Tropomyosin, together with the troponin complex, regulates muscle contraction and, along with tropomodulin and leiomodin, controls the uniform thin-filament lengths crucial for normal sarcomere structure and function. (nih.gov)
We used Förster resonance energy transfer to study effects of the tropomyosin mutations on the structure and kinetics of the cardiac troponin core domain associated with the Ca 2+ -dependent regulation of cardiac thin filaments. (nih.gov)
These studies indicate a loose and flexible interaction of troponin with the middle region of Tm which may be important in Ca2+ regulation by troponin.Tm. (wikigenes.org)
NM is caused by mutations in at least nine genes: Nebulin ( NEB ), α-actin ( ACTA1 ), α-tropomyosin ( TPM3 ), β-tropomyosin ( TPM2 ), troponin T ( TNNT1 ), cofilin-2 ( CFL2 ), Kelch repeat and BTB (POZ) domain-containing 13 ( KBTBD13 ), and Kelch-like family members 40 and 41 ( KLHL40 and KLHL41 ). (biomedcentral.com)
Both mutations gave reduced inhibition of actin-tropomyosin-activated myosin ATPase, both in experiments using cTnI alone and in those using reconstituted human cardiac troponin under relaxing conditions. (ox.ac.uk)
Both mutant troponin complexes also conferred increased calcium sensitivity of ATPase regulation. (ox.ac.uk)
The regulation of vertebrate striated muscle contraction involves a number of different molecules, including the thin-filament accessory proteins tropomyosin and troponin that provide Ca(2+)-dependent regulation by controlling access to myosin binding sites on actin. (egelmanlab.org)
Kinase7
Houle, F., Poirier, A., Dumaresq, J. and Huot, J. (2007) DAP Kinase Mediates the Phosphorylation of Tropomyosin-1 Downstream of the ERK Pathway, Which Regulates the Formation of Stress Fibers in Response to Oxidative Stress. (scirp.org)
An unbiased screen of 150 small molecules that impact actin organization and 32 anti-mitotic drugs identified two molecular targets, Rho kinase (ROCK) and tropomyosin 3.1/2 (Tpm3.1/2), whose inhibition has the greatest impact on mitotic cortical tension. (bvsalud.org)
BDNF binds with high affinity to the tropomyosin receptor kinase B (TrkB), and activates AKT and ERK pathways (Mattson et al. (stemcell.com)
Our previous studies suggested that brain-derived neurotrophic factor (BDNF)/tropomyosin-related kinase B (TrkB) axis inhibited cardiomyocyte apoptosis in myocardial infarction (MI). (ijbs.com)
Metz HE and Houghton AM (2011) Insulin receptor substrate regulation of phosphoinositide 3-kinase. (scielo.br)
In addition to binding to the insulin receptor, IRS1 also binds to and transmits signals from the receptors of prolactin, growth hormone (GH), leptin, vascular endothelial growth factor (VEGF), tropomyosin receptor kinase B (TrkB), anaplastic lymphoma kinase (ALK), insulin like growth factor (IGF1), and integrins ( Vuori and Ruoslathi , 1994 Vuori K and Ruoslahti E (1994) Association of insulin receptor substrate-1 with integrins. (scielo.br)
Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. (biossusa.com)
Proteins7
This gene encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. (wikipedia.org)
When tested for tropomyosin affinity, super repeats containing the p.Glu2431Lys mutation showed stronger binding than WT proteins to tropomyosin, and the super repeat containing the p.Thr7382Pro mutation showed weaker binding than WT proteins to tropomyosin. (biomedcentral.com)
Tropomyosin proteins regulate the tensing of muscle fibers (muscle contraction) by controlling the binding of two muscle proteins, myosin and actin. (medlineplus.gov)
The anti-tropomyosin antibodies detected a single protein at 42.5 kDa in Arabidopsis thaliana extracts and two proteins at 58.5 and 54 kDa in leek extracts, and these localised to plasmodesmata and the cell plate in A. thaliana and to plasmodesmata in leek tissue. (edu.au)
Tropomyosin is an actin-binding protein thought to be involved in a range of functions associated with the actin cytoskeleton, including the regulation of myosin binding to actin filaments, but to date no tropomyosin-like proteins have been conclusively identified in plant genomes. (edu.au)
It thus appears that the ability to bind to at least two distinctly different positions on F-actin, as observed for tropomyosin, may be more common than previously considered for other actin binding proteins. (egelmanlab.org)
TPM33
Tropomyosin alpha-3 chain is a protein that in humans is encoded by the TPM3 gene. (wikipedia.org)
The TPM3 gene provides instructions for making a protein called slow muscle alpha (α)-tropomyosin, which is part of the tropomyosin protein family. (medlineplus.gov)
Mutations of tropomyosin 3 (TPM3) are common and associated with type 1 myofiber hypotrophy in congenital fiber type disproportion. (medlineplus.gov)
Mutations5
Missense mutations K15N and R21H in striated muscle tropomyosin are linked to dilated cardiomyopathy (DCM) and hypertrophic cardiomyopathy (HCM), respectively. (nih.gov)
We also used the GST pull-down assay to test the affinity of WT nebulin super repeats for WT α- and β-tropomyosin, and for β-tropomyosin with six patient mutations: p.Lys7del, p.Glu41Lys, p.Lys49del, p.Glu117Lys, p.Glu139del and p.Gln147Pro. (biomedcentral.com)
Of the tropomyosin mutations, only p.Glu41Lys showed weaker affinity for nebulin (super repeat 18). (biomedcentral.com)
We demonstrate for the first time the existence of direct tropomyosin-nebulin interactions in vitro , and show that nebulin interactions with actin and tropomyosin are altered by disease-causing mutations in nebulin and tropomyosin. (biomedcentral.com)
These mutations change single amino acids in slow muscle α-tropomyosin and are thought to impair the protein's ability to interact with myosin and actin within type I skeletal muscle fibers, disrupting muscle contraction. (medlineplus.gov)
Muscle contraction3
Calponin is a calmodulin, F-actin and tropomyosin binding protein which is thought to be involved in the regulation of smooth muscle contraction. (enzolifesciences.com)
Slow muscle α-tropomyosin helps regulate muscle contraction in type I skeletal muscle fibers. (medlineplus.gov)
To establish α-tropomyosin (Tm)'s structure-function relationships in cooperative regulation of muscle contraction, thin filaments were reconstituted with a variety of Tm mutants (Δ2Tm, Δ3Tm, Δ6Tm, P2sTm, P3sTm, P2P3sTm, P1P5Tm, and wtTm), and force and sliding velocity of the thin filament were studied using an in vitro motility assay. (elsevierpure.com)
Protein9
Background: Tropomyosin 1 alpha chain (Tm1) is an actin-binding protein that regulates the endothelial cell response to oxidative stress following its phosphorylation at Serine 283 (S283). (scirp.org)
Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). (hmdb.ca)
By focusing on the stabilizing protein tropomyosin Cdc8, bundling protein fimbrin Fim1, and severing protein coffin Adf1, we examined how their pairwise and collective interactions with actin filaments regulate their activity and segregation to functionally diverse F-actin networks. (elifesciences.org)
YB-1 is an evolutionary conserved protein with a cold-shock domain, and is crucial to many fundamental cellular processes, including transcription and translation regulation [ 5 ]. (biomedcentral.com)
This gene encodes a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. (affbiotech.com)
A 75-kDa protein, enriched in plasmodesmata-rich cell wall extracts from the green alga Chara corallina, was sequenced and found to contain three peptides with similarity to the animal actin-binding protein tropomyosin. (edu.au)
Western blot analysis with anti-tropomyosin antibodies confirmed the identity of this 75-kDa protein as a tropomyosin-like protein and further identified an additional 55-kDa protein, while immunofluorescence microscopy localised the antibodies to plasmodesmata and to the subcortical actin bundles and associated structures. (edu.au)
Our data suggests that a tropomyosin-like protein is associated with plasmodesmata. (edu.au)
Cardiac myosin binding protein C (cMyBP-C) appears to modulate this Ca(2+)-dependent regulation and has attracted increasing interest due to links with inherited cardiac diseases. (egelmanlab.org)
Genes2
Additional studies associating variation at these loci with change in gene expression highlighted Tropomyosin 1 ( TPM1 ) among our top-ranked candidate genes. (biomedcentral.com)
The higher expression of gremlin 1 and HIF1a genes after exposure to dragonfly larvae indicated an in vivo hypoxic reaction, while down-regulation of syndecan-2 may indicate impairment of angiogenesis. (biomedcentral.com)
Cytoskeleton1
Gunning, P., O'Neill, G. and Hardeman, E. (2008) Tropomyosin-Based Regulation of the Actin Cytoskeleton in Time and Space. (scirp.org)
TPM11
Genetic studies have also suggested a role for Tropomyosin 1 ( TPM1 ) in human platelet trait variation [ 6 ], though no prior studies have elucidated if or how TPM1 impacts human hematopoiesis. (biomedcentral.com)
Thin-filament1
We suggest that the K15N mutation causes DCM by altering Ca 2+ -dependent thin-filament regulation and that one of the possible HCM-causing mechanisms by the R21H mutation is through alteration of leiomodin's function. (nih.gov)
Calmodulin2
This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. (hmdb.ca)
Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. (hmdb.ca)
BDNF2
BDNF regulates synaptic transmission and plasticity at adult synapses in the central nervous system, and contributes to adaptive neuronal responses including long-term potentiation, long-term depression, certain forms of short-term synaptic plasticity, and homeostatic regulation of neuronal excitability (Reichardt). (stemcell.com)
Hang P, Sun C, Guo J, Zhao J, Du Z. BDNF-mediates Down-regulation of MicroRNA-195 Inhibits Ischemic Cardiac Apoptosis in Rats. (ijbs.com)
Phosphorylation2
Zerradi, M. , Houle, F. and Huot, J. (2015) Regulation of Breast Cancer Progression by Phosphorylation of the Tumor Suppressor Tropomyosin-1 Alpha. (scirp.org)
Simoneau, B., Houle, F. and Huot, J. (2012) Regulation of Endothelial Permeability and Transendothelial Migration of Cancer Cells by Tropomyosin-1 Phosphorylation. (scirp.org)
Gene expression2
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. (cancerindex.org)
MicroRNAs (miRNAs or miRs) refer to a group of small noncoding RNA molecules, typically 18~25 nucleotides in length, that function in RNA silencing and post-transcriptional regulation of gene expression [ 9 ]. (ijbs.com)
Actin-myosin1
These observations help to explain many of the seemingly contradictory results obtained with cMyBP-C and show how cMyBP-C can provide an additional layer of regulation to actin-myosin interactions. (egelmanlab.org)
Platelet1
We also show a critical role for the actin regulator Tropomyosin 4 in the final steps of platelet formation in lung vasculature. (bvsalud.org)
Metastasis1
Hypoxic regulation of RIOK3 is a major mechanism for cancer cell invasion and metastasis. (ox.ac.uk)
Role1
Intestinal microbiota transplantation reveals the role of microbiota in dietary regulation of RegIIIβ and RegIIIγ expression in mouse intestine. (shengsci.com)
Affinity1
Super repeats containing the deletion p.Val3924_Asn3929del showed similar affinity for actin and tropomyosin as that seen with WT super repeats. (biomedcentral.com)
Structures1
Because these models suffer Tropomyosin or fragmentation structures to be as, they confer suggested churches. (augenta.net)
Migration1
siRNA-mediated silencing of CORO1C and down-regulation of YBX1 in CORO1C overexpressing MDA-MB-231 cells were performed to evaluate cell migration and invasion. (biomedcentral.com)
Molecular1
Our study reveals a critical step in the spatial regulation of myosin V-dependent organelle transport and may reveal common mechanisms for how molecular motors accurately deposit cargoes at the correct locations. (rupress.org)
Experiments1
We performed F-actin and tropomyosin-binding experiments for the nebulin super repeats, using co-sedimentation and GST (glutathione-S-transferase) pull-down assays. (biomedcentral.com)
Mutant1
Importantly, reversal of mechanical tension with an inhibitory MRLC mutant or tropomyosin inhibitors is sufficient to restore apoptotic extrusion in TNFα-treated monolayers. (bvsalud.org)
Promotes1
Up-regulation of miR-195 in ischemic cardiomyocytes promotes ischemic apoptosis by targeting Bcl-2. (ijbs.com)
Microbiota1
Currently, as a means of intestinal microecological regulation in addition to microecological preparations, fecal microbiota transplantation (FMT) has become popular in recent years. (hindawi.com)
Roles1
In this review, we summarized the biological significance, splicing patterns, research methods of the alternative splicing, as well as its roles in the regulation in the growth, development and responses to environmental stresses. (chinbullbotany.com)
Cells1
It is an important way in post transcriptional regulation in eukaryotic cells. (chinbullbotany.com)
Studies1
Deletion studies revealed that period 3 is important for the positive cooperative effect of Tm on actin filament regulation and that period 2 also contributes to this effect at low ionic strength, but to a lesser degree. (elsevierpure.com)