Recombination. Medical search. Frequent questions

Meiotic recombination introduces variation around that expectation (Mendelian noise) and related pedigree founders systematically bias Pedigree F downward. (nature.com)
Effects of meiotic recombination on Marker F were reversed, such that the same number of molecular markers yielded more precise estimates of GWIBD in zebra finches than in humans. (nature.com)
Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology covers all aspects of recombinational DNA repair, meiotic recombination, and the regulation of these processes. (cshlpress.com)
Meiotic recombination, the characteristics that distinguish it from recombinational repair, and effects of its dysregulation (e.g., aneuploidy) are also covered in depth. (cshlpress.com)
Meiotic recombination is a critical process for plant breeding, as it creates novel allele combinations that can be exploited for crop improvement. (nature.com)
In wheat, a complex allohexaploid that has a diploid-like behaviour, meiotic recombination between homoeologous or alien chromosomes is suppressed through the action of several loci. (nature.com)
The genetics of chromosome pairing and meiotic recombination is complicated by the allopolyploid nature of many crops, a widespread feature in the plant kingdom 3 . (nature.com)
Our studies provide a direct observation of human meiotic recombination products. (nih.gov)
These results are consistent with the hypothesis that minimum efficient processing segments, which have been characterized in Escherichia coli, yeast, and cultured mammalian cells, may be required for efficient homologous meiotic recombination in humans. (nih.gov)
The aim of this thesis is to investigate the effects of these proteins on meiotic DNA topology and axis morphology, and their implications for homologous recombination (HR) in Arabidopsis thaliana. (bham.ac.uk)

ZIP4 is a ZMM protein involved in homologous recombination and may act as a hub through physical interactions with components of the chromosome axis and other ZMMs 19 . (nature.com)

We analyzed the dependence of the integrated-photoluminescence intensity on the excitation-power density and the type of radiative recombination involving the electronic ground state and the excited states inside the quantum dots. (scirp.org)
We concluded that the probability to have more than one exciton by dots must be considered, and the usual equation , must be revised to correctly describe the origin of the recombination and must include other factors as scattering, relaxation time, radiative recombination rate, and others. (scirp.org)
S. Martini, A. Marques, M. Marques, A. Quivy and L. Teles, "Radiative Recombination Mechanisms of Large InAs/GaAs Quantum Dots," World Journal of Condensed Matter Physics , Vol. 1 No. 4, 2011, pp. 161-166. (scirp.org)
A model will be developed and validated for electronic transport calculations using a highly accurate, predictive electronic structure code that currently produces electronic structure, optical absorption, radiative and Auger recombination rates for InAs/InAsSb strained-layer superlattices from 5K-300K. (sbir.gov)
Time-resolved photoinduced luminescence, femtosecond transient absorption, and time-resolved THz transmission measurements were performed to assess radiative and nonradiative recombination and photoconductivity dynamics of photogenerated charges in the NWs. (lu.se)
We conclude that radiative recombination dynamics is limited by hole trapping, whereas electrons are highly mobile until they recombine nonradiatively. (lu.se)
Rault, F & Zahedi, A 2003, ' A probabilistic approach to determine radiative recombination carrier lifetimes in quantum well solar cells ', Microelectronics Journal , vol. 34, no. 4, pp. 265 - 270. (monash.edu)

As part of our coverage of the 2017 ASCO Annual Meeting, we discuss homologous recombination deficiency in ovarian cancer and PARP inhibitors. (cancernetwork.com)
First, what is the link between ovarian cancer and homologous recombination deficiency? (cancernetwork.com)
Homologous recombination deficiency is actually very common in high-grade serous ovarian cancer. (cancernetwork.com)
If you look at the most clear indication of homologous recombination deficiency-loss of BRCA1 or BRCA2 cancer genes, either in the inherited germline or the tumor itself-that number is close to 25% of ovarian cancers. (cancernetwork.com)
Indeed, at least in part, the abnormalities in homologous recombination deficiency have contributed to the very outstanding responses to platinum therapy and very striking new data with PARP (poly [ADP-ribose] polymerase) inhibitors. (cancernetwork.com)
What are the ways to test for this deficiency of homologous recombination in patients with ovarian cancer? (cancernetwork.com)
There are a number of approaches to test for homologous recombination deficiency. (cancernetwork.com)

Any number of homologous recombination events between linear homologous chromosomes generates linear products that have the same overall structure as their parents. (gla.ac.uk)
The HNPP (hereditary neuropathy with liability to pressure palsies) deletion and CMT1A (Charcot-Marie-Tooth disease type 1A) duplication are the reciprocal products of homologous recombination events between misaligned flanking CMT1A-REP repeats on chromosome 17p11. (nih.gov)

Surface recombination can have a major impact both on the short-circuit current and on the open-circuit voltage. (pveducation.org)
Lowering the high top surface recombination is typically accomplished by reducing the number of dangling silicon bonds at the top surface by using a 'passivating' layer on the top surface. (pveducation.org)
Techniques for reducing the impact of surface recombination. (pveducation.org)
Instead, under the top contacts, the effect of the surface recombination can be minimized by increasing the doping. (pveducation.org)
A similar effect is employed at the rear surface to minimize the impact of rear surface recombination velocity on voltage and current if the rear surface is closer than a diffusion length to the junction. (pveducation.org)

The replication terminus region of the E. coli chromosome encodes a locus, dif, that is required for normal chromosome segregation at cell division, dif is a substrate for site-specific recombination catalysed by the related chromosomally encoded recombinases XerC and XerD. (gla.ac.uk)
Viruses like SARS-CoV-2 continuously evolve as changes in the genetic code (caused by genetic mutations or viral recombination) occur during replication of the genome. (cdc.gov)

2013. "A Wisp3 Cre-knockin Allele Produces Efficient Recombination in Spermatocytes during Early Prophase of Meiosis I." PLoS ONE 8 (9): e75116. (harvard.edu)
The only tissue that had high levels of Cre-mediated recombination was the testis, where recombination in spermatocytes occurred by early prophase of meiosis I. As a consequence, males that were double heterozygous for a Wisp3GFP-Cre and a floxed allele only contributed a recombined allele to their offspring. (harvard.edu)

Homologous recombination involves the precise exchange of similar or identical nucleic acid sequences between two DNA molecules. (cshlpress.com)
Homologous recombination, also known as general recombination, is a type of genetic recombination in which nucleotide sequences are exchanged between two similar or identical strands of DNA. (wikipathways.org)
When analyzing a fragment of the 5′ UTR, we characterized at least two subspecies of HRV-C: HRV-Cc, which clustered differently from HRV-A and HRV-B, and HRV-Ca, which resulted from previous recombination in this region with sequences related to HRV-A. The full-length sequence of one strain of each HRV-Ca and HRV-Cc subspecies was obtained for comparative analysis. (plos.org)
It is shown that the only DNA sequences required for wild-type dif function in the terminus region of the chromosome are contained within 33 bp known to bind XerC and XerD, and that certain active site residues of the Xer proteins known to be involved in the catalysis of recombination are required for normal chromosome segregation. (gla.ac.uk)
Kirkham and colleagues identify a molecular mechanism that generates the substrates for end donation reactions, an erroneous V(D)J recombination reaction, where broken recombination signal sequences (RSS) become joined with independently generated double-strand breaks (DSB). (aacrjournals.org)

Combined with the carrier recombination rates already available from this software the quantum efficiencies of these superlattices will be predicted. (sbir.gov)
A Time Resolved Microwave Conductivity technique for investigating direct and trap-mediated recombination dynamics and determining carrier mobilities of thin film semiconductors is presented here. (jove.com)
This method is useful in the field of photovoltaics because it measures photo-induced charge carrier decay via trap states and band-to-band recombination processes. (jove.com)

MCM8- and MCM9-deficient mice reveal gametogenesis defects and genome instability due to impaired homologous recombination. (nih.gov)
Recombination by-product-triggered DNA breaks are a potential cause of chromosomal instability and mutagenesis. (aacrjournals.org)
Cut-and-run: A distinct mechanism by which V(D)J recombination causes genome instability. (aacrjournals.org)

Recombination is the swapping of DNA between the chromosomes within a pair. (thetech.org)
Since the recombination we have been talking about happens in the egg or sperm, this means the recombined chromosomes end up in someone's children. (thetech.org)

This is what is called recombination in cosmology , the period when the temperature dropped enough to allow electrons to bind to nuclei and form the first neutral atoms. (astronoo.com)

In Escherichia coli and related bacteria, we believe that both plasmids and the bacterial chromosome use site-specific recombination to convert multimers to monomers. (gla.ac.uk)
It has been proposed that this recombination converts chromosome multimers formed by homologous recombination back to monomers in order that they can be segregated prior to cell division. (gla.ac.uk)
Since neither the dif/Xer, nor the loxP/Cie system caused this suppression when located in other positions on the chromosome, close to oriC or within lacZ, this reinforces the idea that site-specific recombination must occur in the terminus region in order to allow normal chromosome segregation. (gla.ac.uk)

Between 30% and 40% of lymphoid malignancies bear the hallmarks of errors in the recombination reactions that generate B- and T-cell receptor genes. (aacrjournals.org)
Homologous recombination in E3 genes of human adenovirus species D. (bvsalud.org)
Homologous recombination was identified in open reading frames for E3 CR1α, CR1ß, and CR1Î³, similar to that previously observed with genes encoding the three major structural capsid proteins , the penton base, hexon, and fiber. (bvsalud.org)
To reduce the risk of analyzing cell line- pathway can be divided into distinct stages based on the specific features, we used several representative cell lines for recombination status of the Ig genes and on the expression each of four major stages in B cell development: pro-B, pre-B, pattern of surface markers and the presence of intracellular proteins [1- 6]. (lu.se)

Specifically, another type of recombination process called "Auger recombination" can occur frequently in quantum dots. (sciencedaily.com)
Auger recombination is a nonradiative multicarrier process whereby the exciton recombination energy is not converted into a photon but instead transferred to a third charge. (sciencedaily.com)
Typically, the Auger recombination is one of the biggest hindrances to improving the efficiency of QDs based optoelectronic devices, especially displays. (sciencedaily.com)
To date, numerous spectroscopic studies have been conducted to suppress the Auger recombination process in QDs. (sciencedaily.com)
Therefore, research on active control of the Auger recombination process by manipulating the optical environment is lacking. (sciencedaily.com)
The Center for Molecular Spectroscopy and Dynamics within the Institute for Basic Science (IBS), South Korea has successfully observed the Auger recombination in CdSe QDs occurring at a few picosecond timescales by utilizing transient absorption spectroscopy. (sciencedaily.com)
Based on the fact that the Auger recombination process strongly depends on the transition dipole moment of excitons, the research team revealed that the interaction between transition dipole in QDs and its image formed by the nanostructure can suppress the Auger recombination process by reducing the amplitude of the net transition dipole moment. (sciencedaily.com)
They stressed that they first revealed the fundamental mechanism of suppressing the nonradiative Auger recombination by decreasing the amplitude of the net transition dipole moment through simply combining with external structures without complicating molecular technology. (sciencedaily.com)
The approach will use the novel formulation of Auger recombination pioneered at U. Iowa which divides the electron-electron scattering process into electronic response properties with a given momentum and energy, that are then connected by the Coulomb interaction matrix element. (sbir.gov)

Understanding of recombination and photoconductivity dynamics of photogenerated charge carriers in Ga x In 1-x P NWs is essential for their optoelectronic applications. (lu.se)
The overall goal of this experiment is to use reflected microwave power to measure the recombination dynamics of photo-induced charge carriers and thin-film photovoltaic materials. (jove.com)

From biology to technology, a powerful mechanism to create innovation is recombination - the formation of new systems by combining old parts in new ways. (ox.ac.uk)

We identify that the nonradiative recombination of charges is much slower than the decay of the photoluminescence signal. (lu.se)
Further, we conclude that trapping of both electrons and holes as well as nonradiative recombination become faster with increasing Ga composition in Ga x In 1-x P NWs. (lu.se)

We confirmed the close relationship of their structural proteins but showed apparent additional recombination events in the 2A gene and 3′UTR of the HRV-Ca strain. (plos.org)

In S. cerevisiae, where do hotspots occur and what are the local recombination rates? (slideserve.com)

Here, we report positional cloning of Pairing homoeologous 2 (Ph2) and functional validation of the wheat DNA mismatch repair protein MSH7-3D as a key inhibitor of homoeologous recombination, thus solving a half-century-old question. (nature.com)

the only other clinically relevant test is the homologous recombination defect assay, which is commercially available from Myriad Genetics. (cancernetwork.com)
This was due to an observation that there were strong responses in patients with BRCA1/2 abnormalities, responses that were intermediate in patients with the homologous recombination defect assay. (cancernetwork.com)
This is controversial, since the amount of benefit in those patients without either abnormalities in the pathway or in the homologous recombination defect assay are really quite modest, and whether this warrants the toxicity of the PARP inhibitors in these circumstances will require additional study. (cancernetwork.com)
Confirmed HRD (Homologous recombination defect) in germline and/or somatic DNA analysis (tumour or blood), by a validated assay (see Appendix 1). (urotoday.com)

To achieve computational completeness using only finite components we also propose an extension of the contextual template-guided recombination system (CTGR system) by Daley and McQuillan, by adding an extra control called permitting contexts on the usage of templates. (uwo.ca)

One such process, molecular hydrogen dissociation and recombination, can enhance energy redistribution on ultra-hot Jupiters with temperatures above ∼2000 K. In order to study the impact of H 2 dissociation on ultra-hot Jupiters, we present a phase curve of KELT-9b observed with the Spitzer Space Telescope at 4.5 μm. (harvard.edu)
General circulation models (GCMs) and an energy balance model that include the effects of H 2 dissociation and recombination provide a better match to the data. (harvard.edu)

RecA is a widely conserved cytoplasmic protein that performs a range of functions in Escherichia coli, including: DNA repair, homologous recombination, and induction of the SOS pathway. (wisc.edu)

Immunoglobulin J Recombination Signal Sequence-Binding Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
This graph shows the total number of publications written about "Immunoglobulin J Recombination Signal Sequence-Binding Protein" by people in Harvard Catalyst Profiles by year, and whether "Immunoglobulin J Recombination Signal Sequence-Binding Protein" was a major or minor topic of these publication. (harvard.edu)
Below are the most recent publications written about "Immunoglobulin J Recombination Signal Sequence-Binding Protein" by people in Profiles. (harvard.edu)

We show that the probability for inelastic processes vanishes as the range of the pair-wise interaction is taken to zero and demonstrate numerically that the recombination threshold law manifests itself for large scattering length. (arxiv.org)

British Library EThOS: Charge recombination kinetics in dye sensitised nanocrystalline solar cells. (bl.uk)

Rag-1 and Rag-2 and initiation of Ig recombination events [7]. (lu.se)

Recent evidence now points to TaZIP4-B2 (the additional ZIP4 copy on 5BL) as being responsible for the effect of this locus on homoeologous recombination 20 , 21 . (nature.com)

the double heterozygous offspring had evidence of Cre-mediated recombination in several tissues. (harvard.edu)
We detected no evidence of Cre-mediated recombination in the female ovary, although when double heterozygous females contributed the reporter allele to their offspring it had recombined ~7% of the time. (harvard.edu)

This recombination reaction by-product therefore serves as an unexpected potential underlying cause of lymphoid cell transformation. (aacrjournals.org)

Recombination can repair broken DNA. (thetech.org)
Orthologous to human MCM8 (minichromosome maintenance 8 homologous recombination repair factor). (nih.gov)

Similar to ph2 mutant phenotype, we show that mutating MSH7-3D induces a substantial increase in homoeologous recombination (up to 5.5 fold) in wheat-wild relative hybrids, which is also associated with a reduction in homologous recombination. (nature.com)
The reduction in recombination increases the electron concentration in the base and so the solar cell's voltage. (pveducation.org)

The main processing method of bamboo recombination technology is rolling and compaction, by which a reconstituted material with bamboo fibrotic veneer as matrix and phenolic resin as reinforcement is prepared. (hindawi.com)
This paper mainly introduced the research and development process of bamboo recombination technology in China, analyzed the current research status and main problems of key science and technology, and put forward some useful suggestions for the sustainable development of bamboo recombination industry and the improvement of product performance. (hindawi.com)
Two main models are the reversible guided recombination system by Kari and Landweber and the template-guided recombination (TGR) system by Prescott, Ehrenfeucht and Rozenberg, based on two categories of DNA recombination: the pointer guided and the template directed recombination respectively. (uwo.ca)

This volume is an indispensable reference for biochemists, molecular biologists, and cell biologists who want to understand how DNA recombination maintains genomic integrity in individual organisms and across generations. (cshlpress.com)
However, their circularity makes homologous recombination a threat to their integrity and maintenance. (gla.ac.uk)

The problem is that not all excitons emit light during the recombination process as mentioned above. (sciencedaily.com)
This paper reviewed the research process and progress of bamboo recombination technology, the existing technical problems and prospects, in order to provide references for future research on bamboo recombination theory and production practice. (hindawi.com)

As part of our coverage of the 2017 American Society of Clinical Oncology (ASCO) Annual Meeting, held June 2-6 in Chicago, we are speaking with Gordon Mills, MD, PhD, chair of the department of systems biology and professor of medicine and immunology at the University of Texas MD Anderson Cancer Center in Houston, about ways to incorporate homologous recombination markers into clinical practice for ovarian cancer. (cancernetwork.com)

Typically, the larger this quantity, the greater the recombination rate. (sciencedaily.com)

Anatomy18

Organisms16

Diseases6

Chemicals and Drugs73

Analytical, Diagnostic and Therapeutic Techniques and Equipment23

Phenomena and Processes147

Disciplines and Occupations2

Technology, Industry, Agriculture1

Information Science5

Health Care4

Meiotic10

Involved in homologous recombination1

Radiative7

Deficiency7

Homologous recombination events2

Surface recombination5

Replication2

Meiosis2

Sequences5

Carrier3

Instability3

Chromosomes2

Neutral atoms1

Chromosome3

Genes4

Auger9

Charge carriers2

Mechanism1

Nonradiative2

Gene1

Occur1

Mismatch Repair1

Assay4

Daley1

Dissociation2

Pathway1

Protein3

Processes1

Solar cells1

Initiation1

Locus1

Evidence2

Reaction1

Repair2

Reduction2

Main3

Integrity2

Process2

Practice1

Typically1