• Together with Interleukin-2 (IL-2), Interleukin-4 (IL-4), Interleukin-7 (IL-7), Interleukin-9 (IL-9), granulocyte colony-stimulating factor (G-CSF), and granulocyte-macrophage colony-stimulating factor (GM-CSF), IL-15 belongs to the four α-helix bundle family of cytokines. (wikipedia.org)
  • Other cytokines that signal through receptors containing gp130 are Interleukin-11 (IL-11), ciliary neurotrophic factor (CNTF), cardiotrophin-1 (CT-1), cardiotrophin-like cytokine (CLC), leukemia inhibitory factor (LIF), oncostatin M (OSM), Kaposi's sarcoma associated herpes virus interleukin 6 like protein (KSHV-IL6). (dadamo.com)
  • Gp130 serves as the signal transducing receptor subunit for the IL-6-type cytokines consisting of interleukin (IL)-6, IL-11, leukemia inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor (CNTF), new neurotrophin factor-1 (NNT-1), IL-27, cardiotrophin-1 (CT-1), and cardiotrophin like cytokine (CLC) (2 - 5). (rndsystems.com)
  • These cytokines are involved in a variety of functions including the modulation of inflammatory and immune responses, heart development, fertility, and many other activities (2). (rndsystems.com)
  • Their assembly leads to the activation of proinflammatory caspases (Caspase-1 or Caspase-4/5/11) and cytokines (interleukin (IL)-1 and IL-18) and the pore-forming protein, Gasdermin-D. Pyroptosis is characterized by nuclear condensation, cell swelling, and the formation of plasma membrane pores leading to cell lysis and release of cellular contents such as HMGB1, a DAMP of large size. (invivogen.com)
  • The interleukin-1 (IL-1) family is a growing group of cytokines, consisting of at least 11 members, and the balance between pro- and anti-inflammatory cytokines is crucial in the pathogenesis of many human diseases ( 3 ). (frontiersin.org)
  • IL-33 induces T cells to produce IL-4, IL-5, and IL-13, and potently induces pro-inflammatory cytokines and chemokines through a Th2-dependent pathway, and also promotes Th1-type responses ( 5 ). (frontiersin.org)
  • For example, they have been shown to be of importance in the inflammatory immune response, regulating the induction of secretion of cytokines, such as tumor necrosis factor alpha, interleukin-1, interleukin-12, and gamma interferon (IFN-), and of nitric oxide by monocytes and macrophages and prolonging the survival Kaempferol inhibitor of these cells at sites of inflammation (reviewed in references 23 and 61). (bioskinrevive.com)
  • CD40L then interacts with CD40 on the dendritic cell surface, leading to the induction Kaempferol inhibitor of costimulatory activity mediated by both cell surface molecules and cytokines such as interleukin-12 by the dendritic cell (11, 35). (bioskinrevive.com)
  • Elevated levels of the pro-inflammatory cytokines interleukin (IL)-6, IL-9, and interferon-γ were associated with higher FI scores in aging females, while levels of IL-12p40 rose as FI scores increased in older males. (deepdyve.com)
  • In recent years, much has been learned of the characteristics of immune responses to skin sensitizing chemicals and of the roles played by dendritic cells, cytokines and chemokines. (cdc.gov)
  • Interleukin-11 receptor subunit alpha-1 is required for maximal airway responsiveness to methacholine following acute exposure to ozone. (cdc.gov)
  • IL-6 mediates its responses through cell surface receptors that include the transmambrane protein gp130. (dadamo.com)
  • This protein activates T cells and B cells by binding to IL-7 receptors, promoting the enhancement of immune response. (creativebiomart.net)
  • Exogenous and endogenous opioids can affect the innate and acquired immune systems and influence the immune response by interacting with the activation of different opioid receptors. (uspharmacist.com)
  • Serum interleukin (IL)-1, IL-6, tumour necrosis factor (TNF) and quantitative urinary -2-microglobulin (-2-m) excretion were estimated. (who.int)
  • Babatz J, Röllig C, Löbel B, Folprecht G, Haack M, Günther H, Köhne CH, Ehninger G, Schmitz M, Bornhäuser M. Induction of cellular immune responses against carcinoembryonic antigen in patients with metastatic tumors after vaccination with altered peptide ligand-loaded dendritic cells. (nwbio.com)
  • 11,12 Dendritic cells are essential to the innate immune system through their presentation of foreign antigens to T-cells. (uspharmacist.com)
  • Interleukin-15 (IL-15) is a protein that in humans is encoded by the IL15 gene. (wikipedia.org)
  • A research team from Justus Liebig University Giessen and the Max Planck Institute for Heart and Lung Research in Bad Nauheim, led by Sven Reischauer from Justus Liebig University, has now been able to show that the suppression of scar formation in zebrafish is coupled to the signaling pathway mediated by the protein interleukin-11 receptor alpha. (mpg.de)
  • A positive TST result, consisting of measurable skin induration after the injection of tuberculin purified protein derivative, is part of a delayed-type hypersensitivity response of host immune system memory T cells sensitized by prior mycobacterial exposure [ 3 ]. (cdc.gov)
  • Both IL-10 and IL-4 are upregulated in papillomas and in peripheral blood mononuclear cells exposed to HPV-11 E6 protein, and the tissues and cells express a concomitant decrease in IFN-Y, IL-12 and IL-18 ( 7 ). (biomedcentral.com)
  • Eleven potential N-linked glycosylation sites are found within the rat gp130 ECD (1). (rndsystems.com)
  • The soluble form of IL-6R can bind its ligand and induce cellular responses by association with gp130, thus acting as an IL-6 agonist. (sbhsciences.com)
  • Interestingly, the association of IL-6 with the soluble form of IL-6R alpha is capable of eliciting a biological response in cells that express only the membrane gp130. (sbhsciences.com)
  • This subset of T cells play critical role in maintaining immune homeostasis and controlling excessive immune responses [ 5 ]. (omicsonline.org)
  • Proper regulation of immune responses mediated by NLRs is important as over-activation results in growth defects, while under-activation leads to vulnerability to pathogens. (ubc.ca)
  • NLRs are controlled at multiple levels to ensure immune responses are effective and timely. (ubc.ca)
  • Ubiquitin proteasome system (UPS)-mediated NLR turnover plays a pivotal role in the fine-tuned regulation of immune responses. (ubc.ca)
  • CD40L-CD40 interactions were originally shown to play a key role in thymus-dependent humoral immune responses, mediating cognate interactions between CD4+ T cells and B cells that are essential for B-cell activation and differentiation, class switching, germinal center formation, and the generation of B-cell memory (reviewed in references 21 and 31). (bioskinrevive.com)
  • Among the results was evidence that there was differential chemokine mRNA expression by the papilloma tissues, which suggested that the virus might be able to polarize the patients' innate immune responses. (biomedcentral.com)
  • IL-33 can promote survival, adhesion, and cytokine production in human mast cells [ 11 ], but the mechanism behind its involvement in inflammatory conditions remains unclear. (hindawi.com)
  • however, there is evidence that there is reduced interleukin (IL)-8 and keratinocyte-derived cytokine production, resulting in impaired chemotaxis. (uspharmacist.com)
  • This study identifies temporal transcriptional changes in the acute phase of ischemic stroke that reflect the early response of pericytes to the ischemic insult and its secondary consequences and may constitute potential future therapeutic targets. (lu.se)
  • Objective To determine the association between circulating interleukin-6 (IL-6) levels and risk of incident ischemic stroke in the general population. (medrxiv.org)
  • We pooled association estimates for ischemic stroke risk with random-effect meta-analyses and explored non-linear effects in dose-response meta-analyses. (medrxiv.org)
  • A dose-response meta-analysis showed a linear association between circulating IL-6 levels and ischemic stroke risk. (medrxiv.org)
  • Mouse anti Sheep interleukin 6 antibody, clone 4B6 ( MCA1659 ) used as a capture reagent for the measurement of interleukin 6 in an ELISA with Rabbit anti Sheep polyclonal antibody ( AHP424 ) as a detection reagent using lamb sera samples. (bio-rad-antibodies.com)
  • Interleukin 1β was detected with Mouse anti Sheep IL-1β antibody ( MCA1658 ) as a capture reagent and Rabbit anti IL-1β polyclonal antibody ( AHP423 ) as a detection reagent. (bio-rad-antibodies.com)
  • CD4 + T cells stimulate B cells to induce significant level of antimalarial antibody response and also help in the induction of CD8 + T-cell responses which help in arresting the growth of liver-stage parasites in the host. (omicsonline.org)
  • We report three cases of multicentric Castleman's disease (MCD) successfully treated with anti-interleukin-6 receptor antibody (tocilizumab). (nih.gov)
  • Mouse anti Ovine Interleukin-6 antibody, clone 4B6 ( MCA1659 ) used as a capture antibody in a sandwich ELISA for the evaluation of IL-6 expression in response to LPS treatment using Rabbit anti Ovine IL-6 antibody ( AHP424 ) as a detection reagent. (bio-rad-antibodies.com)
  • The evidence for an autoimmune etiology includes pathological findings of infiltrating T cells, the presence of antigen-antibody complexes in affected cartilage, cellular and humoral responses against collagen type II and other collagen antigens, and the observation that immunosuppressive regimens most often suppress the disease. (medscape.com)
  • It is also a key mediator of immune inflammatory hypernociception normally associated with a Th1 type of response, revealing a hitherto unrecognized function of IL-33 in a key immune pharmacological pathway that may be amenable to therapeutic intervention [ 13 ]. (hindawi.com)
  • Thus, the researchers found that zebrafish in which the interleukin-11 signaling pathway was knocked down using the CRISPR technique formed scars just like humans and other mammals. (mpg.de)
  • In studies on mouse mammary carcinoma, the IL-33/ST2 pathway promotes BC progression and metastasis through increased intratumoral accumulation of immunosuppressive cells and by diminishing innate anti-tumor immunity ( 11 ). (frontiersin.org)
  • Experimental studies have demonstrated that influenza vaccination may protect against tuberculosis (TB) through a Th17 response. (cdc.gov)
  • M. tuberculosis ) by activating a Th17 response ( 11 ). (cdc.gov)
  • [ 6 ] However, defective Th17 responses may be seen in classic disease without STAT3 mutations, with the extent of the defective Th17 response postulated to determine the clinical phenotype. (medscape.com)
  • In the course of RA, the BM microenvironment can promote the development of Th17 cell responses and overproduction of IL-17AF that may lead to increased inflammation and tissue destruction in RA BM. (biomedcentral.com)
  • Interleukin-17 is predominantly expressed by a specific subset of human T-helper cells-Th17 cells. (biomedcentral.com)
  • In the present study we hypothesized that the RA BM microenvironment supports the development of Th17 cells and Th17 cell response. (biomedcentral.com)
  • Anal Toxicol 11:260-262. (cdc.gov)
  • Food Cosmet Toxicol 11:897-901. (cdc.gov)
  • Zebrafish with interleukin-11 signaling turned off respond at the cellular level basically like we humans do to injury and activate a fibrotic gene program. (mpg.de)
  • Interleukin-11 signaling promotes cellular reprogramming and limits fibrotic scarring during tissue regeneration. (mpg.de)
  • Fusion cell vaccination of patients with metastatic breast and renal cancer induces immunological and clinical responses. (nwbio.com)
  • Interleukin-6 (IL-6) is a pro-inflammatory cytokine secreted by T cells and macrophages to stimulate immune response to trauma, especially burns or other tissue damage leading to inflammation. (dadamo.com)
  • macrophages] in response to pathogen associated molecular patterns (PAMPs) binding the Toll-like Receptor (TLR) present on an active macrophage. (dadamo.com)
  • Phagocytosis of invading pathogens by macrophages is a key component of this initial response. (uspharmacist.com)
  • Supporting proteome analyses confirmed that organic PM extracts induce a hierarchical oxidative stress response in macrophages and epithelial cells, in which the induction of electrophile-response element (EpRE) regulated genes (for example, heme oxygenase 1, catalase, and superoxide dismutase) at lower levels of oxidative stress prevented the more damaging pro-inflammatory and pro-apoptotic effects seen at higher levels of oxidative stress [ 10 ]. (biomedcentral.com)
  • The innate immune system functions as the first-line barrier and the most rapid response mechanism to prevent the invasion of microorganisms, whereas the adaptive immune system may take days to weeks to develop the appropriate responses of the T and B lymphocytes. (uspharmacist.com)
  • Interleukin-33 (IL-33) is an important member of the IL-1 family, and in humans is expressed predominantly in skin, lung, adipocytes, and synovial fibroblasts ( 4 ). (frontiersin.org)
  • Recurrent respiratory papillomatosis (RRP), characterized by the recurrent growth of benign tumors of the respiratory tract, is caused by infection with human papillomavirus (HPV), predominantly types 6 and 11. (biomedcentral.com)
  • As mentioned, the innate immune system is our first-line defense against invading pathogens, and opioids, specifically morphine, have been shown to significantly impair various aspects of this response. (uspharmacist.com)
  • PGE 2 can bias the adaptive immune response away from an effective T H 1-like pattern ( 16 ), and can enhance expression of T H 2-like chemokines by innate immunocytes ( 16 , 17 ). (biomedcentral.com)
  • CD8+ cytotoxic T lymphocytes (CTL) play a key role in the control of many virus infections, and the need for vaccines to elicit strong CD8+ T-cell responses in order to provide optimal protection in such infections is increasingly apparent. (bioskinrevive.com)
  • International Immunopharmacology 2 (2002) 201-211 immune response will be provoked at the point of 2.2. (cdc.gov)
  • Interleukin-6 derived from cutaneous deficiency of stearoyl-CoA desaturase- 1 may mediate metabolic organ crosstalk among skin, adipose tissue and liver. (umassmed.edu)
  • Phase I evaluation of thrice-daily intravenous bolus interleukin-4 in patients with refractory malignancy. (nwbio.com)
  • NORTH CHICAGO, IL - AbbVie (NYSE: ABBV) announced the European Commission (EC) approved SKYRIZI ® (risankizumab, 600 mg intravenous [IV] induction and 360 mg subcutaneous [SC] maintenance therapy) as the first specific interleukin-23 (IL-23) inhibitor for the treatment of adults with moderately to severely active Crohn's disease who have had inadequate response, lost response or were intolerant to conventional or biologic therapy. (lifesciencesbc.ca)
  • They are involved in regulating several physiologic and pathologic processes, including immunologic pathways, and we have demonstrated better immune response to vaccines in piglets fed with human milk (HM) in comparison to dairy-based formula (MF). (bvsalud.org)
  • Likewise, persons with genetic mutations in the interferon-gamma or interleukin-12 cytokine pathways can present with widely disseminated TB disease [ 11 , 12 ]. (cdc.gov)
  • Both isoforms shared 11 amino acids between signal sequences of the N-terminus. (wikipedia.org)
  • This changes after the loss of the signal molecule interleukin-11 receptor (il11ra) (right figure). (mpg.de)
  • CONCLUSIONS: IL-13 has a role in allergen-induced airway responses in humans. (mcmaster.ca)
  • ABSTRACT Single nucleotide polymorphisms (SNPs) in the Interleukin (IL)-28B gene, namely rs12979860, could predict response to pegylated interferon--ribavirin (PR) therapy in hepatitis C virus genotype 1 (HCV-1)-infected patients. (who.int)
  • Interleukin-6 is oedema, hypercholesterolaemia and gene- involved in inflammatory responses and im- ralized hyperlipidaemia [ 1 ]. (who.int)
  • Elevated IL-6 concentrations have been reported in numerous clinical disorders (Jones S. A. et al, 2001, The FASEB J. 15:43-58 ), where they appear to orchestrate a variety of inflammatory responses. (sbhsciences.com)
  • Moreover, the ability of IL-33 to induce Th2 responses has functional relevance in the context of intestinal helminth infection [ 10 ]. (hindawi.com)
  • it is a common the chemical allergen sufficient to induce a cutaneous occupational and environmental health issue and immune response of the necessary vigor. (cdc.gov)
  • This study showed that risankizumab was able to improve clinical signs and symptoms of patients who had a suboptimal response with the anti-IL-17 therapies secukinumab and ixekizumab, contributing to the whole of evidence supporting risankizumab use in moderate to severe plaque psoriasis. (biospace.com)
  • In the ADVANCE and MOTIVATE induction trials, a significantly greater proportion of patients treated with SKYRIZI 600 mg IV achieved the co-primary endpoints of clinical remission (per SF/AP) and endoscopic response. (lifesciencesbc.ca)
  • In the FORTIFY maintenance trial, a significantly greater proportion of patients treated with SKYRIZI 360 mg SC achieved the co-primary endpoints of clinical remission (per SF/AP) and endoscopic response. (lifesciencesbc.ca)
  • During the 2000-2001 Gulu Ebola virus disease outbreak, an international response team, including representatives from the US Centers for Disease Control and Prevention, or CDC, provided clinical and technical assistance. (cdc.gov)
  • Various studies find circulating antibodies to cartilage-specific collagen types II, IX, and XI to be present in 30%-70% of patients with relapsing polychondritis. (medscape.com)
  • Using immunocytochemistry and ELISA, we investigated the production of interleukin (IL)-1β in the rat hippocampus after focal application of kainic acid inducing electroencephalographic (EEG) seizures and CA3 neuronal cell loss. (jneurosci.org)
  • With a deeper understanding of the different responses of tissues to injury, it may not only be possible to develop new antifibrotic therapies, but also new approaches to growing tissues in the test tube for therapeutic applications. (mpg.de)
  • 1. Makino T, Noguchi Y, Yoshikawa T, Doi C, Nomura K. Circulating interleukin 6 concentrations and insulin resistance in patients with cancer. (dadamo.com)
  • These moderate to severe plaque psoriasis patients previously had a suboptimal response to treatment with secukinumab or ixekizumab, both IL-17A inhibitor therapies, for at least six months before switching to risankizumab. (biospace.com)
  • Findings from this phase 3b, open-label single-arm study showed that 56.3% of patients who received risankizumab, without a washout period following a suboptimal response to secukinumab or ixekizumab achieved the week 16 primary endpoint of reduced signs and symptoms of psoriasis (sPGA 0/1). (biospace.com)
  • Advanced therapies represent an important option in the treatment of plaque psoriasis, but as a physician, it's critically important to continually assess if patients are having an optimal response to treatment, as residual psoriasis can still have a significant impact on a patient's life," said Professor Richard Warren from the University of Manchester and Norten Care Alliance, UK. (biospace.com)
  • Additionally, 40% and 29% of SKYRIZI treated patients achieved endoscopic response at week 12 compared to 12% and 11% of patients receiving placebo. (lifesciencesbc.ca)
  • Additionally, 47% of patients treated with SKYRIZI achieved endoscopic response at week 52 compared to 22% of patients receiving placebo. (lifesciencesbc.ca)
  • There was no correlation between SVR patients' genotypes and early response to therapy or HCV baseline viral load. (who.int)
  • RÉSUMÉ Les polymorphismes mononucléotidiques du gène de l' Interleukine (IL)-28B , en l'occurence le rs12979860, permettent de prédire la réponse au traitement par interféron- pégylé associé à la ribavirine chez des patients infectés par le virus de l'hépatite C de génotype 1. (who.int)
  • At the other end of the spectrum, patients with a recovering immune system, such as persons with HIV who are initiating antiretroviral therapy or persons stopping anti-tumor necrosis factor therapy, can have an overexuberant immune response to TB infection characterized by extensive cavitary lung lesions and necrotic lymph nodes [ 13 ]. (cdc.gov)
  • The plasma level of interleukin-6 (IL-6) is elevated in patients with acute coronary syndromes and has prognostic value. (elsevierpure.com)
  • Deletion and mutation analysis of the promoter region of the IL-6 gene by using luciferase as a reporter showed that the DNA segment between -228 and -150 bp containing the cAMP response element (CRE) site played a critical role. (elsevierpure.com)
  • OBJECTIVES: We hypothesized that anti-IL-13 treatment would inhibit allergen-induced late-phase asthmatic responses, airway hyperresponsiveness, and inflammation in subjects with asthma. (mcmaster.ca)
  • Interleukin-6 (IL-6) is a multifunctional cytokine that regulates pleiotropic roles in immune regulation, inflammation, hematopoiesis, and oncogenesis. (sbhsciences.com)
  • Treatment with IMA-026 did not attenuate the asthmatic responses on Day 14 or Day 35. (mcmaster.ca)
  • Murine breast carcinoma models suggest disruption of ST2 signaling may enhance the anti-tumor immune response, suggesting IL-33 impedes anti-tumor immunity. (frontiersin.org)
  • Natural Treg cells during primary exposure to malaria enhanced Th1 memory responses and increased disease severity during re-infection. (omicsonline.org)
  • We stress the variability of MRI findings in the course of the disease and also the variable response to corticotherapy. (nel.edu)
  • this is known as "spontane- disease, including treatment response. (who.int)
  • The host response to this infection is an important factor in determining the extent and severity of the disease. (medscape.com)
  • The use of rifabutin-containing antituberculosis regimens should always include an assessment of the patient's response to treatment to decide the appropriate duration of therapy (i.e., 6 months or 9 months). (cdc.gov)
  • Pyroptosis constitutes a strong response to infection and cell stress, by alerting the immune system of imminent danger and by preventing the spread of the threat. (invivogen.com)
  • Sepsis is the body's extreme response to an infection. (cdc.gov)
  • The incidence in the United States among children (under age 14) is estimated to be 4.3/100,000 ( 10 ) and among adults, 1.8/100,000 ( 11 ). (biomedcentral.com)
  • Con A-induced proliferation of EC was readily seen, with the maximal response occurring at a Con A concentration of 2.5 μg/ml on day 5 of culture. (elsevierpure.com)
  • IL-6 is one of the most important mediators of fever and of the acute phase response. (dadamo.com)
  • Foundations of the severe acute respiratory syndrome preparedness and response plan for healthcare facilities. (cdc.gov)
  • The earliest attempt of TIL therapy in the clinic can be traced back to 1988 and achieved a 60% objective response rate (ORR) in metastatic melanoma [ 1 ]. (biomedcentral.com)
  • 1988. Species-specific response to the rodent carcinogens 1,2-dimethylhydrazine and 1,2-dibromo-3-chloropropane in rodent bone-marrow micronucleus assays. (cdc.gov)
  • Finally, to address the functional role of this cytokine, we measured the effect of human recombinant (hr)IL-1β on seizure activity as one marker of the response to kainate. (jneurosci.org)
  • Human Achilles tendon-derived cells were preincubated with or without ciprofloxacin (50?µg/ml) and were then challenged with interleukin-1ß (IL-1ß, 1?ng/ml) for up to 48?h. (uea.ac.uk)
  • Member has had an inadequate response, intolerance, or contraindication to non-steroidal anti-inflammatory drugs (NSAIDs), colchicine and corticosteroids. (aetna.com)
  • This type of activation, called "trans-signalling", renders virtually all cells capable of responding to IL-6/sIL-6R alpha complexes, making for a large new spectrum of IL-6 activities, ranging from the control of the immune response to involvement in pathological states. (sbhsciences.com)
  • bronchoalveolar lavage fluid levels of interleukin (IL)-6, IL-4, and IL-10 were generally low or nondetectable across all of the studied groups at the 18-h postexposure time point. (cdc.gov)
  • The primary end point was the objective response rate (ORR), and secondary end points were toxicity, progression-free survival, and overall survival. (bmj.com)
  • These results suggest strongly that Thy-1 + dEC, which do not have a mature peripheral T cell phenytype, can proliferate in response to Con A and to IL 2. (elsevierpure.com)
  • In Plasmodium chabaudi chabaudi (AS), T helper cells of host have been reported to be necessary for inducing a protective immune response against the blood stages of parasite [1]. (omicsonline.org)
  • Dead cells are swiftly removed by phagocytes without triggering an immune response, thereby preserving homeostatic integrity. (invivogen.com)
  • The Kaempferol inhibitor fact that CD40L and CD40 are expressed in a tightly controlled fashion on T cells and on many different cell populations with which they interact suggests that CD40L-CD40 interactions are probably involved in the regulation of a number of aspects of the immune response. (bioskinrevive.com)
  • We are investigating whether ciprofloxacin modifies signalling responses in tendon cells. (uea.ac.uk)
  • Then TIL is further expanded in a rapid expansion phase (REP) in response to stimulators, such as IL-2 and/or feeder cells. (biomedcentral.com)
  • Furthermore, pretreatment of CBA EC with anti-L3T4, anti-Lyt-2.1, and complement failed to diminish the proliferative response of these cells. (elsevierpure.com)
  • The homozygous C allele genotype (CC) was associated with sustained viral response (SVR) to therapy compared with the homozygous T allele genotype (TT) and the heterozygous genotype (CT). (who.int)
  • Cowardin CA, Kuehne SA, Buonomo EL, Marie CS, Minton NP, Petri WA: Inflammasome activation contributes to interleukin-23 production in response to Clostridium difficile. (msdmanuals.com)
  • Collectively, these results suggest that mechanisms contributing to the enhanced pulmonary inflammatory response to ozone in a hyperthyroid state include an increase in NF-kappaB activation and an upregulation of chemokine production. (cdc.gov)
  • Con A responses were significantly enhanced by the continuous presence of 1 μg/ml indomethacin. (elsevierpure.com)