• Decitabine (5-aza-2-deoxycytidine) is a DNA methyltransferase inhibitor and an archetypal epigenetic medication for the therapy of myeloid leukemias. (woofahs.com)
  • Intro The cytidine analog decitabine (5-aza-2-deoxycytidine, DAC) represents a Foretinib potent anticancer medication for the treatment of myelodysplastic syndromes (MDS) and severe myelogenous leukemia (AML) (1,2). (woofahs.com)
  • Many research that looked into the setting of actions of decitabine possess concentrated on the drug's capability to stimulate DNA hypomethylation and gene reactivation. (woofahs.com)
  • Nevertheless, to our understanding, medication incorporation into DNA offers under no circumstances been reported in human being cancers cell lines, actually though an preliminary research got demonstrated that the incorporation of radioactively tagged decitabine can become quantitatively recognized in a mouse embryonic fibroblast cell range (15). (woofahs.com)
  • The new data, published in the Proceedings of the National Academy of Science (PNAS) showed that vitamin C supplementation along with the cancer drug decitabine (5-aza-2'-deoxycytidine) had positive, synergistic effects on cancer cell lines. (labroots.com)
  • Conversely, increased deoxycytidine kinase activity is associated with increased activation of these agents to cytotoxic nucleoside triphosphate derivatives. (wikipedia.org)
  • Since this epigenetic change is reversible, it is a potential target for chemotherapeutic intervention using an inhibitor of DNA methylation, such as 5-aza-2'-deoxycytidine (DAC). (biomedcentral.com)
  • Reversion of the epigenetic lock by 5-aza-2'-deoxycytidine and trichostatin A resulted in EDN3 mRNA re-expression in vitro . (biomedcentral.com)
  • This study investigated whether the DNA methyltransferase inhibitor, 5-aza-2'-deoxycytidine (aza-dC) would alter the effect of dietary selenium (Se) on the formation of aberrant crypts. (usda.gov)
  • STAT3-mediated effects of methyltransferase inhibitor 5-aza-2'-deoxycytidine on preeclampsia. (e-century.us)
  • Where can buy 2-Deoxycytidine 5-monophosphate sodium salt or if you want to know the price market of 2-Deoxy-5-cytidylic acid disodium salt? (nbinno.com)
  • Deoxycytidine kinase (dCK) is an enzyme which is encoded by the DCK gene in humans. (wikipedia.org)
  • In the present study, the relation between deoxycytidine kinase (dCK) activity and the radiosensitising effect of gemcitabine was investigated in eight different human tumour cell lines. (biomedcentral.com)
  • Our data show that DNMT1 is the main DNMT involved in DNA methylation maintenance in KG1 cells and in mediating DNA damage formation upon exposure to 5-aza-2′-deoxycytidine. (pasteur.fr)
  • Treatment of GBC cell lines with demethylating agent 5-Aza- 2'-deoxycytidine enhances its expression, establishing impact of methylation on DKK3 expression. (amrita.edu)
  • Transfecting these cell lines with a codon optimized ERV-K113 env overexpressing CMV vector was performed with or without 5'-Aza-2'-deoxycytidine (Aza) treatment to sustain promoter de-methylation. (frontiersin.org)
  • 5-Aza-2'-deoxycytidine (d-AZA) replaces cytidine in DNA thereby altering gene expression by passively removing methyl groups. (illinois.edu)
  • Dr. Sallman's research focuses on the development of novel, targeted therapeutic strategies for patients with myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). (moffitt.org)
  • As an example, Dr. Sallman has focused research and clinical trial efforts on patients who have TP53 mutation (often associated with complex genes/cytogenetics) given their high risk of transformation to acute leukemia and poor survival. (moffitt.org)
  • 3′,4′-didehydro-3′-deoxycytidine duphosphate is a metabolite of 3′,4′-didehydro-3′-deoxycytidine triphosphate that has been proven to have antiviral properties. (santiago-lab.com)
  • There has been recent biomedical research interest in investigating dCK's potential as a therapeutic target for different types of cancer. (wikipedia.org)
  • Compiled for your convenience are articles on bone marrow failure research and treatment from the world's major journals on hematology / oncology. (aamds.org)
  • This work strongly suggests that a direct pharmacological inhibition of DNMT1, unlike the use of 5-aza-2′-deoxycytidine, should lead to tumor suppressor gene hypomethylation and re-expression without inducing major DNA damage in leukemia. (pasteur.fr)
  • The artificial lighting which lines the world's coastlines could be having a significant impact on species that rely on the moon and stars to find food, new research suggests. (bangor.ac.uk)
  • Research has intensified to understand ERV protein function and their role as tumor antigens and targets for cancer (immune) therapy. (frontiersin.org)
  • Amrita is a multi-disciplinary, research-intensive university and is accredited with the highest possible A++ NAAC grade and is the country's 5th best-ranked university in the NIRF rankings 2021. (amrita.edu)
  • research associateship at Purdue University. (ohio-state.edu)
  • Dr. Sallman's research interests focus on the development of novel, targeted therapeutic strategies (i.e. (moffitt.org)
  • One hypothesis for the functionality of the "open" conformation is that the "open" conformation may assist in the initial nucleoside binding and the release of the monophosphate product Deoxycytidine kinase (dCK) phosphorylates several deoxyribonucleosides and their nucleoside analogues (a nucleoside with a sugar and a different nucleic acid base substitute or analogue that has unique properties when modified) using phosphate groups from ATP and UTP. (wikipedia.org)
  • Combining GSK343 with 5 AZA-2'-deoxycytidine synergistically suppressed cell proliferation and invasion in vitro, and decreased tumor size and weight in EC cell xenografted mice. (elsevierpure.com)
  • Similar to the in vivo tumor, resistance in this cell line, C 26-G, was not related to deficiency of deoxycytidine kinase (dCK). (amsterdamumc.org)
  • Journal of Psychiatric Research. (illinois.edu)
  • Published in the Journal of Zoology , the research studied to what extent these birds have their sleep disturbed by walkers and their dogs, and by more distant noises from passing boats, and what effect this might be having on both their need for sleep and their alertness to any threats. (bangor.ac.uk)
  • International journal of environmental research and public health. (nyu.edu)
  • China 5-methyl-2'-deoxycytidine CAS:838-07-3 manufacturer supplier producer and factory-NINGBO INNO PHARMCHEM CO.,LTD. (nbinno.com)
  • Are you looking for China or India manufacturers of 5-methyl-2-deoxycytidine CAS:838-07-3, 5-methyl-2-deoxycytidine factory or 2-Deoxy-5-methylcytidine supplier? (nbinno.com)
  • China 2'-Deoxycytidine-5'-monophosphate disodium salt CAS:13085-50-2 manufacturer supplier producer and factory-NINGBO INNO PHARMCHEM CO.,LTD. (nbinno.com)
  • This work was funded by a grant from the Department of Women's Health Educational System, a Grant-in-Aid for Scientific Research (C) (15K10697 and 16K11123) and by the Science and Technology Planning Project of Guangdong Province, China (2013B021800155). (elsevierpure.com)
  • The spectral data and services are available to the research and academic community only. (massbank.eu)
  • Funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under the National Research Data Infrastructure - NFDI4Chem - Projektnummer 441958208. (massbank.eu)
  • 5-azacytidine and 5-aza-2′-deoxycytidine are clinically used to treat patients with blood neoplasia. (pasteur.fr)
  • We're pleased to announce nearly $2 million in funding for research that matters to Saskatchewan's health challenges through our Establishment Grant and Research Fellowship programs. (shrf.ca)
  • With more than 1,000 academic staff researchers and around £80 million new research funding per year, we are dedicated to performing world-leading research with the ultimate goal of improving human health. (birmingham.ac.uk)
  • Most interestingly, by combining DNMT1 siRNA and treatment with low dose of 5-aza-2′-deoxycytidine, it is possible to uncouple DNA damage formation from DNA demethylation. (pasteur.fr)
  • Now scientists at the Van Andel Research Institute reported that vitamin C supplements could enhance a drug's ability to slow down cancer growth. (labroots.com)
  • Researchers will establish their research in our province to tackle cancer, HIV and kidney disease. (shrf.ca)
  • O139 were admitted to the Dhaka Hospital of the cholerae O139 occurred in Dhaka and adjoining areas of International Centre for Diarrhoeal Disease Research, Bangladesh with an estimated 30,000 cases of cholera. (cdc.gov)
  • A total of 63 V. cholerae O139 isolates obtained from *International Centre for Diarrhoeal Disease Research, Dhaka, the recent cholera epidemic were analyzed. (cdc.gov)
  • In addition we addressed the role of DNA damage formation in DNA demethylation by 5-aza-2′-deoxycytidine. (pasteur.fr)