• Background: Connective tissue progenitors (CTPs) from native bone marrow (BM) or their culture-expanded progeny, often referred to as mesenchymal stem/stromal cells, represents a promising strategy for treatment of cartilage injuries. (whiterose.ac.uk)
  • Wnt signaling also controls tissue regeneration in adult bone marrow, skin and intestine. (wikipedia.org)
  • IHC staining analysis revealed that SATB2-overexpressing BMSCs were intensely distributed in the bone tissue surrounding the implant. (nih.gov)
  • Researchers in the U.S. reported on the development of a new technique that uses bone marrow mesenchymal stem cells to partially regenerate bladder tissue in nonhuman primates. (cphi-online.com)
  • Data demonstrate MSC seeded POCfs support partial regeneration of bladder tissue in vivo. (northwestern.edu)
  • 3D printed SiOC(N) ceramic scaffolds for bone tissue regeneration: improved osteogenic differentiation of human bone marrow‐derived mesenchymal stem cells. (appropedia.org)
  • Regardless of monolayer or spheroid cell culture, PLATMC-HPLG constructs represent promising scaffolds for bone tissue engineering applications. (biomedcentral.com)
  • Bone tissue engineering (BTE) strategies are increasingly being used to overcome the limitations of autogenous bone grafts and existing bone-substitute materials to reconstruct such defects [ 1 ]. (biomedcentral.com)
  • Cell therapy involves constantly-evolving clinical processes that are still being researched and explored as a means to replace or repair human cells, tissue or organs. (axiomtek.com)
  • An example of one of these processes is a bone marrow transplant, which requires harvesting healthy red blood cells from the spongy tissue inside a donor's bones and transferring them into a patient's bloodstream. (axiomtek.com)
  • New technology and research led the cell therapy scene to the use of Adipose tissue- or fat tissue. (axiomtek.com)
  • Adipose tissue is a rich source of regenerative cells that can transform into various types of cells, including muscle, bone, fat, cartilage and nerve cells. (axiomtek.com)
  • There are a couple benefits of using adipose tissue as a source of regenerative cells as opposed to bone marrow. (axiomtek.com)
  • The adipose tissue is collected from the patient through a minimally invasive surgery and yields more regenerative cells compared to ones derived from bone marrow. (axiomtek.com)
  • Aslan checked these clinical facts experimentally (5), the research showed Gerovital-H3 ® to have regenerative effects on the liver tissue, bone marrow and it shortened the time required by bone knitting after experimental fractures in rats (5). (antiaging-systems.com)
  • The histologic examination of the wound revealed the appearance of the granulation tissue after a 3-week treatment along with the accumulation of the so-called "regeneration cells" around many vessels (see figure 2 over). (antiaging-systems.com)
  • This article is intended to provide a review of the most current approaches to utilizing stem cells and bioengineering principles for the purpose of salivary tissue regeneration. (biomedcentral.com)
  • Michael Sieweke's role as Humboldt Professor at Technische Universität Dresden will be to position the university more firmly at the interface of immunology and tissue regeneration and to drive new medical applications in this area. (humboldt-foundation.de)
  • Sieweke's special field are the mechanisms by which cells of the immune system are generated and the role of these cells in preserving tissue function and regeneration. (humboldt-foundation.de)
  • Recently, stem cell sheet has been an emerging strategy in bone tissue engineering. (dovepress.com)
  • 2 , 3 Bone tissue engineering (BTE) attempts to solve the referred problems mentioned. (dovepress.com)
  • MSCs were first found in bone marrow, but have since been detected in many different tissues, including adipose tissue (fat) and umbilical cord blood. (rvc.ac.uk)
  • MSCs are naturally present in the body where they help to keep tissues functioning normally and assist with tissue regeneration following injury. (rvc.ac.uk)
  • They divide and the resulting cells develop into specific tissue cells, forming the brain, lungs or bone marrow. (sciencedaily.com)
  • Stem cells are regarded as the ideal resource for tissue regeneration, outside of formal organ transplantation. (empowher.com)
  • However, MSCs have gained considerable attention for tissue regeneration owing to their differentiation ability with immunomodulatory effects. (techscience.com)
  • Another critical question about the MSC-based bone tissue engineering is the necessity to expand the cells prior to use. (bjmu.edu.cn)
  • Regenerative medicine/surgery can be considered as a 'trait de union' between basic research, tissue engineering and clinics, representing a good example of translational research. (iiarjournals.org)
  • These proteins regulate various processes involved in wound healing and tissue regeneration by regulating cell proliferation, cell differentiation, angiogenesis, matrix deposition and tissue remodeling ( 7 ). (iiarjournals.org)
  • PG is also indicated for difficult wound healing, such as chronic cutaneous ulcers, diabetes foot ulcerations ( 11 ) and other chronic non-healing wounds ( 12 ), in the reduction of postoperative pain ( 13 ), in the treatment of soft tissue traumas and in soft tissue and bone reconstruction ( 14 ). (iiarjournals.org)
  • A new tissue-engineered strategy, Bottom-Up strategy (tissue-engineered microtissue strategy), has emerged and made significant research progress in recent years. (biomedcentral.com)
  • The effect of laminin on hard tissue formation using rat bone marrow cells was assessed. (scirp.org)
  • Yoshikawa, M. , Kakigi, H. , Yabuuchi, T. and Hayashi, H. (2014) Effects of laminin on hard tissue formation by bone marrow cells in vivo and in vitro . (scirp.org)
  • In February 2012, early research published by scientists at Cedars-Sinai Medical Center and Johns Hopkins University showed that a patient's own stem cells can be used to regenerate heart tissue and help undo damage caused by a heart attack. (cnn.com)
  • Uncovering the functions of hBMSC-derived EVs in the immune microenvironment of periodontal tissue and their underlying regulatory mechanisms may shed new light on developing potential cell -free immunotherapies for periodontal regeneration . (bvsalud.org)
  • Subsequent regenerative dental procedures include the development of guided tissue or bone regeneration (GTR, GBR) procedures and distraction osteogenesis 2 the application of platelet rich plasma (PRP) for bone augmentation 17 . (bvsalud.org)
  • Postnatal stem cells have been sourced from umbilical cord blood, umbilical cord, bone marrow, peripheral blood, body fat, and almost all body tissues, including the pulp tissue of teeth 8 . (bvsalud.org)
  • The results of a number of experimental animal studies also showed that cell therapy (bone marrow cells (BMCs), hematopoietic stem cells (HSCs), mesenchymal stem cells (MSCs)) might have the potential to rescue animals from organ injuries. (tmu.edu.tw)
  • It is known that MSCs can contribute to renal tubular regeneration after ATN, although the exact mechanism, either transdifferentiation or effects of paracrine/cytokines, is uncertain. (tmu.edu.tw)
  • We found that myocilin is expressed in bone marrow-derived mesenchymal stem cells (MSCs) and affects their differentiation into osteoblasts. (nih.gov)
  • Osteoblast mainly originates from mesenchymal stem cells (MSCs), and it is involved in bone formation, remodeling, and reconstruction via the formation of a bone matrix and regulation of bone resorption ( 6 ). (frontiersin.org)
  • Mesenchymal stem cells (MSCs) are multipotent cells usually isolated from bone marrow, endometrium, adipose tissues, skin, and dental pulp. (techscience.com)
  • In vivo transplantation demonstrated that LIFR+PDGFRB+CD45-CD31-CD235a- MSCs could form bone tissues and reconstitute the hematopoietic microenvironment (HME) effectively in vivo. (bjmu.edu.cn)
  • This work not only expands our understanding of human bone marrow MSCs, but also provides great hints for further expansion of primary MSCs in vitro, which would be great help for MSCs-based bone regeneration. (bjmu.edu.cn)
  • We describe a novel therapeutic approach for cirrhosis using mesenchymal stem cells (MSCs) and colony‐stimulating factor‐1‐induced bone marrow‐derived macrophages (id‐BMMs) and analyze the mechanisms underlying fibrosis improvement and regeneration. (birmingham.ac.uk)
  • Mouse MSCs and id‐BMMs were cultured from mouse bone marrow and their interactions analyzed in vitro. (birmingham.ac.uk)
  • Bone marrow transplantation and organ transplantation studies suggest that bone marrow cells can differentiate into a variety of non-hematological tissues, including renal cells. (tmu.edu.tw)
  • Intravenous infusion of wild-type progenitor cells, but not bone marrow transplantation, rescued the defective neovascularization of Nos3(-/-) mice in a model of hind-limb ischemia, suggesting that progenitor mobilization from the bone marrow is impaired in Nos3(-/-) mice. (nih.gov)
  • His clinical interests include bone marrow transplantation, stem cell regeneration, and autoimmune disease. (ucsd.edu)
  • 2013) Conditioned medium from bone marrow-derived mesenchymal stem cells improves recovery after spinal cord injury in rats: an original strategy to avoid cell transplantation. (ukaachen.de)
  • Here, we analyzed the different phases of regeneration after transplantation. (lu.se)
  • We isolated bone marrow from mice at 8 time points after transplantation and examined the reconstitution dynamics and transcriptional profiles of stem and progenitor populations. (lu.se)
  • Since the iliac crest remains a frequent site of BM harvest for musculoskeletal regeneration, the authors also compared the spatial distribution of these subsets in trabeculae of femoral head and iliac crest and found CD2711CD561 bone-lining cells in both tissues. (whiterose.ac.uk)
  • These processes are necessary for proper formation of important tissues including bone, heart and muscle. (wikipedia.org)
  • In order to address the limits associated with current therapies, many research groups have investigated various regenerative medicine strategies utilizing different stem cell sources to engineer artificial salivary tissues that can mitigate the effects of xerostomia and hyposalivation. (biomedcentral.com)
  • Adult stem cells exist in adult tissues throughout the body, such as bone marrow, brain, muscle and GI tract. (empowher.com)
  • At the same period, it was discovered that a fraction of stem cells of bone marrow origin was able to repair several mesenchymal tissues or organs. (iiarjournals.org)
  • Inspired from developmental processes, human mesenchymal cell lines can be programmed to form cartilage, bone and bone marrow tissues in vitro and in vivo. (lu.se)
  • GALNS deficiency induces the accumulation of glycosaminoglycans (GAGs), keratan sulfate (KS) and chondroitin-6-sulfate (C6S) in multiple tissues, particularly bone, cartilage, heart valves, and cornea, whereas β-galactosidase deficiency induces the accumulation of only KS in those tissues. (medscape.com)
  • But the cartilage regeneration capacity of these cells remains unpredictable because of cell heterogeneity. (whiterose.ac.uk)
  • Hypothesis: The harvest technique of BM may highly influence stem cell heterogeneity and, thus, cartilage formation because these cells have distinct spatial localization within BM from the same bone. (whiterose.ac.uk)
  • Furthermore, evaluation of these CTP subsets in BM revealed that CD2711CD561 cells were localized in the bone-lining regions whereas CD2711CD56- cells were found in the perivascular regions. (whiterose.ac.uk)
  • A medical procedure in which healthy bone marrow stem cells are injected into the body to replace damaged or diseased bone marrow. (mayo.edu)
  • Bladder regeneration studies have yielded inconclusive results possibly due to the use of unfavorable cells and primitive scaffold design. (northwestern.edu)
  • We hypothesized that human mesenchymal stem cells seeded onto poly(1,8-octanediol-co-citrate) elastomeric thin films would provide a suitable milieu for partial bladder regeneration. (northwestern.edu)
  • 2017). Systemic delivery of bone marrow mesenchymal stem cells for in situ intervertebral disc regeneration . (up.pt)
  • StemEnhance by StemTech uses an extract from Aphanizomenon flos-aquae (fresh water botanical) to support the natural release of stem cells from our bone-marrow thus increasing the number of stem cells circulating in our bodies. (agelessway.org)
  • Mobilization of bone marrow stem cells with StemEnhance improves muscle regeneration in cardiotoxin-induced muscle injury. (agelessway.org)
  • Our general aim is to study methods to induce bone regeneration following fractures and severe trauma to bone using scaffolds, cells and growth factors. (rambam.org.il)
  • Specifically, we study the ability of endothelial progenitor cells (EPCs) to enhance bone regeneration. (rambam.org.il)
  • Currently our research expanded to investigate the mechanism of EPCs in bone and blood vessel formation and to analyze the phenotype and genotype of these cells. (rambam.org.il)
  • BTE aims to combine the cellular ( osteogenic cells), extracellular ( osteoconductive scaffolds) and/or molecular elements ( osteoinductive growth factors) required for bone healing [ 2 ]. (biomedcentral.com)
  • Instead of receiving the cells from a bone marrow donor, Adipose-Derived Regenerative Cells (ADRCs) can be harvested from the same patient who is being treated. (axiomtek.com)
  • Regarding the regeneration of cells, I recall Schedel's experiment with procaine injections around a wound (10). (antiaging-systems.com)
  • Our study characterizes miR-211-5p targeting Arhgap11a promotes the osteogenic differentiation of MC3T3-E1 cells, which provides novel targets to promote the osteogenesis process during bone repair. (frontiersin.org)
  • Marrow-derived mesenchymal stem cells ( MSC ) express cardiac specific protein in co-culture. (anl.gov)
  • Bone marrow mesenchymal stem cells secrete factors that exert anti-apoptotic and pro-apoptotic effects on H9c2 cardiac myoblasts. (anl.gov)
  • Sieweke's research also showed that some mature immune cells, called macrophages, can divide indefinitely and keep up their numbers by using similar mechanisms as stem cells. (humboldt-foundation.de)
  • So-called bone-marrow transplants, which transfer tens of thousands of cells of many different kinds to a patient, most critically transfer hematopoietic (adult blood) stem cells. (harvard.edu)
  • The proliferative capacity of these cells is so great, says Scadden, that researchers have demonstrated in mice the regeneration of the entire blood and immune system from a single cell. (harvard.edu)
  • PEI-al nanocomposites carrying BMP-2 gene could efficiently transfect bone marrow mesenchymal stem cells. (dovepress.com)
  • Our results suggested that PEI-al nanocomposites efficiently deliver the BMP-2 gene to bone marrow mesenchymal stem cells and that BMP-2 gene-engineered cell sheet is an effective way for promoting bone regeneration. (dovepress.com)
  • These cells are multipotent, meaning they have the ability to differentiate into several different specialised cell types, such as cartilage cells (chondrocytes), bone cells (osteoblasts) and fat cells (adipocytes). (rvc.ac.uk)
  • The revitalized stem cells improve the regeneration of injured or diseased areas in the brain of old mice. (sciencedaily.com)
  • Scientists from the Luxembourg Centre for Systems Biomedicine (LCSB) of the University of Luxembourg and from the German Cancer Research Center (DKFZ) have been able to rejuvenate stem cells in the brain of aging mice. (sciencedaily.com)
  • Then the long-standing expertise in neural stem cells of the collaborators at the German Cancer Research Center (DKFZ) came in: Studying stem cells first in a dish and then later directly in mice, they could experimentally validate the computational prediction. (sciencedaily.com)
  • Research with these cells has progressed slowly because they are difficult to maintain in culture. (empowher.com)
  • Recently, the team published a research paper titled 'Characteristics of Dental Stem Cells in Human Fetal Bone Marrow by Single Cell Transcriptive and Functional Analysis' in the 'Signal Transmission and Targeted Therapy (STTT)', we reported the expression landscape of human fetal BM nucleated cells (BMNCs) based on the single-cell transcriptomic analysis. (bjmu.edu.cn)
  • In some cases, particularly in bone regeneration, in addiction to PRP and/or stem cells, it is necessary to add to some biomaterials that besides having a support function operate as a guide for stem cells to obtain a spatial repair ( 3 ). (iiarjournals.org)
  • The extent and timing of this phase of thymic regeneration was unaffected by shielding or transplanting substantial amounts of bone marrow, suggesting that the precursor cells responsible for effecting regeneration were not derived directly from the bone marrow. (nebraska.edu)
  • This could indicate that in CBA mice some of the precursor cells effecting regeneration were intra-thymic at the time of irradiation or, alternatively, moderately high doses of X-irradiation (1,200 rads plus) impaired the intra-thymic proliferation of the progeny of the thymic precursor cell population. (nebraska.edu)
  • Since the initial phase of thymic regeneration was observed in thymus grafts which are repopulated by host bone marrow cells, this indicated that the precursor cell population was ultimately, if not immediately, derived from the bone marrow. (nebraska.edu)
  • Sharp, JG & Thomas, DB 1977, ' Origin of the radioresistant precursor cells responsible for the initial phase of thymic regeneration after X irradiation ', RES Journal of the Reticuloendothelial Society , vol. 22, no. 3, pp. 169-179. (nebraska.edu)
  • The present study results indicated that compared with the same number of 2D-cultured cells, microtissue could secrete more nerve regeneration related cytokines to promote SCs proliferation and axons growth. (biomedcentral.com)
  • Fibrosis regression, liver regeneration, and liver‐migrating host cells were evaluated. (birmingham.ac.uk)
  • Host macrophages and neutrophils infiltrated after combination therapy and contributed to liver fibrosis regression and promoted regeneration along with administered cells. (birmingham.ac.uk)
  • Rat bone marrow cells were obtained from femora of 6-week-old male Fischer 344 rats. (scirp.org)
  • Rat bone marrow cells in 200 m l culture medium at 1 × 10 6 cells/ml were seeded in the scaffolds. (scirp.org)
  • For i n vitro examinations, 1 × 10 5 rat bone marrow cells in 2 ml culture medium were then cultured with the addition of dexamethasone and laminin. (scirp.org)
  • Rat bone marrow cells were also cultured in laminin-coated culture plates. (scirp.org)
  • It is concluded that laminin is useful for bone formation, as in an in vitro culture study using bone marrow cells, in hydroxyapatite scaffolds in vivo . (scirp.org)
  • In 2000, the National Institutes of Health issued guidelines for the use of embryonic stem cells in research, specifying that scientists receiving federal funds could use only extra embryos that would otherwise be discarded. (cnn.com)
  • Above, a human stem cell colony, which is no more than 1 millimeter wide and comprises thousands of individual stem cells, grows on mouse embryonic fibroblast in a research laboratory in September 2001. (cnn.com)
  • His action overturned an order approved by President George W. Bush in August 2001 that barred the National Institutes of Health from funding research on embryonic stem cells beyond using 60 cell lines that existed at that time. (cnn.com)
  • Above, dozens of packages containing frozen embryonic stem cells remain in liquid nitrogen in a laboratory at the University of Sao Paulo's human genome research center in Sao Paulo, Brazil, in March 2008. (cnn.com)
  • In May 2011, stem cell therapy in sports medicine was spotlighted after New York Yankees pitcher Bartolo Colon was revealed to have had fat and bone marrow stem cells injected into his injured elbow and shoulder while in the Dominican Republic. (cnn.com)
  • The restoration of the homeostasis between the T helper cell 17 (Th17) and regulatory T cell (Treg) subsets by extracellular vesicles (EVs) obtained from human bone marrow stem cells (hBMSCs) promotes new bone formation and suppresses inflammation . (bvsalud.org)
  • The major areas of research that might have application in the development of regenerative endodontic techniques are (a) postnatal stem cells, (b) scaffold materials, (c) morphogen/growth factors, (d) implantation. (bvsalud.org)
  • There are limited numbers of publications about ES cells in pulp regeneration, due to the restricted policies regarding ES cell research over the past few years. (bvsalud.org)
  • 70 to 80% derives from the breakdown of degenerating red blood cells, and 20 to 30% (early-labeled bilirubin) derives primarily from other heme proteins in the bone marrow and liver. (msdmanuals.com)
  • The practice of dentistry is likely to be revolutionized by biological therapies based on growth and differentiation factors that accelerate and/or induce a natural biological regeneration. (bvsalud.org)
  • A three-stage continuum in the Center for Regenerative Biotherapeutics that represents basic science research (discovery), the movement of those laboratory findings into clinical trials and testing (translation), and their introduction into patient care (application). (mayo.edu)
  • These results provide support for future pharmacological and clinical applications of SATB2, which accelerates bone regeneration around titanium implants. (nih.gov)
  • The company works in collaboration with academic institutions, pharmaceutical companies and contract research organizations for clinical development programmes. (pharmaceutical-technology.com)
  • The Zigdon lab (Bone Regeneration Lab) is located at the Clinical Research Institute at Rambam (CRIR). (rambam.org.il)
  • Committed to the entire spectrum of patient care, ranging from the best treatments and therapies, to the support of clinical research. (rambam.org.il)
  • Reconstruction of advanced maxillofacial bone deficiencies is a clinical challenge. (biomedcentral.com)
  • Ph.D. candidates have the opportunity to do research at the Albert Einstein Cancer Center, in the departments of oncology, surgery, radiation oncology, and epidemiology and population health, and in numerous other basic and clinical science programs to help improve human health and the care of afflicted patients. (einsteinmed.edu)
  • Our Ph.D. in Clinical Investigation track will prepare you to conduct research that will improve the health and welfare of society using clinical and translational research methodology. (einsteinmed.edu)
  • The program is open to Einstein Ph.D. and M.D./Ph.D. students-especially those with a passion for math, computer science or study design-and is supported by Einstein's Institute for Clinical and Translational Research. (einsteinmed.edu)
  • We conduct our studies through hands-on field work that supports basic science research as well as clinical trials. (einsteinmed.edu)
  • The Rose F. Kennedy Intellectual and Developmental Disabilities Research Center represents a community of scientists, physicians, research trainees and clinical fellows at Einstein and Montefiore whose mission is to improve the lives of individuals with such conditions through basic and translational research and clinical advancements. (einsteinmed.edu)
  • Regeneration of large bone defects is a common clinical problem. (dovepress.com)
  • Regeneration of bone remains an important clinical challenge because the regeneration potential of human bone appears to be limited. (dovepress.com)
  • In order to classify FHN into different clinical stages, the Ficat and ARCO (Association Research Circulation Osseous) classification system was used, on the basis of radiographic evaluation of the femoral head. (ijpsonline.com)
  • Human bone marrow mesenchymal stem cell-derived extracellular vesicles restore Th17/Treg homeostasis in periodontitis via miR-1246. (bvsalud.org)
  • Bone marrow stem cell therapy for renal regeneration after acute tubular necrosis: A dream or a reality? (tmu.edu.tw)
  • Dive into the research topics of 'Bone marrow stem cell therapy for renal regeneration after acute tubular necrosis: A dream or a reality? (tmu.edu.tw)
  • To enhance the osteogenic potential of stem cell sheet, we fabricated bone morphogenetic protein 2 ( BMP-2 ) gene-engineered cell sheet using a complex of polyethylenimine-alginate (PEI-al) nanocomposites plus human BMP-2 complementary(c)DNA plasmid, and studied its osteogenesis in vitro and in vivo. (dovepress.com)
  • Development of in vitro organotypic models to study aspects of neuronal degeneration and protection, axon regeneration and remyelination. (ukaachen.de)
  • This project will delve into innate immune cell function, establishing in vitro and in vivo systems test innate immune cell function in regeneration. (lu.se)
  • Her post-doctoral activities have focussed on translational research in renal and transplant pathology, in particular the application of transcript analysis and novel imaging technologies to improve diagnosis. (kcl.ac.uk)
  • 3D printing offers the possibility to produce customized scaffolds for complex bone defects. (biomedcentral.com)
  • The aim of this study was to compare the potential of human BMSC cultured as 2D monolayers or 3D spheroids encapsulated in constructs of 3D-printed poly-L-lactide-co-trimethylene carbonate scaffolds and modified human platelet lysate hydrogels (PLATMC-HPLG) for bone regeneration. (biomedcentral.com)
  • 7 However, the scaffolds still face the problem of biocompatibility, mechanical properties, and bioresorbability, which are not adaptable to the properties of natural bone. (dovepress.com)
  • They hope their achievement will provide new insights into the bladder-regeneration process in vivo, and ultimately lead to new approaches to correcting developmental bladder abnormalities in pediatric patients. (cphi-online.com)
  • Bone regeneration was assessed via in vivo computed tomography (CT), ex vivo micro-CT and histology. (biomedcentral.com)
  • In vivo CT revealed comparable bone formation after 4, 8 and 12 weeks in all groups. (biomedcentral.com)
  • To further test the osteogenic potential of the cell sheet in vivo, enhanced green fluorescent protein or BMP-2-producing cell sheets were treated on the cranial bone defects. (dovepress.com)
  • Later research found that the genes responsible for these abnormalities also influenced breast cancer development in mice. (wikipedia.org)
  • Since previous research by Christiane Nüsslein-Volhard and Eric Wieschaus (which won them the Nobel Prize in Physiology or Medicine in 1995) had already established the function of Wg as a segment polarity gene involved in the formation of the body axis during embryonic development, researchers determined that the mammalian int1 discovered in mice is also involved in embryonic development. (wikipedia.org)
  • Mechanistically, matrix metalloproteinase-9 (MMP-9), which is required for stem cell mobilization, was reduced in the bone marrow of Nos3(-/-) mice. (nih.gov)
  • Female albino mice were first exposed to a dose of whole-body X-irradiation (750 rads) which would permit a substantial degree of thymic regeneration on the tenth day post-irradiation then the thymus was exposed to additional doses of local X-irradiation while the remainder of the mouse was shielded. (nebraska.edu)
  • In CBA mice increasing doses of thymic irradiation decreased the extent of thymic regeneration observed on the tenth day. (nebraska.edu)
  • A second center at Einstein, the Center for Diabetes Translational Research, recently received NIH funding. (einsteinmed.edu)
  • Bone in children and toddlers is more porous than adult bone, with wider haversian canals. (medscape.com)
  • Use of Bone Marrow Aspirate Concentrate (BMAC) Associated with Hyperbaric Oxygenation Therapy in Maxillary Appositional Bone Reconstruction. (mdpi.com)
  • Objectives: The objective of this study was to evaluate bone reconstruction using xenograft alone and associated with bone marrow aspirate concentrate (BMAC) and hyperbaric oxygen therapy. (mdpi.com)
  • Whilst we still don't completely understand the underlying mechanisms, current research suggests that the beneficial effects of stem cell therapy are more likely to be derived from their immunomodulatory properties, rather than being truly regenerative, however some degree of regeneration has been shown in some research. (rvc.ac.uk)
  • Further research into eosinophilic fasciitis has shown elevations of transforming growth factor-beta and interleukin 5, which normalize with corticosteroid therapy. (medscape.com)
  • Taken together, our study provides a detailed functional and molecular characterization of HSCs at different phases of regeneration and identifies a gene set associated with the transition from proliferation to quiescence. (lu.se)
  • This may contribute to impaired regeneration processes in ischemic heart disease patients, who are characterized by a reduced systemic NO bioactivity. (nih.gov)
  • Thus, they were available again to be recruited for the regeneration processes in the aging brain. (sciencedaily.com)
  • You'll join a community of outstanding researchers and skilled professionals devoted to conduct excellent interdisciplinary research at the frontiers of engineering and life sciences. (ibecbarcelona.eu)
  • Our future plans involve the elucidation of possible involvement of myocilin in axon growth and regeneration. (nih.gov)
  • Interestingly, we also identified a subpopulation of bone unipotent progenitor expressing TM4SF1+CD44+CD73+CD45-CD31-CD235a- which had osteogenic potentials, but could not reconstitute HME. (bjmu.edu.cn)
  • Procedure -Medical records of dogs determined to have PRCA, NRIMA, or ineffective erythropoiesis on the basis of bone marrow analysis between 1988 and 1999 were reviewed. (avma.org)
  • Keystone Symposium, Molecular Mechanisms of Cardiac Disease and Regeneration, February 19-24. (anl.gov)
  • 1 The obstacles of current bone substitutes include the limited amounts of donor bone, the bone resorption of autografts, the risk of disease transmission and graft rejection of allografts, and the shortage of osteoinductive property for synthetic grafts. (dovepress.com)
  • To determine whether SATB2 overexpression in BMSCs can enhance the osseointegration of implants, BMSCs were infected with the retrovirus encoding Satb2 (pBABE-Satb2) and were locally applied to bone defects before implanting the titanium implants in the mouse femur. (nih.gov)
  • Histological analysis showed that SATB2-overexpressing BMSCs significantly enhanced new bone formation and bone-to-implant contact 3 weeks after implantation. (nih.gov)
  • Real-time qRT-PCR results showed that the local delivery of SATB2-overexpressing BMSCs enhanced expression levels of potent osteogenic transcription factors and bone matrix proteins in the implantation sites. (nih.gov)
  • μCT analysis demonstrated that SATB2-overexpressing BMSCs significantly increased the density of the newly formed bone surrounding the implant 3 weeks post-operatively. (nih.gov)
  • Novavax, developers behind the Matrix-M adjuvant, have entered into an agreement with the Bill and Melinda Gates Medical Research Institute to provide the adjuvant in preclinical vaccine research. (cphi-online.com)
  • Methods: CTPs obtained from the femur of patients undergoing total hip replacement by 2 harvest techniques-BM aspiration and BM collection-after bone rasping were immunophenotyped by flow cytometry and evaluated for chondrogenic ability. (whiterose.ac.uk)
  • Myelofibrosis is often detected in affected dogs and may prevent bone marrow aspiration. (avma.org)
  • Subperiosteal resection of a child's bone shows the regeneration potential associated with the periosteum: the tubular bone eventually reforms inside the periosteal sleeve. (medscape.com)
  • Outer covering is periosteum, inner lining is endosteum, and contents are bone marrow. (medscape.com)
  • We study genes, proteins and signaling pathways that might be essential for RGC and optic nerve development, function, survival, and regeneration. (nih.gov)
  • Another main area of our research is the identification of new genes involved in glaucoma. (nih.gov)
  • It regulates Sp7 protein expression and induces expression of major bone matrix protein genes, such as Col1a1, Spp1, Ibsp, Bglap2, and Fn1 ( 7 , 8 ). (frontiersin.org)
  • His basic research lab uses mouse and human model systems to elucidate genes involved in tumor rejection. (ucsd.edu)
  • Bone loss caused by congenital defects, traumatic injury, cancer, reconstructive surgery, or periodontal disease has aroused widespread concern all over the world. (dovepress.com)
  • Thus, the child's bone has an innate potential to heal itself. (medscape.com)
  • Bone marrow findings range from the rare PRCA to erythroid hyperplasia. (avma.org)