• Quinoline itself has few applications, but many of its derivatives are useful in diverse applications. (wikipedia.org)
  • Like other nitrogen heterocyclic compounds, such as pyridine derivatives, quinoline is often reported as an environmental contaminant associated with facilities processing oil shale or coal, and has also been found at legacy wood treatment sites. (wikipedia.org)
  • Medications used in the treatment of malaria infection come from the following five groups of chemical compounds: quinolines and aryl amino alcohols, antifolate, artemisinin derivatives, hydroxynaphthoquinones and antibacterial agents. (intechopen.com)
  • These findings implicate the charged Glu441,Ile442,Glu443 domain as necessary for a functional CHE catalytic triad as well as for binding quinoline derivatives. (inrae.fr)
  • In order to affect the binding of quinoline to our bis-benzimidazole derivatives, we have chosen the "azo" bond as a means of attachment. (azurewebsites.net)
  • It is one of the quinoline derivatives and a member of chemically related antimalarial agents. (vedantu.com)
  • Kairine) Several anti-malarial drugs contain quinoline substituents. (wikipedia.org)
  • The increased resistance of the human malaria parasite Plasmodium falciparum to currently employed drugs creates an urgent call for novel anti-malarial drugs. (biomedcentral.com)
  • Accordingly, there is a need for new anti-malarial drugs with novel chemical structures that exploit distinct molecular targets to protect them from cross-resistance mechanisms. (biomedcentral.com)
  • This review concludes with a discussion of the potentially confounding role of the adverse effects of anti-malarial drugs, particularly of the quinoline class, in the unique attribution of certain psychiatric effects to malaria, and of the need for a critical reevaluation of the literature in light of emerging evidence of the chronic nature of these adverse drug effects. (biomedcentral.com)
  • Yet similarly, anti-malarial drugs, particularly of the quinine-like class of quinolines commonly used in treatment and prevention of disease, are also increasingly recognized to exert potentially chronic psychiatric adverse effects that may also contribute to this global burden of morbidity [ 2 ]. (biomedcentral.com)
  • Lastly, the psychiatric effects of anti-malarial drugs, particularly of the quinoline class, are reviewed, including a discussion regarding the potential confounding effect that these may have had on symptoms historically associated with malaria. (biomedcentral.com)
  • Doebner reaction using anilines with an aldehyde and pyruvic acid to form quinoline-4-carboxylic acids Doebner-Miller reaction using anilines and α,β-unsaturated carbonyl compounds. (wikipedia.org)
  • Since 2011, several quinoline compounds have shown Epidermal Growth Factor Receptor (EGFR) inhibition 22 . (nature.com)
  • Biofilms are notorious for their resistance to environmental stresses, including antimicrobial compounds. (southampton.ac.uk)
  • Treatment of biofilms with nitric oxide also reduced their resistance to antimicrobial compounds. (southampton.ac.uk)
  • Particularly, efforts should be devoted to developing fast-acting anti-malarial compounds in case clinical resistance increases to the first-line artemisinin-based combination therapy. (biomedcentral.com)
  • If measures are not applied to contain resistance, the investment put into the development of new drugs will be squandered.Current efforts focus, on the one hand, on research into novel compounds with mechanisms of action that are different to the traditionally used drugs,and, on the other hand, on measures to prevent or delay resistance when drugs are introduced. (ox.ac.uk)
  • However, there is relatively little novelty, as current development projects still rely upon the traditional quinoline, antifolate and, in particular, artemisinin compounds. (ox.ac.uk)
  • Plasmodium falciparum has sequently revised [ 9 ] and have remained developed resistance to nearly all antimalar- basically unchanged since the WHO Scien- ials in current use, although the geographi- tific Group on the Chemotherapy of Malar- cal distribution and prevalence rates of ia and Resistance to Antimalarials in 1972 resistance to individual drugs do vary. (who.int)
  • Minor genotypes confirm the heterogeneous number of multidrug resistance genes ( pfmdr1 ) in P. nature of infection and may affect treatment success. (cdc.gov)
  • Dofequidar, also known as MS-209, is a quinolone-derived sphingomyelin synthase inhibitor that blocks P-glycoprotein and multidrug resistance-associated protein-1, is under development by Schering for the potential treatment of multidrug resistant tumors. (medkoo.com)
  • Neurofilaments), he spent six years as a Post-doc and research fellow at Princess Margaret Cancer Centre working on Multidrug resistance and P-glycoprotein (ABCB1) with Dr. Victor Ling. (mcgill.ca)
  • Our results suggest that (a) inhibition of glucosylceramide synthase does not reverse multidrug resistance and (b) the chemosensitization achieved by PDMP cannot be caused by inhibition of glucosylceramide synthase alone. (ox.ac.uk)
  • Fernando DM, Kumar A. Resistance-nodulation-division multidrug efflux pumps in gram-negative bacteria: role in virulence. (ijmedrev.com)
  • Clinically relevant chromosomally encoded multidrug resistance efflux pumps in bacteria. (ijmedrev.com)
  • Single-nucleotide polymorphisms at several loci have drug resistance, fueled by counterfeiting, overuse, and been correlated with Plasmodium falciparum drug re- underdosing, threatens control and elimination efforts sistance. (cdc.gov)
  • Resis- assessment of in vivo drug response in P. tance to antimalarial drugs has been de- falciparum were developed shortly after scribed for 2 of the 4 species of human the first reports of CQ resistance in this malaria parasites, Plasmodium falciparum species [ 1 ]. (who.int)
  • Resistance of Plasmodium falciparum to chloroquine is widespread and cases of Plasmodium vivax resistance have been reported. (drugs.com)
  • BACKGROUND:The ability of Plasmodium falciparum parasites to develop resistance to widely used anti-malarials threatens malaria control and elimination efforts. (tropmedres.ac)
  • To get insight into the relevance of targeting hemozoin (Hz) crystals, two isomeric series, N5,N10-bis-alkylamine (2a-k) and N10,O11-bis-alkylamine (3a-k) indolo[3,2-b]quinolines, were evaluated for their in vitro activity against chloroquine (CQ)-resistant and sensitive strains of Plasmodium falciparum. (unl.pt)
  • Plasmodium falciparum, has developed resistance to many of the drugs in use. (unl.pt)
  • 4-Hydroxy-2-alkylquinolines (HAQs) are involved in antibiotic resistance. (wikipedia.org)
  • GP provider Docly, along with its Swedish counterpart Min Doktor, is adding its support in the battle against antibiotic resistance. (med-technews.com)
  • Note: This illustration was updated in CDC's Antibiotic Resistance Threats in the United States, 2019 (AR Threats Report). (cdc.gov)
  • We have synthesized a new quinoline (4,7-dichloroquinoline) derivative which showed significant larvicidal and pupicidal properties against a malarial and a dengue vector and a lethal toxicity ranging from 4.408 µM/mL (first instar larvae) to 7.958 µM/mL (pupal populations) for Anopheles stephensi and 5.016 µM/mL (larva 1) to 10.669 µM/mL (pupae) for Aedes aegypti . (nature.com)
  • This is another derivative of quinoline. (vedantu.com)
  • We evaluated single-nucleotide poly- cluding artemisinins, quinolines, and antifolates ( 3 ). (cdc.gov)
  • Mutations conferring proguanil resistance increased proguanil, and artemisinins, and to quantify the copy over time. (cdc.gov)
  • Based on growth inhibition and ring survival assays, no cross-resistance was observed between artemisinins and SC83288, using parasite lines that were resistant to either one of these drugs. (biomedcentral.com)
  • The results obtained in this study are consistent with artemisinins and SC83288 having distinct modes of action and different mechanisms of resistance. (biomedcentral.com)
  • This study further supports efforts to continue the clinical development of SC83288 against severe malaria as an alternative to artemisinins in areas critically affected by artemisinin-resistance. (biomedcentral.com)
  • The chloroquine chemical structure 7-chloro-4-(4-diethylamino-1-methyl butyl amino)-quinoline, is formed while 4,7-di chloroquinoline is reacted with 4-diethylamino-1-methyl butylamine at 180 °C. (vedantu.com)
  • In vitro conditions and the purified quinoline exhibited insignificant toxicity on the host system up to 100 µM/mL. (nature.com)
  • In vitro resistance to SC83288 develops slowly and might involve mutational changes in the Ca 2+ transporting PfATP6, the P. falciparum SERCA orthologue. (biomedcentral.com)
  • It also reviews the way drug resistance develops and spreads, methods used to assess the presence and level of drug resistance, and the extent to which chloroquine and sulfadoxine/pyrimethamine (SP)-the two most widely used antimalarial drugs in the world today-have now lost efficacy. (nationalacademies.org)
  • Current treatment involves either administration of antiobesity drugs or surgical procedures such as Roux-en-Y-gastric bypass or sleeve gastrectomy, both of which are associated with serious side effects and poor patient acceptance. (bvsalud.org)
  • So far, malaria control has relied heavily on a restricted number of chemically related drugs belonging to either the quinoline or the antifolate groups. (ox.ac.uk)
  • Experience has shown that resistance eventually curtails the life span of antimalarial drugs. (ox.ac.uk)
  • Drug combinations that have independent modes of action are seen as a way of enhancing efficacy while ensuring mutual protection against resistance.Most research work has focussed on the use of artesunate combined with currently used standard drugs, namely mefloquine, amodiaquine,sulfadoxine/pyrimethamine and chloroquine. (ox.ac.uk)
  • The scale and impact of resistance has been underestimated, leading to the continued use of failing drugs, which contributes to the rise in resistance and increased morbidity and mortality due to malaria. (ox.ac.uk)
  • Although the problem is complex, much can be done to reverse the course of events: adopt adequate tests to assess resistance, encourage and sustain development of new drugs, protect drugs against resistance through use of combinations, expand access to prompt and effective treatment, and promote evidence-based policies and sensible practices. (ox.ac.uk)
  • Inhibiting glycolipid biosynthesis by blocking glucosylceramide synthase has been proposed to reverse drug resistance in MDR cells by causing an increased accumulation of proapoptotic ceramide during treatment of cells with cytotoxic drugs. (ox.ac.uk)
  • BackgroundDue to anthelmintic resistance problems, there is a need to discover and develop new drugs for the treatment and control of economically important and pathogenic nematodes of livestock animals. (edu.au)
  • Autophagy may represent a mechanism of resistance to oxidative stress induced by chemotherapeutic drugs and may potentiate cancer cell survival to hypoxia and nutrient starvation due to the frequently defective tumor vascularization. (nature.com)
  • The possibility for the emergence of resistance seems to be vastly lower when topical routes of administration are used as compared with drugs that are administered systemically. (medscape.com)
  • Are there only certain resistance genes to be worried about or is the problem more widespread? (thehindu.com)
  • It has been difficult to abandon chloroquine as first-line treatment even though resistance to it is widespread. (who.int)
  • Widespread drug resistance in parasites aggravates the burden of malaria. (ox.ac.uk)
  • Due to widespread drug resistance in parasitic nematodes, there is a need to develop new anthelmintics. (edu.au)
  • One aspect about the antimicrobial resistance debate in India is about the consumption of antibiotics. (thehindu.com)
  • Usually, this concern lies with the rapidly diminishing arsenal of antibiotics following the rise of antimicrobial resistance. (biologists.com)
  • Antimicrobial resistance remains a threat to patient safety and healthcare outcomes and largely arises from inappropriate antimicrobial prescriptions. (bvsalud.org)
  • Going clockwise from top these are: Combes quinoline synthesis using anilines and β-diketones. (wikipedia.org)
  • Quinoline is used as a solvent and reagent in organic synthesis. (wikipedia.org)
  • 2 ). P. falciparum resistance mutations have resulted markers in P. falciparum from imported malaria cases in in waning efficacy in multiple antimalarial classes in- Canada during 3 time periods, 2008-2009, 2013-2014, and 2017-2018. (cdc.gov)
  • Absence of kelch13 artemisinin resistance markers but strong selection for lumefantrine-tolerance molecular markers following 18 years of artemisinin-based combination therapy use in Mpumalanga Province, South Africa (2001-2018). (tropmedres.ac)
  • METHODS:Molecular analyses to determine the prevalence of alleles associated with resistance to lumefantrine (mdr86N, crt76K and mdr1 copy number variation) and sulfadoxine-pyrimethamine (dhfr triple, dhps double, SP quintuple) were conducted between 2001 and 2018, while artemisinin resistance markers (kelch13 mutations) were assessed only in 2018. (tropmedres.ac)
  • CONCLUSION:No kelch13 mutations confirmed or suspected to be associated with artemisinin resistance were identified in 2018. (tropmedres.ac)
  • Although parasites carrying the mdr86N and crt76K alleles associated with reduced lumefantrine susceptibility were strongly selected for over the study period, nearing fixation by 2018, the marker for lumefantrine resistance, namely increased mdr1 copy number, was not observed in this study. (tropmedres.ac)
  • While used primary for ozone resistance, it is more active antioxidant than quinoline or diphenylamine base antioxidants. (yashodadevelopers.in)
  • tmq is a general quinoline antioxidant with excellent heat and oxidative aging resistance performance in the rubber industry. (reclameridders.nl)
  • Thus, activation of AMPK β1 and increasing fatty acid oxidation in macrophages may represent a new therapeutic approach for the treatment of insulin resistance. (edu.au)
  • it has strong heat, oxidation and aging resistance performance. (reclameridders.nl)
  • Starting from a series of previously reported phenoxyquinazoline and quinoline based inhibitors of the tyrosine kinase PDGFRα, potency against a diverse panel of mutant KIT driven Ba/F3 cell lines was optimized, with a particular focus on reducing activity against a KDR driven cell model in order to limit the potential for hypertension commonly seen in second and third line GIST therapies. (rcsb.org)
  • However, the N-alkylated iminosugars C9DGJ and C4DGJ, which are more selective glucosylceramide synthase inhibitors than PDMP, failed to cause any reversal of drug resistance despite depleting glycolipids to the same extent as PDMP. (ox.ac.uk)
  • The inhibition performance and surface protection of green corrosion inhibitor 8-quinoline sulphonyl chloride (8QSC) on copper (Cu) was evaluated by chemical (weight loss) method in 0.5, 1.0 and 2.0 M HNO3 solutions and by electrochemical methods such as potentiodynamic polarization (PDP), AC-impedance spectroscopy (AC-IS) and linear polarization resistance in 1.0 M HNO3 solution at room temperature. (amrita.edu)
  • No artemisinin resistance-associated kelch13 mutations nor amplification of the mdr1 gene copy number associated with lumefantrine resistance were observed. (tropmedres.ac)
  • Wanton prescription, it is said, accelerates resistance but on the other hand the per capita consumption of antibiotics is much higher in the West than India. (thehindu.com)
  • Infections resulting from Pseudomonas aeruginosa are important due to their highest resistance against all clinically used antibiotics. (ijmedrev.com)
  • Bacterial resistance to antibiotics: active efflux and reduced uptake. (ijmedrev.com)
  • All (100%) isolates used in this study showed MDR resistance to tested antibiotics. (bvsalud.org)
  • Treatment of malaria from public health perspective is to reduce transmission of the infection to others, by reducing the infectious reservoir and to prevent the emergence and spread of resistance to antimalarial medicines. (intechopen.com)
  • The spread of resistance could be slowed down by the adoption of effective national policies and control programmes. (who.int)
  • Coordination between counties and with other WHO regions, as opposed to working in isolation, could further reduce the spread of resistance. (who.int)
  • Pharmacological, epidemiological, and operational aspects factor the development and spread of resistance. (ox.ac.uk)
  • Quinoline is readily degradable by certain microorganisms, such as Rhodococcus species Strain Q1, which was isolated from soil and paper mill sludge. (wikipedia.org)
  • We aimed to identify the prevalence of We observed fewer mutations indicative of chloroquine several resistance markers, including genes that confer resistance over time, which may reflect reduced chlo- roquine pressure in specimens from travelers to Africa. (cdc.gov)
  • Such a longitudinal survey of changes in the prevalence of selected molecular markers of resistance was conducted in the malaria-endemic regions of Mpumalanga Province, South Africa, where malaria elimination at a district-level is being pursued. (tropmedres.ac)
  • prevalence, patient genetics, historical use of malaria chemoprophylaxis by the patient, knowledge of local anti-malarial drug resistance, and the patient's pregnancy status. (medscape.com)
  • Quinoline is a heterocyclic aromatic organic compound with the chemical formula C9H7N. (wikipedia.org)
  • A comparative study of antitumor activity of mono- and bis-quinoline based (thio) carbohydrazones was investigated by a series of tests on two human malignant cell lines: acute monocytic leukemia (THP-1) and pancreatic adenocarcinoma cancer stem cells (AsPC-1). (ac.rs)
  • Bioactivity of Lerak Fruit Extract (Sapindusrarak DC) as an Endodontic Irrigant to Inhibition the Fusobacteriumnucleatum virulence and Relate to the Fracture Resistance of Root Canal. (rjptonline.org)
  • Inhibition of glucosylceramide synthase does not reverse drug resistance in cancer cells. (ox.ac.uk)
  • A Ca²⁺ channel blocker Verapamil has found to restore the ability of chloroquine to treat resistance parasites. (vedantu.com)
  • In low transmission settings where therapeutic efficacy studies are often not feasible, routine surveillance for molecular markers associated with anti-malarial resistance provides an alternative for the early detection of emerging resistance. (tropmedres.ac)
  • Because of this high resistance, its importance in nosocomial infections and burns, and that it often causes diseases in immunocompromised patients, finding a therapeutic supplement is essential. (ijmedrev.com)
  • Lenvatinib Plus Anti-PD-1 Combination Therapy for Advanced Cancers: Defining Mechanisms of Resistance in an Inducible Transgenic Model of Thyroid Cancer. (ucdenver.edu)
  • This makes the emergence of bacterial resistance extremely improbable. (medscape.com)
  • The mechanism of resistance for this biotype is either unknown or has not been entered in the database. (weedscience.com)
  • If you know anything about the mechanism of resistance for this biotype then please update the database. (weedscience.com)
  • Unfortunately, we look for no more than 4 markers, but when we do genome sequencing we get to know a lot many more (components) that may be driving resistance. (thehindu.com)
  • We've done studies in Karachi and found that carriers of key resistance markers didn't have a history of antibiotic consumption but stood out in the type of toilet, water supply and sanitation. (thehindu.com)
  • The Cardiff University professor, who reported on the enzyme called New Delhi metallo beta lactamase, says China and Pakistan are more serious about anti-microbial resistance genes than India. (thehindu.com)
  • We'd hoped that the government would then set in place a surveillance system for tracking anti-microbial resistance genes. (thehindu.com)
  • It would be incredibly hard to find all the sources of resistance genes. (thehindu.com)
  • If resistance genes are all around, how worried should we be? (thehindu.com)
  • You and I are chock-full of resistance genes. (thehindu.com)
  • Combination treatments are highly sought as they counter drug resistance and use smaller amounts of active agents. (ukri.org)
  • Evidence from Southeast Asia shows that resistance to artemisinin combination therapy (ACT) is inevitable. (unl.pt)
  • Quinolines are present in small amounts in crude oil within the virgin diesel fraction. (wikipedia.org)
  • The accumulation in adipose tissue of macrophages in an inflammatory state is a hallmark of obesity-induced insulin resistance. (edu.au)
  • ACTs are also to enhance treatment and protect against the development of drug resistance. (intechopen.com)
  • The current situation favors the development of sensible strategies to restrain resistance. (ox.ac.uk)
  • Quinoline is only slightly soluble in cold water but dissolves readily in hot water and most organic solvents. (wikipedia.org)
  • This graph shows the total number of publications written about "Quinolines" by people in this website by year, and whether "Quinolines" was a major or minor topic of these publications. (ucdenver.edu)