• This family, which includes epidermal growth factor receptor (EGFR), plays a pivotal role in normal cell growth, lineage determination, repair, and functional differentiation. (medscape.com)
  • The ErbB/HER family of receptor tyrosine kinases (RTKs) consists of four family members: the epidermal growth factor receptor (EGFR/ErbB1), HER2 (ErbB2/Neu), HER3 (ErbB3), and HER4 (ErbB4). (plos.org)
  • In addition, Gint4.T aptamer prevents PDGFRβ heterodimerization with and resultant transactivation of epidermal growth factor receptor. (unina.it)
  • As a result, the combination of Gint4.T and an epidermal growth factor receptor-targeted aptamer is better at slowing tumor growth than either single aptamer alone. (unina.it)
  • Expression of the neuronal proliferation marker doublecortin revealed that, unlike RA, QA did not decrease the number of mitotic cells. (nih.gov)
  • The ILC cell lines MDA-MB-134-VI, SUM44PE, and BCK4 were used to assess WNT4 gene expression and regulation, as well as the role of WNT4 in estrogen-regulated proliferation. (nih.gov)
  • Further, WNT4 was required for endocrine response in ILC cells, as WNT4 knockdown blocked estrogen-induced proliferation. (nih.gov)
  • ILC-LTED cells remained dependent on WNT4 for proliferation, by either maintaining ER function and WNT4 regulation or uncoupling WNT4 from ER and upregulating WNT4 expression. (nih.gov)
  • In ILC and ILC-LTED cells, WNT4 led to suppression of CDKN1A/p21, which is critical for ILC cell proliferation. (nih.gov)
  • MiaPaCa-2 and CFPAC-1 cells were treated with 100 ng/ml of NGF or the NGF inhibitor Tanezumab for 24 h, CCK-8 and Transwell assays were employed to test cell proliferation, invasion, and migration, respectively. (hindawi.com)
  • Changes in dietary fatty acids, specifically the polyunsaturated fatty acids of the ω-3 and ω-6 families and some derived eicosanoids from lipoxygenases, cyclooxygenases, and cytochrome P-450, seem to control the activity of transcription factor families involved in cancer cell proliferation or cell death. (springer.com)
  • TWEAK-induced TWEAK Receptor-mediated signaling can play roles in inflammation, the induction of apoptosis in certain cell types, the proliferation and migration of endothelial cells, and can promote angiogenesis within healthy and diseased tissues, eg, tumors. (bdbiosciences.com)
  • RAF Kinase Activity Regulates Neuroepithelial Cell Proliferation and Neuronal Progenitor Cell Differentiation during Early Inner Ear Development. (mpg.de)
  • Inhibits the proliferation of a number of tumor cell lines. (joplink.net)
  • Oncostatin M inhibits proliferation of rat oval cells, OC15-5, inducing differentiation into hepatocytes. (joplink.net)
  • Knockdown of KDM1B inhibits cell proliferation and induces apoptosis of pancreatic cancer cells. (cancerindex.org)
  • Platelet-derived growth factor receptor β (PDGFRβ), a cell-surface tyrosine kinase receptor, is an important hallmark involved in glioma since it influences several cellular processes of tumor biology including proliferation, migration, and angiogenesis. (unina.it)
  • Moreover, Gint4.T aptamer drastically inhibits cell migration and proliferation, induces differentiation, and blocks tumor growth in vivo. (unina.it)
  • However, recently Houghton et al ( 7 ) showed increased cell proliferation after silencing of IRS1 gene expression in A549 cells suggesting tumor suppression potential. (spandidos-publications.com)
  • Anti-androgen flutamide suppresses hepatocellular carcinoma cell proliferation via the aryl hydrocarbon receptor mediated induction of transforming growth factor-β1. (oregonstate.edu)
  • however, it also suppresses cancer cell proliferation and recent findings have implicated its role as a tumor suppressor. (oregonstate.edu)
  • In vitro studies based on MCF-7 cell proliferation and induction of vitellogenin in primary culture of rainbow trout hepatocytes. (cdc.gov)
  • Mastocytosis and Mast Cell Activation Syndrome Mastocytosis is mast cell proliferation with infiltration of skin or other tissues and organs. (msdmanuals.com)
  • A high expression of the CD44v2-v10 isoform, which retain all variant exons, was correlated to positive steroid receptor status, low proliferation and luminal A subtype. (lu.se)
  • Some of the new approaches depend on tumor biology and aim specifically to inhibit tumor growth and metastasis by targeting the tumor microenvironment or vasculature (leaving normal cells unaffected) or focusing on specific protein or signal transduction pathways. (medscape.com)
  • Most of the reported effects of TLR4 signaling in tumors are pro-carcinogenic mainly due to contributions of proinflammatory cytokine signaling (whose expression is driven by TLR-mediated signals) to tumor-promoting microenvironment. (wikipedia.org)
  • Differential expression of particular ectonucleotidases in tumor cell variants will determine whether chemotherapy-induced activation of Panx1 channels drives accumulation of immunostimulatory ATP versus immunosuppressive adenosine within the tumor microenvironment. (aspetjournals.org)
  • The tumor microenvironment in the context of colon cancer and with a focus on the inflammatory mediators leukotriene D 4 (LTD 4 ) and prostaglandins (PGE 2 ) and their respective receptors. (lu.se)
  • Our aim is to generate solid support for novel and complementary treatments of colon cancer patients that focus on the inflammatory component of the tumor microenvironment. (lu.se)
  • We investigate how the lack of these receptors affects tumour growth and the surrounding tumour microenvironment in different colon cancer models. (lu.se)
  • Her focus of research is the role of estrogen and thyroid hormones in colon cancer progression and their effects on inflammatory components of the tumor microenvironment, in a big female cohort. (lu.se)
  • Syrina is a pharmacist and her research in cell pathology focuses on neutrophils recruitment in colorectal cancers microenvironment and in cancer related inflammation. (lu.se)
  • Now, she is interested in the interaction between the immune cells (mainly mast cells) present in the colon cancer microenvironment and colon cancer cells. (lu.se)
  • Her focus is to target the tumor microenvironment for developing new and effective therapeutic strategies. (lu.se)
  • This research sheds light into the mechanistics of glioma adaptation in the hypoxic tumor microenvironment and motivates further studies aimed at establishing therapeutic strategies targeted at the endocytic machinery that should be combined with available inhibitors of lipid biosynthesis. (lu.se)
  • However, target identification warrants a better understanding of the surfaceome and how it is modulated by the tumor microenvironment. (lu.se)
  • The TWEAK Receptor is a ~14 kDa type I transmembrane protein that is the 12A family member of the tumor necrosis factor receptor superfamily (TNFRSF12A). (bdbiosciences.com)
  • Infiltration versus metastasis is one of the most characteristic biological properties of tumors [ 5 ]. (hindawi.com)
  • Generally, it is believed that there are four main pathways between tumor invasion and metastasis, including local invasion, blood, lymphatic, and seeding metastasis [ 6 ]. (hindawi.com)
  • In addition to these four pathways, tumors can undergo infiltration around nerve fibers and metastasis along nerves, that is, perineural invasion (PNI), which refers to the phenomenon of perineural invasion by tumor cells filling the perineurial space, wrapping around nerves in a continuous concentric sheath-like pattern, infiltration, and metastasis of extension along nerves around nerve fibers or into perineurium within the perineurium [ 7 ]. (hindawi.com)
  • In this study, Aryl hydrocarbon receptor (AhR) expression was associated with lymph node and distant metastasis in patients with gastric cancer and was correlated with clinicolpathological pattern. (oncotarget.com)
  • Our results demonstrate that tumor growth, peritoneal dissemination and peritoneum or organ metastasis implanted MKN45 cells were significantly decreased in shAhR and Biseugenol-treated mice and that endoplasmic reticulum (ER) stress was caused. (oncotarget.com)
  • Myc Is a Metastasis Gene for Non-Small-Cell Lung Cancer. (mpg.de)
  • Lymph node metastasis is responsible for the high morbidity of head and neck squamous cell carcinoma (HNSCC). (spandidos-publications.com)
  • To date, the role of insulin receptor substrate 1 (IRS-1) in tumorigenesis and metastasis of head and neck cancer has not been elucidated. (spandidos-publications.com)
  • In this study, we found a negative correlation of IRS-1 expression with tumor metastasis both in human tissue samples and in cell lines. (spandidos-publications.com)
  • Furthermore studies in tumor metastasis are quite limited and controversial. (spandidos-publications.com)
  • While in lung cancer, IRS-1 has been confirmed to suppress tumor metastasis ( 11 ). (spandidos-publications.com)
  • The epithelial-mesenchymal transition (EMT) plays important roles in tumor metastasis. (spandidos-publications.com)
  • β-catenin, when translocating to and accumulating in the nucleus, induces transcription of other oncogenes involved in tumor progression, malignancy and metastasis ( 15 ). (spandidos-publications.com)
  • Functional analysis determined that DOCK10 , ITGA11 , DAB2 , PDFGRA , VASN , PPAP2B , and LPAR1 are highly expressed in trailblazer cells and required to initiate collective invasion, with DOCK10 essential for metastasis. (jci.org)
  • Together, our results indicate that spontaneous conversion of the epigenetic state in a subpopulation of cells can promote a transition from in situ to invasive growth through induction of a cooperative form of collective invasion and suggest that therapeutic inhibition of trailblazer cell invasion may help prevent metastasis. (jci.org)
  • Paraneoplastic syndromes are symptoms that occur at sites distant from a tumor or its metastasis. (msdmanuals.com)
  • This task can be accomplished by replacing tumor suppressor genes that have been lost or mutated, selectively inserting genes that produce cytotoxic substances, or modifying the immune system to destroy the tumor cells. (medscape.com)
  • This study shows that PD-1 is a tumor suppressor in CRC. (jcancer.org)
  • Lubnas research is mainly focused on the tumor suppressor protein 15-hydroxyprostaglandin dehydrogenase which is known to be down-regulated in colon cancer. (lu.se)
  • Frequency of myeloid suppressor cells (MDSC). (who.int)
  • Western blotting was employed to determine NGF level in PC and paracarcinoma tissues and in PC cell lines as well as pancreatic ductal epithelial cells. (hindawi.com)
  • NGF level was preeminently higher in PC tissues and cell lines than in paracarcinoma tissues and normal pancreatic epithelial cell lines. (hindawi.com)
  • Biseugenol-exposure tumors showed acquired epithelial features such as phosphorylation of E-cadherin, cytokeratin-18 and loss mesenchymal signature Snail, but not vimentin regulation. (oncotarget.com)
  • Elimination of B-RAF in Oncogenic C-RAF-expressing Alveolar Epithelial Type II Cells Reduces MAPK Signal Intensity and Lung Tumor Growth. (mpg.de)
  • Conditional Expression of Oncogenic C-RAF in Mouse Pulmonary Epithelial Cells Reveals Differential Tumorigenesis and Induction of Autophagy Leading to Tumor Regression. (mpg.de)
  • The directed expression of SV40 T antigen has led to the development of several important transgenic models with spontaneous epithelial tumor formation. (molvis.org)
  • Cells undergoing EMT lose their epithelial characteristics and phenotype, acquire mesenchymal properties, and thus gain enhanced motility ( 12 ). (spandidos-publications.com)
  • Signaling intensification through epithelial growth factor receptor (EGFR), mitogenactivated protein kinase (MAPK) pathway, Phosphatidylinositol 3-kinase (PI3K) pathway and overactivation of the translation initiation complex (TIC) has been previously characterized in RCC cell lines and tumor samples. (usp.br)
  • To investigate the effect of gambogic acid (GA) on apoptosis in the HT-29 human colon cancer cell line. (wjgnet.com)
  • Cell apoptosis was detected by terminal deoxynucleotidyl transferase dUTP nick end labeling and Hoechst 33342 staining, and quantified by flow cytometry. (wjgnet.com)
  • Pannexin-1 (Panx1) channels mediate the efflux of ATP and AMP from cancer cells in response to induction of extrinsic apoptosis by death receptors or intrinsic apoptosis by chemotherapeutic agents. (aspetjournals.org)
  • We previously described the accumulation of extracellular ATP /AMP during chemotherapy-induced apoptosis in Jurkat human leukemia cells. (aspetjournals.org)
  • treatment of both lines with chemotherapeutic drugs elicited similar intrinsic apoptosis. (aspetjournals.org)
  • Moreover, mitochondria control cell death through apoptosis and supply Ca 2+ and metabolites required for cellular homeodynamics [ 3 ]. (hindawi.com)
  • Res effectively suppress the cardiomyocytes hypertrophy and apoptosis induced by ISO, characterized by the reduction of the myocardial cell surface area, the ANP gene expression, the LDH and MDA leakage amount and the rate of cell apoptosis, while decrease of the protein expression of GRP78, GRP94 and CHOP, and reverse the expression of Bcl-2 and Bax. (karger.com)
  • Fas-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. (lu.se)
  • Whether C. tropicalis participates in the progression of CRC and immunotherapy resistance through regulating the tumor cell-intrinsic PD-1 remains to be further elucidated. (jcancer.org)
  • This shows that C. tropicalis promotes CRC progression via controlling the expression of tumor cell-intrinsic PD-1. (jcancer.org)
  • C. tropicalis can down-regulate tumor cell-intrinsic PD-1 expression via enhancing tumor cells autophagy levels to promote CRC progression. (jcancer.org)
  • Cell cycle progression was also affected. (frontiersin.org)
  • The researcher says this study provides a basis for understanding how the complex pattern of estrogen receptor gene alpha methylation and transcriptional silencing is generated, as well as for understanding the relationship between this pattern and its function during breast cancer progression. (sciencedaily.com)
  • Our hypothesis is that the sequence of epigenetic events for establishing and maintaining the silenced state of the estrogen receptor gene alpha during the breast cancer progression is mediated by pRb2/p130 in association with specific proteins that modified the DNA structure through specific mechanisms," said Giordano, who discovered the Rb2 gene while working at Temple's Fels Cancer Institute in the early 1990s. (sciencedaily.com)
  • The specific aim of this proposal is to elucidate the molecular networks that modify RTK signalling output during tumour progression to metastatic disease, with the aim of identifying network nodes that can subsequently be targeted for drug development. (europa.eu)
  • This upregulation was correlated with tumor progression. (molvis.org)
  • The primary endpoint of the study is OS, and secondary endpoints include progression-free survival (PFS) and objective response rate (ORR) as assessed by blinded independent central review (BICR) per Response Evaluation Criteria in Solid Tumors (RECIST) v1.1 modified for mesothelioma, safety and quality of life. (merck.com)
  • The RET kinase inhibitor selpercatinib (Retevmo) more than doubled progression-free survival (PFS) compared with standard chemotherapy with or without pembrolizumab (Keytruda) in the first-line setting among patients with RET fusion advanced/metastatic non-small cell lung cancer (NSCLC). (medscape.com)
  • These mediators and their receptors are enriched in colon cancer cells and colon cancer tissues, which demonstrate there, contribute to tumor development and progression. (lu.se)
  • Efforts to link CD44 to CSCs and tumor progression should consider the expression of various CD44 isoforms. (lu.se)
  • Methods A next-generation sequencing (NGS) panel was created for the human TRPV1 gene and in addition, for the leukotriene receptors BLT1 and BLT2 recently described to modulate TRPV1 mediated sensitisation processes rendering the coding genes LTB4R and LTB4R2 important co-players in pharmacogenetic approaches involving TRPV1. (researchgate.net)
  • In the present studies, we examined the expression of two PDGF receptor genes in human tumor cell lines derived from neural crest. (jci.org)
  • It's the dialogue among the genes that are writing the sentences, and this finding really writes a very important sentence in the book that we are authoring on uncovering the understanding of how a normal cell functions and why some therapies work or some therapies don't work. (sciencedaily.com)
  • Total RNA from tumors the expression of thousands of genes (3) to address complex questions was isolated using two successive rounds of Trizol. (lu.se)
  • To further confirm the central memory properties of treated cells, the team assessed expression of genes involved in differentiating T cells and found expression of central-memory differentiating genes to be highly expressed on the identified central memory cells generated by the combination. (newswise.com)
  • In ER+ cancer cells, PIP5K1α acted on pSer-473 AKT, and was in complexes with VEGFR2, serving as co-factor of ER-alpha to regulate activities of target genes including cyclin D1 and CDK1. (lu.se)
  • Genetic studies of the families at high risk for developing renal cancer led to the cloning of genes whose alteration results in tumor formation. (medscape.com)
  • These genes are either tumor suppressors ( VHL , TSC ) or oncogenes ( MET ). (medscape.com)
  • The effect of QA on cell survival and differentiation has therefore been examined on SH-SY5Y human neuroblastoma cells. (nih.gov)
  • Retinoic acid (RA, 10 μm) induced differentiation of SH-SY5Y cells into a neuronal phenotype showing neurite growth. (nih.gov)
  • These findings suggest that PDGF isoforms are involved not only in the promotion of the neuroblastoma cell growth, but also in neuronal cell migration, growth, and differentiation in human brain development. (jci.org)
  • Insulin receptor substrate 1 (IRS-1) is an adaptor protein that integrates multiple transmembrane signals from growth factors and hormones, to regulate cell growth, survival, differentiation and metabolism ( 4 ). (spandidos-publications.com)
  • She is investigating two different ligands and their receptive G-protein coupled receptors WNT5A/Frizzle and cysteinyl leukotriene C4/CysLTR2 signaling pathways which both upregulates 15-PGDH and induce re-differentiation of colon cancer cells. (lu.se)
  • Temporal multimodal single-cell profiling of native hematopoiesis illuminates altered differentiation trajectories with age. (lu.se)
  • Using ILC cell lines, we previously demonstrated that ER regulates a distinct gene expression program in ILC cells, and we hypothesized that these ER-driven pathways modulate the endocrine response in ILC. (nih.gov)
  • With the increased understanding of molecular mechanisms and basic pathways in the pathogenesis of squamous cell cancer of the head and neck , these pathways may be modified, and rational approaches in cancer therapy at the molecular level may be created. (medscape.com)
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
  • Membrane-bound HER receptors activate numerous tumor promoting signaling cascades via this mechanism, including the PI3K/AKT, Ras/Raf/Mek/Erk, PLCγ/PKC, and signal transducer and activator of transcription (STAT) pathways [1] , [2] . (plos.org)
  • In this study, we compared how different signaling pathways determine extracellular nucleotide pools in control Jurkat cells versus Jurkat lines that lack the Fas-associated death domain (FADD) or receptor-interacting protein kinase 1 (RIP1) cell death regulatory proteins. (aspetjournals.org)
  • Thus, extracellular nucleotide accumulation during regulated tumor cell death involves interplay between ATP/AMP efflux pathways and different cell-autonomous ectonucleotidases. (aspetjournals.org)
  • The HER (erbB) family of transmembrane receptor tyrosine kinases is one of the cytostatic targets in tumor cell growth and survival. (medscape.com)
  • Nuclear localized HER family receptor tyrosine kinases (RTKs) have been observed in primary tumor specimens and cancer cell lines for nearly two decades. (plos.org)
  • In particular, drugs targeting receptor tyrosine kinases (RTKs) have been successful. (europa.eu)
  • Among these miRNAs, we focused on miRNA-31 (miR-31) because miR-31 was the only miR that has been reported to regulate tumor phenotype, an anti-metastatic effect in breast cancer. (nature.com)
  • In vivo, tumour cells are simultaneously exposed to signals initiated by a variety of oncogenes, cytokine receptors and adhesion molecules, and it is the integrated signals that determine the cellular phenotype. (europa.eu)
  • Canonical mesenchymal markers were not sufficient to distinguish trailblazer cells from non-trailblazer cells, suggesting that defining the molecular underpinnings of the trailblazer phenotype could reveal collective invasion-specific mechanisms. (jci.org)
  • Tumors characterized as positive for the CD44+/CD24- phenotype by immunohistochemistry were associated to all isoforms except the CD44 standard (CD44S) isoform, which lacks all variant exons. (lu.se)
  • The paper, titled "Hypoxic Induction of Exosome Uptake through Proteoglycan-Dependent Endocytosis Fuels the Lipid Droplet Phenotype in Glioma" and published at Molecular Cancer Research, shows that exosome-like extracellular vesicles (EVs) may serve anabolic functions by transforming hypoxic, patient-derived human glioblastoma cell lines into a lipid loaded phenotype. (lu.se)
  • In this study, evidence shows that EVs can fuel hypoxic glioma cells to acquire a lipid droplet (LD+) phenotype and such effect is associated with increased EV internalization through a hypoxia-sensitive mechanism dependent on heparan sulfate proteoglycan (HSPG) receptor and lipid raft-mediated endocytosis. (lu.se)
  • Dziegiel P, Podhorska-Okolow M, Zabel M. Melatonin: adjuvant therapy of malignant tumors. (unboundmedicine.com)
  • Choroidal melanoma is the most common primary malignant ocular tumor in human adults. (molvis.org)
  • Malignant pleural mesothelioma is a rapidly progressing cancer that develops in the lining of the lungs and has a poor prognosis," said Dr. Eliav Barr, senior vice president, head of global clinical development and chief medical officer, Merck Research Laboratories. (merck.com)
  • Patients are in need of new treatments that can improve survival outcomes, and these positive results support the potential of KEYTRUDA in combination with chemotherapy as a first-line treatment for patients with the most common form of malignant mesothelioma. (merck.com)
  • Pleural mesothelioma, which develops in the lining of the lungs, is the most common form of malignant mesothelioma, accounting for about 75% of all cases. (merck.com)
  • We examined TLR3- and TLR7-expressing pancreatic adenocarcinomas, squamous cell carcinomas of head and neck and lung carcinomas. (aacrjournals.org)
  • Poly(I:C) treatment of pancreatic adenocarcinomas followed by coculture with γδ T cells resulted in an upregulation of CD54 on the tumor cells. (aacrjournals.org)
  • To induce hyperglycemia, mice were intraperitoneally injected with STZ, which can damage pancreatic β cells resulting in the development of insulin dependent diabetes, a model of type 1 diabetes mellitus (T1DM). (nature.com)
  • Various techniques have been developed for targeting cancer cells: gene therapy, monoclonal antibodies (MAbs), antibody toxin conjugates, small-molecule inhibitors, antisense molecules, and tumor vaccines. (medscape.com)
  • Moreover, blocking antibody against PD-1 promotes tumor growth both in SW480 cells and mice CRC xenografts in an adaptive immune-independent manner. (jcancer.org)
  • however, it remains unknown whether the anti-tumor effects of anti-programmed cell death-1 antibody (PD-1-Ab) treatment are changed in hyperglycemic conditions. (nature.com)
  • To investigate the effect of hyperglycemia on anti-tumor function induced by anti-PD-1 antibody treatment, we treated STZ-induced diabetic mice with subcutaneous MC38 colon carcinoma tumors with anti-PD-1 antibody, and examined changes in tumor growth, the number of tumor-infiltrating immune cells, and the expression of chemokines and chemokine receptors. (nature.com)
  • Mice were intraperitoneally injected with STZ or sodium citrate buffer (CB) 7 days before subcutaneous inoculation with MC38 cells in the right flank on day 0 (Fig. 1 A). Then, the mice were treated with anti-PD-1 antibody or normal rat IgG on days 5, 8, and 11. (nature.com)
  • The effect of anti-PD-1 antibody on MC38 tumor is attenuated in STZ-induced diabetic mice. (nature.com)
  • The ITEM-4 monoclonal antibody specifically binds to the TWEAK Receptor (TWEAK-R/TWEAKR), which is also known as CD266, or Fibroblast growth factor inducible 14 (FGF-inducible 14, FN14). (bdbiosciences.com)
  • The ITEM-4 antibody can induce the death of certain TWEAK-sensitive tumor target cell lines. (bdbiosciences.com)
  • Specific antibody-receptor interactions trigger InlAB-independent uptake of listeria monocytogenes into tumor cell lines. (mpg.de)
  • Data to be presented include studies on the significant reduction in tumor burden and enhanced survival following Cynviloq intraperitoneal therapy, compared to albumin-bound paclitaxel* intravenous therapy in a metastatic model of ovarian cancer, successful development of anti-cancer antibody drug conjugates using novel C- and K-lock linker technology, and significant efficacy of its c-Met/EGFR Bispecific Targeting ADC in a non-small cell lung cancer model. (prnewswire.com)
  • The CAR.TNK technology platform combines Conkwest's proprietary Neukoplast cell line with Sorrento's proprietary G-MAB® fully human antibody technology and CAR designs to further enhance the potency and targeting of Neukoplast. (prnewswire.com)
  • Immunotherapies with antibody-drug-conjugates (ADC) and CAR-T cells, targeted at tumor surface antigens (surfaceome), currently revolutionize clinical oncology. (lu.se)
  • Furthermore, co-treatment of KFr13Tx cells with MET inhibitors sensitized the tumor cells to PTX both in vitro and in vivo . (nature.com)
  • Immune checkpoint inhibitors (ICIs), including antibodies against programmed cell death-1 (PD-1) and PD-1 ligand-1 (PD-L1), induce their anti-tumor effects by improving the function of immune cells 11 . (nature.com)
  • Taking the brakes off these checkpoints with inhibitors allows the immune system to find and destroy cancer cells. (medicalxpress.com)
  • Methods: RCC cell lines (PRC3, WT8, SKRC-02, SKRC-17, SKRC-39, SKRC-45, ACHN and KRCY) were maintained on standard mammalian cells culture conditions and exposed to drugs and/or inhibitors in variable concentrations and for variable periods of time as required in each experiment. (usp.br)
  • Clotrimazole is a broad-spectrum antifungal agent that inhibits yeast growth by altering cell membrane permeability, causing death of fungal cells. (medscape.com)
  • Taken together, these results suggest that QA induces neuritogenesis by promoting oxidizing conditions and affecting the availability of NAD + , independently of NMDA receptors. (nih.gov)
  • The programmed cell death 1 (PD-1) receptor is an immune checkpoint molecule that induces immune tolerance and mediates the immune escape of tumor cells. (jcancer.org)
  • LPS stimulation induces a series of interactions with several accessory proteins which form the TLR4 complex on the cell surface. (wikipedia.org)
  • Membrane proteins implicated in long-chain fatty acid uptake by mammalian cells: CD36, FATP and FABPm. (springer.com)
  • The TWEAK Receptor binds TWEAK (CD255) and can signal intracellularly by interactions with TRAF1, 2, and 3 cytoplasmic proteins leading to NF-κB activation. (bdbiosciences.com)
  • In a previous study, the researchers found that in estrogen receptor-positive and estrogen receptor-negative mammary cell lines of women who have been affected with breast cancer, the tumor-suppressing gene pRb2/p130 binds to a specific region of the estrogen receptor gene alpha and forms molecular complexes recruiting and/or interacting with several proteins. (sciencedaily.com)
  • They discovered that in estrogen receptor-negative cells - which are able to silence the expression of the estrogen receptor - pRb2/p130 forms a specific molecular complex recruiting a different sequence of proteins than in the estrogen receptor-positive cells. (sciencedaily.com)
  • The researchers reported their findings, "Epigenetic Modulation of Estrogen Receptor-α by pRb Family Proteins: A Novel Mechanism in Breast Cancer," in the Aug. 15 issue of the journal Cancer Research (abstract 67/16/7731). (sciencedaily.com)
  • Cells express a pool of thousands of different proteins that need to be tightly controlled for proper cellular structure, organization, and function. (hindawi.com)
  • Their team found that in effector T cells, this process is blocked by histone proteins that intertwine with DNA to form chromatin. (newswise.com)
  • The controlled release of bioactive molecules (especially drug proteins) by hydrogels and the encapsulation of living cells are some of the active areas of drug discovery research. (bvsalud.org)
  • Prime candidates are the streptococcal superantigens (SAgs), a family of highly mitogenic proteins secreted individually or in certain combinations by many Streptococcus pyogenes strains ( 7 - 10 ), although other virulence factors, such as Streptolysin O and various cell wall antigens can also cause toxic shock ( 11 ). (cdc.gov)
  • Our research focuses on proteins involved in inflammation, specifically the involvement of cysteinyl leukotriene receptors. (lu.se)
  • Checkpoints are a safety mechanism on T cells that stop the immune cells from attacking healthy cells, but some cancers use them to hide from the immune system. (medicalxpress.com)
  • The role of two members of the ETS (E26 avian leukemia oncogene) family of transcription factors, ETS-1 and ETS-2, has been investigated in many cancers but has not yet been studied in ocular tumors. (molvis.org)
  • Present cellular therapies include chimeric antigen receptor T cells - genetically modified to attack a specific target and used to treat B cell blood cancers - and tumor-infiltrating leukocytes harvested from tumors used to treat melanoma. (newswise.com)
  • Increasingly, renal cell cancers are diagnosed at an earlier stage, and nephron-sparing surgery and thermal ablation are gaining acceptance as a treatment of choice for smaller tumors. (medscape.com)
  • C ) Representative H&E-stained primary breast tumors. (jci.org)
  • The CD44 cell adhesion molecule is aberrantly expressed in many breast tumors and has been implicated in the metastatic process as well as in the putative cancer stem cell (CSC) compartment. (lu.se)
  • We used q-RT-PCR and exon-exon spanning assays to analyze the expression of four alternatively spliced CD44 isoforms as well as the total expression of CD44 in 187 breast tumors and 13 cell lines. (lu.se)
  • It is mainly expressed on mature cytotoxic T lymphocytes [ 7 , 8 ], and it can inhibit T cell function by binding with PD-L1 or PD-L2 ligand, which is mainly expressed on the surface of tumor cells, to induce immune tolerance and limit autoimmunity [ 9 ]. (jcancer.org)
  • Classically, HER family members function from the cell surface, where binding to cognate ligands can induce receptor homo- or hetero-dimerization with other HER family receptors [3] . (plos.org)
  • Tissues and Cells. (lu.se)
  • Twelve miRNAs showed concordant expression in tumors vs. normal breast tissues and patient survival (n = 1093), with seven as potential tumor suppressors and five as potential oncomiRs. (cdc.gov)
  • SPD-MAA treatment significantly stimulated pro-inflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) release in the macrophage cell line, RAW264.7. (cdc.gov)
  • It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. (joplink.net)
  • Newswise - HOUSTON -- Treating T cells harvested from a patient with a combination of an epigenetic drug and a cytokine while expanding the cells in the lab re-programs them into a stronger T cell type that persists longer than its comrades, researchers at The University of Texas MD Anderson Cancer Center report in Cancer Immunology Research, a journal of the American Association for Cancer Research. (newswise.com)
  • WNT4 drives a novel signaling pathway in ILC cells, with a critical role in estrogen-induced growth that may also mediate endocrine resistance. (nih.gov)
  • Our previous studies have found that Candida tropicalis ( C. tropicalis ) can promote CRC tumor growth and chemotherapy resistance to oxaliplatin by regulating mismatch repair system. (jcancer.org)
  • In this study, we first found that high concentrations of C. tropicalis promote tumor growth in cell cultures and xenografts. (jcancer.org)
  • CRC cell growth induced by C. tropicalis is partially offset in the presence of PD-1 overexpression. (jcancer.org)
  • Combining autophagy inhibitor with C. tropicalis treatment partly blocked the CRC tumor growth and reversed the downregulation of PD-1. (jcancer.org)
  • We analyzed the effect of PD-1-Ab on tumor growth in streptozotocin-induced diabetic mice (STZ-mice) subcutaneously inoculated with MC38 (a colon carcinoma cell line). (nature.com)
  • The suppressive effect of PD-1-Ab on tumor growth was attenuated. (nature.com)
  • These results suggest that the STZ-induced hyperglycemia impairs the effect of PD-1-Ab treatment on MC38 tumor growth, and is accompanied by reduced infiltration of DCs and CD8 + T cells and decreased expression of CCL7 and CXCL9. (nature.com)
  • Human neuroblastoma cells express alpha and beta platelet-derived growth factor receptors coupling with neurotrophic and chemotactic signaling. (jci.org)
  • PDGF isoforms as well as nerve growth factor induced morphological changes showing neuronal cell maturation. (jci.org)
  • Statistical significance in tumor volume growth between groups was determined with 2-way repeated measures ANOVA between day 15-21, and t test at day 21, as indicated in the figure. (medicalxpress.com)
  • We found that flutamide inhibited the growth of several cancer cell lines independent of AR status, and that suppression of AhR expression reversed the anti-proliferative effects of flutamide. (oregonstate.edu)
  • We investigated the AhR-dependent mechanism of action of flutamide in human hepatocellular carcinoma cells and identified that transforming growth factor-β1 (TGF-β1) is induced by flutamide in an AhR-dependent manner. (oregonstate.edu)
  • We investigated the effect of an EGFR inhibitor (gefitinib) as well as a MAPK inhibitor (UO126) and a TIC inhibitor (rapamycin) in the intermediates of cell signaling, in the elements of TIC and in the in vitro growth of RCC cell lines. (usp.br)
  • Research project focuses on colon cancer and how inflammatory receptors affect cancer growth and outcome. (lu.se)
  • In a subset of peri-vascularly located immature neural crest-like neuroblastoma cells, aggressiveness and growth promoting charasteristics have been reported to be instigated by HIF-2α, a key element of the oxygen-sensing machinery. (lu.se)
  • The goal of specific molecular targets in cancer therapy is to create a "magic bullet" that selectively kills cancer cells. (medscape.com)
  • As our understanding of the molecular biology of HNSCC continues to develop, we can target the specific components of cancer cells that are not found in normal cells. (medscape.com)
  • Targeted molecular therapy, like therapy with monoclonal antibodies, gene therapy, and other therapies, has limited or nonexistent side effects on normal cells of the body, unlike present modalities such as surgery, chemotherapy, and radiotherapy. (medscape.com)
  • Targeted molecular therapy against EGFR has shown promise as an adjuvant therapy in preliminary studies in several solid tumors, including head and neck cancer. (medscape.com)
  • Subsequently, the effect of an additional small molecular inhibitor, BMS-777607 (which targets MST1R (RON), MET, Tyro3, and Axl) also resulted in a decreased proliferative capacity of MPM cells. (frontiersin.org)
  • The mechanisms that silence the estrogen receptor gene alpha (ER-α) in certain breast cancer cell lines may be closer to being unlocked, according to a study by researchers at Temple University's Sbarro Institute for Cancer Research and Molecular Medicine. (sciencedaily.com)
  • Positron emission tomography (PET) and single photon computed tomography (SPECT) with high sensitivity, specificity and resolution may help to investigating the staging and restaging of prostate cancer and obtaining molecular tumour information. (rug.nl)
  • This offers significant advantages for studying tumor pathogenesis and molecular mechanisms of oncogenesis caused by a single initiating oncogenic event introduced through the mouse germ line. (molvis.org)
  • Unsupervised hierarchical cluster analysis of CD44 isoform expression data divided tumors into four main clusters, which showed significant correlations to molecular subtypes and differences in 10-year overall survival. (lu.se)
  • BMC Cell Biology, 9 , 45. (springer.com)
  • The fusogenic lectin-like property of CT has been explored for membrane transport, cell signalling, host cell biology and controlling intracellular machineries. (mdpi.com)
  • BT-474 cells, obtained expression of the receptor has important implications for their biology from American Type Culture Collection, were maintained in RPMI 1640 and therapy (1). (lu.se)
  • Microarrays were prepared in tumor biology. (lu.se)
  • Better understanding of tumor cell biology may lead to development of more efficient targeted therapies. (usp.br)
  • We have also demonstrated that PDGF receptors on the human neuroblastoma cell lines were biologically functional. (jci.org)
  • The neuroblastoma cell lines also expressed the transcripts of PDGF A- and B-chains. (jci.org)
  • In addition, expression of IGF-II and HIF-2α correlates in neuroblastoma cell lines, tumors and in sympathetic neuroblasts during embryonic week 6.5, but not later, suggesting that these IGF-II and HIF-2α expressing neuroblastomas originate from sympathetic pre-ganglia at developmental week 6.5 or earlier. (lu.se)
  • Two retrospective studies from Israel 12 and Japan 13 recently reported that diabetes was negatively correlated to overall survival in patients with non-small cell lung cancer (NSCLC) treated with ICIs. (nature.com)
  • Lin9, a Subunit of the Mammalian DREAM Complex, Is Essential for Embryonic Development, for Survival of Adult Mice, and for Tumor Suppression. (mpg.de)
  • Upon LPS recognition, conformational changes in the TLR4 receptors result in recruitment of intracellular TIR-domains containing adaptor molecules. (wikipedia.org)
  • MyD88 signaling involves the activation of IL-1 Receptor-Associated Kinases (IRAKs) and the adaptor molecules TNF Receptor-Associated Factor 6 (TRAF6). (wikipedia.org)
  • Moreover, treatment with imiquimod downregulated MHC class I molecules on tumor cells possibly resulting in a reduced binding affinity for inhibitory receptor NKG2A expressed on γδ T cells. (aacrjournals.org)
  • Their regulation may be carried out either through direct binding to DNA as peroxisome proliferator-activated receptors or via modulation in an indirect manner of signaling pathway molecules (e.g., protein kinase C) and other transcription factors (nuclear factor kappa B and sterol regulatory element binding protein). (springer.com)
  • They can provide various sequential therapeutic agents including macromolecular drugs, small molecule drugs, and cells to control the release of molecules. (bvsalud.org)
  • cortisol excess, leading to hyperglycemia, hypokalemia, hypertension, central obesity, moon facies) may result from ectopic production of adrenocorticotropic hormone (ACTH) or ACTH-like molecules, most often with small cell cancer of the lung. (msdmanuals.com)
  • Superantigens simultaneously bind to major histocompatibility complex class II molecules and T-cell receptor molecules bearing a particular V-β region. (cdc.gov)
  • TLR4 signaling responds to signals by forming a complex using an extracellular leucine-rich repeat domain (LRR) and an intracellular toll/interleukin-1 receptor (TIR) domain. (wikipedia.org)
  • Besides, NGF binding to TrkA receptors encouraged the intracellular Warburg effect in PC and DRG cells. (hindawi.com)
  • CT serves as a model for AB type toxins that act by ADP-ribosylation of an intracellular G-protein in the target cell. (mdpi.com)
  • TWEAK Receptors are relatively highly expressed on HUVEC cells and certain tumor cell lines. (bdbiosciences.com)
  • Chemotherapy is used only occasionally, in certain tumor types. (medscape.com)
  • Sinalização aumentada através do receptor do fator de crescimento epitelial (EGFR), sistema de quinases proteicas ativadas por mitógenos (MAPK) e via da fosfatidilinositol 3-quinase (PI3K) assim como estimulação do complexo de início de tradução (CIT) foram caracterizados em linhagens celulares e amostras tumorais de CCR. (usp.br)
  • In addition, one of the direct targets of miR-31 was found to be receptor tyrosine kinase MET, and upregulation of MET caused the chemoresistance to PTX. (nature.com)
  • These findings displayed that NGF/TrkA encouraged the neuroinvasive potential of PC cells by activating the Warburg effect in DRG cells through upregulation of TDE-miR-21-5p expression. (hindawi.com)
  • Furthermore, we found that knockdown of IRS-1 expression enhanced cell invasive potency and induced EMT in parallel with upregulation of miR-9 expression. (spandidos-publications.com)
  • Here, we investigated the modulation of γδ T cell-mediated tumor cell lysis by TLR ligands. (aacrjournals.org)
  • The HER2 receptor does not bind to any known ligands, however, its dimerization arm is innately positioned in an open conformation. (plos.org)
  • Although the pathogenesis remains unclear, these symptoms may be secondary to substances secreted by the tumor or may be a result of antibodies directed against tumors that cross-react with other tissue. (msdmanuals.com)
  • Resolving the Pathogenesis of Anaplastic Wilms Tumors through Spatial Mapping of Cancer Cell Evolution. (lu.se)
  • Ideal targets should be both specific to cancer cells and commonly found in cancer cells. (medscape.com)
  • The goal of gene therapy is to introduce new genetic material into cancer cells that selectively kills them without causing toxicity to the surrounding cells. (medscape.com)
  • In recent years, studies have shown that tumor cell-intrinsic PD-1 plays different roles in the development of melanoma, Liver cancer and lung cancer. (jcancer.org)
  • However, the expression and function of PD-1 in colon cancer cells has not been reported. (jcancer.org)
  • In addition, we proved that colon cancer cell lines express PD-1 receptors. (jcancer.org)
  • We also demonstrated that high concentrations of C. tropicalis can down-regulate tumor cell-intrinsic PD-1 expression in colon cancer cells. (jcancer.org)
  • Mechanistically, we found that C. tropicalis modulates the expression of PD-1 via increasing the autophagy traffic in colon cancer cells. (jcancer.org)
  • Ovarian cancer is one of the most aggressive female reproductive tract tumors. (nature.com)
  • We investigated the mechanism of chemoresistance by analysis of microRNAs using the ovarian cancer cell line KFr13 and its PTX-resistant derivative (KFr13Tx). (nature.com)
  • Toll-like receptor (TLR) agonists are considered adjuvants in clinical trials of cancer immunotherapy. (aacrjournals.org)
  • Cysts mark the early stage of metastatic tumor development in non-small cell lung cancer. (mpg.de)
  • Combinatorial treatment of mammospheres with trastuzumab and salinomycin efficiently targets HER2-positive cancer cells and cancer stem cells. (mpg.de)
  • Researchers at Weill Cornell Medicine have discovered that radiation therapy combined with two types of immunotherapy-one that boosts T cells, and another that boosts dendritic cells-can control tumors in preclinical models of triple negative breast cancer, a cancer type that's typically resistant to immunotherapy alone. (medicalxpress.com)
  • Immunotherapy activates the body's own immune system to fight cancer but isn't effective for difficult-to-treat "cold" tumors, like this. (medicalxpress.com)
  • Cold tumors are often referred to as impregnable fortresses that can't be infiltrated by the immune system's T cells, which directly attack viruses, bacteria, as well as cancer cells. (medicalxpress.com)
  • Radiation directly kills cancer cells and sends out inflammatory signals that attract "killer" T cells. (medicalxpress.com)
  • The mechanisms that silence the estrogen receptor gene alpha, in certain breast cancer cell lines may be closer to being unlocked, according to a new study. (sciencedaily.com)
  • The company and Conkwest, Inc., a privately-held immuno-oncology company developing proprietary Neukoplast®, a Natural Killer (NK) cell-line based therapy, also entered into an agreement to jointly develop next generation CAR.TNK™ (Chimeric Antigen Receptor Tumor-attacking Neukoplast) immunotherapies for the treatment of cancer. (prnewswire.com)
  • arations verified the presence of cancer cells in all samples. (lu.se)
  • GRPR is highly expressed in several human cancer cell lines and could be used as a potential target for cancer detection. (rug.nl)
  • The aim of this thesis was to develop novel bombesin tracers to target Gastrin Releasing Peptide Receptor (GRPR), which is over-expressed in Prostate Cancer (PCa). (rug.nl)
  • Unlike cancer arising in the human population, tumors in genetically engineered mouse models arise in mice with well defined genetic backgrounds where genetic variability can be minimized. (molvis.org)
  • The combination of panobinostat and interleukin-21 converts the less vigorously expanding effector T cells that attack cancer cells to a more proliferative and enduring central memory T cell type capable of self-renewal, the team found. (newswise.com)
  • Lack of persistence is one major reason cellular therapies that involve harvesting, expanding, and in some instances, genetically modifying, a patient's T cells before returning them to attack cancer fail, Yee says. (newswise.com)
  • NEW YORK, April 12, 2022 (GLOBE NEWSWIRE) -- IO Biotech (Nasdaq: IOBT), a clinical-stage biopharmaceutical company developing novel, immune-modulating cancer therapies based on its T-win ® technology platform, announced today that it has dosed the first patient, in metastatic non-small cell lung cancer (NSCLC), in its Phase 2 IOB-022 / KN-D38 trial ( NCT05077709 ). (biospace.com)
  • The IOB-022 / KN-D38 trial seeks to evaluate IO Biotech's lead candidate, IO102-IO103, in combination with KEYTRUDA ® (pembrolizumab), Merck's anti-PD-1 (programmed death receptor-1) therapy, in previously untreated patients with three different tumor types in the first line setting -NSCLC, squamous cell carcinoma of the head and neck (SCCHN), and urothelial bladder cancer (mUBC). (biospace.com)
  • The T-win ® platform is a novel approach to cancer immunotherapy designed to activate naturally occurring T cells to target immunosuppressive mechanisms. (biospace.com)
  • Breast cancer cell lines contain subpopulations of invasive trailblazer and noninvasive opportunist cells. (jci.org)
  • Flutamide is an androgen receptor (AR) antagonist approved by the United States Food and Drug Administration for the treatment of prostate cancer. (oregonstate.edu)
  • Background: Renal cell carcinoma (RCC) is an increasing cause of cancer mortality. (usp.br)
  • may result from production of vasopressin and parathyroid hormone -like hormones from small cell and non-small cell lung cancer. (msdmanuals.com)
  • Six miRNAs had concordant expression in both tumors and breast cancer patient blood samples compared with the normal control samples. (cdc.gov)
  • Multi-omics biomarkers of response to the discovered drugs were identified using human breast cancer cell lines. (cdc.gov)
  • Her research involves methods as tissue microarray (TMA) of colon cancer patients for immunohistochemistry (IHC) and Western blot, qPCR, transfection, luciferase assay, immunofluorescens on colon cancer cell lines. (lu.se)
  • CD44 isoforms are heterogeneously expressed in breast cancer and correlate with tumor subtypes and cancer stem cell markers. (lu.se)
  • Breast cancer cell lines showed a heterogeneous expression pattern of the CD44 isoforms, which shifted considerably when cells were grown as mammospheres. (lu.se)
  • Renal cell carcinoma (see the image below) is the most common type of kidney cancer in adults. (medscape.com)
  • Neuroblastoma is a childhood tumor of the developing sympathetic nervous system (SNS) and is the most commonly diagnosed form of cancer in children before one year of age. (lu.se)
  • Knockdown of PD-1 enhanced SW480 viability in-vitro, while overexpression of PD-1 diminished cell viability. (jcancer.org)
  • Targeted overexpression or knockdown of PIP5K1α were introduced into BC cell lines. (lu.se)
  • The authors found that the hypoxia-mediated HSPG-dependent EV uptake could be further evidenced by the reversal of EV-mediated lipid droplet loading by targeting of HSPG receptor function. (lu.se)
  • [ 1 ] Early stage head and neck squamous cell carcinoma (HNSCC) is treated relatively well with single-modality therapy (either surgery or radiation alone). (medscape.com)
  • Go to Imaging of Nasopharyngeal and Laryngeal Squamous Cell Carcinoma and Head and Neck Squamous Cell Carcinoma for complete information on these topics. (medscape.com)
  • Both LCRF-0004 and BMS-777607 demonstrated significant anti-tumor efficacy in vitro , however BMS-777607 was far superior to LCRF-0004. (frontiersin.org)
  • CCL4, also known as macrophage inflammatory protein 1 beta (MIP-1 beta ) is a 7.8 kDa beta chemokine that is secreted at sites of inflammation by activated leukocytes, lymphocytes, vascular endothelial cells, and pulmonary smooth muscle cells (1, 2). (rndsystems.com)
  • mRNA expression levels of CXCL9, a chemokine recruiting CD8 + T cells, were lower in dLNs of STZ-mice than in normoglycemic mice after PD-1-Ab treatment, and its protein was expressed in DCs. (nature.com)
  • In MC38 cells cultured with 25 mM glucose, mRNA expression of CCL7, a chemokine recruiting DCs, was decreased compared to cells cultured with 5 mM glucose. (nature.com)
  • This antimicrobial gene encodes a chemokine of the CXC subfamily and ligand for the receptor CXCR3. (cancerindex.org)
  • We found that miR-31 was downregulated in KFr13Tx cells, and that re-introduction of miR31 re-sensitized them to PTX both in vitro and in vivo . (nature.com)
  • To reveal that the NGF-TrkA signaling pathway was closely associated with PC PNI, in vitro neuroinvasion model was established by using MiaPaCa-2 cells via coculturing DRG cells in Matrigel. (hindawi.com)
  • H-29 cells were used for in vitro experiments in this study. (wjgnet.com)
  • Producing more central memory T cells in vitro can address this persistence challenge and increase the effectiveness of cellular therapies," Yee notes. (newswise.com)
  • 1991. Effects of polychlorinated biphenyls with Ah receptor affinity on lymphoid development in the thymus and the bursa of Fabricius on chick embryos in ovo and in mouse thymus anlagen in vitro . (cdc.gov)
  • Binding of this protein to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. (cancerindex.org)
  • Both RA and QA increased expression of the neuronal marker β3-tubulin in whole-cell homogenates and in the neuritic fraction assessed using a neurite outgrowth assay. (nih.gov)
  • In the latter case, WNT4 expression was driven by activated nuclear factor kappa-B signaling in ILC-LTED cells. (nih.gov)
  • TrkA expression was knocked down in MiaPaCa-2 and dorsal root ganglion (DRG) cells treated with NGF to determine its effect on the Warburg effect. (hindawi.com)
  • Mechanistically, NGF could upregulate TDE-miR-21-5p levels, and DRG cells took up TDE to activate the Warburg effect and stimulate nociceptor gene expression. (hindawi.com)
  • SPD-MAA treatment significantly increased SRA mRNA expression, but had no effect on surface receptor protein expression. (cdc.gov)
  • Furthermore, we assessed the expression of chemokines by polymerase chain reaction (PCR) array in tumor-draining lymph nodes (dLNs) of these mice and MC38 cells cultured in different glucose concentrations. (nature.com)
  • The expression of alpha and/or beta PDGF receptors was detected in a wide variety of neural crest-derived human tumor cell lines such as neuroblastoma, primitive neuroectodermal tumor, and Ewing's sarcoma by RNA blot analysis, and confirmed by immunoblot analysis. (jci.org)
  • Expression of B-RAF V600E in Type II Pneumocytes Causes Abnormalities in Alveolar Formation, Airspace Enlargement and Tumor Formation in Mice. (mpg.de)
  • The differences in extracellular ATP/AMP accumulation correlated with cell-line-specific expression of ectonucleotidases that metabolized the released ATP/AMP. (aspetjournals.org)
  • In contrast, the RIP1-deficient cells were defined by increased expression of tartrate-sensitive prostatic acid phosphatase as a broadly acting ectonucleotidase. (aspetjournals.org)
  • Cells which lack ER expression at diagnosis arise from an ER compart- were harvested at 60 - 80% confluency and used as a reference in all hybrid- ment within the mammary epithelium or represent evolution from an izations. (lu.se)
  • Hypertrophy was estimated by measuring the cell surface area and the atrial natriuretic peptide (ANP) gene expression. (karger.com)
  • 1994. Ah receptor in embryonic mouse palate and effects of TCDD on receptor expression. (cdc.gov)
  • Conversely, tumors with strong expression of the CSC marker ALDH1 had elevated expression of CD44S. (lu.se)
  • High expression of CD44S was associated with strong HER2 staining and also a subgroup of basal-like tumors. (lu.se)
  • We establish that IGF-II-induced HIF2A/EPAS1 expression during hypoxia is due to de novo transcription and further present the estrogen-related receptor alpha (ERRα) transcription factor as a positive regulator of HIF2A. (lu.se)
  • We could validate these findings by immunofluorescence analyses in patient tumors and by increased expression in the hypoxic core of GBM spheroids. (lu.se)
  • NGF promoted MiaPaCa-2 and CFPAC-1 cell invasion and migration, while Tanezumab treatment showed the opposite results. (hindawi.com)
  • TrkA blocking-up could restrain NGF induced PC cell migration and neural invasion. (hindawi.com)
  • This review summarizes the most relevant data relating to the potential role of melatonin (pineal secretory product) as an adjuvant therapy of tumors. (unboundmedicine.com)
  • Invasive lobular carcinoma (ILC) of the breast typically presents with clinical biomarkers consistent with a favorable response to endocrine therapies, and over 90 % of ILC cases express the estrogen receptor (ER). (nih.gov)
  • Results of clinical studies were preceded by a description of experiments conducted on tumor cell lines and on laboratory animals. (unboundmedicine.com)
  • A meta-analysis of clinical studies in which melatonin was applied as an adjuvant drug in the therapy of various tumors pointed to some effects of its administration. (unboundmedicine.com)
  • To obtain an independent test set, the remaining 11 of the 58 tumors were selected from an ongoing clinical trial and used here as a blinded sion via ER,3 however the details of the estrogen effect on down- test set. (lu.se)
  • Clinical trials will be required to advance his team's findings in human T cell lines. (newswise.com)
  • In recent years, clinical trials have established targeted therapy as the first-line treatment in patients with metastatic disease. (medscape.com)
  • While the combination of radiation with CTLA4 inhibition converted cold tumors into T-cell-inflamed tumors, this was not enough to significantly reduce the tumor. (medicalxpress.com)
  • Gint4.T aptamer is able to specifically bind to the human PDGFRβ ectodomain (Kd: 9.6 nmol/l) causing a strong inhibition of ligand-dependent receptor activation and of downstream signaling in cell lines and primary cultures of human glioblastoma cells. (unina.it)
  • One potential novel pathway is via the Wnt ligand WNT4, a critical signaling molecule in mammary gland development regulated by the progesterone receptor. (nih.gov)
  • PR, progesterone receptor. (jci.org)
  • Subsequently, we used a model of neuroinvasion in nude mice to assess the effect of NGF in vivo on tumor nerve invasion as well as on nociceptive transmission. (hindawi.com)
  • In vivo tumorigenesis experiments, Tanezumab markedly alleviated nerve invasion of PC cells as well as relieved nociceptive conduction in animal models. (hindawi.com)
  • Gastrin releasing peptide receptor (GRPR) may be a valid target for nuclear imaging of PCa. (rug.nl)
  • It is mainly expressed in immune cells such as T cells, B cells and monocytes. (jcancer.org)
  • CCL4 attracts a variety of immune cells to sites of microbial infection as well as to other pathologic inflammation such as allergic asthma and ischemic myocardium (3 - 8). (rndsystems.com)
  • In other words, the presence of a specific pRb2/p130 multimolecular complex may dictate a local change of the DNA structure of the estrogen receptor alpha gene and influence its susceptibility to chemical modification (DNA methylation), as well as to different epigenetic alterations leading to estrogen receptor alpha silencing," added Marcella Macaluso, research assistant professor at the Sbarro Institute and the study's lead author. (sciencedaily.com)
  • Surgical resection remains the only known effective treatment for localized renal cell carcinoma, and it is also used for palliation in metastatic disease. (medscape.com)
  • While this approach activated the immune system, the T cells couldn't overcome the immune suppression of the tumor. (medicalxpress.com)
  • Though radiation therapy has previously been combined with T-cell boosting immunotherapy, it rarely succeeds in eliminating cold tumors. (medicalxpress.com)
  • These tumors are resistant to immunotherapy and poorly infiltrated by T cells. (medicalxpress.com)
  • They also found that adding a second checkpoint inhibiting immunotherapy did not improve tumor responses. (medicalxpress.com)
  • TLR4 is a transmembrane protein, member of the toll-like receptor family, which belongs to the pattern recognition receptor (PRR) family. (wikipedia.org)
  • In the current study, lead by Antonio Giordano, M.D., Ph.D., director of the Sbarro Institute, the researchers showed that the presence of specific pRb2/p130 multimolecular complexes bound to the estrogen receptor gene strongly correlates with the methylation (chemical modification) of the gene. (sciencedaily.com)
  • The new, preclinical study found that activating another type of immune cell called a dendritic cell, in addition to the other two approaches, produced a synergistic effect that elicited tumor regression. (medicalxpress.com)
  • At physiologic pH, salt dissociates to a cation that binds to bacterial cell walls. (medscape.com)
  • Analysis of peripheral nerve regeneration after transection on the model of rat caudal nerve using tubulization and mesenchymal stem cells. (sav.sk)
  • This was accompanied by fewer tumor-infiltrating CD8 + T cells, and STZ-mice had fewer tumor-infiltrating CD11c + dendritic cells (DCs) than normoglycemic mice. (nature.com)
  • E-cadherin Controls Bronchiolar Progenitor Cells and Onset of Preneoplastic Lesions in Mice. (mpg.de)
  • A CCL4 deficiency in mice promotes the development of autoantibodies, possibly as a result of compromised regulatory T cell recruitment (6). (rndsystems.com)
  • These symptoms may arise from release of cytokines involved in the inflammatory or immune response or from mediators involved in tumor cell death, such as tumor necrosis factor-alpha. (msdmanuals.com)
  • Neutrophils are one of the most common inflammatory mediators in tumors which secretes a large amount of leukotrienes. (lu.se)
  • Sigma-1 and sigma-2 receptors are expressed in a wide variety of human and rodent tumor cell lines. (anavex.com)
  • Recombinant full length protein corresponding to Human Retinoid X Receptor beta/RXRB. (abcam.com)
  • Glioblastoma multiforme is the most common and lethal primary human brain tumor. (unina.it)
  • Measured by its ability to chemoattract BaF3 mouse pro‑B cells transfected with human CCR5. (rndsystems.com)
  • The team treated human T cell lines with the HDAC inhibitor vorinostat and IL-21. (newswise.com)
  • 1999. Transactivation activity of human, zebrafish, and rainbow trout aryl hydrocarbon receptors expressed in COS-7 cells: Greater insight into species differences in toxic potency of polychlorinated dibenzo- p -dioxin, dibenzofuran, and biphenyl congeners. (cdc.gov)
  • Recognition of the human vulvar tumor line A431. (who.int)
  • LINE-1 retrotransposons drive human neuronal transcriptome complexity and functional diversification. (lu.se)
  • In the past biennium, working groups have concluded that there is sufficient evidence to classify infection with human immunodeficiency virus (HIV-1), human T-cell lymphotropic virus (HTLV-1), Epstein-Barr virus (EBV) and the Kaposi sarcoma-associated herpesvirus 8 as carcinogenic to humans (IARC 0RQRJUDSKV, Vol. 67 and 70). (who.int)