Report chemical piperazines. Medical search. Frequent questions

The piperazines are a broad class of chemical compounds, many with important pharmacological properties, which contain a core piperazine functional group. (wikipedia.org)

Although many piperazine derivatives occur naturally, piperazine itself can be synthesized by reacting alcoholic ammonia with 1,2-dichloroethane, by the action of sodium and ethylene glycol on ethylene diamine hydrochloride, or by reduction of pyrazine with sodium in ethanol. (wikipedia.org)
In this study, the effectiveness of (8 Compounds) derivatives containing benzoxazolone and piperazine rings, which have previously been reported to have antiviral properties, against XBB.1.5 and EG.5.1 RBDs, was measured using molecular docking, molecular dynamics simulation, and MM-PBSA methods. (chemmethod.com)
Pyrazine derivatives are multifunctional, e.g. dibenzo pyrazine is an important dye, phenazine is widely known for its anti-tumor, antibacterial and diuretic properties and tetramethylpyazine has been reported to be able to catch the superoxide anions and reduce human granulocyte's production of nitrogen oxides. (chemicalbook.com)
We reported the syntheses of novel cinnamide derivatives containing bis(4-fluorophenyl)methyl moiety starting from commercially available materials. (scielo.org.za)
It treats psychotic disorders and shares a distinct chemical and pharmacological resemblance with piperazine derivatives of the phenothiazine series. (daicelpharmastandards.com)

Piperazine is also a fluid used for CO2 and H2S scrubbing in association with methyl diethanolamine (MDEA). (wikipedia.org)
The thermal degradation rates for methyl diethanolamine (MDEA) and piperazine (PZ) are negligible, and PZ, unlike other metals, protect MDEA from oxidative degradation. (wikipedia.org)
ALSO CALLED 1-Methyl-4-(1-oxo-4,4-diphenylbutyl)piperazine monohydrochloride, 4,4-Diphenylbutyric acid, N-methyl. (pharosproject.net)
Environmental sampling revealed the presence of toluene-diisocyanate (584849) (TDI), N-ethylmorpholine (100743), dimethyl-piperazine (106581), formaldehyde (50000), propionaldehyde (123386), cyclopentanone (120923), methylene - chloride (75092), N-methyl-morpholine (109024), and acetone (67641). (cdc.gov)
The title compound (E)-1-{4-[bis(4-methoxyphenyl)methyl]piperazin-1-yl}-3-(4-chloro- phenyl)prop-2-en-1-one (C 28 H 29 ClN 2 O 3 , Mr = 476.98) (5) was synthesized and studied by the single crystal X-ray diffraction method. (scielo.org.za)
The reaction of cinnamic acid chloride with 1-[bis(4-methoxyphenyl)methyl]piperazine in the presence of triethylamine in dichloromethane at room temperature afforded the corresponding new cinnamide derivative with a total yield of 73.5 % ( Scheme 1 ), which was expected to be a potent neuroprotective agent. (scielo.org.za)
7 In this article, we present our results on the synthesis, crystal structure and anti-ischaemic activity of new cinnamide derivative of (E)-1-{4-[bis(4-methoxyphenyl)methyl]piperazin-1- yl}-3-(4-chlorophenyl)prop-2- en-1-one (5). (scielo.org.za)
E)-1-{4-[bis(4-methoxyphenyl)methyl]piperazin-1-yl}-3-(4-chlorophenyl)prop-2-en-1-one (5). (scielo.org.za)
13 The title compound (E)-1-{4-[bis(4-methoxyphenyl)methyl]piperazin-1-yl}-3-(4-chlorophenyl)prop-2-en-1-one 5 was obtained as follows:thionylchloride (2mL) and piperadine (1 drop) were added to a stirred solution of (E)-3-(4-chlorophenyl)acrylic acid (4,4 mmol) in dichloromethane (15 mL) at room temperature. (scielo.org.za)
The chemical name of Thiothixene is N, N-Dimethyl-9-[3-(4-methyl-1-piperazinyl)propylidene]-9H-thioxanthene-2-sulfonamide. (daicelpharmastandards.com)

6H2O, which melts at 44 °C and boils at 125-130 °C. Two common salts in the form of which piperazine is usually prepared for pharmaceutical or veterinary purposes are the citrate, 3C4H10N2.2C6H8O7 (i.e. containing 3 molecules of piperazine to 2 molecules of citric acid), and the adipate, C4H10N2.C6H10O4 (containing 1 molecule each of piperazine and adipic acid). (wikipedia.org)
Piperazine hydrate, piperazine adipate and piperazine citrate (used to treat ascariasis and enterobiasis) are the most common anthelmintic piperazine compounds. (wikipedia.org)
hexahydropyrazine (also as piperazine) citrate is a commonly used animal repellents, particularly effective against roundworms. (chemicalbook.com)
As per the available data from different handbooks, Piperazine citrate was determined to be insoluble in alcohol, ether and chloroform. (europa.eu)

In fact, a large number of piperazine compounds have an anthelmintic action. (wikipedia.org)
These drugs are often referred to simply as "piperazine" which may cause confusion between the specific anthelmintic drugs, the entire class of piperazine-containing compounds, and the compound itself. (wikipedia.org)
Scientific hazard lists sometimes specify a chemical group (such as trimethyltin compounds) without a defined list of CASRNs. (pharosproject.net)
Nine compounds of 1,4-disubstituted-1,2,3-triazoles by Sharpless's approach have been synthesized in this report. (thesciencein.org)

Piperazines, especially BZP and TFMPP were extremely common adulterants in the club and rave scene, often being passed off as MDMA, although they do not share many similarities in their effects. (wikipedia.org)
The best known piperazines are BZP (benzylpiperazine), TFMPP, DBZP and mCPP. (talktofrank.com)
TFMPP is a piperazine-based drug, which is used as recreational drug for its stimulant effects. (alphabaymarketsdarknet.com)
TFMPP, a serotonin-mimicking piperazine, blocks serotonin reup-take, enhances serotonin release and is a nonselective agonist at serotonin. (alphabaymarketsdarknet.com)
Tfmpp pills: The results show that BZP/TFMPP and MDMA share the ability to evoke monoamine release, but dangerous drugdrug synergism may occur when piperazines. (alphabaymarketsdarknet.com)
28) "Medication order" means an order from deep web deb a practitioner to dispense a drug to 1-(3-trifluoromethylphenyl)piperazine (trade or other name: TFMPP).and. (alphabaymarketsdarknet.com)
pills, TFMPP, drugs of Party pills may also contain other piperazines which, when combined with. (alphabaymarketsdarknet.com)
Background 'Party Pills' containing trifluoromethylphenyl- piperazine (TFMPP) and benzylpiperazine are legally. (alphabaymarketsdarknet.com)

The most common piperidines and piperazine are phencyclidine (PCP), ketamine and benzylpiperazine (BZP). (medscape.com)

the pH of a 10% aqueous solution of piperazine is 10.8-11.8. (wikipedia.org)
The present study reports the thermophysical properties such as density and viscosity for aqueous blends of sarcosine (SAR) with 1-(2-aminoethyl) piperazine (APZ) and diethylenetriamine (DETA). (elsevierpure.com)
Murshid, G, Ahmad Butt, W & Garg, S 2019, ' Investigation of thermophysical properties for aqueous blends of sarcosine with 1-(2-aminoethyl) piperazine and diethylenetriamine as solvents for CO 2 absorption ', Journal of Molecular Liquids , المجلد 278, الصفحات 584-591. (elsevierpure.com)

The piperazine is separated from the product stream, which contains ethylenediamine, diethylenetriamine, aminoethylpiperazine and other related linear and cyclic chemicals of this type. (wikipedia.org)

nonetheless, the CO2 absorption rate, heat of absorption, and solvent capacity are increased through the addition of piperazine to amine gas treating solvents, the most common of which is MDEA due to its unmatched high rate and capacity efficiency. (wikipedia.org)
All chemicals, reagents, and solvents for synthesis of the compound were commercially available and used without further purification. (scielo.org.za)

Diethylcarbamazine, a derivative of piperazine, is used to treat some types of filariasis. (wikipedia.org)
1-Vinylimidazole is a very important imidazole derivative and an important great chemical resources. (zhishangchemical.com)
A first generation antihistamine, derivative of piperazine with sedative and antocholinergic effects. (e-lactancia.org)

The global key manufacturers of Piperazine Phosphate API include Vishal Laboratories, Global Calcium, Ishita Drugs & Industries Ltd, Adani Pharmachem, Varahi International, Hunan Xiangyikang Pharmaceutical, Chongqing Qingyang Pharmaceutical, Sinopharm Shantou Jinshi Pharmaceutical and Jiangsu Hanstone Pharmaceutical, etc. (marketintellix.com)

1-Vinylimidazole is a heterocyclic compound, which is generally utilized in the synthesis of medication and chemicals, as well as the treating agent of epoxy material. (zhishangchemical.com)
Besides, we provide services of custom synthesis and contract manufacturing APIs (Active Pharmaceutical Ingredients), intermediates, fine chemicals for generic and new drugs. (buyersguidechem.com)

Other names given to this group of drugs include research chemicals, analogues, legal highs, herbal highs, bath salts, novel psychoactive substances and synthetic drugs (NDARC 2016). (aihw.gov.au)

The stimulant effects of piperazines are similar to MDMA ( ecstasy ) but dose for dose they are not as potent. (talktofrank.com)

The global Piperazine Phosphate API market was valued at million in 2021 and is projected to reach US$ million by 2028, at a CAGR of % during the forecast period 2022-2028. (marketintellix.com)
Over 1,100 substances have been reported to the United Nations Office on Drugs and Crime (UNODC) Early Warning Advisory, by Governments, laboratories and partner organisations (UNODC 2022). (aihw.gov.au)

Substances established by the European Directorate for the Quality of Medicines and Health Care, which is the custodian centre for International Chemical Reference Substances. (who.int)
The chemical composition of substances sold as piperazines are changing all the time, which is why you can never be sure of what you're getting and how it could affect you. (talktofrank.com)
The author recommends strict personal hygiene and adherence to good work practices, development of a health and safety program, maintenance of toxicity data for all substances used, periodic medical monitoring of workers, and ventilation modifications to reduce employee exposures to chemicals. (cdc.gov)

Hallucinogens can be classified and grouped by chemical structure and the compound from which they are derived. (medscape.com)

Piperazine is freely soluble in water and ethylene glycol, but insoluble in diethyl ether. (wikipedia.org)
This is due or soluble proteins could be responsible for the differing skin to the covalent binding to a protein being the essential step that and respiratory-sensitizing abilities of the two chemicals ( 7 ). (cdc.gov)

As stimulant drugs, piperazines are particularly risky if taken by anyone suffering from high blood pressure or a heart condition. (talktofrank.com)
However, the parkinsonian side effects have been the goal when the drugs were used as "chemical strait jackets" to reduce mobility in violent patients, an approach greatly discouraged. (medlink.com)
However, it is important to note that a 1955 study of "antihistaminic drugs for colds," carried out by the U.S. Army Medical Corps, reported that "there was no significant difference in the proportion of cures reported by patients receiving oral antihistaminic drugs and those receiving oral placebos. (wikidoc.org)
Bath salt" is the informal street name given to designer drugs containing substituted or synthetic cathinone chemicals. (medscape.com)

It is used as a hardener for resin materials, as the nucleus of photosensitive chemical reagent resin inclusions, and also used in the petroleum industry and as a high polymer. (zhishangchemical.com)
It is utilized as the setting agent of material materials, photosensitive chemical reagent, the core of resin additions, as well as also utilized in the oil market and as a high polymer. (zhishangchemical.com)
The 1-(2-methoxyphenyl)- piperazine used as a derivatization reagent in the NIOSH methods was also used on a sorbent (Schmidtke and Seifert 1990) and inert supports (Huynh et al. (cdc.gov)

p-Pentylbenzoic acid is also served by Gihi Chemicals Co., Limited. (buyersguidechem.com)

A form in which piperazine is commonly available industrially is as the hexahydrate, C4H10N2. (wikipedia.org)
The most commonly reported adverse reactions from clinical trials are fatigue, malaise, hypotension, and dizziness. (nih.gov)

Piperazine (/paɪˈpɛrəziːn/) is an organic compound that consists of a six-membered ring containing two nitrogen atoms at opposite positions in the ring. (wikipedia.org)
The -az- infix added to "piperazine" refers to the extra nitrogen atom, compared to piperidine. (wikipedia.org)

To best of our knowledge HPLC-FL for the determination of GEMI in pharmaceutical formulation have not been reported. (biomedres.us)

Piperazines - typically described as 'failed pharmaceuticals' and are frequently sold as ecstasy due to their central nervous system stimulant properties. (aihw.gov.au)

Piperazine readily absorbs water and carbon dioxide from the air. (wikipedia.org)
However, there is some evidence that piperazine may be considered as readily biodegradable. (europa.eu)

From 2009-2021, NPS have been reported in 134 countries and territories in all regions of the world. (aihw.gov.au)

Shandong Ench Chemical Co.Ltd is a professional manufacturers and supplier in the world ,the main product include chemical pharmaceuticals and intermediates, food and feed additives, herbal extracts, agrochemicals and fine chemicals etc. (buyersguidechem.com)

An H 1 antagonist is a histamine antagonist of the H 1 receptor that serves to reduce or eliminate effects mediated by histamine , an endogenous chemical mediator released during allergic reactions . (wikidoc.org)

Piperazine was marketed by Bayer as an anthelmintic in the early 20th century, and was featured in print ads alongside other popular Bayer products at the time, including heroin. (wikipedia.org)

Its chemical formula is C 23 H 29 N 3 O 2 S 2 , and its molecular weight is approximately 443.6 g/mol. (daicelpharmastandards.com)
Certain types of low molecular weight chemicals have the ability to cause respiratory sensitization via haptenation of carrier proteins. (cdc.gov)

The Co(III) ion is six-coordinated with octahedral geometry, the pyridine rings are planar and the piperazine rings assume chair conformations. (mdpi.com)

Piperazine exists as small alkaline deliquescent crystals with a saline taste. (wikipedia.org)
This is essential for molecular recognition, binding, gating, signal the case in protein (micro-)crystals and precipitates, which are transduction, transport, and chemical transformation in all living increasingly being studied with solid-state NMR techniques.5 systems. (lu.se)

Amine blends that are activated by concentrated piperazine are used extensively in commercial CO2 removal for carbon capture and storage (CCS) because piperazine advantageously allows for protection from significant thermal and oxidative degradation at typical coal flue gas conditions. (wikipedia.org)

millisecond range, can be detected via their effects on the The relative positions of protein atoms undergo thermal fluctua- isotropic chemical shift.3 But this still leaves a significant time tions under the influence of interactions within the protein and scale gap, 10-8-10-5 s, that cannot be probed directly by with the solvent. (lu.se)

EMAILWIRE.COM , January 05, 2017 ) The Report provides a basic overview of the Piperazine (CAS 110-85-0) Market including definitions, classifications, applications and chain structure. (emailwire.com)

In most instances, they indicate a hazard is assigned because the chemical is a member of a group. (pharosproject.net)

The aim of this study, therefore, was to perform an electrophilic reaction chemistry analysis to explain the differing respiratory sensitizing potentials of 16 chemicals containing both single and multiple functional groups. (cdc.gov)
cellular mechanisms, in the cytokine and chemokine profiles, For instance, binding studies between cysteine, lysine, and and in the profiles of the types of T-cells involved ( 10 ), an dinitrochlorobenzene (DNCB) and trimellitic anhydride (TMA) understanding of the electrophilic reaction chemistry allows for indicate that a difference in the ability to bind to either cellular the formation of mechanistic chemical categories. (cdc.gov)

1 H NMR and 13 C NMR spectra were recorded on a Bruker ACF-300 MHz instrument (Bruker) with CDCI3 as the solvent and tetramethylsilane as an internal standard (chemical shifts are expressed as d values, J in hertz). (scielo.org.za)

They provide activity against both gram positive and gram-negative organisms by the virtue of their fluorine and piperazine moieties bearing little side effects [1,2]. (biomedres.us)

As a preservative for ophthalmic solutions, we evaluated the physical and chemical properties (absorption to a sterile filter, solubility, heat stress stability, and light/UV stress stability), and also the anti-microbial activity. (bvsalud.org)

Furthermore, essentially the same proportion of patients reported no benefit from either type of treatment. (wikidoc.org)

2 WHO Technical Report Series, No. 996, 2016. (who.int)

Piperazines are also used in the manufacture of plastics, resins, pesticides, brake fluid and other industrial materials. (wikipedia.org)

The Piperazine (CAS 110-85-0) Industry analysis is provided for the international market including development history, competitive landscape analysis, and major regional development status. (emailwire.com)
Next part of the Piperazine (CAS 110-85-0) Market analysis report speaks about the manufacturing process. (emailwire.com)
In this Piperazine (CAS 110-85-0) Market analysis, traders and distributors analysis is given along with contact details. (emailwire.com)
The analysis has been supported by quantum chemical calculations probing the electrophilicities of the reactive chemicals. (cdc.gov)
Read Carefully before Using The Public Health Service Act (Section 308 (d)) provides that the data collected by the National Center for Health Statistics (NCHS), Centers for Disease Control and Prevention (CDC), may be used only for the purpose of health statistical reporting and analysis. (cdc.gov)
Use the data in this dataset for statistical reporting and analysis only. (cdc.gov)

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . (mcw.edu)
2008) ChEBI: a database and ontology for chemical entities of biological interest. (mcw.edu)
Some of the methods used for determining HDI in biological media are reported in Table 6-l. (cdc.gov)

GreenScreen® for Safer Chemicals is a method for chemical hazard assessment designed to identify chemicals of high concern and safer alternatives. (pharosproject.net)

It is important to note, however, that piperazines are not derived from plants in the Piper genus. (wikipedia.org)
After the basic information, the report sheds light on the production, production plants, their capacities, global production and revenue are studied. (emailwire.com)

Amadis Chemical is one of the leading enterprises in medical and health products research,development,manufacture and trading.rnEstablished in 2010, Amadis Chemical are adhering to the " Consummate service Convincing honor " Business strategy. (buyersguidechem.com)

Given that it has been has been shown that DNCB, which causes skin sensitization suggested that detailed mechanistic knowledge is required if but not respiratory sensitization, binds preferentially to the model chemical categories are going to be useful in regulatory nucleophile N-acetyl cysteine. (cdc.gov)

This finding is supported by the chemical structures of 2 -piperazin-1 -ylethanol and piperazin-1,4 -diethanol which indicate a low potential for biodegradation. (europa.eu)

Piperazines are also sold as an off-white powder, in capsules and as a liquid. (talktofrank.com)

The Australian Criminal Intelligence Commission (ACIC) collects national illicit drug seizure data annually from federal, state and territory police services, including the number and weight of seizures to inform the Illicit Drug Data Report (IDDR). (aihw.gov.au)

GIHI CHEMICALS covers whole range from small amount (gram grade) for research to big bulk for industrial production. (buyersguidechem.com)
It has been known LMW respiratory sensitizers that might be associated suggested that in order for a LMW industrial chemical to be with their ability to cause respiratory sensitization. (cdc.gov)

We show the results for the baseline 30 wt% MEA and the low energy piperazine (PZ) solutions. (dtu.dk)

This report aims to provide a comprehensive presentation of the global market for Piperazine Phosphate API study by Market Intellix gives insights concerning the market elements influencing the market, Market scope, Market division, and overlays shadow upon the leading market players featuring the positive cutthroat scene and patterns beating the years. (marketintellix.com)

To report SUSPECTED ADVERSE REACTIONS, contact Upsher-Smith Laboratories, LLC at 1-855-899-9180 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. (nih.gov)

Anatomy4

Organisms6

Diseases4

Chemicals and Drugs53

Analytical, Diagnostic and Therapeutic Techniques and Equipment13

Psychiatry and Psychology3

Phenomena and Processes17

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture2

Information Science2

Broad class of chemical compounds1

Derivatives5

Methyl10

Citrate4

Compounds4

TFMPP8

Benzylpiperazine1

Aqueous3

Diethylenetriamine1

Solvents2

Derivative3

Vishal Laboratories1

Synthesis2

Psychoactive substances1

MDMA1

20222

Substances3

Hallucinogens1

Soluble2

Drugs4

Reagent3

Acid1

Commonly2

Nitrogen2

Pharmaceutical1

Ecstasy1

Readily2

20211

Intermediates1

Allergic reactions1

Bayer1

Molecular Weight2

Pyridine1

Crystals2

Blends1

Atoms1

20171

Group1

Reaction2

Solvent1

Effects1

Properties1

Type1

20161

Materials1

Analysis6

Biological3

Assessment1

Plants2

Manufacture1

Categories1

Structures1

Sold1

Drug1

Industrial2

Solutions1

Aims1

Adverse1