxidant status is an independent predictor of normalized superoxide dismutase isoenzyme messenger ribonucleic acid levels. (balkanmedicaljournal.org)
  • If your tests revealed abnormally high or low levels of one or more LDH isoenzymes, you most likely have some form of tissue illness or damage. (ganeshdiagnostic.com)
  • Depending on which LDH isoenzymes had aberrant levels, the type of sickness or damage will result. (ganeshdiagnostic.com)
  • This allows cortisol to outcompete aldosterone and bind to mineralocorticoid receptors, resulting in the activation of several pathways that increase blood pressure. (wikipedia.org)
  • Because each LDH isoenzyme is found in more than one type of tissue, other more specific tests are often used with or instead of an LDH isoenzymes test. (medlineplus.gov)
  • Lancet 335: 1589 (1990)] found an A-to-G transition which resulted in the substitution of lysine (AAA) by glutamic acid (GAA) at residue 329 of the enzyme (K329E). (coriell.org)
  • Treatment and Outcome -Pyridostigmine bromide was administered (1 mg/kg [0.45 mg/lb], PO, q 8 h), resulting in complete remission of clinical signs. (avma.org)
  • But an LDH isoenzymes test alone cannot diagnose what's causing the damage. (medlineplus.gov)
  • An LDH isoenzyme test may be used with other tests to help diagnose and monitor many types of acute (sudden) and chronic (long-lasting) conditions. (medlineplus.gov)
  • A significant rise or fall in the total CPK or CPK isoenzymes can help your health care provider diagnose certain conditions. (adam.com)
  • In the absence of aromatase, androgens cannot be converted to estrone, estradiol or estriol, and large quantities of androstenedione and testosterone are transferred to the maternal and fetal circulation, resulting in masculinization of the urogenital sinus and external genitalia of the female fetus. (health.am)
  • Hydroxysteroid 11-beta dehydrogenase (HSD11B) isoenzymes regulate which ligand will bind to MR. In this study we aimed to evaluate the expression of the MR and the HSD11B isozymes in peripheral polymorphonuclear cells (PMNs) in critical illness for a 13-day period. (bvsalud.org)
  • mechanism may be CYP2C19 inhibition of nelfinavir conversion to active M8 metabolite, and also PPIs decreasing gastric pH resulting in decreased nelfinavir absorption. (medscape.com)
  • Overexpression of tau kinase cdk5 activator p25 resulted in gliosis. (europa.eu)
  • A registry for persons treated with bedaquiline is being implemented by Janssen Therapeutics to track patient outcomes, adverse reactions, laboratory testing results (e.g., diagnosis, drug susceptibility, and development of drug resistance), use of concomitant medications, and presence of other comorbid conditions. (cdc.gov)
  • An LDH isoenzyme test measures the amount of each type of isoenzyme in your blood. (medlineplus.gov)
  • Down-Regulation of the Mineralocorticoid Receptor (MR) and Up-Regulation of Hydroxysteroid 11-Beta Dehydrogenase Type 2 (HSD11B2) Isoenzyme in Critically Ill Patients. (bvsalud.org)
  • The duration of tuberculosis treatment depends on the regimen chosen, the patient's clinical and radiographical responses, smear and culture results, and susceptibility of Mycobacterium tuberculosis isolates from the patient or the suspected source case. (who.int)
  • CONCLUSIONS AND CLINICAL RELEVANCE Findings suggested that for Thoroughbreds, downhill locomotion resulted in a lower energy cost than did horizontal or uphill locomotion and that this cost changed with speed. (avma.org)
  • Clinical results and laboratory examination findings vary with each disorder. (medscape.com)
  • These results support EAC early diagnosis trials using exhaled aldehyde analysis. (nature.com)
  • This is presumably due to enhanced oxygen delivery as a result of the defect. (medscape.com)
  • FDA and/or any FDA employee will not be liable for injury or other damages resulting to any individuals who view FDA-related materials on this website. (medscape.com)
  • Intravenous neostigmine methylsulfate administration resulted in immediate resolution of muscle weakness. (avma.org)
  • RESULTS Horses completed all treadmill exercises with identical stride frequency and stride length. (avma.org)
  • LDH isoenzyme tests may also be used to find out if treatment for many conditions is working. (medlineplus.gov)
  • Regular LDH isoenzyme testing may be done to see whether cancer is getting better during and/or after treatment. (medlineplus.gov)
  • Most affected individuals do not require treatment, although in the most severe cases, death may occur in utero as a result of severe anemia . (medscape.com)
  • Scholars@Duke publication: The importance of dual 5alpha-reductase inhibition in the treatment of male pattern hair loss: results of a randomized placebo-controlled study of dutasteride versus finasteride. (duke.edu)
  • Dose reductions or interruption of colchicine therapy should be considered in patients with normal renal and hepatic function who require concomitant treatment with a P-glycoprotein or strong cytochrome P 450 isoenzyme 3A4 inhibitor. (medscape.com)
  • In their infantile, acute forms, these diseases rapidly progress with mental and psychomotor deterioration resulting in death by approximately 4 years of age. (nih.gov)
  • As a result, the FDA-approved dose of colchicine in acute gout flares is 1.2 mg followed by a second dose of 0.6 mg administered 1 hour later (total, 1.8 mg). (medscape.com)
  • Our results suggest that, in our cohort of critically ill patients , local endogenous cortisol availability is diminished, pointing towards glucocorticoid resistance. (bvsalud.org)
  • Clinical signs and ancillary test results were diagnostic of acquired myasthenia gravis. (avma.org)
  • Cutaneous leishmaniasis (CL) is still en- comprehensive study on vectors of ZCL in demic and an important health problem in the southern part of the Islamic Republic many countries of the Eastern Mediterra- of Iran. (who.int)
  • Not only GSK3-beta, but also its isoenzyme GSK3-alpha were shown to increase tau phosphorylation. (europa.eu)
  • An LDH isoenzyme testing may be used for many conditions, so it's best to ask your provider why you need this test. (medlineplus.gov)
  • Results of the pharmacokinetic studies demonstrate that CIPRO XR may be administered with or without food (e.g. high-fat and low-fat meals or under fasted conditions). (theodora.com)
  • Results: A total of 98 children aged 3-59 months were enrolled. (bvsalud.org)
  • Some drugs can interfere with test results. (adam.com)
  • What do the test results mean? (healthline.com)
  • According to the submitter, biochemical test results for this subject showed decreased enzyme activity. (coriell.org)
  • If untreated, infantile osteopetrosis usually results in death by the first decade of life due to severe anemia , bleeding, or infections. (medscape.com)