Receptor genes mice knockout. Medical search. Frequent questions

IP is encoded in humans by the PTGIR gene. (wikipedia.org)
Although a large body of research, ranging from rodents to humans, has reported on the effects of OXT and AVP administration on affiliative and trust behaviors, and has highlighted the genetic contributions of OXT and AVP receptor polymorphisms to both social behaviors and to diseases related to social deficits, the consequences of peptide administration on psychiatric symptoms, and the impact of receptor polymorphisms on receptor function, are still unclear. (frontiersin.org)
The discovery that the LPA receptors affect fertility in mice may open a new area of fertility research and treatment for humans. (sciencedaily.com)
If the receptors do turn out to be relevant to embryo implantation in humans, then the mechanisms involving these proteins might make good targets for therapeutic intervention, perhaps even leading to new treatments and successful pregnancies for some of the more than 6 million American women affected by infertility. (sciencedaily.com)
Early progenitor cells, which are designated A spermatogonia in the mouse and A- dark spermatogonia in humans, are defined as "undifferentiated. (jci.org)
Once spermatogonia enter the "differentiation" pathway, they become known as A1 spermatogonia in the mouse and A- pale spermatogonia in humans and begin a series of irreversible differentiation steps leading to meiosis and spermiogenesis ( 1 ) (Figure 1 ). (jci.org)
From this point forward, the steps and cell types of spermatogenesis are conserved between mice and humans. (jci.org)
To test this idea, the researchers examined p11 levels in the brains of depressed humans and "helpless" mice, considered a model of depression since they exhibit behaviors similar to those of depressed humans. (scienceblog.com)
They compared these two groups to non-depressed humans and control mice. (scienceblog.com)
Levels of p11were found to be substantially lower in depressed humans and helpless mice, which suggests that altered p11 levels may be involved in the development of depression-like symptoms. (scienceblog.com)
Since humans and mice with symptoms of depression were found to have substantially lower levels of p11 in brain cells compared to non-depressed animals, Greengard and colleagues hypothesized that if p11 levels were increased, mice would exhibit antidepressant-like behaviors, and if p11 were reduced, mice would exhibit depression-like symptoms. (scienceblog.com)
Immunohistopathological studies of pancreases from individuals with type 1 diabetes are generally compatible with these observations made in mice (see references below) but have exposed additional phenomena peculiar to the natural history of the disease in humans. (springer.com)
This finding was very surprising because these genes- HLA genes in humans- are involved in cellular immunity and were previously not thought to be expressed by neurons at all! (stanford.edu)
In the early 1980s, researchers began genetically manipulating mice by inserting genes from other species (including humans) during the earliest stages of embryonic cell division. (mentalfloss.com)
Partial or complete deficiencies of the components of the complement system, including its receptors and regulatory proteins, are now described in humans and may be of a genetic or familial origin or acquired. (medscape.com)
The receptors are widely expressed in humans. (medscape.com)
TCDD for every step of the mechanism described for 2,3,7,8-TCDD carcinogenesis in humans including receptor binding, gene expression, protein activity changes, cellular replication, oxidative stress, promotion in initiation-promotion studies and complete carcinogenesis in laboratory animals. (who.int)

The pathway that affects implantation involves a particular type of receptor molecule -- a protein called a lysophosphatidic acid (LPA) receptor that can be found on the surfaces of cells in the brains and in the uteruses of mammals, where it binds to LPA, one type of phospholipid. (sciencedaily.com)
The interleukin-1 receptor antagonist (IL-1Ra) is a member of the interleukin (IL)-1 family that binds to IL-1 receptors without inducing a cellular response, thereby antagonizing the effects of IL-1α and -1β ( 1 ). (diabetesjournals.org)
While there he explored the signaling pathways that become activated when acetylcholine binds to its receptor which gave him a solid background in molecular biology. (the-scientist.com)
Glucose-dependent insulinotropic polypeptide (GIP) is a 42-amino acid incretin hormone that binds to a seven-transmembrane G-protein-coupled receptor (GIP-R) that is expressed in numerous tissues including islet β-cells and α-cells ( 1 , 2 ). (diabetesjournals.org)
Once IFN/ has been synthesized, it is secreted and binds to the IFN/ receptor. (cdc.gov)
The CR1 receptor preferentially binds C3b that is covalently attached to immune complexes, and it has a weaker affinity for bound C4b and iC3b. (medscape.com)

What does change dynamically, from one tissue or state to another, is what all those genes are doing: how actively each of them is involved in cranking out the starting materials for the many thousands of proteins critical to each cell's or tissue's identity and to every organism's survival. (stanford.edu)
To explore how a particular serotonin receptor (5-HT1B) functions, Greengard and colleagues conducted tests to find out what proteins these receptors interact with in brain cells. (scienceblog.com)
Effector proteins interacting with the Fc portion of immunoglobulin M (IgM) include complement and complement receptors. (medscape.com)
Defects in the expression of complement or complement receptors may result in loss of tolerance to self-proteins and the development of immune complex-mediated autoimmune diseases such as systemic lupus erythematosus (SLE). (medscape.com)

He then revealed the unanticipated existence of orphan nuclear receptors without known hormone ligands . (mcgill.ca)

He was also among the first to advance genome-wide omics approaches to study the interaction of transcription factors with their target genes at the beginning of the millennium. (mcgill.ca)
Independent experiments confirmed several target genes, including PLOD2 , HADH , LCOR and REEP1 as non-canonical target genes in various colon cancer cells. (nature.com)
Moreover, non-canonical Wnt target genes are regulated via RoR2, Dvl2, ATF2 and ATF4. (nature.com)

Gene expression profiling was performed after silencing of key components of Wnt signaling pathway and an iterative signature algorithm was applied to predict pathway-dependent gene signatures. (nature.com)

Adapting the Cre/loxP system that phage use to insert their genes into bacterial chromosomes, Tsien was able to shut down the activity of the NMDA receptor in the CA1 region of the hippocampus, an area critical for learning and memory. (the-scientist.com)
Like patients who have lesions in this part of the brain, the mutant mice showed profound memory deficits, providing, says Tsien, "strong evidence that the NMDA receptor is indeed important for memory. (the-scientist.com)
The study, which involved ramping up the numbers of functional NMDA receptors in the hippocampus, "was the logical thing to do, and he did it," says Richard Thompson of the University of Southern California. (the-scientist.com)

Despite this enormous diversity, each functional neural pathway can be recognized by its distinctive set of transmitters and receptors employed. (nii.ac.jp)
He used this approach to determine the functional domains of the glucocorticoid receptor , the first mammalian transcription factor to be cloned. (mcgill.ca)
The schematic diagram representing the functional domains of nuclear receptors derived from these experiments has not changed since then and is still in use in many textbooks today. (mcgill.ca)
Functional maturation of steroid hormone receptors requires ordered assembly into a large multichaperone complex consisting of receptor monomer, an Hsp90 dimer, the p23 cochaperone, and an FK506-binding protein (FKBP) family member or alternate peptidylprolyl isomerase-related cochaperone. (unboundmedicine.com)
Here, we aimed at identifying a β-catenin-independent Wnt target gene signature in order to understand the functional significance of non-canonical signaling in colon cancer cells. (nature.com)
They found that 5-HT1B interacts with p11, and according to Greengard, p11 plays a role in the recruitment of receptors to the cell surface where they are more functional. (scienceblog.com)
Functional annotation clustering of the microarray data showed that gene clusters involved in immune and antiviral responses ranked highly, involving genes such as chemokine (C-C motif) ligand 2 ( CCL2 ), chemokine (C-C motif) ligand 5 ( CCL5 ), chemokine (C-X-C motif) ligand 10 ( CXCL10 ), and toll like receptor 3 ( TLR3 ). (molvis.org)
We previously showed that peroxisome proliferator-activated receptor (PPAR)-γ in β-cells regulates pdx-1 transcription through a functional PPAR response element (PPRE). (diabetesjournals.org)
To discover cell and molecular underpinnings of circuit tuning, her lab has conducted functional screens for genes regulated by neural activity. (stanford.edu)

Based on this revolutionary finding, the identification and subsequent study of novel receptor/hormone response systems completely transformed the science of endocrinology. (mcgill.ca)
The Shatz Lab showed that other components of a signaling system for Class I MHC are also present in neurons, including a novel receptor, PirB. (stanford.edu)

To further evaluate the role of CRTC1 in the brain, we generated a knockout mouse line and analyzed its behavioral and molecular phenotype. (nih.gov)

Joe has been one of the pioneers who has really pushed the power of mouse molecular genetics to get at the fundamental questions in learning and memory," says Rob Malenka of Stanford University. (the-scientist.com)
That led me to find a place where I could use genetics to manipulate genes, to try to knock them out, to see what happens," says Tsien. (the-scientist.com)

His identification of some of the most important nuclear receptors , which are transcriptional regulators occupying a central position in normal mammalian development and physiology, as well as being strongly implicated in many diseases, laid the groundwork for decades of subsequent discovery. (mcgill.ca)
Prof. Giguère is a world leader in the field of nuclear hormone receptors, providing him with a very unique position in Canada as an international expert in a field that touches on diverse aspects of the health sciences. (mcgill.ca)
Thyroid Hormone Receptor alpha is encoded by this gene is a nuclear hormone receptor for triiodothyronine. (novusbio.com)
Crtc1(-/-) mice strikingly show, in addition to a reduced dopamine and serotonin turnover in the prefrontal cortex, a concomitant decreased expression of several susceptibility genes involved in neuroplasticity, including Bdnf, its receptor TrkB, the nuclear receptors Nr4a1-3, and several other CREB-regulated genes. (nih.gov)
Although nuclear factor kappa B (NF-κB) DNA-binding activity was increased significantly in MPTP-treated wild-type mice, this increase was not significant in PAF-R antagonist ginkgolide B (GB)-treated mice or PAF-R knockout (PAF-R -/- ) mice. (korea.ac.kr)

In addition, we discuss reports on the interactions of OXT and AVP receptor genes and genes involved in other pathways (such as those of dopamine, serotonin, and reelin), as well as research that has shed some light on the impact of gene polymorphisms on the volume, connectivity, and activation of specific neural structures, differential receptor expression, and plasma levels of the OXT and AVP peptides. (frontiersin.org)
What pathways are this gene/protein implicaed in? (cancerindex.org)

IP is classified as a relaxant type of prostenoid receptor based on its ability, upon activation, to relax certain pre-contracted smooth muscle preparations and smooth muscle-containing tissues such as those of pulmonary arteries and veins. (wikipedia.org)
Studies using animals genetically engineered to lack IP and examining the actions of EP4 receptor agonists in animals as well as animal and human tissues indicate that this receptor serves various functions. (wikipedia.org)
Objective Mitogen-inducible gene 6 (MIG-6) regulates epidermal growth factor receptor (EGFR) signaling in synovial joint tissues. (bepress.com)
Tumor-infiltrated macrophages were isolated from human GC tissues using magnetic beads, gene transcription was determined by real-time PCR, protein expression was monitored using western blots, metabolites were determined using HPLC, and transcriptional regulation was analyzed by the luciferase-based reporter gene system. (cancerindex.org)
This latter method flags differences in genes' activity levels, for example in diseased vs. normal tissues, for each of the 20,000 genes in the entire genome. (stanford.edu)
Oral application of BD (100 mg/kg of body weight for 4 weeks) by intragastric gavage did not affect body weight or activity of liver enzymes and did not show any sign of toxicity in liver, spleen, kidney, lung and heart tissues in mice. (spandidos-publications.com)
Although early studies of IGSF1 ran into roadblocks and blind alleys, armed with the results of detailed clinical investigations, powerful mouse models, and new reagents, the field is now poised to discover IGSF1's function in endocrine tissues, including the pituitary and testes. (medscape.com)

The complement system, interacting with its regulatory molecules and cellular receptors, plays a central role in the induction and regulation of immunity. (medscape.com)

Investigations in two IGSF1 knockout mouse models converged to show that IGSF1 deficiency leads to reduced expression of the receptor for thyrotropin-releasing hormone (TRH) and impaired TRH stimulation of thyrotropin secretion, providing a candidate mechanism for the central hypothyroidism observed in patients. (medscape.com)
Research with animals, particularly mice with specifically targeted mutations, has allowed better comprehension of the specific mechanisms involved in deficiency states and the resulting clinical manifestations and/or associated diseases. (medscape.com)
Note the image below, as well as the article Pediatric Complement Receptor Deficiency may be helpful. (medscape.com)
ZAP-70 deficiency is a rare autosomal recessive form of severe combined immunodeficiency (SCID) caused by mutations in the gene coding for T cell receptor z-chain associated protein kinase [ Chan et al. (lu.se)
1997]. Mutations in the STAT1 gene cause complete STAT1 deficiency. (lu.se)

For example, Prof. Giguère's discovery and characterization of the estrogen-related receptors (ERRs) revealed a major regulatory node of cellular metabolism that is highly relevant to metabolic disorders, cardiovascular disease, several prominent cancers , and many other diseases. (mcgill.ca)
The Endocrine Unit focuses on metabolic bone diseases and mineral metabolism and ranges from trials of novel therapies for osteoporosis to use of genetically altered mice and cell biology to understand calcium and phosphate metabolism. (massgeneral.org)

The PTGIR gene is located on human chromosome 19 at position q13.32 (i.e. 19q13.32), contains 6 exons, and codes for a G protein coupled receptor (GPCR) of the rhodopsin-like receptor family, Subfamily A14 (see rhodopsin-like receptors#Subfamily A14). (wikipedia.org)
Adrenergic receptors (ARs) are members of the 7-transmembrane domain G-protein-coupled receptor superfamily that bind the endogenous catecholamines epinephrine and norepinephrine. (thermofisher.com)

The importance of their phenotypic regulation has been argumented since abnormal expression of neurotransmitters or their receptors are often associated with various neurological diseases. (nii.ac.jp)
The structure, regulation, and cell types of the mouse testis. (jci.org)
Cluster of Differentiation-200 receptor 1 (CD200R1), also known as OX-2 receptor, is a transmembrane protein in the immunoglobulin superfamily expressed on the surface of myeloid cells and important in the regulation of myeloid cell activity (1-3). (rndsystems.com)
Mood disorders are polygenic disorders in which the alteration of several susceptibility genes results in dysfunctional mood regulation. (nih.gov)
Collectively, these findings support a role for the CRTC1-CREB pathway in mood disorders etiology and behavioral response to antidepressants and identify CRTC1 as an essential coactivator of genes involved in mood regulation. (nih.gov)
They are encoded by separate but linked genes termed regulation of complement activation (RCA) genes, located on the q32 region of chromosome 1. (medscape.com)

Some KAR subunit gene variants associate with psychiatric disorders. (helsinki.fi)
It belongs to the type Icytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, areceptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. (creativebiomart.net)

In this proposed project, we aimed at studying their in vivo influences on transmitter/receptor phenotypes using mutant mice whose genes of neurotrophins or related molecules are disrupted. (nii.ac.jp)
It expresses a range of cell surface molecules involved in adaptive and innate immunity, as well as crucial sentinel molecules, including toll-like receptors (TLRs), which are pivotal in early cellular defense against virus infection. (molvis.org)
The ligand binding of this receptor leads to the activation of multiple downstreamsignaling molecules, including JAK1, JAK3, STAT1, and STAT3. (creativebiomart.net)
By studying and/or generating knockout mice, the lab is exploring a role for these molecules in synaptic plasticity, learning, memory and neurological disorders. (stanford.edu)

Knockout and transgenic mice have been developed for specific T-cell disorders and are recognized to have helped predict human genetic disorders. (medscape.com)
The result was 'transgenic mice. (mentalfloss.com)

CR2/CD21 interacts with C3b degradation products C3dg and C3d and can act synergistically with the B-cell antigen receptor (BCR) in B-cell activation. (medscape.com)
In 2009, we had a seminal moment when you published a manuscript in The New England Journal of Medicine describing PLA2R, phospholipase A2 receptor, as the antigen that was responsible for a majority of the cases of MN. (medscape.com)

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene. (jax.org)
A syndrome of autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is caused by mutations in the AIRE gene coding for autoimmune regulator. (medscape.com)
Mutations in the gene coding for interleukin 2a receptor ( IL-2Ra ) have similarly caused diarrhea , candidiasis , and lymphoproliferation. (medscape.com)
But genes don't change from one tissue to the next, and - with the exception of mutations that accrue gradually over a lifetime in particular cells and can lead to cancer and other conditions - they remain largely unaltered by disease and the aging process. (stanford.edu)
Research on IGSF1 nearly ground to a halt until 2011, when next-generation sequencing identified mutations in the X-linked IGSF1 gene in boys and men with congenital central hypothyroidism. (medscape.com)
X-linked agammaglobulinemia (XLA) is an immunodeficiency caused by mutations in the gene coding for Bruton's tyrosine kinase (BTK) [Väliaho et al. (lu.se)
Noonan syndrome (NS) is caused by mutations in PTPN11 , a gene encoding the nonreceptor protein tyrosine phosphatase SHP2. (lu.se)
Mutations in the PIK3R1 gene encoding phosphatidylinositol 3-kinase (PI3-kinase) have been found to cause severe insulin resistance [Baynes et al. (lu.se)

brain-derived neurotrophic factor (BDNF), Fyn, CREB,alpha-CAMK2 and NOS.Molecular, biochemical and histochemical analyzes revealed that the neurotrophin mutant exhibited lower expression of various neurotransmitters, their receptors and the synaptic enzymes, and, in turn, the enzyme mutants contrained abnormal levels of neurotrophins. (nii.ac.jp)

These observations suggest that neurotrophins and these synaptic receptors/enzymes interact with each other during brain development and regulate synergistic synaptic development. (nii.ac.jp)

While the ERRs are orphan receptors, Prof. Giguère discovered their first synthetic ligands and has been instrumental in efforts to develop drugs that modulate their function to treat disease. (mcgill.ca)

Most cells have intracellular sensors of viral za virus and appear partially responsible for the ability of products that, when activated, initiate a signaling cascade influenza viruses to infect multiple animal species, which likely contributes to the generation of new pandemic virus- that results in transcriptional induction of the IFN gene. (cdc.gov)

In turn, neural activity regulates the expression of genes involved in the process of circuit tuning. (stanford.edu)

Their experiments in lab mice and in human blood and tissue samples further showed that this gene not only is associated with the disease, as predicted computationally, but is also likely to play a major causal role. (stanford.edu)
Choose from 1 of 10 beta-1 Adrenergic Receptor antibodies, which have been validated in experiments with 26 publications and 34 images featured in our data gallery. (thermofisher.com)
In gene-knockout experiments, the majority of mice that lack the B1AR gene die prenatally and those that do survive until adulthood display abnormal cardiac function. (thermofisher.com)
In vitro neutralization experiments with TNFalpha and in vivo studies with TNFalpha receptor knockout mice indicated that the metals directly stimulate CXC chemokine secretion without the need for TNFalpha. (cdc.gov)

Kainate receptors (KARs) are glutamate receptors that modulate neurotransmission and neuronal excitability. (helsinki.fi)
glutamate receptor, ionotropic, NMDA1. (wikigenes.org)

This review summarizes findings on the associations between OXT and AVP receptor polymorphism, social behavior, and psychiatric diseases. (frontiersin.org)

Burnstock (1999) recently put forward a hypothesis about purinergic mechanosensory transduction that proposed that in hollow organs, including the ureter and bladder, distension causes release of ATP from epithelial cells lining these organs and that ATP can then activate P2X 3 receptors on subepithelial sensory nerve terminals to evoke neural discharge. (jneurosci.org)

Knockout studies of a similar gene in mouse suggesta role for this gene in regulating immunoglobulin production. (creativebiomart.net)

Treatment with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) resulted in significant increases in PAF species in the striatum of wild-type mice. (korea.ac.kr)

Homozygous knockout mice or mice heterozygoous for a point mutation in exon 7 display an abnormal gait. (jax.org)

Dr. Mak was recognized for his seminal work to clone the T cell receptor. (cancerresearch.org)
CR1 and CR2 have been shown to influence the immune environment in a B-cell receptor-independent manner. (medscape.com)
The loss of ZAP-70 function leads to selective inability to produce CD8+ T lymphocytes and abolishes T cell receptor stimulation in mature CD4+ T lymphocytes [Arpaia, et al. (lu.se)

The Prostacyclin receptor, also termed the prostaglandin I2 receptor or just IP, is a receptor belonging to the prostaglandin (PG) group of receptors. (wikipedia.org)

The arginine vasopressin 1b receptor (Avpr1b) is involved in the modulation of a variety of behaviors and is an important part of the mammalian hormonal stress axis. (frontiersin.org)
However, the nuances of how Avp modulates behavior within specific brain regions via its two centrally expressed receptors, the Avp 1a (Avpr1a) and the Avp 1b receptor (Avpr1b), continues to be a robust and exciting area of research. (frontiersin.org)

Graphical summary of TAIMAN (TAI) /Steroid Receptor Coactivator 2 role in circadian clock. (cas.cz)
Homozygous Steroid Receptor Coactivator-2 ( SRC-2 ) knockout ( SRC-2 -/- ) mice ( Mus musculus ) exhibit a range of aberrant behavioral activities during light/dark cycles, from bimodal/phase-advanced wheel-running locomotor activity to complete arrhythmicity. (cas.cz)

FZD1/2/7 triple-knockout cells are highly resistant to TcdB, and recombinant FZD2-CRD prevented TcdB binding to the colonic epithelium. (nih.gov)
For most lines, the mouse ES cells used in generating the model are of the 129S5 strain. (taconic.com)
In the latest issue of the journal Nature, the scientists detail how mice that lack LPA receptors, which normally appear on the surface of cells in a mouse's womb, have fertility problems. (sciencedaily.com)
In this study, the Stanford scientists wanted to know which genes showed especially marked changes in activity, as indicated in earlier comparisons of diabetic vs. healthy tissue samples (notably fat, muscle, liver and beta cells, the only cells in the body that release insulin). (stanford.edu)
B ) Histological cross section through an adult mouse testis depicting seminiferous tubules, the peritubular myoid cells, and the interstitium (space between tubules). (jci.org)
In the present study, we evaluated whether BD suppresses growth and breast-to lung cancer metastasis in an orthotopic model of human breast cancer cells implanted in mice. (spandidos-publications.com)
In the present study, we evaluated toxicity and anti-cancer activities of BD in an animal model of breast-to-lung cancer metastasis with triple-negative highly invasive humane breast cancer cells MDA-MB-231 implanted in the mammary pad of nude mice. (spandidos-publications.com)
Brain cells communicate with each other by secreting messengers, such as serotonin, which bind to receptors located on the surface of receiving cells. (scienceblog.com)
The researchers also examined the effect of treatments designed to boost weak serotonin systems on p11 levels in brain cells by administering to mice two types of antidepressants - a tricyclic, a monoamine oxidase (MAO) inhibitor - and electroconvulsive therapy (ECT). (scienceblog.com)
RNA extracted from mock-infected and WNV-infected cells was assessed for differential expression of genes using Affymetrix microarray. (molvis.org)
Low-level WNV infection of hRPE cells induced expression of genes that are typically associated with the host cell response to virus infection. (molvis.org)
Using human Hep G2 cells and freshly isolated rodent hepatocytes, it was demonstrated that metals increase gene expression and secretion of CXC chemokines and TNFalpha. (cdc.gov)
This receptor transduces thegrowth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells,and natural killer (NK) cells. (creativebiomart.net)
Photoreceptor cells express the PNPLA2 gene for its receptor PEDF-R, which is responsible for PEDF-mediated neurotrophic activities. (nih.gov)
Chromatin immunoprecipitation assay, siRNA, and luciferase gene transcription assay in INS-1 cells were performed. (diabetesjournals.org)
MPTP treatment significantly increased oxidative damage, the immunoreactivity of ionized calcium binding adaptor molecule 1 (Iba-1)-positive microglial cells, and microglial differentiation of the M1 type in the striatum of wild-type mice. (korea.ac.kr)
However, dopaminergic deficits, oxidative damage, reactive microglial cells, and behavioral impairments induced by MPTP were not significantly observed in GB-treated mice or PAF-R -/- mice. (korea.ac.kr)
Mice with C5a receptor-deficient dendritic cells promote induction of Treg and Th17 cells. (medscape.com)
Because of their high numbers, red blood cells express an average of 90% of the CR1 receptors despite their having a lower number of antigenic sites per cell. (medscape.com)
Among healthy individuals, the number of CR1 receptors on the red blood cells varies widely, yet the phenotypic expression, regulated by 2 codominant alleles, is stable. (medscape.com)

β-catenin then translocates to the nucleus where it forms a complex with TCF/LEF transcription factors and activates Wnt target gene expression 28 , 29 . (nature.com)
STAT5B acts as a part of the growth hormone signalling pathway leading to stimulation of insulin-like growth factor I (IGF-I) gene transcription [Woelfle et al. (lu.se)

Mice deficient in this protein, called p11, display depression-like behaviors, while those with sufficient amounts behave as if they have been treated with antidepressants," explained Paul Greengard, Ph.D., a Rockefeller University neuroscientist who received the 2000 Nobel Prize in Physiology or Medicine for discoveries about the workings of such neuronal signaling systems. (scienceblog.com)
Compared to control mice, knockout mice had fewer receptors at the cell surface, reduced serotonin signaling, decreased responsiveness to sweet reward, and were less mobile, behaviors which are considered depression-like. (scienceblog.com)

Pyrrolidine dithiocarbamate (PDTC), an NF-κB inhibitor, significantly ameliorated the dopaminergic deficits induced by MPTP in wild-type mice. (korea.ac.kr)

For example, extracts or purified compounds from Scutellaria barbata, Astragalus membranaceus and Curcuma longa suppressed growth, induced oxidative stress and apoptosis, inhibited breast cancer cell invasiveness and prevented breast cancer metastases in mice ( 11 - 14 ). (spandidos-publications.com)

Importantly, TAIMAN is related to the mammalian SRC-2 protein, which is involved in regulating circadian clock machinery in mice ( Mus musculus ). (cas.cz)

In the present studies, cytokine gene expression and secretion were investigated in hepatocytes treated with cadmium chloride (CdCl2) or vanadium pentoxide (V2O5). (cdc.gov)
The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). (creativebiomart.net)

The colonic epithelium in FZD7-knockout mice was less susceptible to TcdB-induced tissue damage in vivo. (nih.gov)
In vivo verification was shown by a 70% reduction in GIP-R protein expression in islets from PANC PPARγ −/− mice and a twofold increase in islets of 14-day post-60% Px Sprague-Dawley rats that hyperexpress β-cell PPARγ. (diabetesjournals.org)

To evaluate the role of chondrocytes in this process, Mig6 was conditionally deleted from Col2a1-expressing cell types in the cartilage of mice.Methods Bone and cartilage in the synovial joints of cartilage-specific Mig6-deleted (knockout [KO]) mice and control littermates were compared. (bepress.com)
Scientists at The Scripps Research Institute are reporting that mice created to lack a certain type of molecule known as an LPA receptor have fertility problems, which suggests that these receptors play a major role in conception. (sciencedaily.com)
These data strongly suggest a major sensory role for urothelially released ATP acting via P2X 3 receptors on a subpopulation of pelvic afferent fibers. (jneurosci.org)
What role do such genes play, if any, in the brain's activity or the animal's behavior? (the-scientist.com)
However, little is known about the role of PAF/platelet-activating factor receptor (PAF-R) in Parkinson's disease. (korea.ac.kr)
Complement and complement receptors play a critical role in immune defense by initiating the rapid destruction of invading microorganisms, amplifying the innate and adaptive immune responses, and mediating solubilization and clearance of immune complexes. (medscape.com)

We call it an atypical atypical because it is a partial agonist at dopamine D2 and D3 receptors, meaning it stimulates the receptors a little, but in the presence of high levels of dopamine it blocks excess activity by sitting on the receptor and preventing the actions of the excess dopamine. (bipolarnews.org)
Aripiprazole is also a partial agonist at dopamine and serotonin 5HT1a receptors, but caripazine differs in that it has a particular affinity for the D3 receptor. (bipolarnews.org)

Detailed analysis of the modes of activation of the PTH/PTHrP receptor by PTH and PTHrP analogs. (massgeneral.org)
Thiazolidinedione activation (72 h) of this pathway in normal mouse islets caused a threefold increase of GIP-R protein and a doubling of insulin secretion to 16.7 mmol/l glucose/10 nmol/l GIP. (diabetesjournals.org)
The density of CR1 receptors on cell surfaces varies with the cell type and with the activation of the cell for neutrophils and monocytes. (medscape.com)

We sought to assess the pathogenicity of emerging wildtype filovirus infections in IFNAR-/- mice since filovirus models using immunocompetent mice require a mouse-adapted viral strain. (cdc.gov)

Immunohistochemistry revealed abundant nerve fibers in a suburothelial plexus in the mouse bladder that are immunoreactive to anti-P2X 3 . (jneurosci.org)
Antibodies that detect beta-1 Adrenergic Receptor can be used in several scientific applications, including Immunohistochemistry, Western Blot, Immunocytochemistry, Flow Cytometry and ELISA. (thermofisher.com)
Islet GIP-R expression and immunohistochemistry studies were performed in pancreas-specific PPARγ knockout mice (PANC PPARγ −/− ), normoglycemic 60% pancreatectomy rats (Px), normoglycemic and hyperglycemic Zucker fatty (ZF) rats, and mouse islets incubated with troglitazone. (diabetesjournals.org)

These mice provided some of the first evidence that susceptibility to cancer can be inherited, just like hair color. (mentalfloss.com)

Type I interferon receptor knockout (IFNAR-/-) mice are not able to generate a complete innate immune response, therefore, these mice are often considered to assess the pathogenicity of emerging viruses. (cdc.gov)

However, phosphorylation of the FK linker appears to be an important regulatory determinant of FKBP52-mediated potentiation of steroid receptor activity. (unboundmedicine.com)

Using computational methods, Stanford University School of Medicine investigators have strongly implicated a novel gene in the triggering of type-2 diabetes. (stanford.edu)

A minimum of four (4) mutant mice, heterozygous for the selected mutation on a mixed 129S5;B6 background. (taconic.com)
Based on our previous friendship in Cold Spring Harbor Lovoratory, we have established this collaboration project with its neuroscience group to examine a large variety of these mutant mice. (nii.ac.jp)

Decades of research on this receptor has demonstrated its importance to the modulation of social recognition memory, social forms of aggression, and modulation of the hypothalamic-pituitary-adrenal axis, particularly under conditions of acute stress. (frontiersin.org)

IP(-/-) mice) exhibit increased tendency to thrombosis in response to experimentally-induced Endothelium, a result which appears to reflect, at least in part, the loss of IP's anti-platelet activity. (wikipedia.org)
Crtc1(-/-) mice exhibit impulsive aggressiveness, social withdrawal, and decreased sexual motivation, together with increased behavioral despair, anhedonia, and anxiety-related behavior in the novelty-induced hypophagia test. (nih.gov)

In addition to the increased muscle protein degradation found during cancer growth, the presence of the tumor also induces an increased rate of DNA fragmentation in skeletal muscle in both rats and mice ( 8 ). (spandidos-publications.com)

Organisms2

Diseases7

Chemicals and Drugs14

Analytical, Diagnostic and Therapeutic Techniques and Equipment4

Phenomena and Processes19

Humanities1

Information Science4

Humans17

Binds6

Proteins4

Orphan nuclear receptors1

Target genes3

Signaling pathway1

NMDA3

Functional9

Novel receptor2

Phenotype1

Genetics2

Nuclear5

Pathways2

Tissues7

Cellular receptors1

Deficiency5

Metabolism2

Protein coupled receptor2

Regulation6

Subunit2

Molecules4

Transgenic2

Antigen2

Mutations8

BDNF1

Synaptic1

Ligands1

Transcriptional1

Regulates1

Experiments4

Glutamate2

Diseases1

Neural1

Immunoglobulin1

Species1

Abnormal1

Cell receptor3

Prostaglandin1

Avpr1b2

Coactivator2

Cells20

Transcription2

Behaviors2

Deficits1

Apoptosis1

Mammalian1

Cytokine2

Vivo2

Role6

Dopamine2

Activation3

Viral1

Immunohistochemistry3

Susceptibility1

Pathogenicity1

Steroid1

Implicated a novel1

Mutant2

Pituitary1

Exhibit2

Tumor1