• This protein is secreted into the urine from the renal tubular cells. (wikipedia.org)
  • Because an excessive amount of urate passes through the kidneys to be excreted in urine in people with renal hypouricemia, they have an increased risk of developing kidney stones (nephrolithiasis) formed from urate crystals. (medlineplus.gov)
  • These urate stones can damage the kidneys and lead to episodes of blood in the urine (hematuria). (medlineplus.gov)
  • Within the proximal tubules, both the URAT1 and GLUT9 proteins reabsorb urate into the bloodstream or release it into the urine, depending on the body's needs. (medlineplus.gov)
  • The critical effect is brown urine, increased epithelial cells in the urine, and increased proximal basophilic tubule in the kidney of both sexes of rats at 100 mg/kg-day on 28 days oral exposure. (cdc.gov)
  • Other common signs of the disorder include excess calcium in the urine (hypercalciuria), calcium deposits in the kidneys (nephrocalcinosis), and kidney stones (nephrolithiasis). (medlineplus.gov)
  • Kidney stones can cause abdominal pain and blood in the urine (hematuria). (medlineplus.gov)
  • The kidneys reabsorb needed materials into the blood and excrete everything else into the urine. (medlineplus.gov)
  • The increased values of beta -2 microglobulin in blood and urine is suggestive of tumour and renal disorder. (ganeshdiagnostic.com)
  • beta-2 microglobulin values in urine tell about disorders related to renal filtration. (ganeshdiagnostic.com)
  • Beta-2 microglobulin levels are measured in both serum and urine to distinguish problem cellular activation from renal disorder. (ganeshdiagnostic.com)
  • In renal disease there is more excretion of beta-2 microglobulin protein leading to increased levels in urine. (ganeshdiagnostic.com)
  • RTA is a medical condition that involves an accumulation of acid in the body due to a failure of the kidneys to appropriately acidify the urine. (successcds.net)
  • When blood is filtered by the kidney in renal physiology, the filtrate passes through the tubules of the nephron, allowing for exchange of acid, salts equivalents, and other solutes before it drains into the bladder as urine. (successcds.net)
  • As part of the urinary tract, the kidneys are responsible for blood filtration and excretion of water-soluble waste in the urine. (lecturio.com)
  • To diagnose renal tubular acidosis, doctors do an exam and order blood tests and urine tests. (teenshealth.org)
  • Glucose reabsorption in the proximal tubule (via Sglt1 and Sglt2) has emerged as an important contributor to the development of diabetes. (nih.gov)
  • We hypothesized that Olfr1393 may contribute to the progression of type 2 diabetes, particularly the development of hyperfiltration, which has been linked to increased Na + reabsorption in the proximal tubule via the Sglts. (nih.gov)
  • Urinary citrate concentration, a major factor in the formation of kidney stones, is primarily determined by its rate of reabsorption in the proximal tubule. (elsevierpure.com)
  • In the kidney, the first portion of the nephron, called the proximal tubule (PT), performs the majority of solute reabsorption including about two-thirds of calcium. (ku.edu)
  • The metabolic acidosis that results from RTA may be caused either by failure to reabsorb sufficient bicarbonate ions (which are alkaline) from the filtrate in the early portion of the nephron (the proximal tubule) or by insufficient secretion of hydrogen ions (which are acidic) into the latter portions of the nephron (the distal tubule). (successcds.net)
  • To investigate the role of HIF-1 in hypoxia-induced renal epithelial cell death, we generated mice that allow inactivation of HIF-1alpha by tetracycline-inducible Cre-loxP-mediated recombination in primary renal proximal tubule cells (PRPTC), resulting in a suppression of HIF-1-mediated gene transcription during oxygen deprivation. (nih.gov)
  • Notably, pifithrin-α also ameliorated kidney injury and improved the function of transplanted kidneys in 6 days when it became the sole life-supporting kidney in recipient mice. (elsevierpure.com)
  • Next, I tested the hypothesis that deletion of the claudin-2 gene Cldn2 in mice causes nephrocalcinosis similar to human kidney stone disease using micro-computed tomography (micro-CT) and histological analyses. (ku.edu)
  • To test whether such interactions affect kidney function, we injected mice with either 5 nm dextran-based nanoparticles (DNP) that are similar in composition to FDA-approved materials or poly(amido amine) dendrimer nanoparticles (PNP) of comparable size. (harvard.edu)
  • Compared with wild-type littermates, these knockout mice were markedly more sensitive to cisplatin-induced acute kidney injury as indicated by renal functional loss, tissue damage, and apoptosis. (elsevierpure.com)
  • Mechanistically, these knockout mice had heightened activation of p53 and c-Jun N terminal kinase, the signaling pathways contributing to cisplatin acute kidney injury. (elsevierpure.com)
  • Proximal tubular cells isolated from the knockout mice were more sensitive to cisplatin-induced apoptosis than cells from wild-type mice. (elsevierpure.com)
  • In addition, the knockout mice were more sensitive to renal ischemia-reperfusion injury than their wild-type littermates. (elsevierpure.com)
  • CD-1 mice with streptozotocin-induced diabetes displayed kidney fibrosis that was associated with the EMT at 4 months after diabetes induction. (jci.org)
  • Specifically, microRNA-147 (miR-147) is consistently elevated during CST injury in mice and in dysfunctional renal grafts in humans. (bvsalud.org)
  • METHODS: The kidneys of proximal tubule Dicer (an enzyme for microRNA biogenesis) knockout mice and their wild-type littermates were subjected to CST to determine the function of microRNAs. (bvsalud.org)
  • METHODS: As renal phenotype can be influenced by genetic background, we generated congenic C57BL/6 and FVB/N Ctns(-/-) mice and assayed renal lesions and function by histological and biochemical studies. (cnrs.fr)
  • RESULTS: C57BL/6 Ctns(-/-) mice showed significantly higher renal cystine levels than the FVB/N strain. (cnrs.fr)
  • Moreover, C57BL/6 mice presented with pronounced histological lesions of the proximal tubules as well as a tubulopathy and progressively developed chronic renal failure. (cnrs.fr)
  • In addition to highlighting the influence of genetic background on phenotype, the C57BL/6 Ctns(-/-) mice represent a useful model for further understanding cystinosin function in the kidney and, specifically, in the proximal tubules. (cnrs.fr)
  • Specifically, in the kid neys of mice with chronic kidney disease, they detected that a greater proportion of the proximal tubule cells had a different molecular signature than that found in the kidneys of healthy animals. (ibecbarcelona.eu)
  • These findings have led to a better understanding of renal physiology and paracellular transport and provide a novel treatment target for disorders of calcium balance and homeostasis. (ku.edu)
  • The tubular secretion of diuretics in the proximal tubule has been shown to be critical for the action of drugs. (aspetjournals.org)
  • and renal tubular secretion of chlorothiazide and hydrochlorothiazide in the avian kidney ( Odlind and Lonnerholm, 1982 ). (aspetjournals.org)
  • Tubular secretion of acetazolamide was demonstrated to be important for the elimination of this drug in the study using the isolated rat perfused kidney ( Taft and Sweeney, 1995 ). (aspetjournals.org)
  • The secretion of numerous organic anions, including endogenous metabolites, drugs, and xenobiotics, is an important physiological function of the renal proximal tubule. (aspetjournals.org)
  • A class of compounds that reduces the secretion of H+ ions by the proximal kidney tubule through inhibition of CARBONIC ANHYDRASES. (bvsalud.org)
  • Then I generated renal epithelial cell lines with inducible expression of PT claudins, claudin-2 and either claudin-3 or claudin-10a. (ku.edu)
  • First, I examined the patterns of claudin expression in the proximal nephron and found that claudins-2 and -10a are expressed throughout the PT, in both convoluted and straight segments. (ku.edu)
  • Normally, activation of the CB 1 receptor regulates renal vascular hemodynamics and stimulates the transport of ions and proteins in different nephron compartments. (degruyter.com)
  • Among the different cells that make up these filtration units, the epithelial cells of the proximal tubul e of the nephron are responsible for reabsorbing water and solutes, representing 90% of the total renal mass. (ibecbarcelona.eu)
  • Well, as mentioned previously, neprilysin is highly expressed in the proximal tubule of the nephron. (medscape.com)
  • Chronic metabolic acidosis increases proximal tubule citrate reabsorption, leading to profound hypocitraturia and an increased risk for stone formation. (elsevierpure.com)
  • Although a metabolic acidosis also occurs in those with renal insufficiency, the term RTA is reserved for individuals with poor urinary acidification in otherwise well-functioning kidneys. (successcds.net)
  • These proteins are found in the kidneys, specifically in structures called proximal tubules . (medlineplus.gov)
  • Fig. 2: Monogenic disorders of nephrolithiasis resulting in renal tubular dysfunction. (nature.com)
  • In contrast, renal dysfunction was not observed in the FVB/N strain. (cnrs.fr)
  • In almost all cases of chronic kidney disease, damage occurs in these cells, but until now, it was not known which cellular mechanisms were respon sible for such dysfunction. (ibecbarcelona.eu)
  • Cystatin C is well recognised marker of kidney filtration dysfunction and injury. (randox.com)
  • minimal change nephrotic syndrome possible at present to distinguish whether is found in approximately 85% of INS, IL-6 contributes to renal dysfunction or mesangial proliferative glomerulonephritis whether it reflects renal damage [ 10 ]. (who.int)
  • Mutations that cause renal hypouricemia lead to the production of URAT1 or GLUT9 protein with a reduced ability to reabsorb urate into the bloodstream. (medlineplus.gov)
  • It is likely that individuals with renal hypouricemia who have mild or no symptoms have enough protein function to reabsorb a sufficient amount of urate into the bloodstream to prevent severe kidney problems. (medlineplus.gov)
  • the kidney does not reabsorb or metabolize creatinine. (medscape.com)
  • In particular, extracellular-regulated kinase (ERK) 1/2, one of the MAPK pathway is considered as an important mediator of signal transduction processes, namely cell survival, cell division, gene expression, and cell metabolism that plays role in injury, death, and inflammation of kidney tubular cells due to cisplatin administration [ 5 ]. (thieme-connect.com)
  • The healthy kidney can eliminate endogenous end products of metabolism, as well as exogenous toxins that are both large- and small- molecular-weight substances. (medscape.com)
  • Using innovative techniques such as single cell RNA-sequencing, the researchers unraveled the crucial role tha t lipid metabolism genes play in protecting against chronic kidney failure. (ibecbarcelona.eu)
  • Noting these observations, the IBEC researchers went one s tep further and, using human mini-kidneys, demonstrated that these changes were due to a decrease in the expression of some of the genes that regulate lipid metabolism in proximal tubule cells. (ibecbarcelona.eu)
  • Addition of a diuretic, such as 1-3 mg/kg/d of hydrochlorothiazide, may be necessary to avoid volume expansion, which magnifies the excretion of bicarbonate by lowering the renal threshold. (medscape.com)
  • Kidney stone disease (nephrolithiasis) is a common problem that can be associated with alterations in urinary solute composition including hypercalciuria. (nature.com)
  • Thiazides and loop diuretics exhibit their diuretic effects from the luminal side by inhibiting the Na + -Cl - cotransporter of the distal tubule and the Na + -K + -2Cl - co-transporter of the loop of Henle, respectively ( Ives, 2001 ). (aspetjournals.org)
  • Both forms of Dent disease (type 1 and type 2) are characterized by the features described above, but Dent disease 2 can also be associated with abnormalities unrelated to kidney function. (medlineplus.gov)
  • The most frequently detected abnormalities were hyperechoic rings around renal pyramids (28.3% of patients). (medscape.com)
  • Liver transplantation leads to the rapid disappearance of the renal tubular abnormalities. (medscape.com)
  • Similar effects were shown by the ablation of p53 from proximal tubule cells. (elsevierpure.com)
  • in vitro, cold storage followed by rewarming induced cell death in cultured proximal tubule cells, which was accompanied by p53 activation and suppressed by pifithrin-α and dominant-negative p53. (elsevierpure.com)
  • The proximal tubules of epithelial cells in the kidney express cauxin. (wikipedia.org)
  • Claudin-2 increases the calcium permeability of renal epithelial cells upon overexpression. (ku.edu)
  • The underlying mechanism is most probably a blockade of anion conductance in the plasma membrane at nanomolar concentrations of OTA with subsequent disturbance of cellular acid-base homeostasis as shown in cultured kidney cells. (karger.com)
  • Disturbance of cellular pH homeostasis is probably also involved in OTA-induced transformation of cultured kidney cells. (karger.com)
  • Proximal tubular cells respond to OTA with a dramatic reduction in the secretory capacity for organic anions. (karger.com)
  • Furthermore, OTA has a mitogenic potential on rat proximal tubular cells in primary culture if applied in nanomolar concentrations but inhibits cell growth at micromolar concentrations. (karger.com)
  • While considerable research has been performed On the effects of these materials on targeted tumor or phagocytic cells, relatively little is known about their effects on renal cells. (harvard.edu)
  • These fluorescently tagged nanoparticles were both filtered and internalized by renal tubular epithelial cells in a dose- and time-dependent fashion. (harvard.edu)
  • In various mouse and rat models of obesity and type 1 and 2 diabetes mellitus, eCBs generated in various renal cells activate CB 1 receptors and contribute to the development of oxidative stress, inflammation, and renal fibrosis. (degruyter.com)
  • The efficient uptake of Mn 2+ from apical side of S3 cells may suggest an important role of ZIP8 in proximal tubule in reabsorption of Mn, an essential metal. (go.jp)
  • Our study demonstrated that S1, S2, and S3 cells provide a useful tool for studying the segment-specific and direction-dependent transport of both toxic and essential metals in the kidney's proximal tubules. (go.jp)
  • Over the last few decades, it has been studied that the mechanisms of cisplatin-induced kidney damage are complex and involved numerous cellular and molecular processes including inflammation, apoptosis, accumulation of cisplatin in renal tubular cells via renal drug transporters, Ctr1 and OCT2, and involvement of mitogen-activated protein kinases (MAPK) pathways [ 3 ] [ 4 ]. (thieme-connect.com)
  • It includes primary human proximal tubule epithelial cells and renal microvascular endothelial cells in co-culture, allowing for cell-cell interactions found in vivo . (openwetware.org)
  • [2] The introduction of media flow through the chip leads to greater polarization, cell height, and cilia formation than kidney epithelial cells in other methods of culture. (openwetware.org)
  • Induction of SRY box transcription factor 9 (SOX9) has been shown to occur in response to kidney injury in rodents, where SOX9-positive cells proliferate and regenerate the proximal tubules of injured kidneys. (lu.se)
  • SOX9 expression was found to colocalize with a proportion of so-called scattered tubular cells in the uninjured kidney, a cell population previously shown to be involved in kidney injury and regeneration. (lu.se)
  • Moreover, a kidney explant model was used to demonstrate that only SOX9-positive cells survive the massive injury associated with kidney ischemia and that the surviving SOX9-positive cells spread and repopulate the tubules. (lu.se)
  • HGF is produced and secreted by adjacent stromal and mesenchymal cells, it contributes to the development of epithelial organs in a paracrine fashion, exerts regenerative effects on epithelia in the liver, kidney, lung, and other tissues, and promotes the regression of fibrosis in numerous organs ( 7 , 8 ). (spandidos-publications.com)
  • It is found in membranes of intestinal epithelial cells, proximal kidney tubules and liver hepatocytes. (collie-online.com)
  • The process of secreting organic anions through the proximal tubule cells is achieved via unidirectional transcellular transport involving the uptake of organic anions into the cells from the blood across the basolateral membrane, followed by extrusion across the brush-border membrane into the proximal tubule fluid. (aspetjournals.org)
  • Cystine accumulates in the monocytes and interstitial cells of the transplanted kidney but not in proximal tubule cells. (medscape.com)
  • By sequencing the RNA of each of the thousands of cells present in the kidney, the researchers observed for the first time important differences between healthy and diseased cells in the proximal tubule. (ibecbarcelona.eu)
  • Confocal microscopy image of a kidney organoid generated in vitro from human pluripotent stem cells that have been differentiated for 20 days using three-dimensional cultures. (ibecbarcelona.eu)
  • Furthermore, "thanks to a multidisciplinary approach, using an imal models and human mini-kidneys that we generate through bioengineering at IBEC, we discovered that, by correcting this deficiency, the proximal tubule cells could regain their function in the different study models," explains Dr. Montserrat. (ibecbarcelona.eu)
  • H uman mini-kidneys -also called kidney organoids- are created using bioengineering techniques from human stem cells, and capture some aspects of the complexity of this organ. (ibecbarcelona.eu)
  • Last April, the researchers demonstrated their effectiveness as a study model by u sing them to decipher in record time how SARS-CoV-2 interacts and infects the cells of these mini-kidneys, in addition to identifying a therapy aimed at reducing viral load. (ibecbarcelona.eu)
  • It is produced by Idiopathic nephrotic syndrome (INS) a variety of cells, including monocytes and accounts for 90% of nephrosis in child- mesangial cells in the kidney [ 9 ]. (who.int)
  • This disorder has a low incidence of occurrence, because the kidney is able to eliminate excess magnesium by rapidly reducing its tubular reabsorption to almost negligible amounts. (medscape.com)
  • OTA is the causing agent of Danish porcine nephropathy and increases the incidence of renal carcinomas and adenomas in rats. (karger.com)
  • The high incidence of OTA in human food and blood samples taken together with its diverse effects on renal function should attract further attention to this mycotoxin as a possible candidate for renal malfunction of unknown origin in humans. (karger.com)
  • This study conducted was made thinking about the level of incidence and registraition of kidney comitment in patient with COVID-19 and what was the cause as well, considerating that this disease affects majoritaryly the respiratory tract. (bvsalud.org)
  • In a mouse kidney cold storage/transplantation model, we detected p53 accumulation in proximal tubules in a cold storage time-dependent manner, which correlated with tubular injury and cell death. (elsevierpure.com)
  • accumulation of these substances in the kidneys could cause tissue damage. (medlineplus.gov)
  • Decreasing kidney function represents a risk factor for magnesium accumulation, in the setting of exogenous supplementation. (medscape.com)
  • Empagliflozin normalized the suppressed Sirt3 levels and aberrant glycolysis that was characterized by HIF-1α accumulation, hexokinase 2 induction, and pyruvate kinase isozyme M2 dimer formation in diabetic kidneys. (jci.org)
  • Empagliflozin also suppressed the accumulation of glycolysis byproducts in diabetic kidneys. (jci.org)
  • Here, we report that p53 in kidney proximal tubules plays a critical role in cold storage/transplantation kidney injury and inhibition of p53 can effectively improve the histology and function of transplanted kidneys. (elsevierpure.com)
  • Here, we hypothesized that the SGLT2 inhibitor empagliflozin restores normal kidney histology and function in association with the inhibition of aberrant glycolysis in diabetic kidneys. (jci.org)
  • In its Standards of Medical Care in Diabetes-2020, the American Diabetes Association (ADA) stratifies specific comorbidities that include atherosclerotic CVD, chronic kidney disease (CKD), and HF ( 11 ). (diabetesjournals.org)
  • In contrast, activation of the renal CB 2 receptors reduces the deleterious effects of these chronic diseases. (degruyter.com)
  • Dent disease is a chronic kidney disorder that occurs almost exclusively in males. (medlineplus.gov)
  • Fanconi syndrome and chronic kidney disease in paroxysmal nocturnal hemoglobinuria: effect of eculizumab therapy. (medscape.com)
  • Chronic kidney disease affects more than 697 million people around the world. (ibecbarcelona.eu)
  • Chronic Kidney Disease is an abnormal kidney function and/ or structure, present for a minimum period of 3 months. (randox.com)
  • Utilising patented Biochip Technology, the Randox Chronic Kidney Disease (CKD) arrays could improve patient risk stratification whilst monitoring the effectiveness of treatment. (randox.com)
  • Kidney injury associated with cold storage/transplantation is a primary factor for delayed graft function and poor outcome of renal transplants. (elsevierpure.com)
  • however, most of these patients have normal renal function. (medscape.com)
  • Renal hemodynamics and the secretory function of the proximal tubule are affected by OTA after prolonged but not by acute exposure. (karger.com)
  • According to the above-described effects OTA exerts a complex action on renal function depending on the dose and time of exposure. (karger.com)
  • We conclude that there are no major detrimental renal effects of DNP on overall kidney function, but changes in endocytosis-mediating protein expression do occur. (harvard.edu)
  • The current review focuses on the role of the eCB system in normal kidney function and various diseases, such as diabetes and obesity, that directly contributes to the development of renal pathologies. (degruyter.com)
  • The first models included chips that replicated the function of the liver, gut, kidney and bone marrow. (openwetware.org)
  • The condition does not affect individuals with normal or mildly reduced kidney function or patients with a functioning kidney transplant. (medscape.com)
  • ESRD is a life-threatening failure of kidney function that occurs when the kidneys are no longer able to filter fluids and waste products from the body effectively. (medlineplus.gov)
  • particularly the function of the proximal tubules. (medlineplus.gov)
  • Studies suggest that mutations in the CLCN5 or OCRL gene disrupt the reabsorption function of the proximal tubules, which leads to the progressive kidney problems found in people with Dent disease. (medlineplus.gov)
  • Blockade of miR-147 and overexpression of NDUFA4 reduce CST injury and improve graft function, unveiling miR-147 and NDUFA4 as new therapeutic targets in kidney transplantation. (bvsalud.org)
  • Decrease in creatinine clearance indicates decreased GFR and impaired renal function. (medscape.com)
  • In patients with declining renal function, a progressively higher percentage is secreted. (medscape.com)
  • The net effect is progressive overestimation of the GFR, with more severe loss of renal function. (medscape.com)
  • Inhibition of Sglt2 is accepted as a viable therapeutic treatment option for patients with type 2 diabetes and has been shown to delay development of diabetic kidney disease. (nih.gov)
  • Taken together, SGLT2 inhibitors exhibit renoprotective potential that is partially dependent on the inhibition of glucose reabsorption and subsequent aberrant glycolysis in kidney tubules. (jci.org)
  • OTA increases resistance in the vas efferens with a subsequent decrease in renal blood flow and glomerular filtration rate. (karger.com)
  • The kidney proximal tubule is a target of many renal toxicants, including cadmium (Cd), and also a place of reabsorption of essential metals in glomerular filtrate to systemic circulation. (go.jp)
  • In the normally functioning kidney, beta-2m is cleared by glomerular filtration and is catabolized in the proximal tubules. (medscape.com)
  • But with renal tubular acidosis, the kidney's tubules are damaged, so they can't remove the acid. (teenshealth.org)
  • Kidney transplantation has been performed in many patients with renal failure due to cystinosis. (medscape.com)
  • The kidney and liver chips offer a model to test drug toxicity, and the duodenum chip offers a model for drug absorption. (openwetware.org)
  • Aspergillus -derived mycotoxins, including aflatoxins and ochratoxin A, and fumonisins (members of the fusariotoxin group) can cause pathological damage to vital organs, including the kidney or liver. (frontiersin.org)
  • Vitamin D, administered as 1,25-dihydroxyvitamin D3 or 1a-hydroxyvitamin D3, is preferred because liver and/or renal hydroxylation may be impaired in patients with Fanconi syndrome. (medscape.com)
  • However, some of these conditions can result in failure of organs, such as the liver or kidneys, or in diminution of muscle strength, which, in turn, may limit the ability of children to engage in physically demanding activities. (medscape.com)
  • The active endocytic machinery of kidney proximal tubules avidly internalizes filtered proteins, which may also be the case for filtered nanoparticles. (harvard.edu)
  • Ischemic acute renal failure is a frequent clinical problem in hospitalized patients and is associated with significant mortality. (nih.gov)
  • BACKGROUND: Kidney injury due to cold storage-associated transplantation (CST) is a major factor determining the outcome of renal transplant, for which the role and regulation of microRNAs remain largely unclear. (bvsalud.org)
  • p53 contributes to both ischemic and nephrotoxic kidney injury, but its involvement in kidney cold storage/transplantation is unclear. (elsevierpure.com)
  • The specific cause of the signs and symptoms of renal hypouricemia is unclear. (medlineplus.gov)
  • Because the OCRL gene is active (expressed) throughout the body, it is unclear why Dent disease 2 primarily affects the kidneys and, to a lesser extent, the brain, eyes, and other tissues. (medlineplus.gov)
  • My findings indicate that this papillary pattern of nephrocalcinosis shares striking similarities to human kidney stone disease. (ku.edu)
  • My work suggests that proximal delivery of calcium to the loops of Henle is important in the pathogenesis of nephrocalcinosis and kidney stone formation. (ku.edu)
  • Objective In addition to oxidative stress, inflammation and apoptosis have an important role in the pathogenesis of cisplatin-induced kidney damage. (thieme-connect.com)
  • FABP1 binds long-chain fatty acids, contributing to reducing oxidative stress in the kidneys. (randox.com)
  • Olfactory receptor 1393 (Olfr1393) was recently identified as a novel regulator of Na + -glucose cotransporter 1 (Sglt1) localization in the renal proximal tubule. (nih.gov)
  • Collectively, these data indicate that renal Olfr1393 can contribute to the progression of type 2 diabetes, likely as a regulator of Na + -glucose cotransport in the proximal tubule. (nih.gov)
  • Together, these results support a pathogenic role of p53 in cold storage/transplantation kidney injury and demonstrate the therapeutic potential of p53 inhibitors. (elsevierpure.com)
  • Kidney transplantation is the treatment of choice. (medscape.com)
  • SIGNIFICANCE STATEMENT: Cold storage-associated transplantation (CST) injury occurs in renal transplant from deceased donors, the main organ source. (bvsalud.org)
  • EGF regulates renal cell proliferation, fibrosis and inflammation and is produced in response to renal injury. (randox.com)
  • Paraminophenol (PAP) is oxidized to p-benzoquinoneimine by renal tissue cytochrome P-450 and binds to renal protein. (cdc.gov)
  • 99.99 % of this protein is reabsorbed in proximal tubules of the kidney and metabolised. (ganeshdiagnostic.com)
  • This can be caused by urinary tract infections (UTIs), autoimmune disorders, sickle cell disease, diabetes, kidney transplant rejection, or some medicines. (teenshealth.org)
  • A rat model of diabetes showed substantial improvement in both proteinuria and kidney damage with the use of omapatrilat compared to ACE-inhibitor use. (medscape.com)
  • Even though various treatment strategies namely saline hydration and diuresis have been suggested for prevention of cisplatin-induced kidney damage, but its prevalence is still high. (thieme-connect.com)
  • In fact, the prevalence of cisplatin-induced kidney damage was 34% after fourth cycles and 52% after six cycles of cisplatin chemotherapy in adult cancer patients treated with cisplatin at a dose of ≥60 mg/m 2 at Dharmais National Cancer Hospital, Jakarta, Indonesia [ 6 ]. (thieme-connect.com)
  • Prevalence of kidney stones in the United States. (nature.com)
  • Wilms tumor , or nephroblastoma, is the most common solid renal mass and abdominal malignancy of childhood, with a prevalence of 1 case per 10,000 population. (medscape.com)
  • [ 6 ] Patients with end-stage renal disease often have mild hypermagnesemia, and the ingestion of magnesium-containing medications (eg, antacids, cathartics) can exacerbate the condition. (medscape.com)
  • Our colleagues subsequently identified multiple SNPs in the CLDN2 locus that associate with human kidney stone disease. (ku.edu)
  • In addition, claudin-2 expression is an important mediator of calcium transport that is associated with kidney stone disease in humans. (ku.edu)
  • Increased understanding of the genetic factors contributing to kidney stone disease helps to improve our understanding of the pathogenesis of this condition. (nature.com)
  • Identification of a monogenic cause of kidney stone disease facilitates optimal stone prevention management and identification of associated phenotypes. (nature.com)
  • Advances in our understanding of the polygenic factors contributing to risk of kidney stone disease might enable a precision medicine approach. (nature.com)
  • Fig. 1: Radiographic appearance of kidney stone disease in three patients. (nature.com)
  • In most affected males, progressive kidney problems lead to end-stage renal disease (ESRD) in early to mid-adulthood. (medlineplus.gov)
  • Dent disease is likely underdiagnosed because it may not be identified in people with mild signs and symptoms, and because its features overlap with those of other kidney disorders. (medlineplus.gov)
  • In the absence of treatment, end-stage renal disease is reached by 10 years. (cnrs.fr)
  • however, proximal tubulopathy or end-stage renal disease is not observed. (cnrs.fr)
  • Several kidney biomarkers are used successfully in drug development, however cost-efficient, and reliable kidney biomarkers are urgently needed for monitoring farm animals for early signs of kidney disease. (frontiersin.org)
  • MYO5B mutations in patients with microvillus inclusion disease presenting with transient renal Fanconi syndrome. (medscape.com)
  • Diagnosis of CKD at early stages will allow earlier intervention for the treatment of kidney disease, and the prevention of further kidney damage. (randox.com)
  • Untreated renal (REE-nul) tubular acidosis can affect a child's growth, cause kidney stones , and other problems like bone or kidney disease . (teenshealth.org)
  • But what about kidney disease? (medscape.com)
  • to identify the risk factors that lead patients infected by the new coronavirus to develop kidney disease. (bvsalud.org)
  • The risk factors for developing renal worsening in patients with COVID-19 were the extremes of age, race, sex, pre-existing diseases, and the disease evolution. (bvsalud.org)
  • The majoritary findings concluded that Acute Kidney Injury (AKI) was the main renal finding in patients contaminated by SARS-coV-2, follow by the risk factors identified for developing renal worsening in patients with COVID-19, like the extremes of age, race, sex, pre-existing diseases and disease evolution. (bvsalud.org)
  • We also established a renal proximal tubule-specific autophagy-related gene 7-knockout mouse model shown to be defective in both basal and cisplatin-induced autophagy in kidneys. (elsevierpure.com)
  • The biological effects were quantitated by immunocytochemistry, measuring kidney injury markers and performing functional tests. (harvard.edu)
  • The kidney-chip provides a model of the proximal tubule-peritubular capillary interface, a functional unit of the kidneys. (openwetware.org)
  • These findings shed light on the functional and regulatory aspects of SOX9 activation in the human kidney during injury and regeneration. (lu.se)
  • Despite the enormous financial and personal burden that this entails, until now the biological mechanisms behind this condition were unknown, due to the structural and functional complexity of the kidney. (ibecbarcelona.eu)
  • In healthy adults, each of o ur kidneys contains an average of 1.5 million nephrons, the basic functional units of the kidney that constantly filter waste products from the blood. (ibecbarcelona.eu)
  • Researchers suspect that when additional urate is produced during exercise and passed through the kidneys, it could lead to tissue damage. (medlineplus.gov)
  • Alternatively, without the antioxidant properties of urate, free radicals could cause tissue damage in the kidneys. (medlineplus.gov)
  • Excessive tissue breakdown (sepsis, shock, large burns), especially with concurrent renal failure, can deliver a large amount of magnesium from the intracellular space, along with a massive elevation of phosphorus and potassium. (medscape.com)
  • This study aimed to investigate the molecular mechanisms of protective effects of curcumin against cisplatin-induced kidney inflammation and apoptosis in rats. (thieme-connect.com)
  • Conclusions These data indicate that curcumin has nephroprotective properties against cisplatin-induced kidney damage in rats and this effect is associated with its anti-inflammatory and anti-apoptosis profiles, in addition to its antioxidant. (thieme-connect.com)
  • 9 ] reported curcumin administration provided protection against cisplatin-induced renal tubular cell apoptosis. (thieme-connect.com)
  • However, the molecular mechanisms behind the anti-inflammatory and anti-apoptotic effects of curcumin in the cisplatin-induced kidney damage have not been explored. (thieme-connect.com)
  • Therefore, in this study, we aimed to investigate the possible molecular mechanisms of anti-inflammatory and anti-apoptotic effects of curcumin in cisplatin-induced kidney damage. (thieme-connect.com)
  • Rapamycin, however, activated autophagy and protected against cisplatin-induced acute kidney injury. (elsevierpure.com)
  • Although the mechanisms of metal transport in the convoluted proximal tubule (S1 and S2 segments) and the straight proximal tubule (S3 segment) may differ, little is known about the segment-specific modes of metal transport. (go.jp)
  • Thus, our results establish a renoprotective role of tubular cell autophagy in acute kidney injury where it may interfere with cell killing mechanisms. (elsevierpure.com)
  • Elimination of these substances from the diet results in the disappearance of the renal manifestations of the syndrome. (medscape.com)
  • In affected individuals, kidney problems result from damage to structures called proximal tubules. (medlineplus.gov)
  • These kidney organoids contain renal structures including proximal tubules (marked with LTL, in green) and podocytes (expressing PODXL, in red) t hat partly resemble the renal structures of the human kidney. (ibecbarcelona.eu)
  • The proximal tubules secrete approximately 15% of urinary creatinine in patients with a normal GFR. (medscape.com)
  • Also, cisplatin increased ERK1/2 phosphorylation and NF-κB expression, which subsequently increased mRNA expression of TNF-α, IL-6, KIM-1, NGAL, and Bax/Bcl-2 ratio as well as decreased mRNA expression of IL-10 in kidney tissues. (thieme-connect.com)
  • About 95% of free -2-m is filtered by the branous and proliferative being the most normal glomerulus and a normal kidney is common [ 2 ]. (who.int)
  • Here, we utilized immortalized cell lines derived from the S1, S2, and S3 segments of mouse kidney proximal tubules, and examined the segment-specific and direction-dependent transport of Cd and manganese (Mn) using a trans-well culture system. (go.jp)