Recombinant erythropoietinAnemiaGlycoprotein hormoneReceptorStimulatesErythropoiesisSensitive to erythropoietinApoptosisEpoRConcentrationsHypoxiaAnaemiaHormone calledRenalEndogenousProliferationStimulateInduces1989ProductionHumanCytokineClinicalIntravenousKidneysOutcomeAntibodiesProteinChemotherapyBoneBloodSubsequentPatientsSubstancesHematocritHematopoieticAnemicImprovesResponse
Recombinant erythropoietin2
- In patients receiving long-term dialysis, recombinant erythropoietin (eg, epoetin alfa or darbepoetin alfa ) along with iron supplements is the treatment of choice. (msdmanuals.com)
- The long-term retention of uremic toxins or albuminuria alter many competing physiologic processes that may affect VTE risk, such as platelet function, the coagulation pathway, endothelial activity and inflammation, intravascular volume, and anemia with subsequent recombinant erythropoietin use. (medscape.com)
Anemia16
- BACKGROUND: Among patients with chronic kidney disease (CKD), the use of recombinant human erythropoietin and its derivatives for the treatment of anemia has been linked to a possibly increased risk of stroke, myocardial infarction, and other adverse events. (nih.gov)
- Erythropoietin is a glycoprotein hormone that stimulates red blood cell (RBC) production in bone marrow via binding to the cell-surface receptor on hematopoietic progenitor cells, and it has been widely used for treating anemia [ 13 ]. (hindawi.com)
- To support evidence-based clinical guidelines on erythropoietin use for anemia in oncology, we conducted systematic reviews of controlled trials on four patient groups. (cancernetwork.com)
- Common causes of cellular hypoxia resulting in elevated levels of EPO (up to 10 000 mU/mL) include any anemia, and hypoxemia due to chronic lung disease. (wikipedia.org)
- Acute and severe anemia can result in cardiovascular compromise. (medscape.com)
- Moreover, if individuals with acute anemia are not treated immediately and appropriately, the resulting hypoxemia and hypovolemia can lead to brain damage, multiorgan failure, and death. (medscape.com)
- Long-standing anemia can result in failure to thrive in children. (medscape.com)
- When this impacts RBCs, anemia can result. (healthline.com)
- Depending on your test results, the doctor will recommend treatments to help alleviate anemia symptoms and improve RBC count. (healthline.com)
- Kidney disease may cause anemia because the kidneys are not able to produce enough erythropoietin . (medicalnewstoday.com)
- Chemotherapy for cancer treatment may also affect the production of new red blood cells, resulting in anemia. (medicalnewstoday.com)
- The regulatory mechanism responsible for a paradoxal, rapid drop in the erythropoietin (EPO) plasma level seen 2 to 4 days after acute, phlebotomy-induced anemia was investigated in seven adult sheep. (aspetjournals.org)
- Recombinant human erythropoietins (rHuEPO) are erythropoiesis-stimulating agents (ESA) used in the treatment of anemia resulting from chronic kidney disease, treatments for cancer or HIV infection. (wren-clothing.com)
- Absence of the hormone due to kidney disease results in anemia, which responds to nandrolone. (medindia.net)
- Overview of Decreased Erythropoiesis Anemia, a decrease in the number of red blood cells (RBCs), hemoglobin (Hb) content, or hematocrit (Hct), can result from decreased RBC production (erythropoiesis), increased RBC destruction. (msdmanuals.com)
- generally result in the most severe anemia for their degree of renal excretory failure. (msdmanuals.com)
Glycoprotein hormone2
- Red cell production in vertebrates is controlled by a glycoprotein hormone known as erythropoietin (Ep), which is produced by the kidney in response to hypoxia and acts on the marrow to selectively stimulate erythropoiesis. (nih.gov)
- Erythropoietin (EPO) is a glycoprotein hormone, naturally produced by the peritubular cells of the kidney, that stimulates red blood cell production. (wren-clothing.com)
Receptor8
- The burst-forming unit-erythroid (BFU-E) cells start erythropoietin receptor expression and are sensitive to erythropoietin. (wikipedia.org)
- Subsequent stage, the colony-forming unit-erythroid (CFU-E), expresses maximal erythropoietin receptor density and is completely dependent on erythropoietin for further differentiation. (wikipedia.org)
- Precursors of red cells, the proerythroblasts and basophilic erythroblasts also express erythropoietin receptor and are therefore affected by it. (wikipedia.org)
- Erythropoietin has been shown to exert its effects by binding to the erythropoietin receptor (EpoR). (wikipedia.org)
- EPO binds to the erythropoietin receptor on the red cell progenitor surface and activates a JAK2 signalling cascade. (wikipedia.org)
- High level erythropoietin receptor expression is localized to erythroid progenitor cells. (wikipedia.org)
- Objective: The erythropoietin receptor (EpoR) stimulates erythro- cyte proliferation after erythropoietin binding. (edu.au)
- 4. Initiation of treatment with an erythropoiesis-stimulating agent (eg, erythropoietin), a thrombopoietin receptor agonist (eg, eltrombopag), or danazol within 28 days prior to the screening visit. (who.int)
Stimulates2
- Recombinant Human Erythropoietin/EPO (Tissue Culture Grade) (Catalog # 287-TC ) stimulates proliferation in the TF-1 human erythroleukemic cell line in a dose-dependent manner (orange line). (rndsystems.com)
- Erythropoietin stimulates platelet production as well as red cell production. (ivis.org)
Erythropoiesis6
- In addition to its role in the endogenous control of erythropoiesis, recombinant human erythropoietin (rh-EPO) has been shown to exert tissue protective properties in various experimental models. (nih.gov)
- Exogenous erythropoietin, recombinant human erythropoietin (rhEPO), is produced by recombinant DNA technology in cell culture and are collectively called erythropoiesis-stimulating agents (ESA): two examples are epoetin alfa and epoetin beta. (wikipedia.org)
- Erythropoietin was reported to have a range of actions beyond stimulation of erythropoiesis including vasoconstriction-dependent hypertension, stimulating angiogenesis, and promoting cell survival via activation of EPO receptors resulting in anti-apoptotic effects on ischemic tissues. (wikipedia.org)
- Erythropoietin (EPO) a glycoprotein produced primarily by the kidney, is the principal factor that regulates erythropoiesis by stimulating the proliferation and differentiation of erythroid progenitor cells. (rndsystems.com)
- Erythropoiesis from human embryonic stem cells through erythropoietin-independent AKT signaling. (ca.gov)
- In humans and in dogs, the excessive erythropoiesis is caused by known mutations in the erythropoietin signaling cascade. (vin.com)
Sensitive to erythropoietin1
- With corresponding decreased levels of erythropoietin in older children with the same degree of severe malarial anaemia, conceivably, the bone marrows of younger children with acute malaria may be less sensitive to erythropoietin. (biomedcentral.com)
Apoptosis3
- Erythropoietin has its primary effect on red blood cell progenitors and precursors (which are found in the bone marrow in humans) by promoting their survival through protecting these cells from apoptosis, or cell death. (wikipedia.org)
- AKT activation upregulates the GATA-1 and FOXO3 transcriptional pathways with resulting inhibition of apoptosis, modulation of cell cycle and enhanced maturation of erythroid cells. (ca.gov)
- Erythropoietin prevents dialysis fluid-induced apoptosis of mesothelial cells. (bvsalud.org)
EpoR1
- While there are reports that EPO receptors are found in a number of other tissues, such as heart, muscle, kidney and peripheral/central nervous tissue, those results are confounded by nonspecificity of reagents such as anti-EpoR antibodies. (wikipedia.org)
Concentrations2
- Proliferation elicited by Recombinant Human Erythropoietin/EPO (Tissue Culture Grade) (0.3 units/mL) is neutralized (green line) by increasing concentrations of Mouse Anti-Human Erythropoietin/EPO Monoclonal Antibody (Catalog # MAB287). (rndsystems.com)
- Objective To explore the association between concentrations of endogenous erythropoietin (EPO) in blood the first 2 weeks of life and neonatal disorders in extremely low gestational age newborns (ELGANs). (bmj.com)
Hypoxia2
- A normal PCV is maintained by an endocrine loop that involves generation and release of erythropoietin (EPO) from the kidney in response to renal hypoxia. (ivis.org)
- Immunohistochemical was used to detect the protein expression of hypoxia-inducible factor (HIF)-2α, erythropoietin (EPO), and vascular endothelial growth factor (VEGF) and calculate the value of microvessel density (MVD) in renal tissues. (phcog.com)
Anaemia1
- Erythropoietin and darbopoetin, drugs that improve anaemia, are effective in the management of cancer-related fatigue. (cochrane.org)
Hormone called2
- The erythropoietin test measures the amount of a hormone called erythropoietin (EPO) in blood. (ucsfhealth.org)
- The kidney normally produces a hormone called erythropoietin which is necessary for the production of red blood cells. (medindia.net)
Renal1
- Your doctor may provide special instructions if you're taking medications that could affect the results of the renal scan. (healthline.com)
Endogenous1
- Fever is thought to result from the release of endogenous pyrogens (ie, lymphokines or tissue pyrogenes). (medscape.com)
Proliferation3
- This results in differentiation, survival and proliferation of the erythroid cell. (wikipedia.org)
- Measured by its ability to neutralize Erythropoietin/EPO-induced proliferation in the TF‑1 human erythroleukemic cell line. (rndsystems.com)
- Cell Proliferation Induced by Erythropoietin/EPO and Neutralization by Human Erythropoietin/EPO Antibody. (rndsystems.com)
Stimulate4
- and (4) increased erythropoietin to stimulate RBC production. (medscape.com)
- However, erythropoietin does not stimulate white blood cell (WBC) production. (ivis.org)
- These data show that erythropoietin treatment can stimulate cell oxygen consumption and can contribute to regulation of metabolism and body weight in mice. (wren-clothing.com)
- They found mixed results with some drugs showing an effect on fatigue - most notably drugs that stimulate red blood cell production and also drugs that improve levels of concentration. (cochrane.org)
Induces2
- We present here evidence that ic-MPL dimerization induces erythropoietin (EPO)-independent erythroid differentiation from hESC by inducing the generation of erythroid progenitors and by promoting more efficient erythroid maturation with increased RBC enucleation as well as increased gamma:epsilon globin ratio and production of beta-globin protein. (ca.gov)
- Since recombinant human erythropoietin (rHuEPO) induces a range of cytoprotective cellular responses, rHuEPO treatment may reduce PD fluid (PDF)-induced damage. (bvsalud.org)
19891
- Bioengineered erythropoietin has been used clinically and misused athletically since it first appeared on the market in 1989. (chemistryworld.com)
Production8
- Erythropoietin is an essential hormone for red blood cell production. (wikipedia.org)
- Under hypoxic conditions, the kidney will produce and secrete erythropoietin to increase the production of red blood cells by targeting CFU-E, proerythroblast and basophilic erythroblast subsets in the differentiation. (wikipedia.org)
- In this study we correlated the levels of erythropoietin (EPO), as an indicator of stimulation of haemoglobin production, to the levels of monocyte acquired haemozoin in children with both severe and uncomplicated malaria. (biomedcentral.com)
- Numbers of circulating RBCs are affected by changes in plasma volume, rate of RBC destruction or loss, splenic contraction, erythropoietin (EPO) secretion, and the rate of bone marrow production. (ivis.org)
- We also found that the synthetic protein acts to increase red cell production independently of the well known growth factor erythropoietin. (ca.gov)
- In other cases, paraneoplastic syndromes result from the production and release of physiologically active substances by the tumor. (medscape.com)
- The strategy combines ligation and click chemistry to result in a more precise product than current production methods, which see the core protein bear oligosaccharides of varying length. (chemistryworld.com)
- Erythropoietin is a hormone responsible for regulating red blood cell production. (chemistryworld.com)
Human3
- 323. The Neutralization Dose (ND 50 ) is typically 0.5-1.5 µg/mL in the presence of 0.3 units/mL Recombinant Human Erythropoietin/EPO (Tissue Culture Grade). (rndsystems.com)
- What is Recombinant human erythropoietin injection? (wren-clothing.com)
- Differences occurred between the provision and commissioning of vascular access, recombinant human erythropoietin, conservative management programmes, dedicated transport services and multidisciplinary team members. (ispub.com)
Cytokine1
- Erythropoietin (EPO) is a cytokine that has been shown to play a role in neuroprotection and is endogenously produced in the eye. (molvis.org)
Clinical7
- In 1998, the American Society of Hematology (ASH) and theAmerican Society of Clinical Oncology (ASCO) jointly nominated the topic'Uses of Erythropoietin in Oncology' to AHRQ for an Evidence-basedPractice Center systematic review and evidence report. (cancernetwork.com)
- A panel appointed jointlyby ASH and ASCO intended to use the resulting evidence report to supportdevelopment of a clinical guideline for dissemination to their members. (cancernetwork.com)
- In a recent randomized controlled clinical trial , researchers looked at the hormone erythropoietin (EPO) effects on wound healing after gingival graft surgery. (todaysrdh.com)
- Plain Language Study Results Summaries are descriptions in everyday language of the design and results of clinical studies. (pfizer.com)
- These summaries (also called layperson summaries, plain language summaries, lay language summaries, simple summaries, and trial results summaries) are intended to make the clinical results of these studies understandable and accessible to patients, healthcare providers, caregivers, researchers, and a general audience. (pfizer.com)
- Please use the search function below to find Plain Language Study Results Summaries for Pfizer-sponsored global clinical trials. (pfizer.com)
- Since the publication of the original review increased safety concerns have been raised regarding erythropoietin and this cannot now be recommended in practice.There was a very high degree of statistical and clinical heterogeneity in the trials and the reasons for this are discussed. (cochrane.org)
Intravenous1
- Intravenous erythropoietin in patients with ST-segment elevation myocardial infarction: REVEAL: a randomized controlled trial. (qxmd.com)
Kidneys2
- What would happen if the kidneys could not produce erythropoietin hormone? (wren-clothing.com)
- What does erythropoietin do in the kidneys? (wren-clothing.com)
Outcome1
- There have been studies looking at drug interventions to improve CRF but results have been conflicting depending on the population studied and outcome measures used. (cochrane.org)
Antibodies1
- Unfortunately, in some cases these antibodies cross-react with normal tissues and destroy them, which may result in a paraneoplastic disorder. (medscape.com)
Protein3
- By careful optimisation of the exact nature of saccharides introduced onto the erythropoietin protein backbone it should be possible to mimic the exact biological activity of native erythropoietin. (chemistryworld.com)
- Her team harnessed the combined power of peptide ligation to build the erythropoietin protein and click chemistry to decorate it with sugars. (chemistryworld.com)
- Brimble's team also studied the relationship between glycosylation and protein folding using their erythropoietin analogues and demonstrated how oligosaccharides affect erythropoietin folding and aggregation, which impacts biological activity. (chemistryworld.com)
Chemotherapy1
- Some evidence supports erythropoietin as a preventive intervention to maintain normal cognitive function during and after chemotherapy. (kcl.ac.uk)
Bone2
- The effects of erythropoietin (EPO) on the behaviors of bone marrow mesenchymal stem cells (BMSCs) subjected to mechanical stretch remain unclear. (hindawi.com)
- Large bone defects resulting from trauma, congenital defects, neoplasm, failed arthroplasty, and infection are quite common [ 1 , 2 ], and the incidences of nonunion and delayed union are very high [ 3 ]. (hindawi.com)
Blood3
- However, her doping sample at that competition came back positive for erythropoietin (EPO), a banned blood boosting substance. (wikipedia.org)
- Erythropoietin (EPO) is produced by the kidney and used to make red blood cells. (wren-clothing.com)
- Feline primary erythrocytosis (PE), more commonly referred to as polycythemia in veterinary medicine, is a rare myeloproliferative disorder that results in the increased mass of red blood cells. (vin.com)
Subsequent1
- Following exposure to radioactive strontium compounds, the most severe non carcinogenic effects seen are the result of incorporation of radioactive strontium, an emitter of beta radiation, into the skeleton, with subsequent irradiation of surrounding tissues (ATSDR 2001e). (cdc.gov)
Patients12
- Does Erythropoietin Improve Cognitive Symptoms in Patients with Cancer? (kcl.ac.uk)
- Aim: To review the effectiveness of erythropoietin to improve cognitive symptoms such as memory or attention problem and related symptoms in patients with cancer. (kcl.ac.uk)
- All study designs, cancer patients with symptoms of cognitive impairment (memory or attention problem and related symptoms) receiving erythropoietin were included. (kcl.ac.uk)
- Prevalence of cognitive impairment before receiving erythropoietin was within the normal range for cognition, bar one study including elderly patients with cancer. (kcl.ac.uk)
- Significant improvements in cognitive function were seen in elderly patients receiving high doses of erythropoietin and cognitive domains, particularly memory, in women with breast cancer. (kcl.ac.uk)
- Conclusion: Erythropoietin may improve cognitive function in cancer patients receiving erythropoietin but further evidence is required. (kcl.ac.uk)
- Dive into the research topics of 'Does Erythropoietin Improve Cognitive Symptoms in Patients with Cancer? (kcl.ac.uk)
- Significantimprovements in cognitive function were seen inelderly patients receiving high doses of erythropoietin andcognitive domains, particularly memory, in women withbreast cancer. (kcl.ac.uk)
- Participants with solid malignancy reportedimproved quality of life.Conclusion: Erythropoietin may improve cognitive functionin cancer patients receiving erythropoietin but furtherevidence is required. (kcl.ac.uk)
- the Reduction of Infarct Expansion and Ventricular Remodeling With Erythropoietin After Large Myocardial Infarction (REVEAL) trial was conducted at 28 US sites between October 2006 and February 2010, and included 222 patients with STEMI who underwent successful percutaneous coronary intervention (PCI) as a primary or rescue reperfusion strategy. (qxmd.com)
- During 2003-2014, we identified 26 patients whose laboratory test results showed HEV replication. (cdc.gov)
- Liver test results for 26 patients at diagnosis of hepatitis E and at months 1, 3, and 6, Toulouse, France, 2003-2014. (cdc.gov)
Substances1
- In a broad sense, these syndromes are collections of symptoms that result from substances produced by the tumor, and they occur remotely from the tumor itself. (medscape.com)
Hematocrit1
- Erythropoietin treatment gave rise to the expected increase in hematocrit but resulted in a reduced decrease in body weight compared with saline treatment. (wren-clothing.com)
Hematopoietic1
- It is caused by an erythropoietin-independent expansion of a single hematopoietic stem cell. (vin.com)
Anemic1
- The controlled drop in Hb resulted in a rapid increase in plasma EPO to 836 ± 52 mU/ml (mean ± coefficient of variation percentage) that was followed by a paradoxical rapid drop 2 to 4 days after the phlebotomy while the animals were still very anemic (Hb = 4.3 ± 15 g/dl). (aspetjournals.org)
Improves1
- In experimental models of MI, erythropoietin reduces infarct size and improves left ventricular (LV) function. (qxmd.com)
Response1
- Our results showed that effects of EPO on BMSCs included a dose-response relationship, with the 20 IU/ml EPO yielding the largest. (hindawi.com)