Regulation genes regulator. Medical search. Frequent questions

In molecular biology, the ferric uptake regulator family is a family of bacterial proteins involved in regulating metal ion uptake and in metal homeostasis. (wikipedia.org)
a map is constructed that shows interactions among molecular entities (such as genes, proteins and RNAs), using information from literature and databases. (hindawi.com)
In this sense, we aim to characterize the behaviour of different promoters of genes involved in biofilm regulation under different conditions and to search for possible new DNAbinding proteins associated with their promoter regions. (usp.br)
In order to switch off a gene, they interact with so called Argonaute proteins - the subsequent complex induces the shutdown or even degradation of the genetic information. (mpg.de)
But they also have important regulatory functions: Small noncoding RNAs (miRNAs) influence mRNA stability and are able to switch off genes by stalling their translation into proteins. (mpg.de)
However, miRNAs can't shut off genes on their own: They need to form complexes with other proteins. (mpg.de)
They studied how exactly a group of proteins and non-coding RNAs, namely the MSL complex increases the gene expression of the single X chromosome in male flies to achieve the same dosage as XX females. (mpg.de)
Extensive evidence has revealed that the core clock machinery involves "clock genes" and "clock proteins" functioning as molecular cogs. (bioone.org)
We are interested primarily in mechanisms of post-transcriptional gene expression control, involving small non-coding RNAs and RNA-binding proteins. (unibas.ch)
The two main classes of RNA regulators are miRNAs and RNA-binding proteins. (unibas.ch)
p53 affects the transcription of many target genes and interacts with key cellular proteins. (molvis.org)
Among CRE1 repressed transcripts, genes encoding unknown proteins and transport proteins were overrepresented. (biomedcentral.com)
In chapter 2, by using CRISPR/Cas9 gene editing, genetic analysis and biochemical assays, I identified the differential pairings of typical NLR receptor SOC3 with atypical NLR proteins CHS1 or TN2 to guard the homeostasis of the E3 ligase SAUL1. (ubc.ca)
The VHL gene provides instructions for making a protein that functions as part of a complex (a group of proteins that work together) called the VCB-CUL2 complex. (medlineplus.gov)
Our project offers a unique opportunity for Master's student to gain hands-on experience focused on transcriptional regulators with importance in expression of genes of outer membrane proteins that are essential in host-pathogen interaction. (lu.se)

Members of the ferric uptake regulator family are transcription factors that primarily exert their regulatory effects as repressors: when bound to their cognate metal ion, they are capable of binding DNA and preventing expression of the genes they regulate, but under low concentrations of metal, they undergo a conformational change that prevents DNA binding and lifts the repression. (wikipedia.org)
Transcriptional regulation information for a gene, including any predicted DNA binding site motifs ( YeTFaSCo ) for the gene's protein product, as well as any of its targets (genes it regulates) or regulators (genes that regulate it), based on experimental evidence. (yeastgenome.org)
miRNAs comprise a large group of endogenous non-coding RNAs that can block mRNA translation or negatively regulate mRNA stability and thereby play a central role in regulating gene expression [10] , [11] . (plos.org)
The number of putative Regulators (genes that regulate it) and Targets (genes it regulates) for the given locus, based on experimental evidence. (yeastgenome.org)
The team lead by Asifa Akhtar suggests that the origin of the MSL complex lay in the regulation of these developmental genes and was later reused also to regulate dosage compensation. (mpg.de)
It can function as an enzyme, scaffold various subcellular structures, and regulate gene expression through a variety of mechanisms, as well as act as a key component of the protein synthesis and splicing machinery. (cshlpress.com)
Which genes regulate the prognostic genes in three existing prognostic signatures for breast cancer? (cepheid.com)

Forkhead box protein M1 (FOXM1) is a key transcription factor (TF) that regulates a common set of genes related to the cell cycle in various cell types. (mdpi.com)

The report describes the roles and responsibilities of the Gene Technology Regulator (the Regulator) and the Office of the Gene Technology Regulator (OGTR) during 2021-22. (ogtr.gov.au)

Transcription and expression regulation of some individual cel genes (cel5A, cel5I, cel5D and cel44O) of Clostridium cellulolyticum were investigated. (nottingham.ac.uk)
A team from the US and Korea documents rare variants with apparent ties to gene expression regulation across dozens of human tissue types for another paper in PLOS Genetics . (genomeweb.com)
In our proposed project, you would investigate expression regulation in clinically significant bacterium non-typeable Haemophilus influenzae (NTHi). (lu.se)
2022 ) Gene Expression Regulation in Airway Pathogens: Importance for Otitis Media. (lu.se)

MicroRNAs (miRNAs) are potent effectors in gene regulatory networks where aberrant miRNA expression can contribute to human diseases such as cancer. (hindawi.com)
For a better understanding of the regulatory role of miRNAs in coordinating gene expression, we here present a systems biology approach combining data-driven modeling and model-driven experiments. (hindawi.com)
Although microRNAs (miRNAs) are physically small, they have been shown to play an important role in gene regulation [ 1 ]. (hindawi.com)
However, experimental approaches have limitations when dealing with complex biological systems composed of multiple layers of regulation such as the transcriptional and post-transcriptional regulation by transcription factors (TFs) and miRNAs [ 2 ]. (hindawi.com)
The systems biology approach, combining data-driven modeling and model-driven experiments, provides a systematic and comprehensive perspective on the regulatory roles of miRNAs in gene regulatory networks [ 3 - 5 ]. (hindawi.com)
The application of the systems biology approach to the analysis of a gene regulatory network is demonstrated with a case study of the regulation of p21 by multiple miRNAs [ 4 ]. (hindawi.com)
Besides classical gene regulation, miRNAs have emerged as post-transcriptional regulators of angiogenesis. (plos.org)
Small noncoding ribonucleic acids (miRNAs) are important regulators of genes. (mpg.de)
The book goes on to discuss the evolution of ribosomes and the functions of RNPs, before reviewing the recent work that has revolutionized our understanding of gene regulation by non-coding RNAs, including miRNAs and siRNAs. (cshlpress.com)
Background: MicroRNAs (miRNAs) mediate a form of translational regulation in animals. (utexas.edu)
miRNAs are important regulators of gene expression. (utexas.edu)

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. (yeastgenome.org)
Click "Phenotype Details" to view all phenotype annotations and evidence for this locus as well as phenotypes it shares with other genes. (yeastgenome.org)
These genes were selected based on their role in asthmatic inflammatory processes and History previously reported associations with asthma phenotypes. (cdc.gov)
Of these mediators, cytokines play a single nucleotide polymorphisms (SNP) in pro-inflammatory cytokine genes and asthma phenotypes (Che et al. (cdc.gov)

This gene encodes a member of the regulator of G-protein signaling family. (nih.gov)
Variation in regulator of G-protein signaling 17 gene (RGS17) is associated with multiple substance dependence diagnoses. (nih.gov)
The family is named for its founding member, known as the ferric uptake regulator or ferric uptake regulatory protein (Fur). (wikipedia.org)
In the case of the ferric uptake regulator protein itself, its immediate downstream target is a noncoding RNA called RyhB. (wikipedia.org)
In addition to the ferric uptake regulator protein, members of the Fur family are also involved in maintaining homeostasis with respect to other ions: Mur, responsive to manganese. (wikipedia.org)
Collection of domains associated with the protein based on various sources, including the protein coordinates for the domain, a domain Description, a Source and corresponding accession ID, and the number of S. cerevisiae genes that share the same domain. (yeastgenome.org)
Now his group has identified the first protein factor which is required for gene-silencing by Ago-miRNA-complexes: Importin 8. (mpg.de)
One of those molecules, phosphatidylcholine transfer protein (PCTP), suppresses the activity of the other, PPARdelta, a gene regulator critical in burning fat and energy metabolism, under conditions of overnutrition. (anl.gov)
A guide RNA (gRNA) directs the function of a CRISPR protein effector to a target gene of choice, providing a versatile programmable platform for engineering diverse modes of synthetic regulation (edit, silence, induce, bind). (caltech.edu)
By providing programmable control over both the scope and target of protein effector function, cgRNA regulators offer a promising platform for conditional gene regulation and synthetic biology. (caltech.edu)
algorithm to identify the regulatory models from protein-DNA binding and gene expression data. (mit.edu)
p53 E3 ubiquitin protein ligase homolog (Mdm2) is an important negative regulator of p53. (molvis.org)
Analyzing 5′-upstream non-protein-encoding regions of the human mitochondrial function-associated genes, we speculate that mitochondrial functions could be recovered or improved at a transcriptional level. (intechopen.com)
As opposed to other styles of muscles dystrophy, where mutations take place in genes encoding structural protein, calpainopathy was the initial reported kind of dystrophy predetermined by mutations within a gene encoding a proteolytic enzyme. (exposed-skin-care.net)
As a positive regulator of plant immunity, E3 ligase SAUL1 is guarded by NLR protein SOC3. (ubc.ca)
The VHL protein likely plays a role in other cellular functions, including the regulation of other genes and control of cell division. (medlineplus.gov)
The VHL gene mutations found in nonsyndromic paraganglioma or pheochromocytoma change single amino acids in the VHL protein or create an abnormally short protein. (medlineplus.gov)
The other VHL gene mutations that can cause familial erythrocytosis also change single amino acids in the VHL protein. (medlineplus.gov)
Regulators of the p38 MAPK pathway were down-regulated in the blood from old rats (RPL7, RPL29), while other transcripts (ANXA2) influenced by the expression of these ribosomal protein transcripts were up-regulated in blood from old rats. (cdc.gov)
[ 3 ] In addition, mutations of the gene encoding chromodomain-helicase DNA-binding protein 7 ( CHD7 ) have been found in some patients with Kallmann syndrome or idiopathic hypogonadotropic hypogonadism, some of whom have features of the CHARGE syndrome (characterized by delayed growth and development, congenital cardiac defects, dysmorphic ears, hearing loss, coloboma of the eyes). (medscape.com)
There will be involved gene engineering and molecular biology methods such as PCR, SDS-PAGE, qPCR, western blot, DNA-protein interaction assays, flow cytometry etc. (lu.se)
42] Another study by Nahorski et al demonstrated tumor suppression by the interaction of p0071 (plakophilin-4, a potential novel folliculin-interacting protein) and the regulation of RhoA. (medscape.com)

Mdm2 is a key negative regulator of p53 activity. (molvis.org)
44] Possik et al demonstrated FLCN is an AMPK-binding partner and considered to act as a negative regulator of AMPK, therefore serving as a tumor suppressor. (medscape.com)

For genes with regulatory targets, shared GO Biological Process terms for these targets are listed. (yeastgenome.org)
This table lists putative transcriptional regulatory targets for the central gene represented on this page. (yeastgenome.org)
These targets were identified based on the presence of predicted regulator binding sites or experimental regulator binding in the target promoter, and/or changes in the target gene's transcript levels in regulator mutant strains. (yeastgenome.org)
The network combining putative targets of TF and miRNA regulation with experimentally proven molecular interactions was constructed and visualized. (hindawi.com)
Importin 8 interacts with Ago and miRNA and is necessary for the binding of the AgomiRNA-complex to a variety of mRNA targets: In the cytoplasm - i.e. the intracellular space outside the nucleus - it recruits the complex to its target, allowing for efficient and specific gene-silencing. (mpg.de)
Click "Regulation Details" to view all regulation annotations, shared GO enrichment among regulation Targets, and a regulator/target diagram for the locus. (yeastgenome.org)
But instead of up-regulating the transcription of one entire X chromosome with several hundred genes, here it only targets individual genes. (mpg.de)
Previous analyses of dopaminergic (DAergic) neurons from patients with Lewy-body pathology revealed a deficiency in nuclear-encoded genes for mitochondrial respiration, many of which are targets for the transcription factor estrogen-related receptor gamma ( Esrrg /ERRγ). (nature.com)
in fact, these genes are targets of the transcriptional coactivator and master regulator of transcription of mitochondrial genes peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) 12 . (nature.com)
However, the complete list of its gene targets is not known. (biomedcentral.com)
Our study provides the first global insight into the molecular physiological response of a multicellular fungus to carbon catabolite regulation and identifies several not yet known targets in a growth-controlled environment. (biomedcentral.com)

Air pollution impacts gene expression and pathways affecting cardio-metabolic and respiratory traits, when controlling for genetic ancestry. (nature.com)
The authors also enabled normalization of hippocampal gene expression in specific pathways associated with AD and neuroinflammation, which enabled memory improvements. (news-medical.net)
Therefore, it is important to describe their mechanisms of actions, expression patterns and possible target genes and cellular pathways with which they interact. (mdpi.com)
Metabolism underpins development and physiology, but little is known about how metabolic genes and pathways are regulated, especially in multicellular organisms. (biorxiv.org)

Since the first microRNA was identified in 1993 by Victor Ambros and colleagues (the lin-4 heterochronic gene in C. Elegans ), more than 24,000 microRNAs have now been identified. (mdpi.com)
This Special Issue of "Genes" seeks reviews and original papers covering a wide range of topics related to microRNA biology, such as regulation of expression in various disorders (cancer, metabolism, autoimmunity to mention but a few), genetics of microRNAs and their target sites, functional analysis of microRNA function and studies of interactions between microRNAs and target genes. (mdpi.com)

We used an integrative approach to comprehensively assess the interactions between 1.6 million data points, encompassing a range of environmental exposures, health, and gene expression levels, coupled with whole-genome genetic variation. (nature.com)
Further, in order to capture gene-by-environment interactions through eQTL analyses, we combine whole-transcriptome RNA-Sequencing profiles with whole-genome genotyping and extensive fine-scale environmental exposure data. (nature.com)
Interaction annotations are curated by BioGRID and include physical or genetic interactions observed between at least two genes. (yeastgenome.org)
To see if there are any interactions between epigenetic modifications across metabolic genes, we computed pairwise Pearson's correlation coefficients between the 16 epigenetic modifications based on their relative abundance at each metabolic gene region. (biorxiv.org)
In contrast, metabolic genes involved in specialized and hormone metabolic domains, which are generally involved in interactions with biotic and abiotic environmental stimuli, showed distinct patterns with the enrichment of a repression mark H3K27me3 and an activation mark H3K18ac ( Fig. 1B ). (biorxiv.org)
Our group develops computational methods to infer binding sites for various regulators across the transcriptome and to link these interactions to specific functional outcomes, such as isoform selection and transcript degradation. (unibas.ch)
The effect of expressing a gene is also influenced by which other genes are simultaneously expressed (functional interactions). (lu.se)
We find relatively little sex-bias in embryos and larvae at the gene level, but several sub-networks show sex-biased functional interactions in early developmental stages. (lu.se)

Indole-3-carbinol (I3C), a compound occurring naturally in cruciferous vegetables, exhibits a potent antitumor activity via its regulation of estrogen activity and metabolism. (nih.gov)
These results further suggest that antitumor activities of I3C are associated not only with its regulation of estrogen activity and metabolism, but also its modulation of ER transcription activity. (nih.gov)
The scientists first created a whole-body PCTP knockout male mouse (meaning one in which genes have been activated or deactivated), assessing its fat metabolism under different dietary conditions, including normal and high-fat diet. (anl.gov)
However, compared to developmental processes, knowledge about the epigenetic regulation of metabolism is limited in multicellular organisms. (biorxiv.org)
For example, genes associated with energy metabolism showed higher expression levels compared to those involved in specialized metabolism (Fig. S1B). (biorxiv.org)

Australia's gene technology regulator Raj Bhula has proposed reducing regulations around gene editing techniques such as CRISPR , following a 12 month technical review into the current regulations. (abc.net.au)

Most of this regulation is carried out directly by transcription factors that modulate the activity of promoters aimed at expressing virulence factors. (usp.br)
14 ). It is important to identify the transcription factors involved in regulation of these genes to reveal potential avenues for modulating transcriptional programs that could be dysfunctional in PD. (nature.com)
Various levels of regulation, including epigenetic modifications and transcription factors, play important roles in coordinating the expression of genes. (biorxiv.org)
In this context, DNA-binding transcription factors (TFs) play an important regulatory role by either repressing or activating genes in response to environmental and physiological conditions. (biomedcentral.com)
Hypoxia leads to the up-regulation of hypoxia-induced transcription factors (HIF)-a and HIF-2a, which are the master regulators of proangiogenic signals, mainly the vascular endothelial cell growth factors (VEGFs). (medscape.com)

Increased curiosity about CAPN3 was highly stimulated when it had been reported that mutations in its gene bring about limb-girdle muscular dystrophy (LGMD) type 2A, seen as a the continuous atrophy of hip and make muscle tissues (LGMD2A, or calpainopathy) (21). (exposed-skin-care.net)
You can find over 440 noted mutations within the calpain 3 gene up to now, included in this 212 (50%) are missense mutations, a lot of which alter its catalytic activity (22). (exposed-skin-care.net)
Mutations in the VHL gene increase the risk of developing tumors of the nervous system called paragangliomas or pheochromocytomas (a type of paraganglioma). (medlineplus.gov)
VHL gene mutations associated with nonsyndromic paraganglioma or pheochromocytoma can be inherited or can occur spontaneously. (medlineplus.gov)
At least 10 inherited mutations in the VHL gene have been found to cause familial erythrocytosis, a condition characterized by an increased number of red blood cells and an elevated risk of abnormal blood clots. (medlineplus.gov)
When familial erythrocytosis results from VHL gene mutations, it is often designated ECYT2. (medlineplus.gov)
Mutations of the KAL1 gene, which encodes a putative neural cell adhesion molecule (anosmin), have been described in several patients with X-linked Kallmann syndrome. (medscape.com)
Loss-of-function mutations of the gene encoding fibroblast growth factor receptor 1 (FGFR1) have been described in patients with autosomal dominant Kallmann syndrome. (medscape.com)
[ 2 , 3 ] Heterozygous loss-of-function mutations of the gene encoding FGFR1 have also been described in individuals with idiopathic hypogonadotropic hypogonadism, normal smell sense, and normal MRI of the olfactory system. (medscape.com)
Mutations of the gene encoding fibroblast growth factor 8 have been found in a small minority of patients with autosomal dominant Kallmann syndrome. (medscape.com)
Zettner MA, Flor S, Ludewig G, Wagner J, Robertson LW, Lehmann L. Quinoid metabolites of 4-monochlorobiphenyl induce gene mutations in cultured Chinese hamster v79 cells. (who.int)

High-density oligonucleotide arrays were used to identify genes differentially expressed between high and low ERG expressers. (nih.gov)
We observe sex-biased isoform switching consistently across development, but mostly in genes that are already differentially expressed. (lu.se)

Similarly to the cip-cel operon, cel5A and cel5I expressions are regulated by a carbon catabolite repression mechanism, whereas cel44O and cel5D expressions do not seem to be submitted to this regulation. (nottingham.ac.uk)
Gene expression analysis suggested that the differences derived from repression of PPARdelta gene regulation activity. (anl.gov)
Surprisingly, specialized metabolic genes, often involved in defense, were predominantly regulated by two modifications that have opposite effects on gene expression, H3K27me3 (repression) and H3K18ac (activation). (biorxiv.org)
We found that the regulation of TE transcription during brain development is essential for the establishment of long-term transcriptional repression carried to adulthood (Paper I and IV). (lu.se)

Inositol induction did require another general regulator of phospholipid biosynthesis, Ume6p. (umass.edu)
Using camalexin biosynthesis genes as an example, we confirmed that these two modifications were co-localized to form bivalent chromatin. (biorxiv.org)
Genes responsible for the biosynthesis of these compounds are wired into a complex network. (biorxiv.org)

Moreover, genome instability was attributed to impaired autophagy and several autophagy genes with tumor suppressor functions (e.g. (hindawi.com)
After attributing a regional and/or continental ancestry to each individual using genome-wide polymorphism data, we are able to capture the effect of different environmental exposures on gene expression and health-related traits, while simultaneously controlling for genetic relatedness and migration. (nature.com)
These newly found MSL-linked sites in the genome were practically exclusively genes that control fly development and have a direct impact on cellular processes involved in organ formation," For example, we observed malformed wings or diminished eyes indicating that the MSL complex is directly regulating genes such as Wingless, which is a master controller of development," says Claudia Keller Valsecchi, first author of the study. (mpg.de)
Enrichment of modifications in each metabolic domain, relative to all the genes in the genome, revealed both shared and diverse patterns. (biorxiv.org)
Even though diverse strains of S. aureus have been extensively studied, and subjected to genome sequencing, the function of a large proportion of their genes remains unidentified. (biomedcentral.com)
With the help of an analytical approach called a "likelihood ratio test for quantitative traits" (LRT-q), the investigators analyzed whole-genome sequence and RNA sequence data spanning samples from 49 tissue types in nearly 700 Genotype-Tissue Expression (GTEx) project participants of European ancestry, highlighting genes with particularly pronounced expression patterns or disease associations that appeared to be regulated by rare rather than common variants. (genomeweb.com)
To be able to predict binding sites for these regulators genome-wide, we need to know their sequence specificity. (unibas.ch)
Here we chose to use chemostat cultures on D-glucose as a carbon source at two different growth rates (one repressing and one derepressing [ 16 ]) to investigate the genome-wide changes in gene expression in relation to CRE1 function, using a Δcre1 recombinant mutant strain of T. reesei and corresponding control strain. (biomedcentral.com)
We experimentally determined their genome wide target profiles using RNA-induced silencing complex (RISC) immunoprecipitations and gene expression profiling. (utexas.edu)
Analysis of the genome wide target profiles revealed evidence of extensive regulation of gene expression through non-canonical target pairing by miR-503. (utexas.edu)

DNA methylation, a form of epigenetic control of gene transcription, refers to cytosine methylation at position 5 in the pyrimidine ring, which can result in inappropriate silencing of genes involved in diverse biological processes, including cell proliferation, apoptosis, migration and cell cycle arrest ( 5 ). (spandidos-publications.com)
Groups I and II included mainly the epigenetic modifications that activate gene expression. (biorxiv.org)
The enrichment patterns of epigenetic modifications were consistent with expression levels of genes involved in each domain under healthy conditions (Fig. S1A). (biorxiv.org)
A. Correlation analysis reveals four groups of epigenetic marks, activating (red) and repressing (blue), based on their relative abundance on metabolic genes. (biorxiv.org)
More so, our results show that the epigenetic regulation of TE transcription is dynamically regulated throughout life (Paper II), upon the beginning of neuroinflammation (Paper III), and in a disease-driving polymorphic TE insertion (Paper IV). (lu.se)

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies ( Molecular Function , Biological Process , and Cellular Component ), a reference, and an evidence code. (yeastgenome.org)
However, the molecular mechanisms of MEG3 methylation in the regulation of multiple myeloma (MM) are unknown. (spandidos-publications.com)
In flies, the MSL complex has emerged as a molecular balancing mechanism to ensure the same amount of gene output in both sexes. (mpg.de)
There is very little molecular homology between mammals and plants for these core regulators. (lu.se)
Taken together, our study provides a detailed functional and molecular characterization of HSCs at different phases of regeneration and identifies a gene set associated with the transition from proliferation to quiescence. (lu.se)

The research points to a novel regulator of nuclear receptor activity, and possibly a potential way to target PPARdelta indirectly. (anl.gov)

The role of the putative transcriptional regulator GlyR2 in the regulation of cel5D expression was investigated. (nottingham.ac.uk)

For this, the upstream regions of the gacA, gacS, ladS, retS, rsmA, rsmZ and PA1611 genes were cloned separately into a miniTn7 vector and inserted into the PAO1 chromosome. (usp.br)
Para isso, as regiões upstream dos genes gacA, gacS, ladS, retS, rsmA, rsmZ e PA1611 foram clonadas separadamente em um vetor repórter miniTn7 e inseridas no cromossomo de PAO1. (usp.br)
The promoter region of MEG3 is rich in CpG islands, and the specific methylated and unmethylated CpG islands of differentially methylated regions (DMRs) are located upstream of the MEG3 gene (IG-DMR and MEG3-DMR) ( 17 , 18 ). (spandidos-publications.com)

The most promising form of gene editing is known as CRISPR, which has been called a game changer in the medical and agriculture world. (abc.net.au)

In the genus Corynebacterium , AmtR is a key component of the nitrogen regulatory system, and it belongs to the TetR family of transcription regulators. (frontiersin.org)
Early estrogen-induced gene 1 facilitates osteoclast formation through the inhibition of interferon regulatory factor 8 expression. (nih.gov)
To investigate a gene regulatory network, an iterative process of four steps is needed. (hindawi.com)
In turn, these hypotheses, which provide reasonable explanations for the biological phenomenon, lead to an enhanced understanding of the gene regulatory network. (hindawi.com)
We have elucidated the regulatory pathway for aniA and have identified the regulator of norB. (rochester.edu)
Here, we deciphered the CRE1 regulatory range in the model cellulose and hemicellulose-degrading fungus Trichoderma reesei (anamorph of Hypocrea jecorina ) by profiling transcription in a wild-type and a delta- cre1 mutant strain on glucose at constant growth rates known to repress and de-repress CCR-affected genes. (biomedcentral.com)
Here, we focus on functional homologies by performing a comparison between the circuitry connecting these players in plants and animals and find striking similarities, suggesting that comparable regulatory logics have been evolved for stem cell regulation in both kingdoms. (lu.se)
Their mutagenic potential and gene regulatory effect have shaped the evolution of transcriptional networks involved in development, pluripotency, and inflammation. (lu.se)

mvaT is a major regulator, exerting negative control in many genes described. (usp.br)
It is the major regulator of a hormone called erythropoietin, which controls red blood cell production. (medlineplus.gov)

Ume6p was found to be a positive regulator of PIS1 gene expression. (umass.edu)

The DB consists of a collection of frames , where each frame encodes information about a single object, such as an enzyme, a gene, or a biochemical pathway. (ecocyc.org)

With gene editing you don't always have to use genetic material from another organism, it is just editing the [existing] material within the organism,' Dr Bhula said. (abc.net.au)
These results demonstrate the functional effects of rare variants, especially on gene expression," they report, "which provides important biological insights in understanding the genetic mechanism of rare variants in complex traits and diseases. (genomeweb.com)
These results suggest that genetic variations in TNF, TGFB1, PTGS1 and PTGS2 genes contribute to DA susceptibility. (cdc.gov)

We demonstrate that deletion of ERRγ from DAergic neurons in adult mice was sufficient to cause a levodopa-responsive PD-like phenotype with reductions in mitochondrial gene expression and number, that partial deficiency of ERRγ hastens synuclein-mediated toxicity, and that ERRγ overexpression reduces inclusion load and delays synuclein-mediated cell loss. (nature.com)
While ERRγ deletion did not fully recapitulate the transcriptional alterations observed in postmortem tissue, it caused reductions in genes involved in synaptic and mitochondrial function and autophagy. (nature.com)
Further evidence suggests that during PD progression, transcriptional programs for the expression of genes involved in mitochondrial structure and function are disrupted 11 . (nature.com)
Laser-captured microdissected (LCM) DAergic neurons from postmortem tissue of patients with Lewy-pathology revealed a deficiency in expression for nuclear-encoded genes involved in mitochondrial respiration and function 12 . (nature.com)
Direct regulators of nuclear-encoded mitochondrial genes are members of the estrogen-related receptor (ERR) family, encoded by Esrra , Esrrb and Esrrg . (nature.com)

For the first time, they were able to show that the MSL complex also controls essential developmental genes on other chromosomes. (mpg.de)
If not, in phenomena such as Haploinsufficiency, aneuploidy or other forms of chromosome abnormality, these gene dosage alterations can cause severe defects ultimately resulting in developmental failures and disease. (mpg.de)
These developmental differences are caused by differential expression of genes and isoforms. (lu.se)
These findings suggest that regulators in sex-biased networks evolve more rapidly than regulators of other developmental networks. (lu.se)

Therapeutic strategies for the dystrophinopathies can be categorized into 3 groups based on their approach: (1) Supportive pharmacologic therapy, (2) research gene therapy, and (3) research cellular therapy. (medscape.com)

Finally, the calibrated model is used to study the effect of different miRNA expression profiles and cooperative target regulation on p21 expression levels in different biological contexts. (hindawi.com)

Prediction of the coding sequences of mouse homologues of FLJ genes: the complete nucleotide sequences of 110 mouse FLJ-homologous cDnas identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. (nih.gov)

We have designed a probe for the coding region of the Dicer1 gene (in red), probe which binds to both the short and the long 3' UTR isoform, as well as a probe for the region that is unique to the long 3'UTR isoform (in green). (unibas.ch)

Get notified about applications to release a GMO into the environment, when an application is open for comment and when changes are made to Australia's gene technology legislation. (ogtr.gov.au)

An examination of genes that are only expressed anaerobically may reveal new virulence factors that are important in gonococcal pathogenesis. (rochester.edu)
Given the high number of virulence factors present in these bacteria, and the niche-specific role many of them play during different stages of the infectious process, gene expression must be finely tuned in order to efficiently coordinate their expression, and also continue to preserve energy pools. (biomedcentral.com)
Finally, we examine the conservation of 135 USA300 TFs amongst 11 other S. aureus strains, identifying a key group of regulators that display a high degree of conservation, including many that have previously been demonstrated to play a role in virulence gene regulation. (biomedcentral.com)

In Saccharomyces cerevisiae, transcription of most of the phospholipid biosynthetic genes (e.g. (umass.edu)
By culturing microorganisms under standard laboratory conditions, most biosynthetic gene clusters (BGCs) are not expressed, and thus, the products are not produced. (dtu.dk)
To explore this biosynthetic potential, we developed a novel "semi-targeted" approach focusing on activating "silent" BGCs by concurrently introducing a group of regulator genes into streptomycetes of the Tübingen strain collection. (dtu.dk)
To explore this biosynthetic potential, we developed a novel "semi-targeted" approach focusing on activating "silent" BGCs by concurrently introducing a group of regulator genes into streptomycetes of the T{\"u}bingen strain collection. (dtu.dk)

Altogether, these experiments suggest that ERRγ-deficient mice could provide a model for understanding the regulation of transcription in DAergic neurons and that amplifying ERRγ - mediated transcriptional programs should be considered as a strategy to promote DAergic maintenance in PD. (nature.com)

information about the experiment and assay type, constructs, conditions, and strains, as well as a reference, are provided for each Regulator annotation. (yeastgenome.org)

Proper regulation of immune responses mediated by NLRs is important as over-activation results in growth defects, while under-activation leads to vulnerability to pathogens. (ubc.ca)

We found a significantly lower expression of key autophagy- (ATG-) related genes in primary AML as compared to healthy granulocytes, an increased autophagic activity during all- trans retinoic acid- (ATRA-) induced neutrophil differentiation, and an impaired AML differentiation upon inhibition of ATG3, ATG4D, and ATG5. (hindawi.com)
Studies in yeast have identified a series of autophagy- (ATG-) related genes forming the autophagy machinery. (hindawi.com)

The role of DNA methylation in the mediation of multiple tumor suppressor gene and microRNA silencing has been implicated in the development and progression of MM ( 7 ). (spandidos-publications.com)
Pradella et al suggest that FLCN may not always follow a classic two-hit model of tumorigenesis and may alternatively be a noncanonical tumor suppressor gene. (medscape.com)

download this table as a .txt file using the Download button or click Analyze to further view and analyze the list of target genes using GO Term Finder, GO Slim Mapper, SPELL, or YeastMine. (yeastgenome.org)
shared GO terms, the number of target genes that share them, and the P-value are all indicated in the table. (yeastgenome.org)
One end binds to the target gene (dark red), the other end delivers a DNA-cutting enzyme (in this case, Cas9) to the site. (abc.net.au)
CreA/CRE1 binds to the promoters of the respective target genes via the consensus motif 5'-SYGGRG-3', whose function in vivo has been shown both in Aspergillus nidulans and Trichoderma reesei [ 9 - 12 ]. (biomedcentral.com)
Because of the eminent role of receptors for mediating the biological effects of steroid hormones, changes in receptor expression could alter responsiveness of the target cells and determine the physiological circumstances in which gonadal steroids become important regulators of cell function. (jneurosci.org)

Our group is interested in the mechanisms that control gene expression from very early to very late in human life. (unibas.ch)
Today, a plethora of genes have been shown to be under control of CreA or CRE1 (reviewed in [ 7 ]) but the mechanisms triggering regulation by CreA/CRE1 are less well understood. (biomedcentral.com)

For example, a half dozen biologists could easily supply a half dozen conflicting definitions for the terms "gene," or "metabolic pathway. (ecocyc.org)
Instance frames describe specific biological objects, such as a specific gene or a specific metabolic pathway. (ecocyc.org)

Specific gene-silencing is involved in the development of cancer and plays an essential role in gene regulation. (mpg.de)

Mapping transcriptional regulation of biofilm-related genes promoters in Pseudomonas. (usp.br)

One may ask to what extent there are similarities and differences in the gene regulation circuits and their dynamics when it comes to important processes like stem cell regulation. (lu.se)
This regulation becomes important in the transplantation setting where HSCs undergo proliferation followed by a gradual transition to quiescence and homeostasis. (lu.se)

Deletion of the core circadian clock genes Bmal1 and Per1 in mice triggers oxidative damage and synaptic degeneration. (news-medical.net)
We also revealed that there are raft-positive and -negative synapses in the same neuron, proposing the hypothesis that glycosylation of AMPA―R decides the synaptic localization, resulting in the regulation of synaptic strength in synaptic plasticity. (nii.ac.jp)

To test the prognostic significance of ETS-related gene (ERG) expression in cytogenetically normal primary acute myeloid leukemia (AML). (nih.gov)
In vitro , the sprouting and migratory properties of primary endothelial cell cultures were reduced by inhibiting EZH2 through up-regulation of miR-101, siRNA-mediated knockdown of EZH2, or treatment with 3-Deazaneplanocin-A (DZNep), a small molecule inhibitor of EZH2 methyltransferase activity. (plos.org)
Results: Here we identified miR-503, miR-103, and miR-494 as negative regulators of proliferation in primary human cells. (utexas.edu)
Mutation of RFXAP, a regulator of MHC class II genes, in primary MHC class II deficiency. (lu.se)

In this study, they show that PCTPs can repress the activity of a nuclear receptor called PPARdelta, a gene regulator critical in burning fat, maintaining energy balance, and regulating fatty acid uptake. (anl.gov)

I3C and breast cancer susceptibility gene 1 (BRCA1) synergistically inhibited transcriptional activity of ER-alpha. (nih.gov)
Defects of these regulation processes may lead to cancer and neurodegenerative diseases. (mpg.de)
This multiplex mRNA expression test is designed to measure the expression of six genes (3 biomarkers and 3 controls) in formalin-fixed, paraffin-embedded breast cancer tissue from patients with early stage invasive breast cancer. (cepheid.com)
Delineating transcriptional networks of prognostic gene signatures refines treatment recommendations for lymph node-negative breast cancer patients. (cepheid.com)
In the near future, novel chemo-/gene-therapies might be applied to treat cancer patient converting cancerous cells into normal differentiated cells. (intechopen.com)

Our study suggests that this type of bivalent chromatin, which we name a kairostat, controls the precise timing of gene expression upon stimuli. (biorxiv.org)

Anatomy20

Organisms21

Diseases4

Chemicals and Drugs92

Analytical, Diagnostic and Therapeutic Techniques and Equipment35

Phenomena and Processes83

Disciplines and Occupations1

Information Science5

Proteins15

Regulate7

Regulates1

Office of the Ge1

Expression regulation4

MiRNAs11

Phenotypes4

Protein22

Negative regulator2

Targets11

Pathways4

MicroRNAs2

Interactions8

Metabolism5

Technology Regulator1

Transcription factors5

Mutations11

Differentially expressed2

Repression4

Biosynthesis3

Genome10

Epigenetic5

Molecular5

Novel regulator1

Putative transcriptional1

Upstream3

CRISPR1

Regulatory8

Major regulator2

Positive regulator1

Encodes1

Genetic3

Mitochondrial5

Developmental4

Cellular1

MiRNA1

Nucleotide1

Isoform1

Australia's1

Virulence3

Biosynthetic4

Transcriptional Programs1

Annotation1

Pathogens1

Autophagy2

Tumor supp2

Target5

Mechanisms2

Metabolic2

Role in gene regulation1

Promoters1

Important2

Synaptic2

Primary4

Uptake1

Cancer5

Chromatin1